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MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGGINDEYPFLLGHEAAGIIE AVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLV HSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAV DTDDTKLDWARTFGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGV PTPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMH GGKVLRSVVML
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | - | 100% (361) | Probable zinc-dependent alcohol dehydrogenase AdhE2 |
| M. tuberculosis H37Rv | Rv3086 | adhD | 3e-54 | 34.72% (360) | zinc-type alcohol dehydrogenase AdhD |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 2e-53 | 34.77% (371) | zinc-type alcohol dehydrogenase E subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 0.0 | 100.00% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_2766 | - | 0.0 | 83.24% (364) | alcohol dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 0.0 | 88.92% (361) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 1e-171 | 83.24% (346) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_3350 | adhE2 | 0.0 | 90.30% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. avium 104 | MAV_5022 | - | 3e-52 | 34.65% (355) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_4340 | - | 0.0 | 84.49% (361) | NAD/mycothiol-dependent formaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 1e-180 | 83.66% (361) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 0.0 | 90.30% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 0.0 | 83.66% (361) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2259|M.tuberculosis_H37Rv MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MMAR_3350|M.marinum_M MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
MUL_1292|M.ulcerans_Agy99 MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
Mflv_2766|M.gilvum_PYR-GCK MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD
Mvan_3767|M.vanbaalenii_PYR-1 MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYRE
MSMEG_4340|M.smegmatis_MC2_155 MPQTVRGVISRSKQQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE
MAV_5022|M.avium_104 MLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVD
:.:.:: :. ** .*.:* : *.*:**:** :
Rv2259|M.tuberculosis_H37Rv GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK
Mb2283|M.bovis_AF2122/97 GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK
MLBr_01784|M.leprae_Br4923 GGINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRACK
MMAR_3350|M.marinum_M GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK
MUL_1292|M.ulcerans_Agy99 GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK
Mflv_2766|M.gilvum_PYR-GCK GGINDEFPFLLGHEAAGIVETVGQGVTNVAPGDFVILNWRAVCGQCRACK
Mvan_3767|M.vanbaalenii_PYR-1 GGINDEFPFLLGHEAAGTVESVGAGVTNVAPGDFVVLNWRAVCGQCRACK
MSMEG_4340|M.smegmatis_MC2_155 GGINDEFPFLLGHEAAGTVEAVGEGVTNVAPGDFVILNWRAVCGQCRACK
TH_4627|M.thermoresistible__bu GGINDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRACK
MAB_1869c|M.abscessus_ATCC_199 GGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVCRACK
MAV_5022|M.avium_104 GNRVRPVPMLLGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACA
*. *:******** :* ** **: : * *:* : . ** * **
Rv2259|M.tuberculosis_H37Rv RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS
Mb2283|M.bovis_AF2122/97 RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS
MLBr_01784|M.leprae_Br4923 RGRPSYCFDTFNAQQKMTLI--------DGTELTPALGIGAFADKTLVHS
MMAR_3350|M.marinum_M RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS
MUL_1292|M.ulcerans_Agy99 RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS
Mflv_2766|M.gilvum_PYR-GCK RGRPHLCFDTHNAAQKMTLT--------DGTELTPALGIGAFADKTLVHE
Mvan_3767|M.vanbaalenii_PYR-1 RGRPHLCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHE
MSMEG_4340|M.smegmatis_MC2_155 RGRPHLCFDTFNATQKMTLT--------DGTELTPALGIGAFADKTLVHE
TH_4627|M.thermoresistible__bu RGRPHLCFDTFNATQKMTLG--------DGTELTPALGIGAFAEKTLVHE
MAB_1869c|M.abscessus_ATCC_199 RGRPQYCFDTFNAAQKMTLT--------DGTELTPALGIGAFIEKTLVHA
MAV_5022|M.avium_104 TEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNR
* * ** * : **:..* :::*:
Rv2259|M.tuberculosis_H37Rv GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG
Mb2283|M.bovis_AF2122/97 GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG
MLBr_01784|M.leprae_Br4923 GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVG
MMAR_3350|M.marinum_M GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG
MUL_1292|M.ulcerans_Agy99 GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG
Mflv_2766|M.gilvum_PYR-GCK GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITRDDTVAVIGCGGVG
Mvan_3767|M.vanbaalenii_PYR-1 GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNRDDTVAVIGCGGVG
MSMEG_4340|M.smegmatis_MC2_155 GQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVTRDDTVAVIGCGGVG
TH_4627|M.thermoresistible__bu GQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGCGGVG
MAB_1869c|M.abscessus_ATCC_199 GQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVG
MAV_5022|M.avium_104 ASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVG
....:* . . . ...****.*::* **.:*.. .:****:* ****
Rv2259|M.tuberculosis_H37Rv DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG
Mb2283|M.bovis_AF2122/97 DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG
MLBr_01784|M.leprae_Br4923 DAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELE-VVKTIQ
MMAR_3350|M.marinum_M DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ
MUL_1292|M.ulcerans_Agy99 DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ
Mflv_2766|M.gilvum_PYR-GCK DAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTINAKDLD-PVKTIQ
Mvan_3767|M.vanbaalenii_PYR-1 DAAIAGARLVGAKRIIAVDMDNRKLDWAREFGATHTINAGELD-AVKTIQ
MSMEG_4340|M.smegmatis_MC2_155 DAAIAGAALVGAKKIIAVDMDNKKLDWAREFGATHTVNAKDLD-AVETIQ
TH_4627|M.thermoresistible__bu DAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTD-VVEAIQ
MAB_1869c|M.abscessus_ATCC_199 DAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQ
MAV_5022|M.avium_104 MAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTP---------QQ
**: * .. ::*:* ** *: :** .: .
Rv2259|M.tuberculosis_H37Rv GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL
Mb2283|M.bovis_AF2122/97 GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL
MLBr_01784|M.leprae_Br4923 DLTSGFGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
MMAR_3350|M.marinum_M DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
MUL_1292|M.ulcerans_Agy99 DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
Mflv_2766|M.gilvum_PYR-GCK DLTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLDMPL
Mvan_3767|M.vanbaalenii_PYR-1 DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL
MSMEG_4340|M.smegmatis_MC2_155 DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMKLEMPL
TH_4627|M.thermoresistible__bu ELTDGFGADVVVDAVGRPETWEQAFYARDLAGTVVLVGVPTPDMRIDMPL
MAB_1869c|M.abscessus_ATCC_199 ELTDEFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL
MAV_5022|M.avium_104 AVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITVSP
: . . **:::**:* : : *: .* .: **:*.** : :.
Rv2259|M.tuberculosis_H37Rv VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED
Mb2283|M.bovis_AF2122/97 VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED
MLBr_01784|M.leprae_Br4923 LDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGD
MMAR_3350|M.marinum_M VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG
MUL_1292|M.ulcerans_Agy99 VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG
Mflv_2766|M.gilvum_PYR-GCK IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERITLDQ
Mvan_3767|M.vanbaalenii_PYR-1 IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERIGLDQ
MSMEG_4340|M.smegmatis_MC2_155 IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRLPLEKFVSERIGLDG
TH_4627|M.thermoresistible__bu IDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQGRLPLEKFVTERIALDE
MAB_1869c|M.abscessus_ATCC_199 IDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSERIGIES
MAV_5022|M.avium_104 LGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLED
:.*.:.* :* .*: *..:*. *:* ::.*: **:*: :*:. * :
Rv2259|M.tuberculosis_H37Rv VEEAFHKMHGG---KVLRSVVML--
Mb2283|M.bovis_AF2122/97 VEEAFHKMHGG---KVLRSVVML--
MLBr_01784|M.leprae_Br4923 VEEAFHKIHGG---KVLRSVVML--
MMAR_3350|M.marinum_M IEEAFEKMHAG---KVLRSVVVL--
MUL_1292|M.ulcerans_Agy99 IEEAFEKMHAG---KVLRSVVVL--
Mflv_2766|M.gilvum_PYR-GCK IEDAFHKMHAGSDDVVLRSVVVL--
Mvan_3767|M.vanbaalenii_PYR-1 IEDAFDKMHAG---EVLRSVVVL--
MSMEG_4340|M.smegmatis_MC2_155 IEDAFHKMHAG---EVLRSVVVLDR
TH_4627|M.thermoresistible__bu VEGAFEKMQRG---EVLRSVVVLK-
MAB_1869c|M.abscessus_ATCC_199 IEAAFEKMHHG---EVLRSVVVL--
MAV_5022|M.avium_104 INEAMDHLADG---TAVRQLIRFDA
:: *:.:: * .:*.:: :