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M. bovis AF2122 / 97 Mb0775c (mmsA)

annotation: methylmalonate-semialdehyde dehydrogenase
coordinates: 846611 - 848143
length: 510

MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVL
MRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQP
LGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAV
DAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGE
RCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVV
DGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE
YGNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTV
TSRWPSGIKDGAEFVIPTMS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0775cmmsA-100% (510)methylmalonate-semialdehyde dehydrogenase
M. bovis AF2122 / 97Mb2883caldC6e-5232.20% (472) aldehyde dehydrogenase
M. bovis AF2122 / 97Mb0239cgabD12e-4831.03% (477) succinic semialdehyde dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_5010-0.082.91% (509) methylmalonate-semialdehyde dehydrogenase
M. tuberculosis H37RvRv0753cmmsA0.099.80% (510) methylmalonate-semialdehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD12e-4529.44% (479) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_1189c-0.071.15% (506) methylmalonic acid semialdehyde dehydrogenase MmsA
M. marinum MMMAR_1079mmsA0.090.37% (509) methylmalonate semialdehyde dehydrogenase, MmsA
M. avium 104MAV_4417mmsA0.091.36% (509) methylmalonate-semialdehyde dehydrogenase
M. smegmatis MC2 155MSMEG_1498mmsA0.083.10% (509) methylmalonate-semialdehyde dehydrogenase
M. thermoresistible (build 8)TH_2909-0.085.07% (509) PUTATIVE methylmalonate-semialdehyde dehydrogenase [acylating)
M. ulcerans Agy99MUL_0837mmsA0.090.18% (509) methylmalonate semialdehyde dehydrogenase, MmsA
M. vanbaalenii PYR-1Mvan_1362-0.084.09% (509) methylmalonate-semialdehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5010|M.gilvum_PYR-GCK          ----------------------------MTTRIPHFIDGKRSELASTRTA
Mvan_1362|M.vanbaalenii_PYR-1       MTHTTRAPCQGRVRITRISKYPPLEGSLMTTRIPHFIDGKRSDLSSTRTA
MSMEG_1498|M.smegmatis_MC2_155      ----------------------------MTTQIQHFINGRRTSAGSTRTA
Mb0775c|M.bovis_AF2122/97           ----------------------------MTTQISHFIDGQRTAGQSTRSA
Rv0753c|M.tuberculosis_H37Rv        ----------------------------MTTQISHFIDGQRTAGQSTRSA
MAV_4417|M.avium_104                ----------------------------MTTQIPHFIDGQRTAGQSTRTA
MMAR_1079|M.marinum_M               ----------------------------MTTQIPHFIDGRRTPGQSTRTA
MUL_0837|M.ulcerans_Agy99           ----------------------------MTTQIPHFIDGRRTPGQSTRTA
TH_2909|M.thermoresistible__bu      ----------------------------MTRQIHHFINGQHTAGQSTRTA
MAB_1189c|M.abscessus_ATCC_199      --------------------------MSSLPQLTHFVAGKPVPGTSGRFA
MLBr_02573|M.leprae_Br4923          -----------------------------------------------MSI
                                                                                      

Mflv_5010|M.gilvum_PYR-GCK          GVLNPSTGEVQSEVLLASAADVDTAVASAVEAQKEWAAWNPQRRARVFMK
Mvan_1362|M.vanbaalenii_PYR-1       DVLNPSTGAVQAEVLLASAADVDTAVASAVEAQKEWAAWNPQRRARVMMK
MSMEG_1498|M.smegmatis_MC2_155      DVMNPSTGEVQAQVLLASAADVDAAVTGAAEAQKEWAAYNPQRRARVLMK
Mb0775c|M.bovis_AF2122/97           DVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMR
Rv0753c|M.tuberculosis_H37Rv        DVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMR
MAV_4417|M.avium_104                EVFDPSTGAVQAQVPMAGRADIDAAVASAIEAQKGWAATNPQRRARVLMR
MMAR_1079|M.marinum_M               DVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQIGWAAWNPQRRARVLMR
MUL_0837|M.ulcerans_Agy99           DVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQVGWAAWNPQRRARVLMR
TH_2909|M.thermoresistible__bu      DVMNPSTGKVQAKVVMGTAADIDAAVAGAAEAQKEWAAWNPQRRARVLMK
MAB_1189c|M.abscessus_ATCC_199      DVYDPTQGKPVRQVPLADVSEVEAAISNAAEAQPGWAARNPQQRARVLAK
MLBr_02573|M.leprae_Br4923          ATINPATGETVKTFTPTTQDEVEDAIARAYARFDNYRHTTFTQRAKWANA
                                     . :*  *     .      ::: *:: *      :   .  :**:    

Mflv_5010|M.gilvum_PYR-GCK          FIQLVNDHVDELAELLSIEHGKTVADSKGDIQRGIEVIEFAIG-IPHLLK
Mvan_1362|M.vanbaalenii_PYR-1       FIELVNANIDELAELLSIEHGKTVPDAKGDIQRGIEVIEFAIG-IPHLLK
MSMEG_1498|M.smegmatis_MC2_155      FIDLVNQNADELARLLSIEHGKTVADSLGDIQRGIEVIEFAVG-IPHLLK
Mb0775c|M.bovis_AF2122/97           FIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLG-IPHLLK
Rv0753c|M.tuberculosis_H37Rv        FIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLG-IPHLLK
MAV_4417|M.avium_104                FIELVNQHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVG-IPHLLK
MMAR_1079|M.marinum_M               FIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLG-IPHLLK
MUL_0837|M.ulcerans_Agy99           FIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLG-IPHLLK
TH_2909|M.thermoresistible__bu      FIDLVNQNVDELAELLSLEHGKTLADAKGDIQRGIEVIEFSIG-IPHLQK
MAB_1189c|M.abscessus_ATCC_199      FVDLVRAEIDDLAAMLSQEHGKTLADAKGDIERGLEVCEFATG-IPHLIK
MLBr_02573|M.leprae_Br4923          TADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLA
                                      :*:.   :: * ::: * ***: .: .:  :  :  .:       *  

Mflv_5010|M.gilvum_PYR-GCK          GEFTENAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
Mvan_1362|M.vanbaalenii_PYR-1       GEFTEGAGSGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MSMEG_1498|M.smegmatis_MC2_155      GEFTEGAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
Mb0775c|M.bovis_AF2122/97           GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
Rv0753c|M.tuberculosis_H37Rv        GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MAV_4417|M.avium_104                GEYSEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MMAR_1079|M.marinum_M               GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MUL_0837|M.ulcerans_Agy99           GEYTEGAGPGIDVYSLR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
TH_2909|M.thermoresistible__bu      GEYTEGAGPGIDVYSMR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MAB_1189c|M.abscessus_ATCC_199      GEYTSGAGTGIDVYSIR-QPLGVVAGITPFNFPAMIPLWKAGPALACGNA
MLBr_02573|M.leprae_Br4923          DEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNV
                                    .* :. *. * .    * ****** .: *:***   .:  *.*** .**.

Mflv_5010|M.gilvum_PYR-GCK          FILKPSERDPSVPLRLAELFLEAGLPAGVFQVVQGDKEAVDAILTHPDIQ
Mvan_1362|M.vanbaalenii_PYR-1       FILKPSERDPSVPVRLAELFLEAGLPAGVFQVVHGDKEAVDAILTHPDIQ
MSMEG_1498|M.smegmatis_MC2_155      FILKPSERDPSVPVRLAELFIEAGLPPGVFQVVQGDKEAVDAILTHPTVQ
Mb0775c|M.bovis_AF2122/97           FVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIK
Rv0753c|M.tuberculosis_H37Rv        FVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIK
MAV_4417|M.avium_104                FVLKPSERDPSVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQ
MMAR_1079|M.marinum_M               FVLKPSERDPSVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIK
MUL_0837|M.ulcerans_Agy99           FVLKPSERDPSVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIK
TH_2909|M.thermoresistible__bu      FILKPSERDPSVPVRLAELFLQAGLPSGLFQVVHGDKEAVDAILEHPTIQ
MAB_1189c|M.abscessus_ATCC_199      FVLKPSERDPSVPLRLAELFLEAGLPPGVFNVVNGDKTAVDALLHDPRVA
MLBr_02573|M.leprae_Br4923          GLLKHASNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVA
                                     :** :.. *. .: **::: ..*:* . *:.:  .  .*:*:* .* : 

Mflv_5010|M.gilvum_PYR-GCK          AVGFVGSSDIAQYIYSTAAAHGKRSQCFGGAKNHMIIMPDADLDQAVDAL
Mvan_1362|M.vanbaalenii_PYR-1       AVGFVGSSDIAQYIYSTAAANGKRSQCFGGAKNHMIIMPDADLDQAVDAL
MSMEG_1498|M.smegmatis_MC2_155      AVGFVGSSDIAQYIYSTAAAHGKRSQCFGGAKNHMIIMPDADLDQAVDAL
Mb0775c|M.bovis_AF2122/97           AVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDAL
Rv0753c|M.tuberculosis_H37Rv        AVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDAL
MAV_4417|M.avium_104                AVGFVGSSDIAQYIYAGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL
MMAR_1079|M.marinum_M               AVGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL
MUL_0837|M.ulcerans_Agy99           AVGFVGSSDIAQYIYSGAAATGKRSQCFGGAKNHMIVMPDADLDQAVDAL
TH_2909|M.thermoresistible__bu      AVGFVGSSDIAQYIYAGATAHGKRAQCFGGAKNHMIVMPDADLDQAVDAL
MAB_1189c|M.abscessus_ATCC_199      AVGFVGSTPIAQYIYETATANGKRAQCFGGAKNHMIIMPDADIDQAIDAL
MLBr_02573|M.leprae_Br4923          AATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATA
                                    *. :.**   .* :   *    * :    *..: :*:**.**:* *: : 

Mflv_5010|M.gilvum_PYR-GCK          IGAGYGSAGERCMAISVAVPVGEETANRLRNRLVERVNQLRVGHSLDPKA
Mvan_1362|M.vanbaalenii_PYR-1       IGAGYGSAGERCMAISVAVPVGEETANRLRNRLVERVNQLRVGHSLDPKA
MSMEG_1498|M.smegmatis_MC2_155      IGAGYGSAGERCMAISVAVPVGEETANRLRARLTERVKQLRVGHSLDPKA
Mb0775c|M.bovis_AF2122/97           IGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKA
Rv0753c|M.tuberculosis_H37Rv        IGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKA
MAV_4417|M.avium_104                IGAGYGSAGERCMAISVAVPVGDKTADRLRARLVERINNLRVGHSLDPKA
MMAR_1079|M.marinum_M               IGAGYGSAGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKA
MUL_0837|M.ulcerans_Agy99           IGAGYGSTGERCMAISVAVPVGEQTADRLRAKLVERINNLRVGHSLDPKA
TH_2909|M.thermoresistible__bu      IGAGYGSAGERCMAISVAVPVGDEIADRLRARLIERVANLRVGHSLDPKA
MAB_1189c|M.abscessus_ATCC_199      IGAGYGSAGERCMAISVAVPVGEATAERLVDGLTKRARELVVGASLDEGV
MLBr_02573|M.leprae_Br4923          VTGRVQNNGQSCIAAKRFIAH-ADIYDEFVEKFVARMETLRVGDPTDPDT
                                    : .   . *: *:* .  :.      :.:   :  *   * ** . *  .

Mflv_5010|M.gilvum_PYR-GCK          DYGPLVTGAALERVRDYIGQGVEAGAELVVDGRERATDELSF----DDQD
Mvan_1362|M.vanbaalenii_PYR-1       DYGPLVTGAALERVRDYIGQGVDAGAELVVDGRERTTDELSF----DDQD
MSMEG_1498|M.smegmatis_MC2_155      DYGPLVTEAALNRVKDYIGQGVEAGAELVVDGRERATDELTF----DDQS
Mb0775c|M.bovis_AF2122/97           DYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDAN
Rv0753c|M.tuberculosis_H37Rv        DYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDAN
MAV_4417|M.avium_104                DYGPLVTGAAVARVRDYIDQGVAAGAEIVVDGRERRSDDLTF----GDAN
MMAR_1079|M.marinum_M               DYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDAN
MUL_0837|M.ulcerans_Agy99           DYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDLAF----GDAN
TH_2909|M.thermoresistible__bu      DYGPLVTEAALQRVRDYIGQGVEAGAELLVDGRERGSDDLQF----GDDS
MAB_1189c|M.abscessus_ATCC_199      DFGPLVGADALKRVRDYIDIGVAEGAELVLDGRDLTVD-----------G
MLBr_02573|M.leprae_Br4923          DVGPLATESGRAQVEQQVDAAAAAGAVIRCGGKR---------------P
                                    * ***.   .  :*.: :. ..  ** :  .*:                 

Mflv_5010|M.gilvum_PYR-GCK          LSKGYFIGPTLFDHVTTDMSIYTDEIFGPVLCIVRAADYDEALSLPTKHE
Mvan_1362|M.vanbaalenii_PYR-1       LSKGFFIGPTLFDHVTTDMSIYTGEIFGPVLCIVRAKDYDEALSLPSKHE
MSMEG_1498|M.smegmatis_MC2_155      LEGGYFIGPTLFDHVKTDMSIYTDEIFGPVLCIVRAHDYEEALSLPTKHE
Mb0775c|M.bovis_AF2122/97           LEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE
Rv0753c|M.tuberculosis_H37Rv        LEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE
MAV_4417|M.avium_104                LEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAQNYEEALRLPSEHE
MMAR_1079|M.marinum_M               LEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE
MUL_0837|M.ulcerans_Agy99           LEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE
TH_2909|M.thermoresistible__bu      LEGGYFIGPTLFDRVTTDMSIYRDEIFGPVLCMVRAKNYEEALALPSEHE
MAB_1189c|M.abscessus_ATCC_199      HKDGFFIGASLFDHVTPEMRIYKEEIFGPVVSVVRAKDYDEAVRLPSEHE
MLBr_02573|M.leprae_Br4923          DRPGWFYPPTVITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATP
                                       *:*  .:::  :  .* :*  *:**** .:  * : ::*: :..   

Mflv_5010|M.gilvum_PYR-GCK          YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
Mvan_1362|M.vanbaalenii_PYR-1       YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
MSMEG_1498|M.smegmatis_MC2_155      YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
Mb0775c|M.bovis_AF2122/97           YGNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGF
Rv0753c|M.tuberculosis_H37Rv        YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
MAV_4417|M.avium_104                YGNGVAVFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
MMAR_1079|M.marinum_M               YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
MUL_0837|M.ulcerans_Agy99           YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGF
TH_2909|M.thermoresistible__bu      YGNGVAIFTRDGDTARDFVSRVQCGMVGVNVPIPVPVAYHTFGGWKRSGF
MAB_1189c|M.abscessus_ATCC_199      FGNGVAIFTRDGDTARDFCAKVNTGMVGVNVPIPVPVAYHTFGGWKASGF
MLBr_02573|M.leprae_Br4923          FGLGSNAWTQNESEQRHFIDNIVAGQVFING-MTVSYPELPFGGIKRSGY
                                    :* *   :*:: .  *.*  .   * * :*  :.*. .  .*** * **:

Mflv_5010|M.gilvum_PYR-GCK          G-DLNQHGPASIQFYTKVKTVTERWPSGIKDGAEFVIPTMK
Mvan_1362|M.vanbaalenii_PYR-1       G-DLNQHGPASIQFYTKVKTVTERWPSGIKDGAEFVIPTMK
MSMEG_1498|M.smegmatis_MC2_155      G-DLNQHGPASIQFYTKTKTVTERWPSGIKDGAEFVIPTMK
Mb0775c|M.bovis_AF2122/97           G-DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS
Rv0753c|M.tuberculosis_H37Rv        G-DLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS
MAV_4417|M.avium_104                G-DLNQHGPASIQFYTKVKTVTSRWPSGIKDGAEFVIPTMD
MMAR_1079|M.marinum_M               G-DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK
MUL_0837|M.ulcerans_Agy99           G-DLNQHGPTSIQFYTKVKTVTSRWPSGIKDGAEFVIPTMK
TH_2909|M.thermoresistible__bu      G-DLNQHGPHSILFYTKTKTVTQRWPSGIKDGAEFSIPTMK
MAB_1189c|M.abscessus_ATCC_199      G-DLNQHGPDSIRFYTKTKTVTQRWPSGIKEGASFVIPTMD
MLBr_02573|M.leprae_Br4923          GRELSTHG---IREFCNIKTVWIA-----------------
                                    * :*. **   *  : : ***