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TASDVINPATEEVLRTVEHTDEAGVDDAVARAKAAQRSWARQAPAERAAALRAFAAVVDAHVEELAALEV ANSGHPIGNARWEAGHVRDVLQYYSASPERLSGKQIPVAGGLDVTFNEPLGVVGVITPWNFPMTIASWGF APALAAGNAVLVKPAEWTPLTTIRLGELAVEAGLPADLFQVLPGRGSVVGERFVTHPDVRKIVFTGSTEV GTRVMAQAATQVKRVTLELGGKSANIVFDDCDLERAAATAPYGVFDNSGQDCCARSRILVQRSVFDRFME LLEPAVKGVVVGDPGAEGTEMGPLVSKAHWNSVSSYVPDDAPVAFRGSAPQGPGFWFPPTVLTPARDDRT VVEEIFGPVVTVLPFDDEADAIALANDTVYGLSGSIWTDNISRAMRVSRAVEAGNLSVNSHSSVRYSTPF GGFKQSGLGRELGPDAPLSFTETKNVFFAVEEN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4063 | - | - | 100% (454) | betaine-aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4860 | - | 4e-86 | 40.22% (450) | gamma-aminobutyraldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0643 | - | 2e-81 | 39.43% (454) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 0.0 | 81.68% (453) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv2858c | aldC | 0.0 | 81.68% (453) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-61 | 33.55% (453) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 3e-92 | 42.57% (451) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 8e-92 | 40.65% (460) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2765 | - | 3e-91 | 40.87% (460) | P-cumic aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2597 | - | 0.0 | 86.03% (451) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3902 | - | 4e-76 | 37.53% (469) | PUTATIVE putative 5-carboxymethyl-2-hydroxymuconate |
| M. ulcerans Agy99 | MUL_2877 | - | 2e-90 | 40.43% (460) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2280 | - | 0.0 | 93.57% (451) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4063|M.gilvum_PYR-GCK ----------MT--------------------ASDVINPATEEVLRTVEH
Mvan_2280|M.vanbaalenii_PYR-1 ----------MTG-----------------ALASDVINPATEELLRTVEQ
MSMEG_2597|M.smegmatis_MC2_155 ----------MT--------------------ACQVINPATEQVLTTVEL
Mb2883c|M.bovis_AF2122/97 ----------MS--------------------TTQLINPATEEVLASVDH
Rv2858c|M.tuberculosis_H37Rv ----------MS--------------------TTQLINPATEEVLASVDH
MAV_2765|M.avium_104 ----------MTVQAVLDDIRKRPG----TGDVIAVIDPATEEKITEFTD
MMAR_2875|M.marinum_M ----------MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDESPVATVAC
MUL_2877|M.ulcerans_Agy99 ----------MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDESPVATVAC
TH_3902|M.thermoresistible__bu LRANRFQPKDNTVTWKYDLYIDGKWDTGTSGRALTVVNPATEETIGTVPD
MAB_3328|M.abscessus_ATCC_1997 ----------MSVPSSWINGRPVAT----HGDTHRVINPATGEAVADLKL
MLBr_02573|M.leprae_Br4923 -------------------------------MSIATINPATGETVKTFTP
::*. . : .
Mflv_4063|M.gilvum_PYR-GCK TDEAGVDDAVARAKAAQRS--WARQAPAERAAALRAFAAVVDAHVEELAA
Mvan_2280|M.vanbaalenii_PYR-1 TDEAGVDDAVARARAAQRR--WAALAPAERAAGLRAFAAVVDAHVEELAA
MSMEG_2597|M.smegmatis_MC2_155 LDEAAVDDAVARATVAQRR--WAALAPAERAAALRAFAAAVDAHIDELAA
Mb2883c|M.bovis_AF2122/97 TDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAA
Rv2858c|M.tuberculosis_H37Rv TDANAVDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAA
MAV_2765|M.avium_104 CGAEAVDEAAARAKASFESGVWSQLPGRERAKILWRIGDLIDEHAEEFAQ
MMAR_2875|M.marinum_M GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
MUL_2877|M.ulcerans_Agy99 GDASHVDAAVAAAKASFEDGSWSRATPQERAAVMRRIVAAADQVTDELIE
TH_3902|M.thermoresistible__bu ASLDDIRRAIAAARTAFDEGPWPCMTPLERAAVIRRIAEVLQRRRSELVD
MAB_3328|M.abscessus_ATCC_1997 ATTADVDAAVAAARAAGPA--WASSTPVDRSSVLAKLAAVLSANADTLVA
MLBr_02573|M.leprae_Br4923 TTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAA
: * * . : . :*: . .
Mflv_4063|M.gilvum_PYR-GCK LEVANSGHPIGNAR-WEAGHVRDVLQYYSASPERLS-GKQIPVAGG----
Mvan_2280|M.vanbaalenii_PYR-1 LEVANSGHPIGNAR-WEAGHVRDVLHYYSASPERLS-GKQIPVAGG----
MSMEG_2597|M.smegmatis_MC2_155 LEVSNSGHPIGQAE-WEAGHVRDVLNFYAATPERLS-GKQIPVAGG----
Mb2883c|M.bovis_AF2122/97 LEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLS-GRQIPVAGG----
Rv2858c|M.tuberculosis_H37Rv LEVANSGHPIVSAE-WEAGHVRDVLAFYAASPERLS-GRQIPVAGG----
MAV_2765|M.avium_104 LDSLNTGMPLLQAQ-LQMSTCSEFFRYYAGWCSKIN-GTAYDVKTDGIAT
MMAR_2875|M.marinum_M LEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETFPVLS
MUL_2877|M.ulcerans_Agy99 LEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETFPVLS
TH_3902|M.thermoresistible__bu LVRAETGSPQWIVEMLQVGVPLRVCADVADRVLPQFRFVEPMLPSFDLRP
MAB_3328|M.abscessus_ATCC_1997 DEVAQTGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSADH---
MLBr_02573|M.leprae_Br4923 LMTLEMGKTLQSAK-DEAMKCAKGFRYYAEKAETLLADEPAEAAAVG---
* . . . :
Mflv_4063|M.gilvum_PYR-GCK ------LDVTFNEPLGVVGVITPWNFPMTIASWGFAPALAAGNAVLVKPA
Mvan_2280|M.vanbaalenii_PYR-1 ------LDVTFNEPLGVVGVITPWNFPMTIAAWGFAPALAAGNAVLVKPA
MSMEG_2597|M.smegmatis_MC2_155 ------LDVTFNEPLGVVGVITPWNFPMTIAAWGFAPALAAGCAVLLKPA
Mb2883c|M.bovis_AF2122/97 ------VDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPA
Rv2858c|M.tuberculosis_H37Rv ------VDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPA
MAV_2765|M.avium_104 DTFVNMHAYTLKEPYSVVGLIFPWNGPIFNASAKLAPALAAGCSLLVKPA
MMAR_2875|M.marinum_M ------QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPD
MUL_2877|M.ulcerans_Agy99 ------QSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPD
TH_3902|M.thermoresistible__bu G-----QGIISKEPIGVAALITPFNFPLFLNVMKLAPALAAGCTVVLKPS
MAB_3328|M.abscessus_ATCC_1997 ------TSSIRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPS
MLBr_02573|M.leprae_Br4923 ----ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHA
:. .*. : *:* *: **: ** ::*
Mflv_4063|M.gilvum_PYR-GCK EWTPLTTIRLGELAVEAGLPADLFQVLPGRGSVVGERFVTHPDVRKIVFT
Mvan_2280|M.vanbaalenii_PYR-1 EWTPLTTMRLGELAVESGLPADLFQVLPGRGSVVGERFVSHPDVRKIVFT
MSMEG_2597|M.smegmatis_MC2_155 EWTPLTTIRIGEIARESGLPEGLFQVLPGKGSVVGERFVSHPGIRKVVFT
Mb2883c|M.bovis_AF2122/97 ELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFT
Rv2858c|M.tuberculosis_H37Rv ELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFT
MAV_2765|M.avium_104 EETPLSALLLDRLVHEAGVPEGVVNLLTGYGHTAGAAITAHPDVEKVAFT
MMAR_2875|M.marinum_M EHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFT
MUL_2877|M.ulcerans_Agy99 EHTPLSILEFARIAERSGLPPGVINVVPGEGPEAGARLASHPDVGKIAFT
TH_3902|M.thermoresistible__bu PLTPLEALVLGEVADEVGLPPGVLNIVTG-GAEESAELTTNPMVDLVSFT
MAB_3328|M.abscessus_ATCC_1997 ELTPLTTLTLARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFT
MLBr_02573|M.leprae_Br4923 SNVPQCALYLADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLT
.* : : : . *. . .: : . : .* : :*
Mflv_4063|M.gilvum_PYR-GCK GSTEVGTRVMAQAATQVKRVTLELGGKSANIVFDDCDLERAAATAPYGVF
Mvan_2280|M.vanbaalenii_PYR-1 GSTEVGTRVMAGAAAQVKRVTLELGGKSANIVFDDCDLERAAATAPYGVF
MSMEG_2597|M.smegmatis_MC2_155 GSTEVGRRVMAGAAAQIKRVTLELGGKSANIVFEDCDLEKAAATAPYGVF
Mb2883c|M.bovis_AF2122/97 GSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVF
Rv2858c|M.tuberculosis_H37Rv GSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVF
MAV_2765|M.avium_104 GSTEVGKEIVRASAGNLKKVTLELGGKSPVLIFDDADLDKAILMASLGIF
MMAR_2875|M.marinum_M GSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCF
MUL_2877|M.ulcerans_Agy99 GSTAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEMAVEGVLYGCF
TH_3902|M.thermoresistible__bu GSDTVGRQVMNQASATLKKVVLELGGKSANVIFADADLDAAAAHVVGEFT
MAB_3328|M.abscessus_ATCC_1997 GSTAVGRKVMAAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAGAI
MLBr_02573|M.leprae_Br4923 GSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRV
** .* : :. : . *****. . ::: ..*:: * .
Mflv_4063|M.gilvum_PYR-GCK DNSGQDCCARSRILVQRSVFDRFMELLEPAVKGVVVGDPGAEGTEMGPLV
Mvan_2280|M.vanbaalenii_PYR-1 DNSGQDCCARSRILVQRNVFDRFMDLMEPAVKGVVVGDPAAEDTEMGPLV
MSMEG_2597|M.smegmatis_MC2_155 DNAGQDCCARSRILVQRSVYDRFMEMLEPAVKGVVVGDPSVRDTEMGPLV
Mb2883c|M.bovis_AF2122/97 DNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLV
Rv2858c|M.tuberculosis_H37Rv DNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLV
MAV_2765|M.avium_104 VHSGQGCVCGSRIFVQRGVYDRVVEGIAMMANTFKLGAPSEEGCVSGPLI
MMAR_2875|M.marinum_M AYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVI
MUL_2877|M.ulcerans_Agy99 AYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPVI
TH_3902|M.thermoresistible__bu LHAGQGCSLLTRTLVEESIHDELVDWVNKQLAALKVGDPADPSVMMGPLI
MAB_3328|M.abscessus_ATCC_1997 INSGQDCTAATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLI
MLBr_02573|M.leprae_Br4923 QNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLA
** * .* :. :.: .: . . :* . **:
Mflv_4063|M.gilvum_PYR-GCK SKAHWNSVSSYVP----DDAPVAFRGSAPQG----PGFWFPPTVLTPAR-
Mvan_2280|M.vanbaalenii_PYR-1 SRAHWNSVASYVP----DDAPVAFRGDAPSG----PGFWFPPTVLTPQR-
MSMEG_2597|M.smegmatis_MC2_155 SRPHWESVHSYVP----DDAPVAFRGSAPDG----PGFWFPPTVLTPSR-
Mb2883c|M.bovis_AF2122/97 SRAHRDKVAGYVP----DDAPVAFRGTAPAG----RGFWFPPTVLTPKR-
Rv2858c|M.tuberculosis_H37Rv SRAHRDKVAGYVP----DDAPVAFRGTAPAG----RGFWFPPTVLTPKR-
MAV_2765|M.avium_104 SQKQLNRVMGFIDEGKNDGVEVVTGGYRLDR----KGYFVHPTVLTNVDP
MMAR_2875|M.marinum_M DAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHN
MUL_2877|M.ulcerans_Agy99 DAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVHN
TH_3902|M.thermoresistible__bu SEAQRNRVEGYIKAGVDEGAEIAFGGGRPSH--LERGYFVEPTLFTGVRN
MAB_3328|M.abscessus_ATCC_1997 SAAHRAKVSSIVDRAPAQGGRIVTGATAPDL----PGSFYRPTLIADVAE
MLBr_02573|M.leprae_Br4923 TESGRAQVEQQVDAAAAAGAVIRCGGKRPDR----PGWFYPPTVITDITK
: : . : . * : **:::
Mflv_4063|M.gilvum_PYR-GCK DDRTVVEEIFGPVVTVLPFDDEADAIALANDTVYGLSGSIWTDNISRAMR
Mvan_2280|M.vanbaalenii_PYR-1 DDRTVVEEIFGPVVTVLPFEDEADAIALANDTVYGLSGSIWTDNLSRALR
MSMEG_2597|M.smegmatis_MC2_155 DDRTVSEEIFGPVVTVLPFDDEADAIAVANDTAYGLSGSIWTDNVSRAIR
Mb2883c|M.bovis_AF2122/97 GDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALR
Rv2858c|M.tuberculosis_H37Rv GDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALR
MAV_2765|M.avium_104 GMRLYQQEIFGPVVAILPFDDEDEAVAMANDTTYGLAATAWTENLGRAHR
MMAR_2875|M.marinum_M DMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGLA
MUL_2877|M.ulcerans_Agy99 DMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGLA
TH_3902|M.thermoresistible__bu EMKIAQEEIFGPVGVVIPFTSEHEAVRLANDSDFGLGGGVWSTDVERALR
MAB_3328|M.abscessus_ATCC_1997 TSEVYRDEIFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQR
MLBr_02573|M.leprae_Br4923 DMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRH
:*:**** : . :*: ** : :**.. *: : .
Mflv_4063|M.gilvum_PYR-GCK VSRAVEAGNLSVN-SHSSVRYSTPFGGFKQSGLGRELGPDAPLSFTETKN
Mvan_2280|M.vanbaalenii_PYR-1 VSRAVESGNLSVN-SHSSVRYSTPFGGFKQSGLGRELGPDAPLSFTETKN
MSMEG_2597|M.smegmatis_MC2_155 VSRAIEAGNLSVN-SHSSVRYNTPFGGFKQSGLGRELGPDAPLSFTETKN
Mb2883c|M.bovis_AF2122/97 VARAVESGNLSVN-SHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKN
Rv2858c|M.tuberculosis_H37Rv VARAVESGNLSVN-SHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKN
MAV_2765|M.avium_104 IVKRLQAGSVQVN-CQLVFDHDVPFGGYKQSGWGHEFGKEGLEIYLKTKS
MMAR_2875|M.marinum_M MAERIQSGSVWIN-DAHQINCRLPFGGYKQSGVGRELGPDALDAYTEVKT
MUL_2877|M.ulcerans_Agy99 MAERIRSGSVWIN-DAHQINCRLLFGGYKQSGVGRELGPDTLDAYTEVKT
TH_3902|M.thermoresistible__bu VAQRIRTGMVAINGGGGSMGKTGPFGGFKASGLGREWGEWGLDEFLEMKQ
MAB_3328|M.abscessus_ATCC_1997 ASREIRAGCVWIN-DHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKH
MLBr_02573|M.leprae_Br4923 FIDNIVAGQVFIN-GMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKT
: :* : :* .** ** *:: . : *
Mflv_4063|M.gilvum_PYR-GCK VFFAVEEN----------------
Mvan_2280|M.vanbaalenii_PYR-1 VFFAVQEEH---------------
MSMEG_2597|M.smegmatis_MC2_155 VFIAV-------------------
Mb2883c|M.bovis_AF2122/97 VFIAVGEEM---------------
Rv2858c|M.tuberculosis_H37Rv VFIAVGEEM---------------
MAV_2765|M.avium_104 VWAQL-------------------
MMAR_2875|M.marinum_M IHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 IHLDLSGGREAKPYDVLLGHPETG
TH_3902|M.thermoresistible__bu IIWPIAGG----------------
MAB_3328|M.abscessus_ATCC_1997 VMSDITGTADKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 VWIA--------------------
: