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MTNAQNLIGGAWVGEPIIERRNPANPDDVVAIAPSASAADVHDAVAAATDAQPGWAALTAVQRGAILMDA ADLLRRRHEEIATDLTREEGKTRAEAMGEVRRAIDVLRFFGSAGWRPSGETLPSTMPNTSVHTRREPLGV VGLVTPWNFPIAIPAWKMAPALVSGNAVVIKPAELTPLSINHLATALIDAGLPAGVLNVVHGSGSLAGDA LVRHQEVAAVSFTGSTGVGMAIRDVVNARNARVQLEMGGKNAYLVLDDADVEAAAATVAAGAFSLTGQAC TATSRVYVTPGVREVFVKALREKAGAVKSGNGLDPGTTMGPVVSDAQLAKDVTAIHAAVEAGFDAGEVTE PKGQFLAPVVFSGVPHDHPLVTREVFGPVVGVIDVADYQEGLNLVNDSPYGLTAGICTRDLGKAYDFAAR VRVGVVKINRPTTGLDLNVPFGGVRDSSTNTFREQGERAVDFYTWTKSVYIGHDL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1158 | - | - | 100% (475) | 5-oxovalerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1461 | - | e-103 | 45.45% (473) | 5-oxovalerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6687 | - | e-102 | 44.03% (477) | aldehyde dehydrogenase, thermostable |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0775c | mmsA | 2e-70 | 35.78% (464) | methylmalonate-semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4063 | - | 2e-68 | 36.30% (449) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0753c | mmsA | 3e-71 | 35.99% (464) | methylmalonate-semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 6e-46 | 28.70% (460) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0823 | - | 1e-102 | 44.86% (477) | aldehyde dehydrogenase |
| M. marinum M | MMAR_1079 | mmsA | 5e-71 | 35.22% (460) | methylmalonate semialdehyde dehydrogenase, MmsA |
| M. avium 104 | MAV_1897 | - | 3e-80 | 38.57% (446) | betaine-aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4137 | - | 3e-68 | 35.75% (456) | PUTATIVE putative [NADP+] succinate-semialdehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0837 | mmsA | 6e-72 | 35.43% (460) | methylmalonate semialdehyde dehydrogenase, MmsA |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 1e-105 | 45.83% (480) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4063|M.gilvum_PYR-GCK ------------MTASDVINPATEEVLR----------------------
MAV_1897|M.avium_104 ------------MTDTTISNGVTEQLVHFDLVIGGESVAAESGRTYDSID
MLBr_02573|M.leprae_Br4923 -------------MSIATINPATGETVK----------------------
TH_4137|M.thermoresistible__bu MYIDGEWQSAASGKTFASINPANGAVLD----------------------
MAB_0823|M.abscessus_ATCC_1997 ------------MHINEIQSFVGGRWISGGGQAVISVCPAFPDR------
Mvan_1856|M.vanbaalenii_PYR-1 -----------MTGPASVRHLIDGEWLPGGGDALVSVNPARPTV------
MSMEG_1158|M.smegmatis_MC2_155 --------------MTNAQNLIGGAWV--GEPIIERRNPANPDD------
Mb0775c|M.bovis_AF2122/97 -------------MTTQISHFIDGQRTAGQSTRSADVFDPNTGQ------
Rv0753c|M.tuberculosis_H37Rv -------------MTTQISHFIDGQRTAGQSTRSADVFDPNTGQ------
MMAR_1079|M.marinum_M -------------MTTQIPHFIDGRRTPGQSTRTADVLDPNTGQ------
MUL_0837|M.ulcerans_Agy99 -------------MTTQIPHFIDGRRTPGQSTRTADVLDPNTGQ------
Mflv_4063|M.gilvum_PYR-GCK --------TVEHTDEAGVDDAVARAKAAQR-SWARQAPAERAAALRAFAA
MAV_1897|M.avium_104 PYTALPWARVPDCGPADVDRAVAAARAALRGPWGQLTGTARGKLLWRLGE
MLBr_02573|M.leprae_Br4923 --------TFTPTTQDEVEDAIARAYARFD-NYRHTTFTQRAKWANATAD
TH_4137|M.thermoresistible__bu --------SVPDGEREDARRAIDAAAAALP-DWRSRTAYERAEVLVEAHR
MAB_0823|M.abscessus_ATCC_1997 -----VIAEGLAAGPAEFDEAAAAARAAQP-GWAAMSLHARGAMLSHAAA
Mvan_1856|M.vanbaalenii_PYR-1 -----VVAEGSCAVASDVDAAVGAAAAAAP-SWAATGMHQRGARLLAAAE
MSMEG_1158|M.smegmatis_MC2_155 -----VVAIAPSASAADVHDAVAAATDAQP-GWAALTAVQRGAILMDAAD
Mb0775c|M.bovis_AF2122/97 -----IQAKVPMAGKSDIDAAVASAVEAQK-GWAAWNPQRRARVLMRFIE
Rv0753c|M.tuberculosis_H37Rv -----IQAKVPMAGKSDIDAAVASAVEAQK-GWAAWNPQRRARVLMRFIE
MMAR_1079|M.marinum_M -----VQATVPMAAQADIDAAVAGAAEAQI-GWAAWNPQRRARVLMRFIE
MUL_0837|M.ulcerans_Agy99 -----VQATVPMAAQADIDAAVAGAAEAQV-GWAAWNPQRRARVLMRFIE
* * : *.
Mflv_4063|M.gilvum_PYR-GCK VVDAHVEELAALEVANSGHPIGNARWEAGHVRDVLQYYSASPERLSGKQI
MAV_1897|M.avium_104 LIAREAESLAELEVRDGGKLVREMIGQMKALPDYYIYYAGLADKLQGEVV
MLBr_02573|M.leprae_Br4923 LLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEP
TH_4137|M.thermoresistible__bu IMLERRDDLAELMTREQGKPLRMARTEVGYAADFLLWFAEEAKRVYGEVI
MAB_0823|M.abscessus_ATCC_1997 VVDRNADAWGLELAAEEGKTKAEGIAEVRRAAQILRYYGNEGDRQTGEIF
Mvan_1856|M.vanbaalenii_PYR-1 IVERNAERWGLELATEEGKTRAEGVGEVRRAAQILRYYGNEGDRQAGEIY
MSMEG_1158|M.smegmatis_MC2_155 LLRRRHEEIATDLTREEGKTRAEAMGEVRRAIDVLRFFGSAGWRPSGETL
Mb0775c|M.bovis_AF2122/97 LVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYT
Rv0753c|M.tuberculosis_H37Rv LVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYT
MMAR_1079|M.marinum_M LVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLGIPHLLKGEYT
MUL_0837|M.ulcerans_Agy99 LVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLGIPHLLKGEYT
:: : . : *: : . : ..
Mflv_4063|M.gilvum_PYR-GCK PVAGG----LDVTFNEPLGVVGVITPWNFPMTIASWGFAPALAAGNAVLV
MAV_1897|M.avium_104 PVDKPN--FFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVV
MLBr_02573|M.leprae_Br4923 AEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLL
TH_4137|M.thermoresistible__bu PSARAD--QRFIVLAQPVGVCAAITPWNYPISMLTRKLAPALAAGCTSVL
MAB_0823|M.abscessus_ATCC_1997 SSPRRG--EHILVTRKPLGVVGVITPFNFPIAIPAWKIAPALVYGNAVLW
Mvan_1856|M.vanbaalenii_PYR-1 SSPRPG--EQILVTRKPLGVVGVVTPFNFPIAIPAWKIAPALVYGNTVVW
MSMEG_1158|M.smegmatis_MC2_155 PSTMPN--TSVHTRREPLGVVGLVTPWNFPIAIPAWKMAPALVSGNAVVI
Mb0775c|M.bovis_AF2122/97 EGAGPG--IDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVL
Rv0753c|M.tuberculosis_H37Rv EGAGPG--IDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVL
MMAR_1079|M.marinum_M EGAGPG--IDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVL
MUL_0837|M.ulcerans_Agy99 EGAGPG--IDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVL
:*:** : *:* * ...* * . :
Mflv_4063|M.gilvum_PYR-GCK KPAEWTPLTTIRLGELAVEAGLPADLFQVLPG-RGSVVGERFVTHPDVRK
MAV_1897|M.avium_104 KPSDHTPASTLAFAKLFAEAGFPPGVINVVTG-WGPQTGAALAAHPDVDK
MLBr_02573|M.leprae_Br4923 KHASNVPQCALYLADVIARGGFPEDCFQTLLISANG--VEAILRDPRVAA
TH_4137|M.thermoresistible__bu KPAEQTPLCAVETFKVFADAGVPAGVVNLVTCSDPEPVADELLGDPRVRK
MAB_0823|M.abscessus_ATCC_1997 KPASTVPLLAMRLAQAFDAAGLPPGVLNLVVG--DTGVGDAMVNDSRVDA
Mvan_1856|M.vanbaalenii_PYR-1 KPASTVPLLALRFAEALTDAGLPPGVLNLVVG--GADIGDAIVNHPGIDG
MSMEG_1158|M.smegmatis_MC2_155 KPAELTPLSINHLATALIDAGLPAGVLNVVHGS-GSLAGDALVRHQEVAA
Mb0775c|M.bovis_AF2122/97 KPSERDPSVPVRLAELFIEAGLPAGVFQVVHG--DKEAVDAILHHPDIKA
Rv0753c|M.tuberculosis_H37Rv KPSERDPSVPVRLAELFIEAGLPAGVFQVVHG--DKEAVDAILHHPDIKA
MMAR_1079|M.marinum_M KPSERDPSVPLRLAELFVEAGLPPGVFQVVHG--DKEAVDAILNHPEIKA
MUL_0837|M.ulcerans_Agy99 KPSERDPSVPLRLAELFVEAGLPPGVFQVVHG--DKEAVDAILNHPEIKA
* :. * .*.* . .: : : . :
Mflv_4063|M.gilvum_PYR-GCK IVFTGSTEVGTRVMAQAATQVKRVTLELGGKSANIVFDDCDLERAAATAP
MAV_1897|M.avium_104 IAFTGSTATGISVGKAAIDNMTRFTLELGGKSAQVVFDDADLDAAANGVI
MLBr_02573|M.leprae_Br4923 ATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAV
TH_4137|M.thermoresistible__bu ISFTGSTEVGRMIASRAGATMKRVSMELGGHAPFLVFPDADPEHAAKGGA
MAB_0823|M.abscessus_ATCC_1997 LTFTGSTGVGRRIAAAGAARGIPVQAEMGGKNAAVVLDDADVDLAVEQVL
Mvan_1856|M.vanbaalenii_PYR-1 ITFTGSTGVGRRIAAAAAARGVPAQAEMGGKNAAVVLDDADLDLAVEQVM
MSMEG_1158|M.smegmatis_MC2_155 VSFTGSTGVGMAIRDVVNARNARVQLEMGGKNAYLVLDDADVEAAAATVA
Mb0775c|M.bovis_AF2122/97 VGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALI
Rv0753c|M.tuberculosis_H37Rv VGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALI
MMAR_1079|M.marinum_M VGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDALI
MUL_0837|M.ulcerans_Agy99 VGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDALI
:.** . : *. :*: ..* : *.
Mflv_4063|M.gilvum_PYR-GCK YGVFDNSGQDCCARSRILVQ-RSVFDRFMELLEPAVKGVVVGDPGAEGTE
MAV_1897|M.avium_104 AGVFAATGQTCLAGSRLLVH-ESVADALVERIVARASTIKLGDPKDPATE
MLBr_02573|M.leprae_Br4923 TGRVQNNGQSCIAAKRFIAH-ADIYDEFVEKFVARMETLRVGDPTDPDTD
TH_4137|M.thermoresistible__bu AVKFLNTGQACICPNRFIVH-RSIAEPFIATLRARIEKLVPGDGLAAGTT
MAB_0823|M.abscessus_ATCC_1997 LGAFRSTGQKCTATSRLVLT-EGIADAFLSLLKDRADALVVGDPTADDTQ
Mvan_1856|M.vanbaalenii_PYR-1 LGAFRSTGQKCTATSRLIVT-AGIADAFSEALLAQARALRVGDPVDDATQ
MSMEG_1158|M.smegmatis_MC2_155 AGAFSLTGQACTATSRVYVT-PGVREVFVKALREKAGAVKSGNGLDPGTT
Mb0775c|M.bovis_AF2122/97 GAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKAD
Rv0753c|M.tuberculosis_H37Rv GAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKAD
MMAR_1079|M.marinum_M GAGYGSAGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKAD
MUL_0837|M.ulcerans_Agy99 GAGYGSTGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKAD
*: * . . : : : : *. :
Mflv_4063|M.gilvum_PYR-GCK MGPLVSKAHWNSVSSYVP----DDAPVAFRG-SAPQGP------------
MAV_1897|M.avium_104 MGPVSNQPQYEKVLSHFASAREQGATVAYGGEPAGELG------------
MLBr_02573|M.leprae_Br4923 VGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP-------------
TH_4137|M.thermoresistible__bu VGPLIDEVALKKMQRQVDDAVDKGAKLELGGSRLQGPAFDN---------
MAB_0823|M.abscessus_ATCC_1997 MGPVVSESAFGTITAGIGGAVAQGAVTLAGGHG-----------YGDGPL
Mvan_1856|M.vanbaalenii_PYR-1 MGPVVSDSAQQSITAGIDTAVTQGATVLTGGRP-----------YQDGAL
MSMEG_1158|M.smegmatis_MC2_155 MGPVVSDAQLAKDVTAIHAAVEAG---FDAG---------------EVTE
Mb0775c|M.bovis_AF2122/97 YGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANL
Rv0753c|M.tuberculosis_H37Rv YGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANL
MMAR_1079|M.marinum_M YGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDANL
MUL_0837|M.ulcerans_Agy99 YGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDANL
**: . . *
Mflv_4063|M.gilvum_PYR-GCK --GFWFPPTVLT-PARDDRTVVEEIFGPVVTVLPFDDEADAIALANDTVY
MAV_1897|M.avium_104 --GFFVKPTVLTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEF
MLBr_02573|M.leprae_Br4923 --GWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPF
TH_4137|M.thermoresistible__bu --GHFYAPTILTGVTPDMLICSEETFGPIAPVMVFDDEDEAIAMANSTEY
MAB_0823|M.abscessus_ATCC_1997 AAGYFIAPTIMELGMGAVDLWTEELFGPVLAVRRAADTEEAFRLANDSEY
Mvan_1856|M.vanbaalenii_PYR-1 AEGYFVAPTVVELGAAPVDVWTDELFGPVLAIRRATDAEEAFALANDSEF
MSMEG_1158|M.smegmatis_MC2_155 PKGQFLAPVVFSGVPHDHPLVTREVFGPVVGVIDVADYQEGLNLVNDSPY
Mb0775c|M.bovis_AF2122/97 EGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEY
Rv0753c|M.tuberculosis_H37Rv EGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEY
MMAR_1079|M.marinum_M EGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHEY
MUL_0837|M.ulcerans_Agy99 EGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHEY
* : *.:. * ***: : : :.: . :
Mflv_4063|M.gilvum_PYR-GCK GLSGSIWTDNISRAMRVSRAVEAGNLSVN-SHSSVRYSTPFGGFKQSGLG
MAV_1897|M.avium_104 GLAAGVWTKDVHRAHRVAARLNAGTVWVN-AYRVVSPHVPFGGMGHSGIG
MLBr_02573|M.leprae_Br4923 GLGSNAWTQNESEQRHFIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYG
TH_4137|M.thermoresistible__bu GLAGYIYTRDISRAIRVGEALDFGMIGIN-DINPTSAAVPFGGIKQSGLG
MAB_0823|M.abscessus_ATCC_1997 GLSAAIFTKDLTRALSAVDHVDVGILHVNSESAGADPHVPFGGAKKSGLG
Mvan_1856|M.vanbaalenii_PYR-1 GLSAAVFTQDMTRALQAVERIDVGVLHVNSESAGADPHVPFGGAKKSGLG
MSMEG_1158|M.smegmatis_MC2_155 GLTAGICTRDLGKAYDFAARVRVGVVKINRPTTGLDLNVPFGGVRDSSTN
Mb0775c|M.bovis_AF2122/97 GNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGFG
Rv0753c|M.tuberculosis_H37Rv GNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFG
MMAR_1079|M.marinum_M GNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFG
MUL_0837|M.ulcerans_Agy99 GNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFG
* * : * : :* .*** *. .
Mflv_4063|M.gilvum_PYR-GCK R--ELGPDAPLSFTETKNVFFAVEEN-------------
MAV_1897|M.avium_104 R--ENGIDAVKDFTETKAVWVELSGATRDPFTLG-----
MLBr_02573|M.leprae_Br4923 R--ELSTHGIREFCNIKTVWIA-----------------
TH_4137|M.thermoresistible__bu R--EGARAGIEEYLDTKVLGIAL----------------
MAB_0823|M.abscessus_ATCC_1997 P-KEQGRAAREFFTHTTTVYLRGEEAM------------
Mvan_1856|M.vanbaalenii_PYR-1 P-KEQGGAAREFFTHTTTVYLRGGRAGS-----------
MSMEG_1158|M.smegmatis_MC2_155 TFREQGERAVDFYTWTKSVYIGHDL--------------
Mb0775c|M.bovis_AF2122/97 DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS
Rv0753c|M.tuberculosis_H37Rv DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS
MMAR_1079|M.marinum_M DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK
MUL_0837|M.ulcerans_Agy99 DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK
: . . : . :