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MKMRAARMYGYKQPLRLEEVDVPSPGPEEVLVRVGGAGMCRTDFQLIDGYFDNGLSMDFPITPGHEVAGW VDGVGSAVPKSAGLAEGDQVVVFGSWGDGACRQCHEGNEQLCAHGVWAGFGRHGGYQEYLPVNYRYLIKI PGGGELSPDNLAPLTDAGLTPYRGLKKLRNAGHLGPGRTVAVSGIGGLGSYATQYAKLLGGGAEVVAFAR SDEKLKIAKDNGADHVVNVRDKDTEDVRAELESATGRTELDAVIECAGSEDSIRLAFSLLAAEGAVASVG LIGNRVDIPLFPLVAREYTFYGSFWGNYNDLTEVLALARTGQLKHSVTRVRFDDVNETLEAIARGDVLGR AVIVYD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5450 | - | - | 100% (356) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2080 | - | 4e-31 | 30.20% (351) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3073 | - | 3e-27 | 29.97% (347) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3071 | adhC | 4e-26 | 27.07% (351) | NADP-dependent alcohol dehydrogenase ADHC |
| M. gilvum PYR-GCK | Mflv_4951 | - | 8e-48 | 36.44% (354) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3045 | adhC | 4e-26 | 27.07% (351) | NADP-dependent alcohol dehydrogenase ADHC |
| M. leprae Br4923 | MLBr_02053 | - | 1e-27 | 33.69% (282) | putative alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 8e-33 | 29.26% (352) | NADP-dependent alcohol dehydrogenase C |
| M. marinum M | MMAR_4911 | adhX | 2e-45 | 35.23% (352) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_2812 | - | 3e-28 | 30.62% (307) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3915 | - | 1e-166 | 76.97% (356) | NAD-dependent alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 3e-51 | 36.67% (360) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 3e-46 | 35.31% (354) | Zn-dependent alcohol dehydrogenase, AdhX |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5450|M.vanbaalenii_PYR-1 --------------MKMRAARMYGYK----QPLRLEEVDVPSPGPEEVLV
MSMEG_3915|M.smegmatis_MC2_155 --------------MKMRAARMHGYK----QPLRLEEIPVPTPGPEEVLV
TH_4349|M.thermoresistible__bu ----------------MKALRLMDWK----SEPELVEVPDPTPGPGQVLV
MMAR_4911|M.marinum_M MTQTLANPGATQATETLCAAVVTGFG----EPLQIKELALPTPGYGEALV
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFG----EPLQIKELALPTPGYGEALV
Mflv_4951|M.gilvum_PYR-GCK ----------------MQAAVVTAFG----EPLVVEERDLPAPGPGEALV
MLBr_02053|M.leprae_Br4923 ----------------MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSELLV
Mb3071|M.bovis_AF2122/97 -------------MSTVAAYAAMSAT----EPLTKTTITRRDPGPHDVAI
Rv3045|M.tuberculosis_H37Rv -------------MSTVAAYAAMSAT----EPLTKTTITRRDPGPHDVAI
MAB_3400|M.abscessus_ATCC_1997 -------------MVTVSAYAATSGK----DPLVPTTIERREVGPHDVFI
MAV_2812|M.avium_104 --------------------------------MELVDTETRPPGRDEVRL
: :
Mvan_5450|M.vanbaalenii_PYR-1 RVGGAGMCRTDFQLIDGYFDNGLSMDFPITPGHEVAGWVDGVGSAVPKSA
MSMEG_3915|M.smegmatis_MC2_155 EVGGAGMCRTDFQLIDGYFDRGQDMGFPFTPGHEIAGWVDSIGSQVPASA
TH_4349|M.thermoresistible__bu KIGGAGACHSDLHLMHDFEPGMMPWQLPFTLGHENAGWVAAVGAGVGT--
MMAR_4911|M.marinum_M KLETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALG---DGVT
MUL_0495|M.ulcerans_Agy99 KLETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALG---DGVT
Mflv_4951|M.gilvum_PYR-GCK KLVTSGVCHTDLHAAHGDWP--VKPSPPFIPGHEGYGTVVAVG---DGVD
MLBr_02053|M.leprae_Br4923 AVRACGVCRTDLHVAEGDLP--VHR-EHVTPGHEVVGEVLGVGSDVDAAA
Mb3071|M.bovis_AF2122/97 DIKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVG---SEVT
Rv3045|M.tuberculosis_H37Rv DIKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVG---SEVT
MAB_3400|M.abscessus_ATCC_1997 DIKFAGICHSDIHTVRDEWG---RANYPIVPGHEIAGVITEVG---SEVT
MAV_2812|M.avium_104 TVGACGICGTDAHFVNGAFP---GLSWPLTPGHEIAGRIAELG---EGVE
: .* * :* : . *** * : :*
Mvan_5450|M.vanbaalenii_PYR-1 GLAEGDQVVVFGSWG-DGACRQCHEGNEQLCAHGV--------WAGFGRH
MSMEG_3915|M.smegmatis_MC2_155 GLSEGDQVVVYGGWG-DGTCRQCQGGNEQICPQGH--------WVGFGGH
TH_4349|M.thermoresistible__bu -VTEGDAVAVYGPWG-CGTCERCMGGAENYCENPAGA-PVLSGGAGLGMD
MMAR_4911|M.marinum_M DLKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------NGGYTVN
MUL_0495|M.ulcerans_Agy99 DLKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------NGGYTVN
Mflv_4951|M.gilvum_PYR-GCK DLSVGDMVGNAWLWSSCGRCEYCRTGWETLCEQQR--------NGGYSVD
MLBr_02053|M.leprae_Br4923 GFDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQSR--------YTGWDVD
Mb3071|M.bovis_AF2122/97 KYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQ
Rv3045|M.tuberculosis_H37Rv KYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQ
MAB_3400|M.abscessus_ATCC_1997 KFKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQ
MAV_2812|M.avium_104 GFAVGQRVAVGWFGGCCYRCDPCRAGLFIHCVNGKVPSWHYP--------
*: . * * * *
Mvan_5450|M.vanbaalenii_PYR-1 GGYQEYLPVNYRYLIKIPGGGELSPDNLAPLTDAGLTPYRGLKKLRNAGH
MSMEG_3915|M.smegmatis_MC2_155 GGYQEYVPVHHRYLIPVAGRDGLTPATLAPLTDAGLTPYRGLKKLRAAGV
TH_4349|M.thermoresistible__bu GGMAEYLLVPAERLVVKLP-ESMTPVTAAALTDAGLTPYHAIR--RSWPK
MMAR_4911|M.marinum_M GSFGTYMLVNADYAARIPD--GADPLEVAPILCAGVTVYKGLK----VTD
MUL_0495|M.ulcerans_Agy99 GSFGTYMLVNADYAARIPD--GADPLEVAPILCAGVTVYKGLK----VTD
Mflv_4951|M.gilvum_PYR-GCK GSFGTYMLVDAAYAARIPD--GVDPVEVAPILCAGVTVYKGLK----VTD
MLBr_02053|M.leprae_Br4923 GGYAEFTTVPAAFAHHLPS--GYSDCELAPLLCAGIIGYRSLL----RSE
Mb3071|M.bovis_AF2122/97 GGYSEAIVVDENYVLRIPD--VLPLDVAAPLLCAGITLYSPLR----HWN
Rv3045|M.tuberculosis_H37Rv GGYSEAIVVDENYVLRIPD--VLPLDVAAPLLCAGITLYSPLR----HWN
MAB_3400|M.abscessus_ATCC_1997 GGYSQAIVVDENYVLRIPD--SLPLDAAAPLLCAGITTFSPLR----HWN
MAV_2812|M.avium_104 GGYAESVTVPTSALARIPE--ELTDAEAAPMGCAGVTTYNALR----HTK
*. * *.: **: : :
Mvan_5450|M.vanbaalenii_PYR-1 LGPGRTVAVSGIGGLGSYATQYAKLLGGGAEVVAFARSDEKLKIAKDNGA
MSMEG_3915|M.smegmatis_MC2_155 LGAGRTVAVTGIGGLGSYGTQYAKLLGGGAAVVAFARSDEKLKVATDNGA
TH_4349|M.thermoresistible__bu LTPTSTAVVIGVGGLGHVAVQLVKATT-AARLIAVDNRSEALELAREMGA
MMAR_4911|M.marinum_M TRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLALAARLGA
MUL_0495|M.ulcerans_Agy99 TRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLALAARLGA
Mflv_4951|M.gilvum_PYR-GCK TRPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDVDDSKLDLATGLGA
MLBr_02053|M.leprae_Br4923 LPPGGRLGIYGFGGSAHIAAQVALVQG--AEVHVMTRGARAQELALELG-
Mb3071|M.bovis_AF2122/97 AGANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMEDGLRLGA
Rv3045|M.tuberculosis_H37Rv AGANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMEDGLRLGA
MAB_3400|M.abscessus_ATCC_1997 AGPGKRVAVVGLGGLGHMAVKLGKAMG--AEVTVLSQSLKKMEDGLRLGA
MAV_2812|M.avium_104 ALPGDRVAILGVGGLGHLGVQFAAAMG--FETIAINRGTGKADDARKLGA
. : *.** . ..: .. . *
Mvan_5450|M.vanbaalenii_PYR-1 DHVVNVRDKDTEDVRAELESATGRTELDAVIECAGSEDSIRLAFSLLAAE
MSMEG_3915|M.smegmatis_MC2_155 DHAINVRDKSAEEVRGELQNLTGRGEIDAVIECAGSVESIQLAFDLLATE
TH_4349|M.thermoresistible__bu DHVV----RSDEQAVEAIWELTGGRGADVLLDFVGADATIELARAAARPL
MMAR_4911|M.marinum_M ELVVN---ARTSDVVAQVQEATGG--VHGVLVTAVHPQAFGQAIGLARRG
MUL_0495|M.ulcerans_Agy99 ELVVN---ARTSDVVAQVQEATGG--VHGVLVTAVHPQAFGQAIGLARRG
Mflv_4951|M.gilvum_PYR-GCK EVVVN---ARTADVVAEVHRATGG--VHGVLVTAVHRDAFGQAIGLARRG
MLBr_02053|M.leprae_Br4923 --------AASAQGVADLPPVP----LDAAIVFAPVGDLVLPACEALNRG
Mb3071|M.bovis_AF2122/97 KSYYA------TADPDTFRKLR--GGFDLILNTVSANLDLGQYLNLLDVD
Rv3045|M.tuberculosis_H37Rv KSYYA------TADPDTFRKLR--GGFDLILNTVSANLDLGQYLNLLDVD
MAB_3400|M.abscessus_ATCC_1997 SHYYA------TADPDTFKSLR--NSFDLILNTVSSNLDMGKYLGLLGVD
MAV_2812|M.avium_104 HHYID------STAEDPAEALRALGGAAVVLATAGNSQAMAATVGGLAPQ
: . .
Mvan_5450|M.vanbaalenii_PYR-1 GAVASVGLIGNRVDIPLFPLVAREYTFYG-SFWGNYNDLTEVLALARTGQ
MSMEG_3915|M.smegmatis_MC2_155 GAVASVGLIGNRIDIPLFPLVAREFSYFG-SFWGNYNDLTEVLALAEAGQ
TH_4349|M.thermoresistible__bu GDVTIVGIAGGSVPLSFFS-QPYEVSIQT-TYWGTRPELVELLDLAARGL
MMAR_4911|M.marinum_M GTIVFNGLPPGDFPAPIFDIVLKG-LTIRGSIVGTRQDMAEALDFYARGL
MUL_0495|M.ulcerans_Agy99 GTIVFNGLPPGDFPAPIFVIVLKG-LTIRGSIVGTRQDMAEALDFYARGL
Mflv_4951|M.gilvum_PYR-GCK GTIVFVGLPPGDFPAPIFDIVLKG-LTIRGSIVGTRQDMVEAIDFFARGL
MLBr_02053|M.leprae_Br4923 GTLAIAGIHLSDIPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHH
Mb3071|M.bovis_AF2122/97 GTLVELGIPEHPMAVPAFALALMRRSLAG-SNIGGIAETQEMLNFCAEHG
Rv3045|M.tuberculosis_H37Rv GTLVELGIPEHPMAVPAFALALMRRSLAG-SNIGGIAETQEMLNFCAEHG
MAB_3400|M.abscessus_ATCC_1997 GTLVELGLPENPIEVPGFPLLTNRRSISG-SLIGGIPETQEMLDFCAKHG
MAV_2812|M.avium_104 GELVTIGVTPEPLPISPLQLITPGLSIVG-HPSGTAKDVEDTMQFAVLSG
* :. *: . . : : :
Mvan_5450|M.vanbaalenii_PYR-1 LKHSVTRVRFDDVNETLEAIARGDVLGRAVIVYD--
MSMEG_3915|M.smegmatis_MC2_155 IRHTVTPVQFDDINATIDAIAAGEVLGRAVVVYD--
TH_4349|M.thermoresistible__bu VHVESTTYPLDDALQAYRDLRAGRVRGRAVIVP---
MMAR_4911|M.marinum_M IHPTVEGAALEDINHVFERMERGQIDGRVVIDYR--
MUL_0495|M.ulcerans_Agy99 IHPTVEGAALEDINHVFERMERGQIDGRVVIDYR--
Mflv_4951|M.gilvum_PYR-GCK VHPTVHTTRLDDINDVFDRMERGQIDGRVVIDYR--
MLBr_02053|M.leprae_Br4923 IAVTTPEYPLEQADQALTDLSVGRISGAAVLLA---
Mb3071|M.bovis_AF2122/97 VTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
Rv3045|M.tuberculosis_H37Rv VTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
MAB_3400|M.abscessus_ATCC_1997 IGSEIEVIDASYINEAYERVVASDVRYRFVIDTQTL
MAV_2812|M.avium_104 VRAWIEELPLSRAADGYAALEGGRAHYRTVLTM---
: . : . *: