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MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVL MRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQP LGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAV DAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGE RCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVV DGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE YGNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTV TSRWPSGIKDGAEFVIPTMS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0775c | mmsA | - | 100% (510) | methylmalonate-semialdehyde dehydrogenase |
M. bovis AF2122 / 97 | Mb2883c | aldC | 6e-52 | 32.20% (472) | aldehyde dehydrogenase |
M. bovis AF2122 / 97 | Mb0239c | gabD1 | 2e-48 | 31.03% (477) | succinic semialdehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5010 | - | 0.0 | 82.91% (509) | methylmalonate-semialdehyde dehydrogenase |
M. tuberculosis H37Rv | Rv0753c | mmsA | 0.0 | 99.80% (510) | methylmalonate-semialdehyde dehydrogenase |
M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-45 | 29.44% (479) | succinic semialdehyde dehydrogenase |
M. abscessus ATCC 19977 | MAB_1189c | - | 0.0 | 71.15% (506) | methylmalonic acid semialdehyde dehydrogenase MmsA |
M. marinum M | MMAR_1079 | mmsA | 0.0 | 90.37% (509) | methylmalonate semialdehyde dehydrogenase, MmsA |
M. avium 104 | MAV_4417 | mmsA | 0.0 | 91.36% (509) | methylmalonate-semialdehyde dehydrogenase |
M. smegmatis MC2 155 | MSMEG_1498 | mmsA | 0.0 | 83.10% (509) | methylmalonate-semialdehyde dehydrogenase |
M. thermoresistible (build 8) | TH_2909 | - | 0.0 | 85.07% (509) | PUTATIVE methylmalonate-semialdehyde dehydrogenase [acylating) |
M. ulcerans Agy99 | MUL_0837 | mmsA | 0.0 | 90.18% (509) | methylmalonate semialdehyde dehydrogenase, MmsA |
M. vanbaalenii PYR-1 | Mvan_1362 | - | 0.0 | 84.09% (509) | methylmalonate-semialdehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5010|M.gilvum_PYR-GCK ----------------------------MTTRIPHFIDGKRSELASTRTA Mvan_1362|M.vanbaalenii_PYR-1 MTHTTRAPCQGRVRITRISKYPPLEGSLMTTRIPHFIDGKRSDLSSTRTA MSMEG_1498|M.smegmatis_MC2_155 ----------------------------MTTQIQHFINGRRTSAGSTRTA Mb0775c|M.bovis_AF2122/97 ----------------------------MTTQISHFIDGQRTAGQSTRSA Rv0753c|M.tuberculosis_H37Rv ----------------------------MTTQISHFIDGQRTAGQSTRSA MAV_4417|M.avium_104 ----------------------------MTTQIPHFIDGQRTAGQSTRTA MMAR_1079|M.marinum_M ----------------------------MTTQIPHFIDGRRTPGQSTRTA MUL_0837|M.ulcerans_Agy99 ----------------------------MTTQIPHFIDGRRTPGQSTRTA TH_2909|M.thermoresistible__bu ----------------------------MTRQIHHFINGQHTAGQSTRTA MAB_1189c|M.abscessus_ATCC_199 --------------------------MSSLPQLTHFVAGKPVPGTSGRFA MLBr_02573|M.leprae_Br4923 -----------------------------------------------MSI Mflv_5010|M.gilvum_PYR-GCK GVLNPSTGEVQSEVLLASAADVDTAVASAVEAQKEWAAWNPQRRARVFMK Mvan_1362|M.vanbaalenii_PYR-1 DVLNPSTGAVQAEVLLASAADVDTAVASAVEAQKEWAAWNPQRRARVMMK MSMEG_1498|M.smegmatis_MC2_155 DVMNPSTGEVQAQVLLASAADVDAAVTGAAEAQKEWAAYNPQRRARVLMK Mb0775c|M.bovis_AF2122/97 DVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMR Rv0753c|M.tuberculosis_H37Rv DVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMR MAV_4417|M.avium_104 EVFDPSTGAVQAQVPMAGRADIDAAVASAIEAQKGWAATNPQRRARVLMR MMAR_1079|M.marinum_M DVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQIGWAAWNPQRRARVLMR MUL_0837|M.ulcerans_Agy99 DVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQVGWAAWNPQRRARVLMR TH_2909|M.thermoresistible__bu DVMNPSTGKVQAKVVMGTAADIDAAVAGAAEAQKEWAAWNPQRRARVLMK MAB_1189c|M.abscessus_ATCC_199 DVYDPTQGKPVRQVPLADVSEVEAAISNAAEAQPGWAARNPQQRARVLAK MLBr_02573|M.leprae_Br4923 ATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANA . :* * . ::: *:: * : . :**: Mflv_5010|M.gilvum_PYR-GCK FIQLVNDHVDELAELLSIEHGKTVADSKGDIQRGIEVIEFAIG-IPHLLK Mvan_1362|M.vanbaalenii_PYR-1 FIELVNANIDELAELLSIEHGKTVPDAKGDIQRGIEVIEFAIG-IPHLLK MSMEG_1498|M.smegmatis_MC2_155 FIDLVNQNADELARLLSIEHGKTVADSLGDIQRGIEVIEFAVG-IPHLLK Mb0775c|M.bovis_AF2122/97 FIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLG-IPHLLK Rv0753c|M.tuberculosis_H37Rv FIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLG-IPHLLK MAV_4417|M.avium_104 FIELVNQHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVG-IPHLLK MMAR_1079|M.marinum_M FIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLG-IPHLLK MUL_0837|M.ulcerans_Agy99 FIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLG-IPHLLK TH_2909|M.thermoresistible__bu FIDLVNQNVDELAELLSLEHGKTLADAKGDIQRGIEVIEFSIG-IPHLQK MAB_1189c|M.abscessus_ATCC_199 FVDLVRAEIDDLAAMLSQEHGKTLADAKGDIERGLEVCEFATG-IPHLIK MLBr_02573|M.leprae_Br4923 TADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLA :*:. :: * ::: * ***: .: .: : : .: * Mflv_5010|M.gilvum_PYR-GCK GEFTENAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA Mvan_1362|M.vanbaalenii_PYR-1 GEFTEGAGSGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MSMEG_1498|M.smegmatis_MC2_155 GEFTEGAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA Mb0775c|M.bovis_AF2122/97 GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA Rv0753c|M.tuberculosis_H37Rv GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MAV_4417|M.avium_104 GEYSEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MMAR_1079|M.marinum_M GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MUL_0837|M.ulcerans_Agy99 GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA TH_2909|M.thermoresistible__bu GEYTEGAGPGIDVYSMR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MAB_1189c|M.abscessus_ATCC_199 GEYTSGAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA MLBr_02573|M.leprae_Br4923 DEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNV .* :. *. * . * ****** .: *:*** .: *.*** .**. Mflv_5010|M.gilvum_PYR-GCK FILKPSERDPSVPLRLAELFLEAGLPAGVFQVVQGDKEAVDAILTHPDIQ Mvan_1362|M.vanbaalenii_PYR-1 FILKPSERDPSVPVRLAELFLEAGLPAGVFQVVHGDKEAVDAILTHPDIQ MSMEG_1498|M.smegmatis_MC2_155 FILKPSERDPSVPVRLAELFIEAGLPPGVFQVVQGDKEAVDAILTHPTVQ Mb0775c|M.bovis_AF2122/97 FVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIK Rv0753c|M.tuberculosis_H37Rv FVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIK MAV_4417|M.avium_104 FVLKPSERDPSVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQ MMAR_1079|M.marinum_M FVLKPSERDPSVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIK MUL_0837|M.ulcerans_Agy99 FVLKPSERDPSVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIK TH_2909|M.thermoresistible__bu FILKPSERDPSVPVRLAELFLQAGLPSGLFQVVHGDKEAVDAILEHPTIQ MAB_1189c|M.abscessus_ATCC_199 FVLKPSERDPSVPLRLAELFLEAGLPPGVFNVVNGDKTAVDALLHDPRVA MLBr_02573|M.leprae_Br4923 GLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVA :** :.. *. .: **::: ..*:* . *:.: . .*:*:* .* : Mflv_5010|M.gilvum_PYR-GCK AVGFVGSSDIAQYIYSTAAAHGKRSQCFGGAKNHMIIMPDADLDQAVDAL Mvan_1362|M.vanbaalenii_PYR-1 AVGFVGSSDIAQYIYSTAAANGKRSQCFGGAKNHMIIMPDADLDQAVDAL MSMEG_1498|M.smegmatis_MC2_155 AVGFVGSSDIAQYIYSTAAAHGKRSQCFGGAKNHMIIMPDADLDQAVDAL Mb0775c|M.bovis_AF2122/97 AVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDAL Rv0753c|M.tuberculosis_H37Rv AVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDAL MAV_4417|M.avium_104 AVGFVGSSDIAQYIYAGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL MMAR_1079|M.marinum_M AVGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL MUL_0837|M.ulcerans_Agy99 AVGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL TH_2909|M.thermoresistible__bu AVGFVGSSDIAQYIYAGATAHGKRAQCFGGAKNHMIVMPDADLDQAVDAL MAB_1189c|M.abscessus_ATCC_199 AVGFVGSTPIAQYIYETATANGKRAQCFGGAKNHMIIMPDADIDQAIDAL MLBr_02573|M.leprae_Br4923 AATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATA *. :.** .* : * * : *..: :*:**.**:* *: : Mflv_5010|M.gilvum_PYR-GCK IGAGYGSAGERCMAISVAVPVGEETANRLRNRLVERVNQLRVGHSLDPKA Mvan_1362|M.vanbaalenii_PYR-1 IGAGYGSAGERCMAISVAVPVGEETANRLRNRLVERVNQLRVGHSLDPKA MSMEG_1498|M.smegmatis_MC2_155 IGAGYGSAGERCMAISVAVPVGEETANRLRARLTERVKQLRVGHSLDPKA Mb0775c|M.bovis_AF2122/97 IGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKA Rv0753c|M.tuberculosis_H37Rv IGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKA MAV_4417|M.avium_104 IGAGYGSAGERCMAISVAVPVGDKTADRLRARLVERINNLRVGHSLDPKA MMAR_1079|M.marinum_M IGAGYGSAGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKA MUL_0837|M.ulcerans_Agy99 IGAGYGSTGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKA TH_2909|M.thermoresistible__bu IGAGYGSAGERCMAISVAVPVGDEIADRLRARLIERVANLRVGHSLDPKA MAB_1189c|M.abscessus_ATCC_199 IGAGYGSAGERCMAISVAVPVGEATAERLVDGLTKRARELVVGASLDEGV MLBr_02573|M.leprae_Br4923 VTGRVQNNGQSCIAAKRFIAH-ADIYDEFVEKFVARMETLRVGDPTDPDT : . . *: *:* . :. :.: : * * ** . * . Mflv_5010|M.gilvum_PYR-GCK DYGPLVTGAALERVRDYIGQGVEAGAELVVDGRERATDELSF----DDQD Mvan_1362|M.vanbaalenii_PYR-1 DYGPLVTGAALERVRDYIGQGVDAGAELVVDGRERTTDELSF----DDQD MSMEG_1498|M.smegmatis_MC2_155 DYGPLVTEAALNRVKDYIGQGVEAGAELVVDGRERATDELTF----DDQS Mb0775c|M.bovis_AF2122/97 DYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDAN Rv0753c|M.tuberculosis_H37Rv DYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDAN MAV_4417|M.avium_104 DYGPLVTGAAVARVRDYIDQGVAAGAEIVVDGRERRSDDLTF----GDAN MMAR_1079|M.marinum_M DYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDAN MUL_0837|M.ulcerans_Agy99 DYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDAN TH_2909|M.thermoresistible__bu DYGPLVTEAALQRVRDYIGQGVEAGAELLVDGRERGSDDLQF----GDDS MAB_1189c|M.abscessus_ATCC_199 DFGPLVGADALKRVRDYIDIGVAEGAELVLDGRDLTVD-----------G MLBr_02573|M.leprae_Br4923 DVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKR---------------P * ***. . :*.: :. .. ** : .*: Mflv_5010|M.gilvum_PYR-GCK LSKGYFIGPTLFDHVTTDMSIYTDEIFGPVLCIVRAADYDEALSLPTKHE Mvan_1362|M.vanbaalenii_PYR-1 LSKGFFIGPTLFDHVTTDMSIYTGEIFGPVLCIVRAKDYDEALSLPSKHE MSMEG_1498|M.smegmatis_MC2_155 LEGGYFIGPTLFDHVKTDMSIYTDEIFGPVLCIVRAHDYEEALSLPTKHE Mb0775c|M.bovis_AF2122/97 LEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE Rv0753c|M.tuberculosis_H37Rv LEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE MAV_4417|M.avium_104 LEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAQNYEEALRLPSEHE MMAR_1079|M.marinum_M LEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE MUL_0837|M.ulcerans_Agy99 LEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE TH_2909|M.thermoresistible__bu LEGGYFIGPTLFDRVTTDMSIYRDEIFGPVLCMVRAKNYEEALALPSEHE MAB_1189c|M.abscessus_ATCC_199 HKDGFFIGASLFDHVTPEMRIYKEEIFGPVVSVVRAKDYDEAVRLPSEHE MLBr_02573|M.leprae_Br4923 DRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATP *:* .::: : .* :* *:**** .: * : ::*: :.. Mflv_5010|M.gilvum_PYR-GCK YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGF Mvan_1362|M.vanbaalenii_PYR-1 YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGF MSMEG_1498|M.smegmatis_MC2_155 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF Mb0775c|M.bovis_AF2122/97 YGNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGF Rv0753c|M.tuberculosis_H37Rv YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF MAV_4417|M.avium_104 YGNGVAVFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF MMAR_1079|M.marinum_M YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF MUL_0837|M.ulcerans_Agy99 YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF TH_2909|M.thermoresistible__bu YGNGVAIFTRDGDTARDFVSRVQCGMVGVNVPIPVPVAYHTFGGWKRSGF MAB_1189c|M.abscessus_ATCC_199 FGNGVAIFTRDGDTARDFCAKVNTGMVGVNVPIPVPVAYHTFGGWKASGF MLBr_02573|M.leprae_Br4923 FGLGSNAWTQNESEQRHFIDNIVAGQVFING-MTVSYPELPFGGIKRSGY :* * :*:: . *.* . * * :* :.*. . .*** * **: Mflv_5010|M.gilvum_PYR-GCK G-DLNQHGPASIQFYTKVKTVTERWPSGIKDGAEFVIPTMK Mvan_1362|M.vanbaalenii_PYR-1 G-DLNQHGPASIQFYTKVKTVTERWPSGIKDGAEFVIPTMK MSMEG_1498|M.smegmatis_MC2_155 G-DLNQHGPASIQFYTKTKTVTERWPSGIKDGAEFVIPTMK Mb0775c|M.bovis_AF2122/97 G-DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS Rv0753c|M.tuberculosis_H37Rv G-DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS MAV_4417|M.avium_104 G-DLNQHGPASIQFYTKVKTVTSRWPSGIKDGAEFVIPTMD MMAR_1079|M.marinum_M G-DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK MUL_0837|M.ulcerans_Agy99 G-DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK TH_2909|M.thermoresistible__bu G-DLNQHGPHSILFYTKTKTVTQRWPSGIKDGAEFSIPTMK MAB_1189c|M.abscessus_ATCC_199 G-DLNQHGPDSIRFYTKTKTVTQRWPSGIKEGASFVIPTMD MLBr_02573|M.leprae_Br4923 GRELSTHG---IREFCNIKTVWIA----------------- * :*. ** * : : ***