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RFSIAIPQLDTDGFDAAGLRAYLARAEELGFEGGWVLEQIIGSSPLLAPLELLAYCAACTNRLRLGVAVL VTSLHDPLQLASSVTAVDRLSNGRLDLGVAAGGGSRKFAAFGVDRATHVSYFTEGLQLMKAAWSDEPRVR FHGRFRDVDDLPIQPKPVQRPHPPIWFGGRAPKALARAVRHGDAFLGAGSSTTADFATAVTTLRHELAEQ GRDPAGFTIGKRVYLMVDDDPERARERVLAGLRSIYGKMGGLDAVAVAGTPDDVTRGLAEVIAAGAQTLL LNPVGPDVGQNHEQMERLAAEVIPRLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1055 | - | - | 100% (308) | flavin-dependent oxidoreductase |
| M. marinum M | MMAR_0393 | - | 4e-24 | 32.57% (218) | hypothetical protein MMAR_0393 |
| M. marinum M | MMAR_3559 | - | 1e-20 | 31.87% (160) | hypothetical protein MMAR_3559 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0815c | - | 5e-23 | 30.88% (272) | hypothetical protein Mb0815c |
| M. gilvum PYR-GCK | Mflv_4098 | - | 9e-26 | 28.62% (311) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0791c | - | 6e-23 | 30.88% (272) | hypothetical protein Rv0791c |
| M. leprae Br4923 | MLBr_00131 | - | 4e-11 | 26.42% (159) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3792 | - | 1e-126 | 72.64% (307) | luciferase-like protein |
| M. avium 104 | MAV_4445 | - | 1e-142 | 81.76% (307) | hypothetical protein MAV_4445 |
| M. smegmatis MC2 155 | MSMEG_1475 | - | 1e-128 | 74.92% (307) | hypothetical protein MSMEG_1475 |
| M. thermoresistible (build 8) | TH_2146 | - | 5e-24 | 33.18% (220) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0814 | - | 1e-173 | 98.70% (308) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2247 | - | 1e-24 | 30.13% (312) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0815c|M.bovis_AF2122/97 ------------MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEY
Rv0791c|M.tuberculosis_H37Rv ------------MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEY
Mflv_4098|M.gilvum_PYR-GCK ---------------MRRPEIGVYLPQMG-----FSFDEVLHRARRCEDL
Mvan_2247|M.vanbaalenii_PYR-1 ---------------MSRPEIGVYLPQMG-----FSFDELLHRARRCEKL
MMAR_1055|M.marinum_M ------------------MRFSIAIPQLDTDG--FDAAGLRAYLARAEEL
MUL_0814|M.ulcerans_Agy99 ------------------MRFSIAIPQLDTDG--FDAAGLRAYLARAEEL
MAV_4445|M.avium_104 ------------------MRFSIAIPQFDYDG--FDGAGLRSFLTRAEQL
MAB_3792|M.abscessus_ATCC_1997 ------------------MRFSISIPQFDTGS--FDGDGVRDYLARAEEL
MSMEG_1475|M.smegmatis_MC2_155 MTFHMRATLTASRRTVGRVTFSISIPQFDTGR--FDASGVKNYLTRAEEL
TH_2146|M.thermoresistible__bu ----------------MRFAFTYPMDSHPYHPDLATGAAVARVAATAETA
MLBr_00131|M.leprae_Br4923 -----------------MAGFRFGFVDALVHTLFPPSLPARASIVSGAVL
: :
Mb0815c|M.bovis_AF2122/97 GFDSVWLCDHFLTISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLP
Rv0791c|M.tuberculosis_H37Rv GFDSVWLCDHFLTISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLP
Mflv_4098|M.gilvum_PYR-GCK GIDSLWLYDHLYGPG------------------------------MPDYP
Mvan_2247|M.vanbaalenii_PYR-1 GIDSLWLYDHLYGPG------------------------------MPDYP
MMAR_1055|M.marinum_M GFEGGWVLEQIIGSS----------------------------------P
MUL_0814|M.ulcerans_Agy99 GFEGGWGLEQIIGSS----------------------------------P
MAV_4445|M.avium_104 GFEGGWALEQIIGPA----------------------------------P
MAB_3792|M.abscessus_ATCC_1997 GFAGGWTLEQTVGSS----------------------------------P
MSMEG_1475|M.smegmatis_MC2_155 GFEGGWTLEQTVGHA----------------------------------P
TH_2146|M.thermoresistible__bu GFSGFGFTDHPAPTQKWLDHG--------------------------GHD
MLBr_00131|M.leprae_Br4923 GADSYWVGDHLNALVPRSVATPKYLG-------------VAAKVVPKIDA
* . ::
Mb0815c|M.bovis_AF2122/97 LLECWTALAALSR--DTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQG
Rv0791c|M.tuberculosis_H37Rv LLECWTALAALSR--DTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQG
Mflv_4098|M.gilvum_PYR-GCK SMEAWTLATALLS--RTERLRIGHMVLCNQFRHPVTLAKMVTTLDQISGG
Mvan_2247|M.vanbaalenii_PYR-1 SMEAWTLATALLS--RTDTLRVGHMVLCNQFRHPVTLAKMATTLDQISGG
MMAR_1055|M.marinum_M LLAPLELLAYCAA--CTNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNG
MUL_0814|M.ulcerans_Agy99 LLAPLQLLAYCAA--CTNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNG
MAV_4445|M.avium_104 PLAPLELLAYCAA--CTERLRLGVAVLVTSLHDPLQLASAVTAVDRLSHG
MAB_3792|M.abscessus_ATCC_1997 IIAPLELLAYAAA--CTTRLRLGVAVLVASQHDPLQLAAAVTAVDRLSHG
MSMEG_1475|M.smegmatis_MC2_155 LIAPLELLSYAAA--VTTRLRLGVAVLVTSLHDPLQLASSITAVDRLSHG
TH_2146|M.thermoresistible__bu TLDPFVAMGFAAA--HTTTLRLIPHIVVLPYRNPFVVAKAGASVDLLSGG
MLBr_00131|M.leprae_Br4923 NYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG
**: : :.* * :::. :: *
Mb0815c|M.bovis_AF2122/97 RLDLGLGAGWFRRESQAYGIPFPPVGDRVSALAESLQVIKAVWTE--PNP
Rv0791c|M.tuberculosis_H37Rv RLDLGLGAGWFRRESQAYGIPFPPVGDRVSALAESLQVIKAVWTE--PNP
Mflv_4098|M.gilvum_PYR-GCK RLSLGIGSGSIEDEHRRAGLPWGTFAERSAQLGETLQILRQAFTD--ERV
Mvan_2247|M.vanbaalenii_PYR-1 RLSLGIGSGSIEDEHRRAGLPWGSFAERSEQLGETLQILHQAFGD--ERI
MMAR_1055|M.marinum_M RLDLGVAAGGGSRKFAAFGVDRATHVSY---FTEGLQLMKAAWSDE-PRV
MUL_0814|M.ulcerans_Agy99 RLDLGVAAGGGSRKFAAFGVDRATHVSY---FTEGLQLMKAAWSDE-PRV
MAV_4445|M.avium_104 RLDIGVAPGGGTRKFAAFGVDKDTFVAY---FTEGLKLMKAAWSDD-PRV
MAB_3792|M.abscessus_ATCC_1997 RLDVGVAPGGGARNFAAFGVDKQTFIAR---FTEGLDLMKLAWSDE-ERI
MSMEG_1475|M.smegmatis_MC2_155 RLDVGVAPGGGSRQFRAFGVDPSTFIAN---FTEGLALMKAAWSDE-PRV
TH_2146|M.thermoresistible__bu RFTLGVGVGYLKREFAALGVDFEERAAL---FEEALEVIRAIWTT--DNV
MLBr_00131|M.leprae_Br4923 KAMLGIGVGE-REGNEPYGVEWTKPVAR---FQEALATIRALWDSNGELV
: :*:. * *: : * * :: :
Mb0815c|M.bovis_AF2122/97 TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQR-IAAKHAQGLNVR
Rv0791c|M.tuberculosis_H37Rv TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQR-IAAKHAQGLNVR
Mflv_4098|M.gilvum_PYR-GCK DFAGRHFTVTDFPIKPGPVQKSGPPIVVGGVGEKYTLPLVARYADVWNVP
Mvan_2247|M.vanbaalenii_PYR-1 DFTGKHFTVTDMPIKPGPVQRPRPPIVVGGVGEKFTLPLVARYADVWNVP
MMAR_1055|M.marinum_M RFHGRFRDVDDLPIQPKPVQRPHPPIWFGGRAPKALARAVRHGDAFLGAG
MUL_0814|M.ulcerans_Agy99 RFHGRFRDVDDLPIQPKRVQRPHPPIWFGGRAPKALARAVRHGDAFLGAG
MAV_4445|M.avium_104 TFHGRFRDVDDLPIAPKPVQRPHPPIWFGGLAPKALARAVRHGDAFMGAG
MAB_3792|M.abscessus_ATCC_1997 TFRGRFRDVADLAFQPKPVQRPHPPIWFGGHAPAALARAVRFGDAFLGAG
MSMEG_1475|M.smegmatis_MC2_155 TFHGRFRDVDGLPITPKPVQRPHPPIWFGANAPKALARAVRLGDAFLGAG
TH_2146|M.thermoresistible__bu SYTGRHFTADGITAHPHPVTKPHPPIWIGGNTGAARQRVADHGAGWCPFP
MLBr_00131|M.leprae_Br4923 SRESQFFPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIV
.:. . * : ...
Mb0815c|M.bovis_AF2122/97 WWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGE-------
Rv0791c|M.tuberculosis_H37Rv WWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGE-------
Mflv_4098|M.gilvum_PYR-GCK TYALDQIEPKIAVLRSICEDIGRDPDSIVLSIEAVMAVAPDQESLESVRM
Mvan_2247|M.vanbaalenii_PYR-1 TYALGQIKEKIAALRSICEDVGRDPQTITLSIEAVMALAPDEASLPTVRS
MMAR_1055|M.marinum_M SSTTADFATAVTTLRHELAEQGRDPAGFTIGKRVYLMVDDDPERARERVL
MUL_0814|M.ulcerans_Agy99 SSTTADFATAVTTLRHELAEQGRDPAGFTIGKRVYLMVDDDPERARERVL
MAV_4445|M.avium_104 SSTTEAFAGAVAVLRRELDEQQRDPAEFTIGKRVYLTVDDDAARARERVL
MAB_3792|M.abscessus_ATCC_1997 SSTTAAFAEEVTTIHRELAIQGKDPARFTIGKRVYLMIDDDRDRAHTRVQ
MSMEG_1475|M.smegmatis_MC2_155 SSTTAHFAEAVRIVREELDKQGKDPQSFRIGKRVYLIVDDDGARARERVA
TH_2146|M.thermoresistible__bu APAVLAQTARTAAMD--------SAEALAAGITDLHRRLEATGRDPADVD
MLBr_00131|M.leprae_Br4923 LVRPTDYSCALEVVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALD
: .. : .
Mb0815c|M.bovis_AF2122/97 -EEVRIREE-----------------------------------------
Rv0791c|M.tuberculosis_H37Rv -EEVRIREE-----------------------------------------
Mflv_4098|M.gilvum_PYR-GCK LAEKRFRGP-----------------------------------------
Mvan_2247|M.vanbaalenii_PYR-1 LAEKRFGGE-----------------------------------------
MMAR_1055|M.marinum_M AGLRSIYGK-----------------------------------------
MUL_0814|M.ulcerans_Agy99 AGLRSIYGK-----------------------------------------
MAV_4445|M.avium_104 AGLSRIYGR-----------------------------------------
MAB_3792|M.abscessus_ATCC_1997 TGLRRIYGE-----------------------------------------
MSMEG_1475|M.smegmatis_MC2_155 EGLRRIYGP-----------------------------------------
TH_2146|M.thermoresistible__bu VVFSNLTG------------------------------------------
MLBr_00131|M.leprae_Br4923 SVLVRMIALGVPGEAWARHGVEHPMGADFAGVQDIIPQTIDEETVVSYAA
:
Mb0815c|M.bovis_AF2122/97 --FASIPEPGLIVGTPDRCVERIREYQDRGVGHFLFTIP---HVVKSDYL
Rv0791c|M.tuberculosis_H37Rv --FASIPEPGLIVGTPDRCVERIREYQDRGVGHFLFTIP---HVVKSDYL
Mflv_4098|M.gilvum_PYR-GCK --GFGLHDTGLIG-TPAEIAAKLGRLVEIGFGQIVLFTH---DRCSDQTL
Mvan_2247|M.vanbaalenii_PYR-1 --GFGLHDTDLIG-TPAEMVDRLGALAEMGFGQIVLFTH---DRCSDQTL
MMAR_1055|M.marinum_M --MGGLDAVAVAG-TPDDVTRGLAEVIAAGAQTLLLNPVGPDVGQNHEQM
MUL_0814|M.ulcerans_Agy99 --MGGLDAVAVAG-TPDDVTRGLAEVIAAGAQTLLLNPVGPDVGQNHEQT
MAV_4445|M.avium_104 --MPGVADVPVSG-TPGDVVRGLREVIDAGAQTLLLNPVGADVAENHEQM
MAB_3792|M.abscessus_ATCC_1997 --MKGIDAVPVSG-PPEEVAAGLRAVADAGAEMILLNPVGKDVAEDREQM
MSMEG_1475|M.smegmatis_MC2_155 --KADYADVAVAG-TPGEVVRGLREVIEAGAQTVLLNPTGVDVAEDREQM
TH_2146|M.thermoresistible__bu ------GTPGRADFNADAYLDGVAKLGALGVTWLQVPIPGDSLNHALEAI
MLBr_00131|M.leprae_Br4923 KVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLRKTV
. : * . . .
Mb0815c|M.bovis_AF2122/97 HIIG--SDIIPRVKTEVTIP
Rv0791c|M.tuberculosis_H37Rv HIIG--SDIIPRVKTEVTIP
Mflv_4098|M.gilvum_PYR-GCK ELLA--SEIIPRL-------
Mvan_2247|M.vanbaalenii_PYR-1 ELLA--AEVIPRL-------
MMAR_1055|M.marinum_M ERLA--AEVIPRLR------
MUL_0814|M.ulcerans_Agy99 ERLA--AEVIPRLR------
MAV_4445|M.avium_104 ERLA--AEVIPQLN------
MAB_3792|M.abscessus_ATCC_1997 ERLA--AEVIPQLA------
MSMEG_1475|M.smegmatis_MC2_155 ERLA--AEVIPQLT------
TH_2146|M.thermoresistible__bu EAFG--SEVIGKL-------
MLBr_00131|M.leprae_Br4923 SALLPHARVLRGLKKL----
: : :: :