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RTRAAVTYGLNTRFEVKEVELDEPGPNEVLVHLVASGVCHSDMHHVTGDQIAALPMIFGHEGAGVVEKVG NNVTHVGPGDHVVMSYLPSCGTCRWCTDGQTNLCDLGAHTVEGPQLDGTYRFHDDDGVNLGQFCLVSTFS EWTVVPAQSVVKVDEHYRLERACLVACGVTTGVGTAIYRGGVEPGEDVMVYGVGGIGMNIVQGAKIAGAK RIIACDTNDWKLEQAKLFGATHTVNPNTTDPVEFATELTWGVGVDKAFEAIATPETIGQAVRSVRKSGTV AVVGLTRHDQPTIPVNPSDFVLWQKTLTGSLNGGCNPRNDIPKMLKLWDSGQINLDGLVTKEYRIEQINE AYDDLLAGKNLRGVIRYEWADNGVPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4167 | - | - | 100% (377) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_3388 | - | 7e-96 | 46.09% (371) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 2e-84 | 43.09% (376) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 2e-95 | 47.01% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_4588 | - | 3e-94 | 46.76% (370) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 2e-95 | 47.01% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-53 | 34.76% (351) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 4e-95 | 47.03% (370) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0127 | adhD_1 | 2e-95 | 45.28% (371) | zinc-containing alcohol dehydrogenase NAD- dependent, |
| M. avium 104 | MAV_1943 | - | 1e-87 | 45.48% (376) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_2499 | - | 2e-92 | 46.90% (371) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_4872 | adhD | 9e-82 | 43.86% (383) | zinc-type alcohol dehydrogenase AdhD |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 8e-95 | 47.45% (373) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4588|M.gilvum_PYR-GCK --MKTRAAVLWGLGEKWEVDEIELDPPGVDEVLVQLTASGLCHSDEHLVT
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
Mvan_0013|M.vanbaalenii_PYR-1 --MKTKAAVLWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVT
TH_2499|M.thermoresistible__bu --MKMNAAVLWDVNGDWSIEEVELDGPQEGEVLVSFTATGMCHSDHHVRT
Mb3113|M.bovis_AF2122/97 --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
Rv3086|M.tuberculosis_H37Rv --MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTD
MMAR_0127|M.marinum_M --MKTTAAVLLEAGKPFEIMELELDGPRVGEVLIKYTAAGLCHSDLHLTD
MAV_1943|M.avium_104 --MQTQAAVLFERNTPWSIETIELDGPKATEVLVELHASGMCHSDDHLVT
MUL_4872|M.ulcerans_Agy99 --MRSRAAILYGYGHPWTVEEFELDPPRAGEVLLQLSATGLCHSDEHIRR
MSMEG_4167|M.smegmatis_MC2_155 --MRTRAAVTYGLNTRFEVKEVELDEPGPNEVLVHLVASGVCHSDMHHVT
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
..: : . : * *.:: * *:**:*
Mflv_4588|M.gilvum_PYR-GCK G------------DLPFPLPVVGGHEGAGTVVEVGAGVEDLAVGDSVILT
MAB_2084|M.abscessus_ATCC_1997 G------------DLPIPLPVVGGHEGAGTVVECGEGVEDLSEGDSVILT
Mvan_0013|M.vanbaalenii_PYR-1 G------------DMPMNLPVVGGHEGAGVVVDVGPGVTEVEAGDHVVLS
TH_2499|M.thermoresistible__bu G------------DFPAPLPIIGGHEGAGVVQEVGPGVRDLKPGDHVVAS
Mb3113|M.bovis_AF2122/97 G------------DLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCS
Rv3086|M.tuberculosis_H37Rv G------------DLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCS
MMAR_0127|M.marinum_M G------------DLPPRYPIVGGHEGSGVIEEVGPGVSKVKPGDHVVCS
MAV_1943|M.avium_104 G------------DMPIALPCIGGHEGAGVVKAVGEHVSWLAPGDHVVFS
MUL_4872|M.ulcerans_Agy99 GNLAPPPETLRSFGLPTMSPTIGGHEGSGVVLEVGEGVTRFAPGDHVVTS
MSMEG_4167|M.smegmatis_MC2_155 G------------DQIAALPMIFGHEGAGVVEKVGNNVTHVGPGDHVVMS
MLBr_01784|M.leprae_Br4923 G------------GINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILN
* . * : ***.:*.: * * . ** *: .
Mflv_4588|M.gilvum_PYR-GCK FLPSCGHCSYCARGMGNLCDMGAAIMMGPQI-DGTYRFH----ARGEDVG
MAB_2084|M.abscessus_ATCC_1997 FLPSCGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFH----ARGEDVG
Mvan_0013|M.vanbaalenii_PYR-1 FIPACGRCTECARGRSNLCVYGAAIVAGPQL-DGTFRFHGSSGGRAYDIG
TH_2499|M.thermoresistible__bu FLPACGRCRWCATGRSNLCDLGAMLLAGTQL-DGTYRRH---LPDGRDVG
Mb3113|M.bovis_AF2122/97 FIPNCGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFG
Rv3086|M.tuberculosis_H37Rv FIPNCGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFG
MMAR_0127|M.marinum_M FIPNCGTCRYCSTGRQNLCDMGATILEGCMS-DGSFRFH----RKGVDFG
MAV_1943|M.avium_104 FIPSCGRCPSCSTGHQSLCDLGAKIYSGMQIHDGTARHH----LNDKDLA
MUL_4872|M.ulcerans_Agy99 FIAVCGQCRWCATGMEYLCDTGYGTLAPGMPTDGTFRHHS---LDGRDLG
MSMEG_4167|M.smegmatis_MC2_155 YLPSCGTCRWCTDGQTNLCDLGAHTVEGPQL-DGTYRFHD---DDGVNLG
MLBr_01784|M.leprae_Br4923 WRAVCGQCRACKRGRPSYCFDTFNAQQKMTL------------IDGTELT
: . ** * * * * :.
Mflv_4588|M.gilvum_PYR-GCK QMCLLGTFSEYTVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSAVRTGE
MAB_2084|M.abscessus_ATCC_1997 QMCLLGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGE
Mvan_0013|M.vanbaalenii_PYR-1 QMCVLGTFSEYTVVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGE
TH_2499|M.thermoresistible__bu VALLLGTFAQYGVVSEASLVKIDDDLPLTRACLIGCGVTTGWGSAVNTAK
Mb3113|M.bovis_AF2122/97 AMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGN
Rv3086|M.tuberculosis_H37Rv AMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGN
MMAR_0127|M.marinum_M AMCMLGTFSERATISQHSVVKIDDWLPLTTAVLVGCGVPTGWGTSVYAGG
MAV_1943|M.avium_104 LACGIGSFAHHTVVHEASCVKIPDHYRLDLACLLGCGFITGWGSAVYAAE
MUL_4872|M.ulcerans_Agy99 HVSKIGPFAEHTVVSADSLVKIDQTFPLVPAALLACAIPTRYGSAARRAQ
MSMEG_4167|M.smegmatis_MC2_155 QFCLVSTFSEWTVVPAQSVVKVDEHYRLERACLVACGVTTGVGTAIYRGG
MLBr_01784|M.leprae_Br4923 PALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAA
:..*:. : . .*: * *:.*.. : *:: .
Mflv_4588|M.gilvum_PYR-GCK VRAGDTVVVIGAGGIGMNAIQGARIAGALTIVAVDPVEFKREQAGGFGAT
MAB_2084|M.abscessus_ATCC_1997 VRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGAT
Mvan_0013|M.vanbaalenii_PYR-1 AADGDTVVVMGVGGLGINAIQGAAIAGARNVVALDPVAYKRERSFEFGAT
TH_2499|M.thermoresistible__bu VQPGDTVVVIGFGGVGSGAVQGARLAGAEKIVVVDIVEDKRAKALEFGAT
Mb3113|M.bovis_AF2122/97 LRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGAT
Rv3086|M.tuberculosis_H37Rv LRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGAT
MMAR_0127|M.marinum_M VRPGDTTVIYGAGGLGINAVQGAVSAGAKHVVVVDPVAFKRDTALKFGAT
MAV_1943|M.avium_104 VRPGDTVAIAGVGGIGAAAVQGAKLAGARTITVIDPSEHKREEAMKMGAT
MUL_4872|M.ulcerans_Agy99 VRGGDIAVVIGAGGIGTAAIQGARIQGATRIIAVDPVEFERKSALTFGAT
MSMEG_4167|M.smegmatis_MC2_155 VEPGEDVMVYGVGGIGMNIVQGAKIAGAKRIIACDTNDWKLEQAKLFGAT
MLBr_01784|M.leprae_Br4923 VSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGAT
.: . : * **:* :.** *. : . * : : :***
Mflv_4588|M.gilvum_PYR-GCK HAV-ATIDEAWSLISDITRGKLADVCVLTTDVAEGAYTAEALSLVGKRGR
MAB_2084|M.abscessus_ATCC_1997 HTA-ASMDEAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGR
Mvan_0013|M.vanbaalenii_PYR-1 HAA-ADVAEAQALITDLTRGTMADVCVVTTDSAEGAYVAQALSLVGKRGR
TH_2499|M.thermoresistible__bu HFV-TSMAEATALVGDLTRGVMADSAILTVGLVEGPMIGECIDIIRKGGA
Mb3113|M.bovis_AF2122/97 HAF-ADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGT
Rv3086|M.tuberculosis_H37Rv HAF-ADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGT
MMAR_0127|M.marinum_M HAF-PDAASAAAKVNEITWGQGADQALILVGTVDTEVVSAAAAVIGKGGT
MAV_1943|M.avium_104 HTA-ADWQEAKGVVAKATWDRGVDKFICAMGVGDGQLIGQALAMTAKRGK
MUL_4872|M.ulcerans_Agy99 HTA-ATTDEAVETVRELTRGVMADVVVVSPATIGPADVAAALSLTRKGGT
MSMEG_4167|M.smegmatis_MC2_155 HTVNPNTTDPVEFATELTWGVGVDKAFEAIATPET--IGQAVRSVRKSGT
MLBr_01784|M.leprae_Br4923 HTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPET--WKQAFYARDLAGT
* . . . * . .* . . *
Mflv_4588|M.gilvum_PYR-GCK VVITAIGHPEDTSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYN
MAB_2084|M.abscessus_ATCC_1997 VVVTAIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYS
Mvan_0013|M.vanbaalenii_PYR-1 VVMTAIPHPTDTVVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYG
TH_2499|M.thermoresistible__bu VVLTGIAALADVTPTLPMAMFTLFQKRLLGSLYGEANPRADIPRLLSLYR
Mb3113|M.bovis_AF2122/97 VVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYD
Rv3086|M.tuberculosis_H37Rv VVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYD
MMAR_0127|M.marinum_M VVITGLANPEKLTVQLSGLDLTLNEKTIKGTLFGSANPQYDIVRLLRLYD
MAV_1943|M.avium_104 LVVTNIHPMLEREIRANLMDLTLTEKQIIGTLYGSGNPRADIPKILELFS
MUL_4872|M.ulcerans_Agy99 CVLTGLPDPAMHSIAVGLQDFVLMNKTLCGTVFGSCNPKSDIPLLATMYQ
MSMEG_4167|M.smegmatis_MC2_155 VAVVGLTRHDQPTIPVNPSDFVLWQKTLTGSLNGGCNPRNDIPKMLKLWD
MLBr_01784|M.leprae_Br4923 VVLVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYL
.:. : : : . * . *: : ::
Mflv_4588|M.gilvum_PYR-GCK SGQLKLDELITREYTLDEINEGYDDMRSGRNIRGLIRF---------
MAB_2084|M.abscessus_ATCC_1997 AGLLKLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF---------
Mvan_0013|M.vanbaalenii_PYR-1 SGRLKLDELITREYTLEEINQGYEDMHNGRNLRGVIRF---------
TH_2499|M.thermoresistible__bu EGKLLLDETVTHEYKLHDINQGYDDMLAGRIIRGVIVHDHS------
Mb3113|M.bovis_AF2122/97 AGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH---------
Rv3086|M.tuberculosis_H37Rv AGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH---------
MMAR_0127|M.marinum_M AGQLKLDELITTQYRLEDVNQGYQDLRDGKNIRGVIVHD--------
MAV_1943|M.avium_104 AGQVDLEAMVTRTYPLDKVNDGYADMHAGANIRGVLLYPPAENANC-
MUL_4872|M.ulcerans_Agy99 SGQLLLDAMITKRYSLHSINDAYADLVAGELIRGVIDFSLS------
MSMEG_4167|M.smegmatis_MC2_155 SGQINLDGLVTKEYRIEQINEAYDDLLAGKNLRGVIRYEWADNGVPQ
MLBr_01784|M.leprae_Br4923 QGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML---------
* : * :: : .:::.: .: * :*.::