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TFHMRATLTASRRTVGRVTFSISIPQFDTGRFDASGVKNYLTRAEELGFEGGWTLEQTVGHAPLIAPLEL LSYAAAVTTRLRLGVAVLVTSLHDPLQLASSITAVDRLSHGRLDVGVAPGGGSRQFRAFGVDPSTFIANF TEGLALMKAAWSDEPRVTFHGRFRDVDGLPITPKPVQRPHPPIWFGANAPKALARAVRLGDAFLGAGSST TAHFAEAVRIVREELDKQGKDPQSFRIGKRVYLIVDDDGARARERVAEGLRRIYGPKADYADVAVAGTPG EVVRGLREVIEAGAQTVLLNPTGVDVAEDREQMERLAAEVIPQLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1475 | - | - | 100% (326) | hypothetical protein MSMEG_1475 |
| M. smegmatis MC2 155 | MSMEG_3609 | - | 1e-21 | 31.54% (241) | hydride transferase 1 |
| M. smegmatis MC2 155 | MSMEG_1996 | - | 2e-20 | 32.50% (160) | N5,N10- methylenetetrahydromethanopterin reductase-related |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0815c | - | 8e-23 | 27.17% (265) | hypothetical protein Mb0815c |
| M. gilvum PYR-GCK | Mflv_4098 | - | 4e-25 | 28.97% (321) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0791c | - | 8e-23 | 27.17% (265) | hypothetical protein Rv0791c |
| M. leprae Br4923 | MLBr_00131 | - | 1e-10 | 25.76% (229) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3792 | - | 1e-126 | 74.43% (305) | luciferase-like protein |
| M. marinum M | MMAR_1055 | - | 1e-128 | 74.92% (307) | flavin-dependent oxidoreductase |
| M. avium 104 | MAV_4445 | - | 1e-134 | 76.55% (307) | hypothetical protein MAV_4445 |
| M. thermoresistible (build 8) | TH_4465 | - | 6e-23 | 36.27% (204) | PUTATIVE putative hydride transferase 1 |
| M. ulcerans Agy99 | MUL_0814 | - | 1e-126 | 73.94% (307) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2247 | - | 5e-23 | 28.04% (321) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0815c|M.bovis_AF2122/97 ------------MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEY
Rv0791c|M.tuberculosis_H37Rv ------------MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEY
Mflv_4098|M.gilvum_PYR-GCK ---------------MRRPEIGVYLPQMG-----FSFDEVLHRARRCEDL
Mvan_2247|M.vanbaalenii_PYR-1 ---------------MSRPEIGVYLPQMG-----FSFDELLHRARRCEKL
MMAR_1055|M.marinum_M ------------------MRFSIAIPQLDTDG--FDAAGLRAYLARAEEL
MUL_0814|M.ulcerans_Agy99 ------------------MRFSIAIPQLDTDG--FDAAGLRAYLARAEEL
MAV_4445|M.avium_104 ------------------MRFSIAIPQFDYDG--FDGAGLRSFLTRAEQL
MSMEG_1475|M.smegmatis_MC2_155 MTFHMRATLTASRRTVGRVTFSISIPQFDTGR--FDASGVKNYLTRAEEL
MAB_3792|M.abscessus_ATCC_1997 ------------------MRFSISIPQFDTGS--FDGDGVRDYLARAEEL
TH_4465|M.thermoresistible__bu -------------------LATIGLSAYG-----MAGGELVELAACADEL
MLBr_00131|M.leprae_Br4923 ---------------MAGFRFGFVDALVHTLFP--PSLPARASIVSGAVL
. .
Mb0815c|M.bovis_AF2122/97 GFDSVWLCDHFLTISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLP
Rv0791c|M.tuberculosis_H37Rv GFDSVWLCDHFLTISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLP
Mflv_4098|M.gilvum_PYR-GCK GIDSLWLYDHLYGPG------------------------------MPDYP
Mvan_2247|M.vanbaalenii_PYR-1 GIDSLWLYDHLYGPG------------------------------MPDYP
MMAR_1055|M.marinum_M GFEGGWVLEQIIGSS----------------------------------P
MUL_0814|M.ulcerans_Agy99 GFEGGWGLEQIIGSS----------------------------------P
MAV_4445|M.avium_104 GFEGGWALEQIIGPA----------------------------------P
MSMEG_1475|M.smegmatis_MC2_155 GFEGGWTLEQTVGHA----------------------------------P
MAB_3792|M.abscessus_ATCC_1997 GFAGGWTLEQTVGSS----------------------------------P
TH_4465|M.thermoresistible__bu GFDTLWLGEHVVRPLTQRSAHPTSGTRQHHSG----------PLVAERTE
MLBr_00131|M.leprae_Br4923 GADSYWVGDHLNALVPRSVATPKYLG-------------VAAKVVPKIDA
* * ::
Mb0815c|M.bovis_AF2122/97 LLECWTALAALSR--DTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQG
Rv0791c|M.tuberculosis_H37Rv LLECWTALAALSR--DTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQG
Mflv_4098|M.gilvum_PYR-GCK SMEAWTLATALLS--RTERLRIGHMVLCNQFRHPVTLAKMVTTLDQISGG
Mvan_2247|M.vanbaalenii_PYR-1 SMEAWTLATALLS--RTDTLRVGHMVLCNQFRHPVTLAKMATTLDQISGG
MMAR_1055|M.marinum_M LLAPLELLAYCAA--CTNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNG
MUL_0814|M.ulcerans_Agy99 LLAPLQLLAYCAA--CTNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNG
MAV_4445|M.avium_104 PLAPLELLAYCAA--CTERLRLGVAVLVTSLHDPLQLASAVTAVDRLSHG
MSMEG_1475|M.smegmatis_MC2_155 LIAPLELLSYAAA--VTTRLRLGVAVLVTSLHDPLQLASSITAVDRLSHG
MAB_3792|M.abscessus_ATCC_1997 IIAPLELLAYAAA--CTTRLRLGVAVLVASQHDPLQLAAAVTAVDRLSHG
TH_4465|M.thermoresistible__bu LIDPWAVHAAIAA--VTTGIKLGTAVYVAALRHPLHTARTTITVQELSGG
MLBr_00131|M.leprae_Br4923 NYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG
:::* * :.* * ::. :: *
Mb0815c|M.bovis_AF2122/97 RLDLGLGAGWFRRESQAYGIPFPPVGDRVSALAESLQVIKAVWTE--PNP
Rv0791c|M.tuberculosis_H37Rv RLDLGLGAGWFRRESQAYGIPFPPVGDRVSALAESLQVIKAVWTE--PNP
Mflv_4098|M.gilvum_PYR-GCK RLSLGIGSGSIEDEHRRAGLPWGTFAERSAQLGETLQILRQAFTD--ERV
Mvan_2247|M.vanbaalenii_PYR-1 RLSLGIGSGSIEDEHRRAGLPWGSFAERSEQLGETLQILHQAFGD--ERI
MMAR_1055|M.marinum_M RLDLGVAAGGGSRKFAAFGVDRATHVSY---FTEGLQLMKAAWSDE-PRV
MUL_0814|M.ulcerans_Agy99 RLDLGVAAGGGSRKFAAFGVDRATHVSY---FTEGLQLMKAAWSDE-PRV
MAV_4445|M.avium_104 RLDIGVAPGGGTRKFAAFGVDKDTFVAY---FTEGLKLMKAAWSDD-PRV
MSMEG_1475|M.smegmatis_MC2_155 RLDVGVAPGGGSRQFRAFGVDPSTFIAN---FTEGLALMKAAWSDE-PRV
MAB_3792|M.abscessus_ATCC_1997 RLDVGVAPGGGARNFAAFGVDKQTFIAR---FTEGLDLMKLAWSDE-ERI
TH_4465|M.thermoresistible__bu RVVFGVGVGWLEEEFDAFDVPFRTRVSR---TEECLAILRAAWRG--EPF
MLBr_00131|M.leprae_Br4923 KAMLGIGVGE-REGNEPYGVEWTKPVAR---FQEALATIRALWDSNGELV
: .*:. * .: * * :: :
Mb0815c|M.bovis_AF2122/97 TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQR-IAAKHAQGLNVR
Rv0791c|M.tuberculosis_H37Rv TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQR-IAAKHAQGLNVR
Mflv_4098|M.gilvum_PYR-GCK DFAGRHFTVTDFPIKPGPVQKSGPPIVVGGVGEKYTLPLVARYADVWNVP
Mvan_2247|M.vanbaalenii_PYR-1 DFTGKHFTVTDMPIKPGPVQRPRPPIVVGGVGEKFTLPLVARYADVWNVP
MMAR_1055|M.marinum_M RFHGRFRDVDDLPIQPKPVQRPHPPIWFGGRAPKALARAVRHGDAFLGAG
MUL_0814|M.ulcerans_Agy99 RFHGRFRDVDDLPIQPKRVQRPHPPIWFGGRAPKALARAVRHGDAFLGAG
MAV_4445|M.avium_104 TFHGRFRDVDDLPIAPKPVQRPHPPIWFGGLAPKALARAVRHGDAFMGAG
MSMEG_1475|M.smegmatis_MC2_155 TFHGRFRDVDGLPITPKPVQRPHPPIWFGANAPKALARAVRLGDAFLGAG
MAB_3792|M.abscessus_ATCC_1997 TFRGRFRDVADLAFQPKPVQRPHPPIWFGGHAPAALARAVRFGDAFLGAG
TH_4465|M.thermoresistible__bu SHHGRHFRIDRVQVHSRPVDIP---VVLGGNGPKALARAATLGDGWFTSG
MLBr_00131|M.leprae_Br4923 SRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIV
.:. : : ... .
Mb0815c|M.bovis_AF2122/97 WWSPQQVTQRRGFLTQASEAAGRD-----------------------PDT
Rv0791c|M.tuberculosis_H37Rv WWSPQQVTQRRGFLTQASEAAGRD-----------------------PDT
Mflv_4098|M.gilvum_PYR-GCK TYALDQIEPKIAVLRSICEDIGRD-----------------------PDS
Mvan_2247|M.vanbaalenii_PYR-1 TYALGQIKEKIAALRSICEDVGRD-----------------------PQT
MMAR_1055|M.marinum_M SSTTADFATAVTTLRHELAEQGRD-----------------------PAG
MUL_0814|M.ulcerans_Agy99 SSTTADFATAVTTLRHELAEQGRD-----------------------PAG
MAV_4445|M.avium_104 SSTTEAFAGAVAVLRRELDEQQRD-----------------------PAE
MSMEG_1475|M.smegmatis_MC2_155 SSTTAHFAEAVRIVREELDKQGKD-----------------------PQS
MAB_3792|M.abscessus_ATCC_1997 SSTTAAFAEEVTTIHRELAIQGKD-----------------------PAR
TH_4465|M.thermoresistible__bu TPEFDDALRMVREIRRVREQHGRPGPFTCYVRIPSVDEVGRYRDHDMTDL
MLBr_00131|M.leprae_Br4923 LVRPTDYSCALEVVRTAASDAGRD-----------------------PMS
: : .
Mb0815c|M.bovis_AF2122/97 LRLSVTLLLAPTQSGE--------EEVRIREEFASIPEPGLIVG------
Rv0791c|M.tuberculosis_H37Rv LRLSVTLLLAPTQSGE--------EEVRIREEFASIPEPGLIVG------
Mflv_4098|M.gilvum_PYR-GCK IVLSIEAVMAVAPDQESLESVRMLAEKRFRGPGFGLHDTGLIG-------
Mvan_2247|M.vanbaalenii_PYR-1 ITLSIEAVMALAPDEASLPTVRSLAEKRFGGEGFGLHDTDLIG-------
MMAR_1055|M.marinum_M FTIGKRVYLMVDDDPERARERVLAGLRSIYGKMGGLDAVAVAG-------
MUL_0814|M.ulcerans_Agy99 FTIGKRVYLMVDDDPERARERVLAGLRSIYGKMGGLDAVAVAG-------
MAV_4445|M.avium_104 FTIGKRVYLTVDDDAARARERVLAGLSRIYGRMPGVADVPVSG-------
MSMEG_1475|M.smegmatis_MC2_155 FRIGKRVYLIVDDDGARARERVAEGLRRIYGPKADYADVAVAG-------
MAB_3792|M.abscessus_ATCC_1997 FTIGKRVYLMIDDDRDRAHTRVQTGLRRIYGEMKGIDAVPVSG-------
TH_4465|M.thermoresistible__bu VLWADTVWQGRTLDEKRDRLAAAADRLGLVSRSSGDPPAAAAGRSQRRRS
MLBr_00131|M.leprae_Br4923 ITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHG-------
. . :
Mb0815c|M.bovis_AF2122/97 -----TPDRCVERIREYQDRGVGHFLFTIP---HVVKSD-----------
Rv0791c|M.tuberculosis_H37Rv -----TPDRCVERIREYQDRGVGHFLFTIP---HVVKSD-----------
Mflv_4098|M.gilvum_PYR-GCK -----TPAEIAAKLGRLVEIGFGQIVLFTH---DRCSDQ-----------
Mvan_2247|M.vanbaalenii_PYR-1 -----TPAEMVDRLGALAEMGFGQIVLFTH---DRCSDQ-----------
MMAR_1055|M.marinum_M -----TPDDVTRGLAEVIAAGAQTLLLNPVGPDVGQNHE-----------
MUL_0814|M.ulcerans_Agy99 -----TPDDVTRGLAEVIAAGAQTLLLNPVGPDVGQNHE-----------
MAV_4445|M.avium_104 -----TPGDVVRGLREVIDAGAQTLLLNPVGADVAENHE-----------
MSMEG_1475|M.smegmatis_MC2_155 -----TPGEVVRGLREVIEAGAQTVLLNPTGVDVAEDRE-----------
MAB_3792|M.abscessus_ATCC_1997 -----PPEEVAAGLRAVADAGAEMILLNPVGKDVAEDRE-----------
TH_4465|M.thermoresistible__bu GSALRMGDDVPRRVQNTGARSAGVRDTRPQNSRAGANGARTARDEHRGEV
MLBr_00131|M.leprae_Br4923 --VEHPMGADFAGVQDIIPQTIDEETVVSYAAKVPAALMK----------
:
Mb0815c|M.bovis_AF2122/97 -------YLHIIGSDIIPRVKTEVTIP-----------------------
Rv0791c|M.tuberculosis_H37Rv -------YLHIIGSDIIPRVKTEVTIP-----------------------
Mflv_4098|M.gilvum_PYR-GCK -------TLELLASEIIPRL------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 -------TLELLAAEVIPRL------------------------------
MMAR_1055|M.marinum_M -------QMERLAAEVIPRLR-----------------------------
MUL_0814|M.ulcerans_Agy99 -------QTERLAAEVIPRLR-----------------------------
MAV_4445|M.avium_104 -------QMERLAAEVIPQLN-----------------------------
MSMEG_1475|M.smegmatis_MC2_155 -------QMERLAAEVIPQLT-----------------------------
MAB_3792|M.abscessus_ATCC_1997 -------QMERLAAEVIPQLA-----------------------------
TH_4465|M.thermoresistible__bu SLLRPLKAAESVARMIVDEIKTKGLQPGDSLPLEATMLKQYGVSRESLRE
MLBr_00131|M.leprae_Br4923 -----EVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTVSAL
:: .:
Mb0815c|M.bovis_AF2122/97 --------------------------------------------------
Rv0791c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4098|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
MUL_0814|M.ulcerans_Agy99 --------------------------------------------------
MAV_4445|M.avium_104 --------------------------------------------------
MSMEG_1475|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3792|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4465|M.thermoresistible__bu GLRLLEVQGMISIRRGPGGGPVVGTVDAGHLGRVSALFYNMADATYEELL
MLBr_00131|M.leprae_Br4923 LPHARVLRGLKKL-------------------------------------
Mb0815c|M.bovis_AF2122/97 --------------------------------------------------
Rv0791c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4098|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
MUL_0814|M.ulcerans_Agy99 --------------------------------------------------
MAV_4445|M.avium_104 --------------------------------------------------
MSMEG_1475|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3792|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4465|M.thermoresistible__bu EAWVWAEGELAERAARNPDAQLRSARMTPYLTDHDGSAEGLAPYLEGHTA
MLBr_00131|M.leprae_Br4923 --------------------------------------------------
Mb0815c|M.bovis_AF2122/97 --------------------------------------------------
Rv0791c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4098|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1055|M.marinum_M --------------------------------------------------
MUL_0814|M.ulcerans_Agy99 --------------------------------------------------
MAV_4445|M.avium_104 --------------------------------------------------
MSMEG_1475|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3792|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4465|M.thermoresistible__bu FHRAVADLSNNRVLALSLQTYGQIVSHHVAVLSDPRSLRDVLVDEHRHIA
MLBr_00131|M.leprae_Br4923 --------------------------------------------------
Mb0815c|M.bovis_AF2122/97 -----------------------------------------
Rv0791c|M.tuberculosis_H37Rv -----------------------------------------
Mflv_4098|M.gilvum_PYR-GCK -----------------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 -----------------------------------------
MMAR_1055|M.marinum_M -----------------------------------------
MUL_0814|M.ulcerans_Agy99 -----------------------------------------
MAV_4445|M.avium_104 -----------------------------------------
MSMEG_1475|M.smegmatis_MC2_155 -----------------------------------------
MAB_3792|M.abscessus_ATCC_1997 -----------------------------------------
TH_4465|M.thermoresistible__bu EAVISGHARRARALMRSHLEGVTAFVRENIPVPLDQPIEWL
MLBr_00131|M.leprae_Br4923 -----------------------------------------