For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KMRAARMHGYKQPLRLEEIPVPTPGPEEVLVEVGGAGMCRTDFQLIDGYFDRGQDMGFPFTPGHEIAGWV DSIGSQVPASAGLSEGDQVVVYGGWGDGTCRQCQGGNEQICPQGHWVGFGGHGGYQEYVPVHHRYLIPVA GRDGLTPATLAPLTDAGLTPYRGLKKLRAAGVLGAGRTVAVTGIGGLGSYGTQYAKLLGGGAAVVAFARS DEKLKVATDNGADHAINVRDKSAEEVRGELQNLTGRGEIDAVIECAGSVESIQLAFDLLATEGAVASVGL IGNRIDIPLFPLVAREFSYFGSFWGNYNDLTEVLALAEAGQIRHTVTPVQFDDINATIDAIAAGEVLGRA VVVYD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3915 | - | - | 100% (356) | NAD-dependent alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1977 | - | 8e-55 | 36.26% (353) | alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6834 | - | 2e-33 | 31.49% (343) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3071 | adhC | 3e-25 | 28.21% (351) | NADP-dependent alcohol dehydrogenase ADHC |
| M. gilvum PYR-GCK | Mflv_4951 | - | 3e-41 | 33.33% (354) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3045 | adhC | 3e-25 | 28.21% (351) | NADP-dependent alcohol dehydrogenase ADHC |
| M. leprae Br4923 | MLBr_01730 | adhA | 4e-25 | 26.29% (350) | alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 2e-28 | 27.76% (353) | NADP-dependent alcohol dehydrogenase C |
| M. marinum M | MMAR_4911 | adhX | 1e-39 | 32.39% (352) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_2812 | - | 2e-27 | 30.67% (313) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4349 | - | 1e-52 | 37.05% (359) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 2e-40 | 32.49% (354) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_5450 | - | 1e-166 | 76.97% (356) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3915|M.smegmatis_MC2_155 -----------------MKMRAARMHGYKQPLRLEEIPVPTPGPEEVLVE
Mvan_5450|M.vanbaalenii_PYR-1 -----------------MKMRAARMYGYKQPLRLEEVDVPSPGPEEVLVR
TH_4349|M.thermoresistible__bu -------------------MKALRLMDWKSEPELVEVPDPTPGPGQVLVK
MMAR_4911|M.marinum_M ---MTQTLANPGATQATETLCAAVVTGFGEPLQIKELALPTPGYGEALVK
MUL_0495|M.ulcerans_Agy99 ---MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTPGYGEALVK
Mflv_4951|M.gilvum_PYR-GCK -------------------MQAAVVTAFGEPLVVEERDLPAPGPGEALVK
Mb3071|M.bovis_AF2122/97 ----------------MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAID
Rv3045|M.tuberculosis_H37Rv ----------------MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAID
MLBr_01730|M.leprae_Br4923 MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQ
MAB_3400|M.abscessus_ATCC_1997 ----------------MVTVSAYAATSGKDPLVPTTIERREVGPHDVFID
MAV_2812|M.avium_104 -------------------------------MELVDTETRPPGRDEVRLT
* :. :
MSMEG_3915|M.smegmatis_MC2_155 VGGAGMCRTDFQLIDGYFDRGQDMGFPFTPGHEIAGWVDSIGSQVPASAG
Mvan_5450|M.vanbaalenii_PYR-1 VGGAGMCRTDFQLIDGYFDNGLSMDFPITPGHEVAGWVDGVGSAVPKSAG
TH_4349|M.thermoresistible__bu IGGAGACHSDLHLMHDFEPGMMPWQLPFTLGHENAGWVAAVGAGVGT---
MMAR_4911|M.marinum_M LETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALGDGVTD---
MUL_0495|M.ulcerans_Agy99 LETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALGDGVTD---
Mflv_4951|M.gilvum_PYR-GCK LVTSGVCHTDLHAAHGDWP--VKPSPPFIPGHEGYGTVVAVGDGVDD---
Mb3071|M.bovis_AF2122/97 IKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGSEVTK---
Rv3045|M.tuberculosis_H37Rv IKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGSEVTK---
MLBr_01730|M.leprae_Br4923 IKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGTEVTK---
MAB_3400|M.abscessus_ATCC_1997 IKFAGICHSDIHTVRDEWG---RANYPIVPGHEIAGVITEVGSEVTK---
MAV_2812|M.avium_104 VGACGICGTDAHFVNGAFP---GLSWPLTPGHEIAGRIAELGEGVEG---
: .* * :* : *. *** * : :* *
MSMEG_3915|M.smegmatis_MC2_155 LSEGDQVVVYGGWG-DGTCRQCQGGNEQICPQGH--------WVGFGGHG
Mvan_5450|M.vanbaalenii_PYR-1 LAEGDQVVVFGSWG-DGACRQCHEGNEQLCAHGV--------WAGFGRHG
TH_4349|M.thermoresistible__bu VTEGDAVAVYGPWG-CGTCERCMGGAENYCENPAGA-PVLSGGAGLGMDG
MMAR_4911|M.marinum_M LKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------NGGYTVNG
MUL_0495|M.ulcerans_Agy99 LKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------NGGYTVNG
Mflv_4951|M.gilvum_PYR-GCK LSVGDMVGNAWLWSSCGRCEYCRTGWETLCEQQR--------NGGYSVDG
Mb3071|M.bovis_AF2122/97 YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQG
Rv3045|M.tuberculosis_H37Rv YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQG
MLBr_01730|M.leprae_Br4923 HKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQG
MAB_3400|M.abscessus_ATCC_1997 FKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQTQG
MAV_2812|M.avium_104 FAVGQRVAVGWFGGCCYRCDPCRAGLFIHCVNGKVPSWHYP--------G
*: . . * * * * *
MSMEG_3915|M.smegmatis_MC2_155 GYQEYVPVHHRYLIPVAGRDGLTPATLAPLTDAGLTPYRGLKKLRAAGVL
Mvan_5450|M.vanbaalenii_PYR-1 GYQEYLPVNYRYLIKIPGGGELSPDNLAPLTDAGLTPYRGLKKLRNAGHL
TH_4349|M.thermoresistible__bu GMAEYLLVPAERLVVKLP-ESMTPVTAAALTDAGLTPYHAIR--RSWPKL
MMAR_4911|M.marinum_M SFGTYMLVNADYAARIPD--GADPLEVAPILCAGVTVYKGLK----VTDT
MUL_0495|M.ulcerans_Agy99 SFGTYMLVNADYAARIPD--GADPLEVAPILCAGVTVYKGLK----VTDT
Mflv_4951|M.gilvum_PYR-GCK SFGTYMLVDAAYAARIPD--GVDPVEVAPILCAGVTVYKGLK----VTDT
Mb3071|M.bovis_AF2122/97 GYSEAIVVDENYVLRIPD--VLPLDVAAPLLCAGITLYSPLR----HWNA
Rv3045|M.tuberculosis_H37Rv GYSEAIVVDENYVLRIPD--VLPLDVAAPLLCAGITLYSPLR----HWNA
MLBr_01730|M.leprae_Br4923 GYSQAIVVDENFVVHIPD--ALPLDAAAPLLCAGITLYSPLR----HWNA
MAB_3400|M.abscessus_ATCC_1997 GYSQAIVVDENYVLRIPD--SLPLDAAAPLLCAGITTFSPLR----HWNA
MAV_2812|M.avium_104 GYAESVTVPTSALARIPE--ELTDAEAAPMGCAGVTTYNALR----HTKA
. : * *.: **:* : ::
MSMEG_3915|M.smegmatis_MC2_155 GAGRTVAVTGIGGLGSYGTQYAKLLGGGAAVVAFARSDEKLKVATDNGAD
Mvan_5450|M.vanbaalenii_PYR-1 GPGRTVAVSGIGGLGSYATQYAKLLGGGAEVVAFARSDEKLKIAKDNGAD
TH_4349|M.thermoresistible__bu TPTSTAVVIGVGGLGHVAVQLVKATT-AARLIAVDNRSEALELAREMGAD
MMAR_4911|M.marinum_M RPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLALAARLGAE
MUL_0495|M.ulcerans_Agy99 RPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLALAARLGAE
Mflv_4951|M.gilvum_PYR-GCK RPGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDVDDSKLDLATGLGAE
Mb3071|M.bovis_AF2122/97 GANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMEDGLRLGAK
Rv3045|M.tuberculosis_H37Rv GANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMEDGLRLGAK
MLBr_01730|M.leprae_Br4923 KPGTRLAIIGLGGLGHMGVKLGRKMG--CEVTVLSQSLKKMEDGLQLGAS
MAB_3400|M.abscessus_ATCC_1997 GPGKRVAVVGLGGLGHMAVKLGKAMG--AEVTVLSQSLKKMEDGLRLGAS
MAV_2812|M.avium_104 LPGDRVAILGVGGLGHLGVQFAAAMG--FETIAINRGTGKADDARKLGAH
. .: *:**** ..: .. . **
MSMEG_3915|M.smegmatis_MC2_155 HAINVRDKSAEEVRGELQNLTGRGEIDAVIECAGSVESIQLAFDLLATEG
Mvan_5450|M.vanbaalenii_PYR-1 HVVNVRDKDTEDVRAELESATGRTELDAVIECAGSEDSIRLAFSLLAAEG
TH_4349|M.thermoresistible__bu HVV----RSDEQAVEAIWELTGGRGADVLLDFVGADATIELARAAARPLG
MMAR_4911|M.marinum_M LVVN---ARTSDVVAQVQEATGG--VHGVLVTAVHPQAFGQAIGLARRGG
MUL_0495|M.ulcerans_Agy99 LVVN---ARTSDVVAQVQEATGG--VHGVLVTAVHPQAFGQAIGLARRGG
Mflv_4951|M.gilvum_PYR-GCK VVVN---ARTADVVAEVHRATGG--VHGVLVTAVHRDAFGQAIGLARRGG
Mb3071|M.bovis_AF2122/97 SYYA------TADPDTFRKLR--GGFDLILNTVSANLDLGQYLNLLDVDG
Rv3045|M.tuberculosis_H37Rv SYYA------TADPDTFRKLR--GGFDLILNTVSANLDLGQYLNLLDVDG
MLBr_01730|M.leprae_Br4923 NYYA------TADPDTFRKLR--GSFDLILNTVSANLDLGKYLNLLDVNG
MAB_3400|M.abscessus_ATCC_1997 HYYA------TADPDTFKSLR--NSFDLILNTVSSNLDMGKYLGLLGVDG
MAV_2812|M.avium_104 HYID------STAEDPAEALRALGGAAVVLATAGNSQAMAATVGGLAPQG
:: . : *
MSMEG_3915|M.smegmatis_MC2_155 AVASVGLIGNRIDIPLFPLVAREFSYFGSFWGNYNDLTEVLALAEAGQIR
Mvan_5450|M.vanbaalenii_PYR-1 AVASVGLIGNRVDIPLFPLVAREYTFYGSFWGNYNDLTEVLALARTGQLK
TH_4349|M.thermoresistible__bu DVTIVGIAGGSVPLSFFS-QPYEVSIQTTYWGTRPELVELLDLAARGLVH
MMAR_4911|M.marinum_M TIVFNGLPPGDFPAPIFDIVLKGLTIRGSIVGTRQDMAEALDFYARGLIH
MUL_0495|M.ulcerans_Agy99 TIVFNGLPPGDFPAPIFVIVLKGLTIRGSIVGTRQDMAEALDFYARGLIH
Mflv_4951|M.gilvum_PYR-GCK TIVFVGLPPGDFPAPIFDIVLKGLTIRGSIVGTRQDMVEAIDFFARGLVH
Mb3071|M.bovis_AF2122/97 TLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVT
Rv3045|M.tuberculosis_H37Rv TLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVT
MLBr_01730|M.leprae_Br4923 TLVELGIPEHPMLVPAFALALMRRSLAGSNIGGITETQEMMNFSAEHSVT
MAB_3400|M.abscessus_ATCC_1997 TLVELGLPENPIEVPGFPLLTNRRSISGSLIGGIPETQEMLDFCAKHGIG
MAV_2812|M.avium_104 ELVTIGVTPEPLPISPLQLITPGLSIVGHPSGTAKDVEDTMQFAVLSGVR
:. *: . . : : * : : : : :
MSMEG_3915|M.smegmatis_MC2_155 HTVTPVQFDDINATIDAIAAGEVLGRAVVVYD--
Mvan_5450|M.vanbaalenii_PYR-1 HSVTRVRFDDVNETLEAIARGDVLGRAVIVYD--
TH_4349|M.thermoresistible__bu VESTTYPLDDALQAYRDLRAGRVRGRAVIVP---
MMAR_4911|M.marinum_M PTVEGAALEDINHVFERMERGQIDGRVVIDYR--
MUL_0495|M.ulcerans_Agy99 PTVEGAALEDINHVFERMERGQIDGRVVIDYR--
Mflv_4951|M.gilvum_PYR-GCK PTVHTTRLDDINDVFDRMERGQIDGRVVIDYR--
Mb3071|M.bovis_AF2122/97 PEIELIEPDYINDAYERVLASDVRYRFVIDISAL
Rv3045|M.tuberculosis_H37Rv PEIELIEPDYINDAYERVLASDVRYRFVIDISAL
MLBr_01730|M.leprae_Br4923 PEIELIEPDYINEAYERVLASDVRYRFVINISSL
MAB_3400|M.abscessus_ATCC_1997 SEIEVIDASYINEAYERVVASDVRYRFVIDTQTL
MAV_2812|M.avium_104 AWIEELPLSRAADGYAALEGGRAHYRTVLTM---
. : . * *: