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M. bovis AF2122 / 97 Mb2283 (adhE2)

annotation: zinc-dependent alcohol dehydrogenase AdhE2
coordinates: 2511201 - 2512286
length: 361

MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGGINDEYPFLLGHEAAGIIE
AVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLV
HSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAV
DTDDTKLDWARTFGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGV
PTPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMH
GGKVLRSVVML
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2283adhE2-100% (361)zinc-dependent alcohol dehydrogenase AdhE2
M. bovis AF2122 / 97Mb3113adhD2e-5434.72% (360) zinc-type alcohol dehydrogenase AdhD
M. bovis AF2122 / 97Mb0167cadhE12e-5334.77% (371) putative zinc-type alcohol dehydrogenase (e subunit) adhE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2766-0.083.24% (364) alcohol dehydrogenase
M. tuberculosis H37RvRv2259adhE20.0100.00% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. leprae Br4923MLBr_01784adhE20.088.92% (361) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977MAB_1869c-1e-17183.24% (346) zinc-dependent alcohol dehydrogenase AdhE2
M. marinum MMMAR_3350adhE20.090.30% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. avium 104MAV_5022-3e-5234.65% (355) oxidoreductase, zinc-binding dehydrogenase family protein
M. smegmatis MC2 155MSMEG_4340-0.084.49% (361) NAD/mycothiol-dependent formaldehyde dehydrogenase
M. thermoresistible (build 8)TH_4627-1e-18083.66% (361) PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein
M. ulcerans Agy99MUL_1292adhE20.090.30% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. vanbaalenii PYR-1Mvan_3767-0.083.66% (361) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2283|M.bovis_AF2122/97            MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Rv2259|M.tuberculosis_H37Rv         MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923          MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MMAR_3350|M.marinum_M               MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
MUL_1292|M.ulcerans_Agy99           MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
Mflv_2766|M.gilvum_PYR-GCK          MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD
Mvan_3767|M.vanbaalenii_PYR-1       MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYRE
MSMEG_4340|M.smegmatis_MC2_155      MPQTVRGVISRSKQQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu      MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
MAB_1869c|M.abscessus_ATCC_199      ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE
MAV_5022|M.avium_104                MLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVD
                                                    :.:.:: :. ** .*.:* : *.*:**:**   :

Mb2283|M.bovis_AF2122/97            GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK
Rv2259|M.tuberculosis_H37Rv         GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK
MLBr_01784|M.leprae_Br4923          GGINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRACK
MMAR_3350|M.marinum_M               GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK
MUL_1292|M.ulcerans_Agy99           GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK
Mflv_2766|M.gilvum_PYR-GCK          GGINDEFPFLLGHEAAGIVETVGQGVTNVAPGDFVILNWRAVCGQCRACK
Mvan_3767|M.vanbaalenii_PYR-1       GGINDEFPFLLGHEAAGTVESVGAGVTNVAPGDFVVLNWRAVCGQCRACK
MSMEG_4340|M.smegmatis_MC2_155      GGINDEFPFLLGHEAAGTVEAVGEGVTNVAPGDFVILNWRAVCGQCRACK
TH_4627|M.thermoresistible__bu      GGINDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRACK
MAB_1869c|M.abscessus_ATCC_199      GGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVCRACK
MAV_5022|M.avium_104                GNRVRPVPMLLGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACA
                                    *.     *:******** :* ** **: :  *  *:* : . ** * ** 

Mb2283|M.bovis_AF2122/97            RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS
Rv2259|M.tuberculosis_H37Rv         RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS
MLBr_01784|M.leprae_Br4923          RGRPSYCFDTFNAQQKMTLI--------DGTELTPALGIGAFADKTLVHS
MMAR_3350|M.marinum_M               RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS
MUL_1292|M.ulcerans_Agy99           RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS
Mflv_2766|M.gilvum_PYR-GCK          RGRPHLCFDTHNAAQKMTLT--------DGTELTPALGIGAFADKTLVHE
Mvan_3767|M.vanbaalenii_PYR-1       RGRPHLCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHE
MSMEG_4340|M.smegmatis_MC2_155      RGRPHLCFDTFNATQKMTLT--------DGTELTPALGIGAFADKTLVHE
TH_4627|M.thermoresistible__bu      RGRPHLCFDTFNATQKMTLG--------DGTELTPALGIGAFAEKTLVHE
MAB_1869c|M.abscessus_ATCC_199      RGRPQYCFDTFNAAQKMTLT--------DGTELTPALGIGAFIEKTLVHA
MAV_5022|M.avium_104                TEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNR
                                          *     *    **          *  :   **:..*  :::*: 

Mb2283|M.bovis_AF2122/97            GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG
Rv2259|M.tuberculosis_H37Rv         GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG
MLBr_01784|M.leprae_Br4923          GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVG
MMAR_3350|M.marinum_M               GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG
MUL_1292|M.ulcerans_Agy99           GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG
Mflv_2766|M.gilvum_PYR-GCK          GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITRDDTVAVIGCGGVG
Mvan_3767|M.vanbaalenii_PYR-1       GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNRDDTVAVIGCGGVG
MSMEG_4340|M.smegmatis_MC2_155      GQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVTRDDTVAVIGCGGVG
TH_4627|M.thermoresistible__bu      GQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGCGGVG
MAB_1869c|M.abscessus_ATCC_199      GQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVG
MAV_5022|M.avium_104                ASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVG
                                    ....:* . . . ...****.*::* **.:*..    .:****:* ****

Mb2283|M.bovis_AF2122/97            DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG
Rv2259|M.tuberculosis_H37Rv         DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG
MLBr_01784|M.leprae_Br4923          DAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELE-VVKTIQ
MMAR_3350|M.marinum_M               DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ
MUL_1292|M.ulcerans_Agy99           DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ
Mflv_2766|M.gilvum_PYR-GCK          DAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTINAKDLD-PVKTIQ
Mvan_3767|M.vanbaalenii_PYR-1       DAAIAGARLVGAKRIIAVDMDNRKLDWAREFGATHTINAGELD-AVKTIQ
MSMEG_4340|M.smegmatis_MC2_155      DAAIAGAALVGAKKIIAVDMDNKKLDWAREFGATHTVNAKDLD-AVETIQ
TH_4627|M.thermoresistible__bu      DAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTD-VVEAIQ
MAB_1869c|M.abscessus_ATCC_199      DAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQ
MAV_5022|M.avium_104                MAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTP---------QQ
                                     **:  *   ..  ::*:*    **  *: :** .:  .           

Mb2283|M.bovis_AF2122/97            GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL
Rv2259|M.tuberculosis_H37Rv         GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL
MLBr_01784|M.leprae_Br4923          DLTSGFGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
MMAR_3350|M.marinum_M               DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
MUL_1292|M.ulcerans_Agy99           DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL
Mflv_2766|M.gilvum_PYR-GCK          DLTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLDMPL
Mvan_3767|M.vanbaalenii_PYR-1       DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL
MSMEG_4340|M.smegmatis_MC2_155      DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMKLEMPL
TH_4627|M.thermoresistible__bu      ELTDGFGADVVVDAVGRPETWEQAFYARDLAGTVVLVGVPTPDMRIDMPL
MAB_1869c|M.abscessus_ATCC_199      ELTDEFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL
MAV_5022|M.avium_104                AVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITVSP
                                     :   . . **:::**:* : : *:     .* .: **:*.**  : :. 

Mb2283|M.bovis_AF2122/97            VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED
Rv2259|M.tuberculosis_H37Rv         VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED
MLBr_01784|M.leprae_Br4923          LDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGD
MMAR_3350|M.marinum_M               VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG
MUL_1292|M.ulcerans_Agy99           VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG
Mflv_2766|M.gilvum_PYR-GCK          IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERITLDQ
Mvan_3767|M.vanbaalenii_PYR-1       IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERIGLDQ
MSMEG_4340|M.smegmatis_MC2_155      IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRLPLEKFVSERIGLDG
TH_4627|M.thermoresistible__bu      IDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQGRLPLEKFVTERIALDE
MAB_1869c|M.abscessus_ATCC_199      IDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSERIGIES
MAV_5022|M.avium_104                LGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLED
                                    :.*.:.* :* .*: *..:*. *:* ::.*:  **:*:  :*:. * :  

Mb2283|M.bovis_AF2122/97            VEEAFHKMHGG---KVLRSVVML--
Rv2259|M.tuberculosis_H37Rv         VEEAFHKMHGG---KVLRSVVML--
MLBr_01784|M.leprae_Br4923          VEEAFHKIHGG---KVLRSVVML--
MMAR_3350|M.marinum_M               IEEAFEKMHAG---KVLRSVVVL--
MUL_1292|M.ulcerans_Agy99           IEEAFEKMHAG---KVLRSVVVL--
Mflv_2766|M.gilvum_PYR-GCK          IEDAFHKMHAGSDDVVLRSVVVL--
Mvan_3767|M.vanbaalenii_PYR-1       IEDAFDKMHAG---EVLRSVVVL--
MSMEG_4340|M.smegmatis_MC2_155      IEDAFHKMHAG---EVLRSVVVLDR
TH_4627|M.thermoresistible__bu      VEGAFEKMQRG---EVLRSVVVLK-
MAB_1869c|M.abscessus_ATCC_199      IEAAFEKMHHG---EVLRSVVVL--
MAV_5022|M.avium_104                INEAMDHLADG---TAVRQLIRFDA
                                    :: *:.::  *    .:*.:: :