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KTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVG AGVVGLAPGDHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGTYRRHINGQDVGVMALVGTFSQ YGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEK IVVVEPVETKRDLAFRFGATHFVTSMEEATALVAELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAV VMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYKLAEVNE GYEDMREGRNIRGVILHDH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1486 | - | - | 100% (370) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4588 | - | e-123 | 57.38% (366) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1593 | - | e-113 | 54.47% (369) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0784c | adhB | 1e-111 | 52.45% (368) | zinc-containing alcohol dehydrogenase NAD dependant ADHB |
| M. tuberculosis H37Rv | Rv0761c | adhB | 1e-111 | 52.45% (368) | zinc-containing alcohol dehydrogenase NAD dependent ADHB |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-51 | 35.47% (358) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-123 | 57.92% (366) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_3150 | - | 1e-122 | 56.83% (366) | zinc-containing alcohol dehydrogenase NAD- dependent |
| M. avium 104 | MAV_0705 | - | 1e-109 | 51.09% (368) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 1e-111 | 52.17% (368) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_2499 | - | 1e-169 | 76.28% (371) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 1e-109 | 52.17% (368) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 0.0 | 97.30% (370) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1486|M.gilvum_PYR-GCK --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRT
Mvan_5270|M.vanbaalenii_PYR-1 --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRT
TH_2499|M.thermoresistible__bu --MKMNAAVLWDVNGDWSIEEVELDGPQEGEVLVSFTATGMCHSDHHVRT
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
MMAR_3150|M.marinum_M --MKTRAAVLWGLGEKWEVEDIELDPPGPDEVLVQLTATGLCHSDEHLVT
Mb0784c|M.bovis_AF2122/97 --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
Rv0761c|M.tuberculosis_H37Rv --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
MUL_0470|M.ulcerans_Agy99 --MKTKGALIWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCRSDNHLVT
MAV_0705|M.avium_104 --MKTKGALIWEFNQPWSIEEIEIGDPQAHEVKIQMEAAGMCHSDHHLVT
MSMEG_5866|M.smegmatis_MC2_155 --MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCHSDHHLVT
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
. ...: : :: : * *. : * *:*::*
Mflv_1486|M.gilvum_PYR-GCK GDLPAP-LPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPACGRCRFC
Mvan_5270|M.vanbaalenii_PYR-1 GDLPAP-LPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPACGRCRFC
TH_2499|M.thermoresistible__bu GDFPAP-LPIIGGHEGAGVVQEVGPGVRDLKPGDHVVASFLPACGRCRWC
MAB_2084|M.abscessus_ATCC_1997 GDLPIP-LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYC
MMAR_3150|M.marinum_M GDLPIP-LPVVGGHEGAGTVVEVGAGVENVAEGDSVILTFLPSCGHCSYC
Mb0784c|M.bovis_AF2122/97 GDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSC
Rv0761c|M.tuberculosis_H37Rv GDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSC
MUL_0470|M.ulcerans_Agy99 GGIPMAGFPVLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPSCGRCPTC
MAV_0705|M.avium_104 GGIPMAGFPVLGGHEGAGIVTEVGPGVEDIAPGDHVVLSFIPSCGSCPTC
MSMEG_5866|M.smegmatis_MC2_155 GGIPMGGFPVLGGHEGAGIVTEVGPGVEGIEPGDHVVLSFIPSCGSCPSC
MLBr_01784|M.leprae_Br4923 GGINDR-YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
*.: *.: ***.** * * ** . ** *: : . ** * *
Mflv_1486|M.gilvum_PYR-GCK STGHQNLCDLGAMIMAGTQL-DGTYRRHIN-GQDVGVMALVGTFSQYGTV
Mvan_5270|M.vanbaalenii_PYR-1 STGHQNLCDLGAMIMAGTQL-DGTYRRHVR-GQDVGVMALVGTFSQYGTV
TH_2499|M.thermoresistible__bu ATGRSNLCDLGAMLLAGTQL-DGTYRRHLPDGRDVGVALLLGTFAQYGVV
MAB_2084|M.abscessus_ATCC_1997 ARGMGNLCELGAALMMGPQI-DGTYRFHAR-GEDVGQMCLLGTFSEYTVV
MMAR_3150|M.marinum_M ARGMGNMCDLGAALMMGPQI-DGTYRFHAR-GEDVGQMCLLGTFSEYTVV
Mb0784c|M.bovis_AF2122/97 QAGMRNLCDLGAGLLAGESVTDGSFRIQAR-GQNVYPMTLLGTFSPYMVV
Rv0761c|M.tuberculosis_H37Rv QAGMRNLCDLGAGLLAGESVTDGSFRIQAR-GQNVYPMTLLGTFSPYMVV
MUL_0470|M.ulcerans_Agy99 QAGLRNLCDLGAGLLAGAAVSDGTFRIQAR-GQNVYPMTLLGTFSPYMVV
MAV_0705|M.avium_104 QAGMRNLCDLGAGLLGGEAVSDGTFRIQAR-GQNVYPMTLLGTFSPYMVV
MSMEG_5866|M.smegmatis_MC2_155 QAGLRNLCDLGAGLLGGVAVADGTHRIHAN-GKPVFPMTLLGTFSPYMVV
MLBr_01784|M.leprae_Br4923 KRGRPSYCFD---------TFNAQQKMTLIDGTELTPALGIGAFADKTLV
* . * :. : * : :*:*: *
Mflv_1486|M.gilvum_PYR-GCK PEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGG
Mvan_5270|M.vanbaalenii_PYR-1 PEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGG
TH_2499|M.thermoresistible__bu SEASLVKIDDDLPLTRACLIGCGVTTGWGSAVNTAKVQPGDTVVVIGFGG
MAB_2084|M.abscessus_ATCC_1997 PQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGG
MMAR_3150|M.marinum_M PKASLVKIDQGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVAVIGAGG
Mb0784c|M.bovis_AF2122/97 HRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGG
Rv0761c|M.tuberculosis_H37Rv HRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGG
MUL_0470|M.ulcerans_Agy99 HRSSVVKIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDVAIVGLGG
MAV_0705|M.avium_104 HRSSVVKIDPSIPFEVAALVGCGVTTGYGSAVRTADIRPGQDVAIVGVGG
MSMEG_5866|M.smegmatis_MC2_155 HKSSVVKIDKSIPFEVACLVGCGVTTGYGSAVRSGDIRPGDDVAIFGIGG
MLBr_01784|M.leprae_Br4923 HSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGG
.. .*:* * *:**** :* *:*:.:. : .: *.:.* **
Mflv_1486|M.gilvum_PYR-GCK IGSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVTSMEEATAL-V
Mvan_5270|M.vanbaalenii_PYR-1 IGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTSMEEATAL-V
TH_2499|M.thermoresistible__bu VGSGAVQGARLAGAEKIVVVDIVEDKRAKALEFGATHFVTSMAEATAL-V
MAB_2084|M.abscessus_ATCC_1997 IGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMDEAWSL-V
MMAR_3150|M.marinum_M IGMNAIQGARIAGALNIVAVDPVAFKREQAGGFGATHAVATIDEAWSL-I
Mb0784c|M.bovis_AF2122/97 VGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDINAALMG-I
Rv0761c|M.tuberculosis_H37Rv VGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDINAALMG-I
MUL_0470|M.ulcerans_Agy99 VGMAALQGAVTAGARYIFAVEPVEWKRDQALKFGATHVYPDMEAALMG-I
MAV_0705|M.avium_104 VGMAALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDIMAAMAG-M
MSMEG_5866|M.smegmatis_MC2_155 VGMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDVFSAMAG-I
MLBr_01784|M.leprae_Br4923 VGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTI
:* *:.** .** :..:: * * ***** : :
Mflv_1486|M.gilvum_PYR-GCK AELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMTALSTMADNQP
Mvan_5270|M.vanbaalenii_PYR-1 ADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMTALSTMADNQP
TH_2499|M.thermoresistible__bu GDLTRGVMADSAILTVGLVEGPMIGECIDIIRKGGAVVLTGIAALADVTP
MAB_2084|M.abscessus_ATCC_1997 SDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSI
MMAR_3150|M.marinum_M SDITRGKLADVCVLTTDVAEGSYIGEALSLVGKRGRVVVTAIGHPEDTSM
Mb0784c|M.bovis_AF2122/97 AEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQV
Rv0761c|M.tuberculosis_H37Rv AEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQV
MUL_0470|M.ulcerans_Agy99 AEVTYGLMAKKVMITVGELQGSDIDTYLAITSKGGTCVVTAIGSLLDTQV
MAV_0705|M.avium_104 AEVTYGLMAHKVVVTVGELQGADVDNYLNITQKGGTCVLTAIGSLLDTNV
MSMEG_5866|M.smegmatis_MC2_155 AEVTAGGMAKKVIVTVGELHGEDIDNYLNVTSKGGTCVVTAVGSMLDTNA
MLBr_01784|M.leprae_Br4923 QDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP-DMRL
::* * .. : *.. * *:..: :
Mflv_1486|M.gilvum_PYR-GCK TLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEY
Mvan_5270|M.vanbaalenii_PYR-1 TLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEY
TH_2499|M.thermoresistible__bu TLPMAMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEY
MAB_2084|M.abscessus_ATCC_1997 SGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREY
MMAR_3150|M.marinum_M SGSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYNAGHLKLDELITREY
Mb0784c|M.bovis_AF2122/97 TLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAY
Rv0761c|M.tuberculosis_H37Rv TLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAY
MUL_0470|M.ulcerans_Agy99 NLNLAMLTLMQKNLQGTIFGGGNPQYDIPHLLSMYKARNLNIDDMITRQY
MAV_0705|M.avium_104 TLNLAMLTLMQKNLQGTIFGGGNPQYDIPQLLSMYKAGKLNLDDMITRQY
MSMEG_5866|M.smegmatis_MC2_155 NINLAMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLDDMVTRQY
MLBr_01784|M.leprae_Br4923 DMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERI
: : : .: :* . *:* *:.:* * :.. ::
Mflv_1486|M.gilvum_PYR-GCK KLAEVNEGYEDMREGRNIRGVILHDH---
Mvan_5270|M.vanbaalenii_PYR-1 KLAEVNEGYEDMRAGRNIRGVILHDH---
TH_2499|M.thermoresistible__bu KLHDINQGYDDMLAGRIIRGVIVHDHS--
MAB_2084|M.abscessus_ATCC_1997 SLDQINEGYQDMRSGRNIRGLVRF-----
MMAR_3150|M.marinum_M TLDQINEGYADMRSGRNIRGLIRF-----
Mb0784c|M.bovis_AF2122/97 KLEQINDGYQDMLNGKNIRGVIRYTDDDR
Rv0761c|M.tuberculosis_H37Rv KLEQINDGYQDMLNGKNIRGVIRYTDDDR
MUL_0470|M.ulcerans_Agy99 RLEQINEGYQDMIDGKNIRGVIRFTDADR
MAV_0705|M.avium_104 RLEQINDGYQDMLDGKNIRGVIRYTDADR
MSMEG_5866|M.smegmatis_MC2_155 RLEQINDGYQDMLEGRNIRGVIRYTDADR
MLBr_01784|M.leprae_Br4923 GLGDVEEAFHKIHGGKVLRSVVML-----
* ::::.: .: *: :*.::