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MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYREGGINDEFPFLLGHEAAGTVE SVGAGVTNVAPGDFVVLNWRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDGTELTPALGIGAFADKTLV HEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNRDDTVAVIGCGGVGDAAIAGARLVGAKRIIAV DMDNRKLDWAREFGATHTINAGELDAVKTIQDLTDGFGADVVIDAVGRPETWKQAFYARDLAGTVVLVGV PTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQGRFPLDKFVSERIGLDQIEDAFDKMH AGEVLRSVVVL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | - | 100% (361) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 4e-56 | 37.46% (355) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 6e-51 | 35.81% (363) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 0.0 | 83.66% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_2766 | - | 0.0 | 91.48% (364) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 0.0 | 83.66% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 0.0 | 84.21% (361) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 1e-173 | 84.68% (346) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_3350 | adhE2 | 0.0 | 87.53% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. avium 104 | MAV_1614 | - | 2e-55 | 35.19% (378) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_4340 | - | 0.0 | 92.24% (361) | NAD/mycothiol-dependent formaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 0.0 | 86.98% (361) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 0.0 | 87.53% (361) | zinc-dependent alcohol dehydrogenase AdhE2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3767|M.vanbaalenii_PYR-1 MTQTVRGVISRTKGQPVEVVEIVIPDPGPGEVVVDIQACGVCHTDLHYRE
Mflv_2766|M.gilvum_PYR-GCK MTQTVRGVIARAKGRPVEVVDVVIPDPGPGEVVVDIQACGVCHTDLTYRD
MSMEG_4340|M.smegmatis_MC2_155 MPQTVRGVISRSKQQPVELVDIVIPDPGPGEVVVDIIACGVCHTDLTYRE
Mb2283|M.bovis_AF2122/97 MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
Rv2259|M.tuberculosis_H37Rv MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHTDLTYRE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MMAR_3350|M.marinum_M MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
MUL_1292|M.ulcerans_Agy99 MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
MAB_1869c|M.abscessus_ATCC_199 ----------------MELVDIVIPDPGPGEVVVKVQACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
MAV_1614|M.avium_104 --MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILK
.: :. : * .**.:*.: *.*:**:* .
Mvan_3767|M.vanbaalenii_PYR-1 G------------GINDEFPFLLGHEAAGTVESVGAGVTNVAPGDFVVLN
Mflv_2766|M.gilvum_PYR-GCK G------------GINDEFPFLLGHEAAGIVETVGQGVTNVAPGDFVILN
MSMEG_4340|M.smegmatis_MC2_155 G------------GINDEFPFLLGHEAAGTVEAVGEGVTNVAPGDFVILN
Mb2283|M.bovis_AF2122/97 G------------GINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILN
Rv2259|M.tuberculosis_H37Rv G------------GINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILN
MLBr_01784|M.leprae_Br4923 G------------GINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILN
MMAR_3350|M.marinum_M G------------GINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILN
MUL_1292|M.ulcerans_Agy99 G------------GINDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILN
MAB_1869c|M.abscessus_ATCC_199 G------------GINDEFPFLLGHEAAGIVETVGEGVTTVEPGDFVILN
TH_4627|M.thermoresistible__bu G------------GINDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLN
MAV_1614|M.avium_104 GDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMS
* *: :* : ***.:* :. ** *** . ***.*::.
Mvan_3767|M.vanbaalenii_PYR-1 WRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDGTELTPALG--------
Mflv_2766|M.gilvum_PYR-GCK WRAVCGQCRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALG--------
MSMEG_4340|M.smegmatis_MC2_155 WRAVCGQCRACKRGRPHLCFDTFNATQKMTLTDGTELTPALG--------
Mb2283|M.bovis_AF2122/97 WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALG--------
Rv2259|M.tuberculosis_H37Rv WRAVCGQCRACKRGRPRYCFDTFNAEQKMTLTDGTELTAALG--------
MLBr_01784|M.leprae_Br4923 WRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG--------
MMAR_3350|M.marinum_M WRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGTELTPALG--------
MUL_1292|M.ulcerans_Agy99 WRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGTELTPALG--------
MAB_1869c|M.abscessus_ATCC_199 WRAVCGVCRACKRGRPQYCFDTFNAAQKMTLTDGTELTPALG--------
TH_4627|M.thermoresistible__bu WRAVCGQCRACKRGRPHLCFDTFNATQKMTLGDGTELTPALG--------
MAV_1614|M.avium_104 FVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGGNLGHIA
: **** ** * * * .: *** : *
Mvan_3767|M.vanbaalenii_PYR-1 -IGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGAVNR
Mflv_2766|M.gilvum_PYR-GCK -IGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAAINTGGITR
MSMEG_4340|M.smegmatis_MC2_155 -IGAFADKTLVHEGQCTKVDADADPAVAGLLGCGVMAGIGAAINTGAVTR
Mb2283|M.bovis_AF2122/97 -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTR
Rv2259|M.tuberculosis_H37Rv -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTGGVTR
MLBr_01784|M.leprae_Br4923 -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSR
MMAR_3350|M.marinum_M -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTR
MUL_1292|M.ulcerans_Agy99 -IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAVNTGGVTR
MAB_1869c|M.abscessus_ATCC_199 -IGAFIEKTLVHAGQCTKVDPTADPAVVGLLGCGVMAGLGAAVNTGNVGR
TH_4627|M.thermoresistible__bu -IGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSR
MAV_1614|M.avium_104 KIGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCG
**** ::*:* .. .*:: * .**.*.: :* *:* * . :
Mvan_3767|M.vanbaalenii_PYR-1 DDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWAREFGATHTI
Mflv_2766|M.gilvum_PYR-GCK DDTVAVIGCGGVGDAAIAGAALVGAKTIIAVDTDNRKLDWARQFGATHTI
MSMEG_4340|M.smegmatis_MC2_155 DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDMDNKKLDWAREFGATHTV
Mb2283|M.bovis_AF2122/97 DDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTV
Rv2259|M.tuberculosis_H37Rv DDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFGATHTV
MLBr_01784|M.leprae_Br4923 DDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTV
MMAR_3350|M.marinum_M DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTV
MUL_1292|M.ulcerans_Agy99 DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARAFGATHTV
MAB_1869c|M.abscessus_ATCC_199 DDTVAVIGCGGVGDAAIAGARLAGARKIIAIDTDDTKLAWAKDFGATDTI
TH_4627|M.thermoresistible__bu DDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREFGATHTI
MAV_1614|M.avium_104 GDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSV
.*:*.***.**:* .** ** : ** *:*:* * * ****.::
Mvan_3767|M.vanbaalenii_PYR-1 NAGELD-AVKTIQDLTDGFGADVVID--AVGRPETWKQAFYARDLAGTVV
Mflv_2766|M.gilvum_PYR-GCK NAKDLD-PVKTIQDLTDGFGTDVVID--AVGRPETWKQAFYARDLAGTVV
MSMEG_4340|M.smegmatis_MC2_155 NAKDLD-AVETIQDLTDGFGADVVID--AVGRPETWKQAFYARDLAGTVV
Mb2283|M.bovis_AF2122/97 NAREVD-VVQAIGGLTDGFGADVVID--AVGRPETYQQAFYARDLAGTVV
Rv2259|M.tuberculosis_H37Rv NAREVD-VVQAIGGLTDGFGADVVID--AVGRPETYQQAFYARDLAGTVV
MLBr_01784|M.leprae_Br4923 NALELE-VVKTIQDLTSGFGVDVVID--TVGRPETWKQAFYARDLAGTVV
MMAR_3350|M.marinum_M NARELD-VVETIQDLTGGFGVDVVID--AVGRPETWKQAFYARDLAGTVV
MUL_1292|M.ulcerans_Agy99 NARELD-VVETIQDLTGGFGVDVVID--AVGRPETWKQAFYARDLAGTVV
MAB_1869c|M.abscessus_ATCC_199 NARKVDDVVTAIQELTDEFGADVVID--AVGRPETWKQAFYARDLAGTVV
TH_4627|M.thermoresistible__bu DASSTD-VVEAIQELTDGFGADVVVD--AVGRPETWEQAFYARDLAGTVV
MAV_1614|M.avium_104 ATIAEA--LDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCV
: : : ** . .*.*: :: .: .:*: .** *
Mvan_3767|M.vanbaalenii_PYR-1 LVGVPTPDMT-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
Mflv_2766|M.gilvum_PYR-GCK LVGVPTPDMT-LDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
MSMEG_4340|M.smegmatis_MC2_155 LVGVPTPDMK-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISLYLQG
Mb2283|M.bovis_AF2122/97 LVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQG
Rv2259|M.tuberculosis_H37Rv LVGVPTPDMR-LDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQG
MLBr_01784|M.leprae_Br4923 LVGVPTPDMR-LDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQG
MMAR_3350|M.marinum_M LVGVPTPDMR-LDMPLVDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQG
MUL_1292|M.ulcerans_Agy99 LVGVPTPDMR-LDMPLVDFFSRGGALKSSWYGDCLPERDFPTLIDLYLQG
MAB_1869c|M.abscessus_ATCC_199 LVGVPTPDMT-LEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLVSLYQQG
TH_4627|M.thermoresistible__bu LVGVPTPDMR-IDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLINLYLQG
MAV_1614|M.avium_104 LTGMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTG
*.*:.: ::: * **: . :* .: :*.* *. *:. * ** *
Mvan_3767|M.vanbaalenii_PYR-1 RFPLDKFVSERIGLDQIEDAFDKMHAG---EVLRSVVVL---
Mflv_2766|M.gilvum_PYR-GCK RFPLDKFVSERITLDQIEDAFHKMHAGSDDVVLRSVVVL---
MSMEG_4340|M.smegmatis_MC2_155 RLPLEKFVSERIGLDGIEDAFHKMHAG---EVLRSVVVLDR-
Mb2283|M.bovis_AF2122/97 RLPLQRFVSERIGLEDVEEAFHKMHGG---KVLRSVVML---
Rv2259|M.tuberculosis_H37Rv RLPLQRFVSERIGLEDVEEAFHKMHGG---KVLRSVVML---
MLBr_01784|M.leprae_Br4923 RLPLGKFVSERIGLGDVEEAFHKIHGG---KVLRSVVML---
MMAR_3350|M.marinum_M RLPLDKFVSEQIGLGGIEEAFEKMHAG---KVLRSVVVL---
MUL_1292|M.ulcerans_Agy99 RLPLDKFVSEQIGLGGIEEAFEKMHAG---KVLRSVVVL---
MAB_1869c|M.abscessus_ATCC_199 RLPLDRFVSERIGIESIEAAFEKMHHG---EVLRSVVVL---
TH_4627|M.thermoresistible__bu RLPLEKFVTERIALDEVEGAFEKMQRG---EVLRSVVVLK--
MAV_1614|M.avium_104 QLQLDEMITKRYRLDEVNDAYDDLLNG---KIVRGIIDFGIA
:: * .::::: : :: *:..: * ::*.:: :