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MRAVQVVGYHQNLELADVEKPTPTGPFDVVVKIGGAGVCRTDLHILEGQWAEKSQVQLPYTIGHENAGWV ESVGSAVTNVTEGDKVIVHPLITCGLCRACRSGDDVHCESNAFPGIDTNGGYAEYLKTSARSVVKIDDAL EPADVAALADAGLTAYHAAAKAARRLTPRDRVVVIGAGGLGHIGIQVLKALSPAELIVVDRNPEALKLAE AIGADHCVIADGNQIEQVRDLTGGHGAETVVDFVGEGGATSEGIAMLRRAGDYHVVGYGENIDVPTIDVI STEINFIGNLVGSYNDLCDLMALAARGAVNLHTQKYALDDFQSAITDLDNGNVRGRAILVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1977 | - | - | 100% (341) | alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3915 | - | 7e-55 | 36.26% (353) | NAD-dependent alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3464 | - | 2e-34 | 30.23% (344) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 8e-31 | 29.86% (355) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_4951 | - | 3e-38 | 30.03% (343) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 8e-31 | 29.86% (355) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 6e-31 | 29.63% (351) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 8e-33 | 30.52% (367) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_4911 | adhX | 5e-40 | 30.50% (341) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_2812 | - | 1e-31 | 28.57% (329) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4349 | - | 6e-72 | 42.69% (349) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 6e-40 | 30.32% (343) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_5450 | - | 6e-56 | 36.54% (353) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1977|M.smegmatis_MC2_155 ----------------MRAVQVVGYHQNLELADVEKPTPTGPFDVVVKIG
TH_4349|M.thermoresistible__bu ----------------MKALRLMDWKSEPELVEVPDPTP-GPGQVLVKIG
Mvan_5450|M.vanbaalenii_PYR-1 --------------MKMRAARMYGYKQPLRLEEVDVPSP-GPEEVLVRVG
MMAR_4911|M.marinum_M MTQTLANPGATQATETLCAAVVTGFGEPLQIKELALPTP-GYGEALVKLE
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTP-GYGEALVKLE
Mflv_4951|M.gilvum_PYR-GCK ----------------MQAAVVTAFGEPLVVEERDLPAP-GPGEALVKLV
MAV_2812|M.avium_104 ----------------------------MELVDTETRPP-GRDEVRLTVG
Mb2283|M.bovis_AF2122/97 ------------MSQTVRGVIARQKGEPVELVNIVVPDP-GPGEAVVDVT
Rv2259|M.tuberculosis_H37Rv ------------MSQTVRGVIARQKGEPVELVNIVVPDP-GPGEAVVDVT
MLBr_01784|M.leprae_Br4923 ------------MSQTVRGVISRKKDEPVELVDIVIPDP-GPGEAVVDVT
MAB_2084|M.abscessus_ATCC_1997 --------------MKTRAAVLWGLEQKWEVEEVDLDPP-GPGEVLVRLA
: : * * :. : :
MSMEG_1977|M.smegmatis_MC2_155 GAGVCRTDLHILEGQWAEKSQVQLPYTIGHENAGWVESVGSAVTN---VT
TH_4349|M.thermoresistible__bu GAGACHSDLHLMHDFEPGMMPWQLPFTLGHENAGWVAAVGAGVGT---VT
Mvan_5450|M.vanbaalenii_PYR-1 GAGMCRTDFQLIDGYFDNGLSMDFPITPGHEVAGWVDGVGSAVPKSAGLA
MMAR_4911|M.marinum_M TSGVCHTDLHAAHGDWPVK--PAPPFVPGHEGCGTVVALGDGVTD---LK
MUL_0495|M.ulcerans_Agy99 TSGVCHTDLHAAHGDWPVK--PAPPFVPGHEGCGTVVALGDGVTD---LK
Mflv_4951|M.gilvum_PYR-GCK TSGVCHTDLHAAHGDWPVK--PSPPFIPGHEGYGTVVAVGDGVDD---LS
MAV_2812|M.avium_104 ACGICGTDAHFVNGAFPG---LSWPLTPGHEIAGRIAELGEGVEG---FA
Mb2283|M.bovis_AF2122/97 ACGVCHTDLTYREGGINDE----YPFLLGHEAAGIIEAVGPGVTA---VE
Rv2259|M.tuberculosis_H37Rv ACGVCHTDLTYREGGINDE----YPFLLGHEAAGIIEAVGPGVTA---VE
MLBr_01784|M.leprae_Br4923 ACGVCHTDLTYREGGINDR----YPFLLGHEAAGTVEVVGPGVTA---VE
MAB_2084|M.abscessus_ATCC_1997 ATGLCHSDEHLVTGDLPIP----LPVVGGHEGAGTVVECGEGVED---LS
* * :* . * *** * : * .* .
MSMEG_1977|M.smegmatis_MC2_155 EGDKVIVHPLIT-CGLCRACRSGDDVHCESNAFP-------GIDTNGGYA
TH_4349|M.thermoresistible__bu EGDAVAVYGPWG-CGTCERCMGGAENYCENPAGAPVLSGGAGLGMDGGMA
Mvan_5450|M.vanbaalenii_PYR-1 EGDQVVVFGSWG-DGACRQCHEGNEQLCAHGVWA-------GFGRHGGYQ
MMAR_4911|M.marinum_M VGDKVGNAWLWSACGSCEQCRTGWETLCENQRNG-------GYTVNGSFG
MUL_0495|M.ulcerans_Agy99 VGDKVGNAWLWSACGSCEQCRTGWETLCENQRNG-------GYTVNGSFG
Mflv_4951|M.gilvum_PYR-GCK VGDMVGNAWLWSSCGRCEYCRTGWETLCEQQRNG-------GYSVDGSFG
MAV_2812|M.avium_104 VGQRVAVGWFGGCCYRCDPCRAGLFIHCVNGKVP-------SWHYPGGYA
Mb2283|M.bovis_AF2122/97 PGDFVILN-WRAVCGQCRACKRGRPRYCFDTFNAEQK----MTLTDGTEL
Rv2259|M.tuberculosis_H37Rv PGDFVILN-WRAVCGQCRACKRGRPRYCFDTFNAEQK----MTLTDGTEL
MLBr_01784|M.leprae_Br4923 PGDFVILN-WRAVCGQCRACKRGRPSYCFDTFNAQQK----MTLIDGTEL
MAB_2084|M.abscessus_ATCC_1997 EGDSVILT-FLPSCGRCSYCARG-MGNLCELGAALMM----GPQIDGTYR
*: * * * * *
MSMEG_1977|M.smegmatis_MC2_155 EYLKT---------------SARSVVKID--DALEPADVAALADAGLTAY
TH_4349|M.thermoresistible__bu EYLLVP--------------AERLVVKLP--ESMTPVTAAALTDAGLTPY
Mvan_5450|M.vanbaalenii_PYR-1 EYLPV---------------NYRYLIKIPGGGELSPDNLAPLTDAGLTPY
MMAR_4911|M.marinum_M TYMLV---------------NADYAARIP--DGADPLEVAPILCAGVTVY
MUL_0495|M.ulcerans_Agy99 TYMLV---------------NADYAARIP--DGADPLEVAPILCAGVTVY
Mflv_4951|M.gilvum_PYR-GCK TYMLV---------------DAAYAARIP--DGVDPVEVAPILCAGVTVY
MAV_2812|M.avium_104 ESVTV---------------PTSALARIP--EELTDAEAAPMGCAGVTTY
Mb2283|M.bovis_AF2122/97 TAALG--------IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAG
Rv2259|M.tuberculosis_H37Rv TAALG--------IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAG
MLBr_01784|M.leprae_Br4923 TPALG--------IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAG
MAB_2084|M.abscessus_ATCC_1997 FHARGEDVGQMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTG
* : .*:
MSMEG_1977|M.smegmatis_MC2_155 HAAA--KAARRLTPRDRVVVIGAGGLGHIGIQVLKALS-PAELIVVDRNP
TH_4349|M.thermoresistible__bu HAIR--RSWPKLTPTSTAVVIGVGGLGHVAVQLVKATT-AARLIAVDNRS
Mvan_5450|M.vanbaalenii_PYR-1 RGLKKLRNAGHLGPGRTVAVSGIGGLGSYATQYAKLLGGGAEVVAFARSD
MMAR_4911|M.marinum_M KGLK----VTDTRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDD
MUL_0495|M.ulcerans_Agy99 KGLK----VTDTRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDD
Mflv_4951|M.gilvum_PYR-GCK KGLK----VTDTRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDVDD
MAV_2812|M.avium_104 NALR----HTKALPGDRVAILGVGGLGHLGVQFAAAMG--FETIAINRGT
Mb2283|M.bovis_AF2122/97 LGAAIN--TGGVTRDDTVAVIGCGGVGDAAIAGAALVG-AKRIIAVDTDD
Rv2259|M.tuberculosis_H37Rv LGAAIN--TGGVTRDDTVAVIGCGGVGDAAIAGAALVG-AKRIIAVDTDD
MLBr_01784|M.leprae_Br4923 LGAAIN--TAAVSRDDTVAVIGCGGVGDAAISGAALVG-ANRIIAVDIDD
MAB_2084|M.abscessus_ATCC_1997 YGSAVR--TGEVRAGDTVVVVGAGGIGMNAIQGARIAG-ALAIVAVDPVN
. ..: * **:* . :..
MSMEG_1977|M.smegmatis_MC2_155 EALKLAEAIGADHCVIADGNQIEQVR----DLTGGHGAETVVDFVGEGG-
TH_4349|M.thermoresistible__bu EALELAREMGADHVVRSDEQAVEAIW----ELTGGRGADVLLDFVGADA-
Mvan_5450|M.vanbaalenii_PYR-1 EKLKIAKDNGADHVVNVRDKDTEDVRAELESATGRTELDAVIECAGSED-
MMAR_4911|M.marinum_M DKLALAARLGAELVVNARTSDVVAQV-----QEATGGVHGVLVTAVHPQ-
MUL_0495|M.ulcerans_Agy99 DKLALAARLGAELVVNARTSDVVAQV-----QEATGGVHGVLVTAVHPQ-
Mflv_4951|M.gilvum_PYR-GCK SKLDLATGLGAEVVVNARTADVVAEV-----HRATGGVHGVLVTAVHRD-
MAV_2812|M.avium_104 GKADDARKLGAHHYIDS-TAEDPAEA-----LRALGGAAVVLATAGNSQ-
Mb2283|M.bovis_AF2122/97 TKLDWARTFGATHTVNAREVDVVQAIG---GLTDGFGADVVIDAVGRPE-
Rv2259|M.tuberculosis_H37Rv TKLDWARTFGATHTVNAREVDVVQAIG---GLTDGFGADVVIDAVGRPE-
MLBr_01784|M.leprae_Br4923 TKLEWARTFGATHTVNALELEVVKTIQ---DLTSGFGVDVVIDTVGRPE-
MAB_2084|M.abscessus_ATCC_1997 FKREQASGFGATHTAASMD-EAWSLVS---DMTRGKLADVCILTTDVAEG
* ** : .
MSMEG_1977|M.smegmatis_MC2_155 -ATSEGIAMLRRAGDYHVVGY---GEN-IDVPTIDVISTEINFIGNLVG-
TH_4349|M.thermoresistible__bu -TIELARAAARPLGDVTIVGI---AGG-SVPLSFFSQPYEVSIQTTYWG-
Mvan_5450|M.vanbaalenii_PYR-1 -SIRLAFSLLAAEGAVASVGL---IGNRVDIPLFPLVAREYTFYGSFWG-
MMAR_4911|M.marinum_M -AFGQAIGLARRGGTIVFNGL---PPGDFPAPIFDIVLKGLTIRGSIVG-
MUL_0495|M.ulcerans_Agy99 -AFGQAIGLARRGGTIVFNGL---PPGDFPAPIFVIVLKGLTIRGSIVG-
Mflv_4951|M.gilvum_PYR-GCK -AFGQAIGLARRGGTIVFVGL---PPGDFPAPIFDIVLKGLTIRGSIVG-
MAV_2812|M.avium_104 -AMAATVGGLAPQGELVTIGV---TPEPLPISPLQLITPGLSIVGHPSG-
Mb2283|M.bovis_AF2122/97 -TYQQAFYARDLAGTVVLVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGD
Rv2259|M.tuberculosis_H37Rv -TYQQAFYARDLAGTVVLVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGD
MLBr_01784|M.leprae_Br4923 -TWKQAFYARDLAGTVVLVGVPTPDMR-LDMPLLDFFSHGGSLKSSWYGD
MAB_2084|M.abscessus_ATCC_1997 SYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGS
* . . : *
MSMEG_1977|M.smegmatis_MC2_155 -----SYNDLCDLMALAARGAVNLHTQKYALDDFQSAITDLDNGNVRGRA
TH_4349|M.thermoresistible__bu -----TRPELVELLDLAARGLVHVESTTYPLDDALQAYRDLRAGRVRGRA
Mvan_5450|M.vanbaalenii_PYR-1 -----NYNDLTEVLALARTGQLKHSVTRVRFDDVNETLEAIARGDVLGRA
MMAR_4911|M.marinum_M -----TRQDMAEALDFYARGLIHPTVEGAALEDINHVFERMERGQIDGRV
MUL_0495|M.ulcerans_Agy99 -----TRQDMAEALDFYARGLIHPTVEGAALEDINHVFERMERGQIDGRV
Mflv_4951|M.gilvum_PYR-GCK -----TRQDMVEAIDFFARGLVHPTVHTTRLDDINDVFDRMERGQIDGRV
MAV_2812|M.avium_104 -----TAKDVEDTMQFAVLSGVRAWIEELPLSRAADGYAALEGGRAHYRT
Mb2283|M.bovis_AF2122/97 CLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMHGGKVLRSV
Rv2259|M.tuberculosis_H37Rv CLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMHGGKVLRSV
MLBr_01784|M.leprae_Br4923 CLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSV
MAB_2084|M.abscessus_ATCC_1997 SNAPHDIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGL
: : . : : *
MSMEG_1977|M.smegmatis_MC2_155 ILVP-
TH_4349|M.thermoresistible__bu VIVP-
Mvan_5450|M.vanbaalenii_PYR-1 VIVYD
MMAR_4911|M.marinum_M VIDYR
MUL_0495|M.ulcerans_Agy99 VIDYR
Mflv_4951|M.gilvum_PYR-GCK VIDYR
MAV_2812|M.avium_104 VLTM-
Mb2283|M.bovis_AF2122/97 VML--
Rv2259|M.tuberculosis_H37Rv VML--
MLBr_01784|M.leprae_Br4923 VML--
MAB_2084|M.abscessus_ATCC_1997 VRF--
: