For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_4627 (-)

annotation: Alcohol dehydrogenase, zinc-binding domain protein
coordinates: 2837497 - 2838585
length: 363

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_4627 - - 100% (363) Alcohol dehydrogenase, zinc-binding domain protein
M. thermoresistible (build 8) TH_2499 - 1e-57 37.29% (354) PUTATIVE Alcohol dehydrogenase GroES domain protein
M. thermoresistible (build 8) TH_0605 - 2e-53 33.33% (366) alcohol dehydrogenase B

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2283 adhE2 1e-180 83.66% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. gilvum PYR-GCK Mflv_2766 - 0.0 84.34% (364) alcohol dehydrogenase
M. tuberculosis H37Rv Rv2259 adhE2 1e-180 83.66% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. leprae Br4923 MLBr_01784 adhE2 1e-180 83.66% (361) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977 MAB_1869c - 1e-171 83.53% (346) zinc-dependent alcohol dehydrogenase AdhE2
M. marinum M MMAR_3350 adhE2 0.0 85.04% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. avium 104 MAV_1614 - 2e-54 34.56% (379) alcohol dehydrogenase B
M. smegmatis MC2 155 MSMEG_4340 - 0.0 87.53% (361) NAD/mycothiol-dependent formaldehyde dehydrogenase
M. ulcerans Agy99 MUL_1292 adhE2 0.0 85.04% (361) zinc-dependent alcohol dehydrogenase AdhE2
M. vanbaalenii PYR-1 Mvan_3767 - 0.0 86.98% (361) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2283|M.bovis_AF2122/97            MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Rv2259|M.tuberculosis_H37Rv         MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923          MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MMAR_3350|M.marinum_M               MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
MUL_1292|M.ulcerans_Agy99           MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
Mflv_2766|M.gilvum_PYR-GCK          MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD
Mvan_3767|M.vanbaalenii_PYR-1       MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYRE
MSMEG_4340|M.smegmatis_MC2_155      MPQTVRGVISRSKQQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRE
MAB_1869c|M.abscessus_ATCC_199      ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu      MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
MAV_1614|M.avium_104                --MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILK
                                                     .: :. :  * .**.:*.: *.*:**:*    .

Mb2283|M.bovis_AF2122/97            G------------GINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILN
Rv2259|M.tuberculosis_H37Rv         G------------GINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILN
MLBr_01784|M.leprae_Br4923          G------------GINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILN
MMAR_3350|M.marinum_M               G------------GINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILN
MUL_1292|M.ulcerans_Agy99           G------------GINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILN
Mflv_2766|M.gilvum_PYR-GCK          G------------GINDEFPFLLGHEAAGIVETVGQGVTNVAPGDFVILN
Mvan_3767|M.vanbaalenii_PYR-1       G------------GINDEFPFLLGHEAAGTVESVGAGVTNVAPGDFVVLN
MSMEG_4340|M.smegmatis_MC2_155      G------------GINDEFPFLLGHEAAGTVEAVGEGVTNVAPGDFVILN
MAB_1869c|M.abscessus_ATCC_199      G------------GINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILN
TH_4627|M.thermoresistible__bu      G------------GINDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLN
MAV_1614|M.avium_104                GDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMS
                                    *            *:   :* : ***.:* :. ** *** . ***.*::.

Mb2283|M.bovis_AF2122/97            WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALG--------
Rv2259|M.tuberculosis_H37Rv         WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALG--------
MLBr_01784|M.leprae_Br4923          WRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG--------
MMAR_3350|M.marinum_M               WRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGTELTPALG--------
MUL_1292|M.ulcerans_Agy99           WRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGTELTPALG--------
Mflv_2766|M.gilvum_PYR-GCK          WRAVCGQCRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALG--------
Mvan_3767|M.vanbaalenii_PYR-1       WRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDGTELTPALG--------
MSMEG_4340|M.smegmatis_MC2_155      WRAVCGQCRACKRGRPHLCFDTFNATQKMTLTDGTELTPALG--------
MAB_1869c|M.abscessus_ATCC_199      WRAVCGVCRACKRGRPQYCFDTFNAAQKMTLTDGTELTPALG--------
TH_4627|M.thermoresistible__bu      WRAVCGQCRACKRGRPHLCFDTFNATQKMTLGDGTELTPALG--------
MAV_1614|M.avium_104                FVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGGNLGHIA
                                    : **** ** *  *    *    .:       ***    : *        

Mb2283|M.bovis_AF2122/97            -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTR
Rv2259|M.tuberculosis_H37Rv         -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTR
MLBr_01784|M.leprae_Br4923          -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSR
MMAR_3350|M.marinum_M               -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTR
MUL_1292|M.ulcerans_Agy99           -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTR
Mflv_2766|M.gilvum_PYR-GCK          -IGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITR
Mvan_3767|M.vanbaalenii_PYR-1       -IGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNR
MSMEG_4340|M.smegmatis_MC2_155      -IGAFADKTLVHEGQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVTR
MAB_1869c|M.abscessus_ATCC_199      -IGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGR
TH_4627|M.thermoresistible__bu      -IGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSR
MAV_1614|M.avium_104                KIGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCG
                                     **** ::*:*  .. .*::     *  .**.*.: :* *:* * . :  

Mb2283|M.bovis_AF2122/97            DDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTV
Rv2259|M.tuberculosis_H37Rv         DDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTV
MLBr_01784|M.leprae_Br4923          DDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTV
MMAR_3350|M.marinum_M               DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTV
MUL_1292|M.ulcerans_Agy99           DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTV
Mflv_2766|M.gilvum_PYR-GCK          DDTVAVIGCGGVGDAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTI
Mvan_3767|M.vanbaalenii_PYR-1       DDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWAREFGATHTI
MSMEG_4340|M.smegmatis_MC2_155      DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDMDNKKLDWAREFGATHTV
MAB_1869c|M.abscessus_ATCC_199      DDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTI
TH_4627|M.thermoresistible__bu      DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTI
MAV_1614|M.avium_104                GDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSV
                                    .*:*.***.**:* .** ** : **  *:*:*    *   *  ****.::

Mb2283|M.bovis_AF2122/97            NAREVD-VVQAIGGLTDGFGADVVID--AVGRPETYQQAFYARDLAGTVV
Rv2259|M.tuberculosis_H37Rv         NAREVD-VVQAIGGLTDGFGADVVID--AVGRPETYQQAFYARDLAGTVV
MLBr_01784|M.leprae_Br4923          NALELE-VVKTIQDLTSGFGVDVVID--TVGRPETWKQAFYARDLAGTVV
MMAR_3350|M.marinum_M               NARELD-VVETIQDLTGGFGVDVVID--AVGRPETWKQAFYARDLAGTVV
MUL_1292|M.ulcerans_Agy99           NARELD-VVETIQDLTGGFGVDVVID--AVGRPETWKQAFYARDLAGTVV
Mflv_2766|M.gilvum_PYR-GCK          NAKDLD-PVKTIQDLTDGFGTDVVID--AVGRPETWKQAFYARDLAGTVV
Mvan_3767|M.vanbaalenii_PYR-1       NAGELD-AVKTIQDLTDGFGADVVID--AVGRPETWKQAFYARDLAGTVV
MSMEG_4340|M.smegmatis_MC2_155      NAKDLD-AVETIQDLTDGFGADVVID--AVGRPETWKQAFYARDLAGTVV
MAB_1869c|M.abscessus_ATCC_199      NARKVDDVVTAIQELTDEFGADVVID--AVGRPETWKQAFYARDLAGTVV
TH_4627|M.thermoresistible__bu      DASSTD-VVEAIQELTDGFGADVVVD--AVGRPETWEQAFYARDLAGTVV
MAV_1614|M.avium_104                ATIAEA--LDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCV
                                     :      :  :  **  . .*.*:   ::  .:  .:*:     .** *

Mb2283|M.bovis_AF2122/97            LVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQG
Rv2259|M.tuberculosis_H37Rv         LVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQG
MLBr_01784|M.leprae_Br4923          LVGVPTPDMR-LDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQG
MMAR_3350|M.marinum_M               LVGVPTPDMR-LDMPLVDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQG
MUL_1292|M.ulcerans_Agy99           LVGVPTPDMR-LDMPLVDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQG
Mflv_2766|M.gilvum_PYR-GCK          LVGVPTPDMT-LDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
Mvan_3767|M.vanbaalenii_PYR-1       LVGVPTPDMT-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
MSMEG_4340|M.smegmatis_MC2_155      LVGVPTPDMK-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
MAB_1869c|M.abscessus_ATCC_199      LVGVPTPDMT-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQG
TH_4627|M.thermoresistible__bu      LVGVPTPDMR-IDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQG
MAV_1614|M.avium_104                LTGMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTG
                                    *.*:.:     ::: * **:  . :* .: :*.* *. *:. *  **  *

Mb2283|M.bovis_AF2122/97            RLPLQRFVSERIGLEDVEEAFHKMHGG---KVLRSVVML---
Rv2259|M.tuberculosis_H37Rv         RLPLQRFVSERIGLEDVEEAFHKMHGG---KVLRSVVML---
MLBr_01784|M.leprae_Br4923          RLPLGKFVSERIGLGDVEEAFHKIHGG---KVLRSVVML---
MMAR_3350|M.marinum_M               RLPLDKFVSEQIGLGGIEEAFEKMHAG---KVLRSVVVL---
MUL_1292|M.ulcerans_Agy99           RLPLDKFVSEQIGLGGIEEAFEKMHAG---KVLRSVVVL---
Mflv_2766|M.gilvum_PYR-GCK          RFPLDKFVSERITLDQIEDAFHKMHAGSDDVVLRSVVVL---
Mvan_3767|M.vanbaalenii_PYR-1       RFPLDKFVSERIGLDQIEDAFDKMHAG---EVLRSVVVL---
MSMEG_4340|M.smegmatis_MC2_155      RLPLEKFVSERIGLDGIEDAFHKMHAG---EVLRSVVVLDR-
MAB_1869c|M.abscessus_ATCC_199      RLPLDRFVSERIGIESIEAAFEKMHHG---EVLRSVVVL---
TH_4627|M.thermoresistible__bu      RLPLEKFVTERIALDEVEGAFEKMQRG---EVLRSVVVLK--
MAV_1614|M.avium_104                QLQLDEMITKRYRLDEVNDAYDDLLNG---KIVRGIIDFGIA
                                    :: * .:::::  :  :: *:..:  *    ::*.:: :

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_4627	-	-	100% (363)	Alcohol dehydrogenase, zinc-binding domain protein
M. thermoresistible (build 8)	TH_2499	-	1e-57	37.29% (354)	PUTATIVE Alcohol dehydrogenase GroES domain protein
M. thermoresistible (build 8)	TH_0605	-	2e-53	33.33% (366)	alcohol dehydrogenase B