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MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYREGGINDEYPFLLGHEAAGIIE AVGPGVTAVEPGDFVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLV HSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAV DTDDTKLDWARTFGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGV PTPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLEDVEEAFHKMH GGKVLRSVVML
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2283 | adhE2 | - | 100% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
M. bovis AF2122 / 97 | Mb3113 | adhD | 2e-54 | 34.72% (360) | zinc-type alcohol dehydrogenase AdhD |
M. bovis AF2122 / 97 | Mb0167c | adhE1 | 2e-53 | 34.77% (371) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2766 | - | 0.0 | 83.24% (364) | alcohol dehydrogenase |
M. tuberculosis H37Rv | Rv2259 | adhE2 | 0.0 | 100.00% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
M. leprae Br4923 | MLBr_01784 | adhE2 | 0.0 | 88.92% (361) | putative alcohol dehydrogenase (Zn dependent) |
M. abscessus ATCC 19977 | MAB_1869c | - | 1e-171 | 83.24% (346) | zinc-dependent alcohol dehydrogenase AdhE2 |
M. marinum M | MMAR_3350 | adhE2 | 0.0 | 90.30% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
M. avium 104 | MAV_5022 | - | 3e-52 | 34.65% (355) | oxidoreductase, zinc-binding dehydrogenase family protein |
M. smegmatis MC2 155 | MSMEG_4340 | - | 0.0 | 84.49% (361) | NAD/mycothiol-dependent formaldehyde dehydrogenase |
M. thermoresistible (build 8) | TH_4627 | - | 1e-180 | 83.66% (361) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
M. ulcerans Agy99 | MUL_1292 | adhE2 | 0.0 | 90.30% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
M. vanbaalenii PYR-1 | Mvan_3767 | - | 0.0 | 83.66% (361) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE Rv2259|M.tuberculosis_H37Rv MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE MMAR_3350|M.marinum_M MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE MUL_1292|M.ulcerans_Agy99 MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE Mflv_2766|M.gilvum_PYR-GCK MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD Mvan_3767|M.vanbaalenii_PYR-1 MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYRE MSMEG_4340|M.smegmatis_MC2_155 MPQTVRGVISRSKQQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRE TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE MAV_5022|M.avium_104 MLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVD :.:.:: :. ** .*.:* : *.*:**:** : Mb2283|M.bovis_AF2122/97 GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK Rv2259|M.tuberculosis_H37Rv GGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACK MLBr_01784|M.leprae_Br4923 GGINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRACK MMAR_3350|M.marinum_M GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK MUL_1292|M.ulcerans_Agy99 GGINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRACK Mflv_2766|M.gilvum_PYR-GCK GGINDEFPFLLGHEAAGIVETVGQGVTNVAPGDFVILNWRAVCGQCRACK Mvan_3767|M.vanbaalenii_PYR-1 GGINDEFPFLLGHEAAGTVESVGAGVTNVAPGDFVVLNWRAVCGQCRACK MSMEG_4340|M.smegmatis_MC2_155 GGINDEFPFLLGHEAAGTVEAVGEGVTNVAPGDFVILNWRAVCGQCRACK TH_4627|M.thermoresistible__bu GGINDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRACK MAB_1869c|M.abscessus_ATCC_199 GGINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILNWRAVCGVCRACK MAV_5022|M.avium_104 GNRVRPVPMLLGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACA *. *:******** :* ** **: : * *:* : . ** * ** Mb2283|M.bovis_AF2122/97 RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS Rv2259|M.tuberculosis_H37Rv RGRPRYCFDTFNAEQKMTLT--------DGTELTAALGIGAFADKTLVHS MLBr_01784|M.leprae_Br4923 RGRPSYCFDTFNAQQKMTLI--------DGTELTPALGIGAFADKTLVHS MMAR_3350|M.marinum_M RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS MUL_1292|M.ulcerans_Agy99 RGRPSYCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHS Mflv_2766|M.gilvum_PYR-GCK RGRPHLCFDTHNAAQKMTLT--------DGTELTPALGIGAFADKTLVHE Mvan_3767|M.vanbaalenii_PYR-1 RGRPHLCFDTFNAEQKMTLT--------DGTELTPALGIGAFADKTLVHE MSMEG_4340|M.smegmatis_MC2_155 RGRPHLCFDTFNATQKMTLT--------DGTELTPALGIGAFADKTLVHE TH_4627|M.thermoresistible__bu RGRPHLCFDTFNATQKMTLG--------DGTELTPALGIGAFAEKTLVHE MAB_1869c|M.abscessus_ATCC_199 RGRPQYCFDTFNAAQKMTLT--------DGTELTPALGIGAFIEKTLVHA MAV_5022|M.avium_104 TEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNR * * ** * : **:..* :::*: Mb2283|M.bovis_AF2122/97 GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG Rv2259|M.tuberculosis_H37Rv GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTRDDTVAVIGCGGVG MLBr_01784|M.leprae_Br4923 GQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVG MMAR_3350|M.marinum_M GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG MUL_1292|M.ulcerans_Agy99 GQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVG Mflv_2766|M.gilvum_PYR-GCK GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITRDDTVAVIGCGGVG Mvan_3767|M.vanbaalenii_PYR-1 GQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNRDDTVAVIGCGGVG MSMEG_4340|M.smegmatis_MC2_155 GQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVTRDDTVAVIGCGGVG TH_4627|M.thermoresistible__bu GQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGCGGVG MAB_1869c|M.abscessus_ATCC_199 GQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGRDDTVAVIGCGGVG MAV_5022|M.avium_104 ASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVG ....:* . . . ...****.*::* **.:*.. .:****:* **** Mb2283|M.bovis_AF2122/97 DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG Rv2259|M.tuberculosis_H37Rv DAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTVNAREVD-VVQAIG MLBr_01784|M.leprae_Br4923 DAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELE-VVKTIQ MMAR_3350|M.marinum_M DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ MUL_1292|M.ulcerans_Agy99 DAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELD-VVETIQ Mflv_2766|M.gilvum_PYR-GCK DAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTINAKDLD-PVKTIQ Mvan_3767|M.vanbaalenii_PYR-1 DAAIAGARLVGAKRIIAVDMDNRKLDWAREFGATHTINAGELD-AVKTIQ MSMEG_4340|M.smegmatis_MC2_155 DAAIAGAALVGAKKIIAVDMDNKKLDWAREFGATHTVNAKDLD-AVETIQ TH_4627|M.thermoresistible__bu DAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTD-VVEAIQ MAB_1869c|M.abscessus_ATCC_199 DAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTINARKVDDVVTAIQ MAV_5022|M.avium_104 MAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTP---------QQ **: * .. ::*:* ** *: :** .: . Mb2283|M.bovis_AF2122/97 GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL Rv2259|M.tuberculosis_H37Rv GLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVVLVGVPTPDMRLDMPL MLBr_01784|M.leprae_Br4923 DLTSGFGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL MMAR_3350|M.marinum_M DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL MUL_1292|M.ulcerans_Agy99 DLTGGFGVDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPL Mflv_2766|M.gilvum_PYR-GCK DLTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLDMPL Mvan_3767|M.vanbaalenii_PYR-1 DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL MSMEG_4340|M.smegmatis_MC2_155 DLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMKLEMPL TH_4627|M.thermoresistible__bu ELTDGFGADVVVDAVGRPETWEQAFYARDLAGTVVLVGVPTPDMRIDMPL MAB_1869c|M.abscessus_ATCC_199 ELTDEFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMTLEMPL MAV_5022|M.avium_104 AVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITVSP : . . **:::**:* : : *: .* .: **:*.** : :. Mb2283|M.bovis_AF2122/97 VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED Rv2259|M.tuberculosis_H37Rv VDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVSERIGLED MLBr_01784|M.leprae_Br4923 LDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGD MMAR_3350|M.marinum_M VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG MUL_1292|M.ulcerans_Agy99 VDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGG Mflv_2766|M.gilvum_PYR-GCK IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERITLDQ Mvan_3767|M.vanbaalenii_PYR-1 IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERIGLDQ MSMEG_4340|M.smegmatis_MC2_155 IDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRLPLEKFVSERIGLDG TH_4627|M.thermoresistible__bu IDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQGRLPLEKFVTERIALDE MAB_1869c|M.abscessus_ATCC_199 IDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQGRLPLDRFVSERIGIES MAV_5022|M.avium_104 LGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLED :.*.:.* :* .*: *..:*. *:* ::.*: **:*: :*:. * : Mb2283|M.bovis_AF2122/97 VEEAFHKMHGG---KVLRSVVML-- Rv2259|M.tuberculosis_H37Rv VEEAFHKMHGG---KVLRSVVML-- MLBr_01784|M.leprae_Br4923 VEEAFHKIHGG---KVLRSVVML-- MMAR_3350|M.marinum_M IEEAFEKMHAG---KVLRSVVVL-- MUL_1292|M.ulcerans_Agy99 IEEAFEKMHAG---KVLRSVVVL-- Mflv_2766|M.gilvum_PYR-GCK IEDAFHKMHAGSDDVVLRSVVVL-- Mvan_3767|M.vanbaalenii_PYR-1 IEDAFDKMHAG---EVLRSVVVL-- MSMEG_4340|M.smegmatis_MC2_155 IEDAFHKMHAG---EVLRSVVVLDR TH_4627|M.thermoresistible__bu VEGAFEKMQRG---EVLRSVVVLK- MAB_1869c|M.abscessus_ATCC_199 IEAAFEKMHHG---EVLRSVVVL-- MAV_5022|M.avium_104 INEAMDHLADG---TAVRQLIRFDA :: *:.:: * .:*.:: :