For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KIRGAVLERIGAPRPYAESRPLTISELDLADPGPDELLVRIESAGLCHSDLSVVDGNRVRPVPMLLGHEA AGVVETPGADLETGQRVVMTFLPRCGSCPACGTDGLTPCGPGSVANGAGTLMNGDIRLRRDGEPVFHHLG VSGFATHAVVDRRSIVPVPDDVPATVAALLGCAVLTGGGAVLNVGRPKPGQTVVVVGLGGVGMAAALTAL AHDDVRVVGVDQLSDKLARAAELGVHETFTPEQAADLRAEVVIEAAGHPAALETAIGLTGPGGRTITVGL PRPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIALDDINAGMDELA EGRAVRQVIDFA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0127 | - | - | 100% (363) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_1138 | - | 5e-62 | 38.92% (352) | alcohol dehydrogenase 1 |
| M. smegmatis MC2 155 | MSMEG_0217 | - | 1e-49 | 30.77% (377) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 1e-147 | 71.51% (365) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_4588 | - | 8e-51 | 33.95% (377) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 1e-147 | 71.51% (365) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-45 | 31.83% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 1e-100 | 51.92% (364) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 1e-155 | 74.25% (365) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 1e-158 | 77.84% (361) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3466 | - | 1e-123 | 78.55% (275) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 8e-46 | 32.39% (355) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 1e-48 | 34.66% (352) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0127|M.smegmatis_MC2_155 -------------MKIRGAVLERIGAPRPYAESRPLTISELDLADPGPDE
TH_3466|M.thermoresistible__bu --------------------------------------------------
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MAB_0983c|M.abscessus_ATCC_199 -------------MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGE
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
MUL_1292|M.ulcerans_Agy99 -------------------MSQTVRGVISRKKGEPVELVDIVVPDPGPGE
Mflv_4588|M.gilvum_PYR-GCK ---------------------MKTRAAVLWGLGEKWEVDEIELDPPGVDE
Mvan_5270|M.vanbaalenii_PYR-1 ---------------------MKTNAAILWEYGGDWTVEEIDLDPPGDGE
MSMEG_0127|M.smegmatis_MC2_155 LLVRIESAGLCHSDLSVVDGNRVRPVPMLLGHEAAGVVETPG---ADLET
TH_3466|M.thermoresistible__bu --------------------------------------------------
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGDRVDDLAV
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLAV
MAB_0983c|M.abscessus_ATCC_199 VLVRIEAAGLCHSDLSVVDGNRIRPVPMALGHEAAGVIAAVGPGVRDVSP
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREGGINDRYPFLLGHEAAGTVEVVGPGVTAVEP
MUL_1292|M.ulcerans_Agy99 AVVDISACGVCHTDLTYREGGINDEYPFLLGHEAAGTVEAVGPGVTNVEP
Mflv_4588|M.gilvum_PYR-GCK VLVQLTASGLCHSDEHLVTGDLPFPLPVVGGHEGAGTVVEVGAGVEDLAV
Mvan_5270|M.vanbaalenii_PYR-1 VLVSWEATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVGPGVVGLAP
MSMEG_0127|M.smegmatis_MC2_155 GQRVVMTFLPRCGSCPACGTDGLTPCGPGSVANGAGTLMNGDIRLR-RDG
TH_3466|M.thermoresistible__bu ---VVMTFLPRCGHCPACATDGLTPCEPGSAANTAGTLLSGAIRLT-RDG
Mb0167c|M.bovis_AF2122/97 GQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RGG
Rv0162c|M.tuberculosis_H37Rv GQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RGG
MMAR_0405|M.marinum_M GQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRIS-RSG
MAV_5022|M.avium_104 GARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS-RAG
MAB_0983c|M.abscessus_ATCC_199 GDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDG
MLBr_01784|M.leprae_Br4923 GDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG---------
MUL_1292|M.ulcerans_Agy99 GDFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDG---------
Mflv_4588|M.gilvum_PYR-GCK GDSVILTFLPSCGHCSYCARGMGNLCDMG-AAIMMGPQIDGTYRFH-ARG
Mvan_5270|M.vanbaalenii_PYR-1 GDHVVASFLPACGRCRFCSTGHQNLCDLG-AMIMAGTQLDGTYRRH-VRG
*: : . ** * * * *
MSMEG_0127|M.smegmatis_MC2_155 EPVFHHLGVSGFATHAVVDRRSIVPVPDDVPATVAALLGCAVLTGGGAVL
TH_3466|M.thermoresistible__bu QPVHHHLGISGFASHAVVDRRSVVPVDSDVPPSVAALLGCAVLTGGGAVL
Mb0167c|M.bovis_AF2122/97 RPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVL
Rv0162c|M.tuberculosis_H37Rv RPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVL
MMAR_0405|M.marinum_M QPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAVL
MAV_5022|M.avium_104 RPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVL
MAB_0983c|M.abscessus_ATCC_199 TEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAVT
MLBr_01784|M.leprae_Br4923 TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAI
MUL_1292|M.ulcerans_Agy99 TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAV
Mflv_4588|M.gilvum_PYR-GCK EDVGQMCLLGTFSEYTVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSAV
Mvan_5270|M.vanbaalenii_PYR-1 QDVGVMALVGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAV
: :. *: * . . : * *:**.: :* *:.
MSMEG_0127|M.smegmatis_MC2_155 NVGRPKPGQTVVVVGLGGVGMAAALTALAHDDVRVVGVDQLSDKLARAAE
TH_3466|M.thermoresistible__bu NVGRPRPGQRVIVVGLGGVGLAAVLTALAHPDVRVVGVDQRTDKLHTART
Mb0167c|M.bovis_AF2122/97 NVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAKA
Rv0162c|M.tuberculosis_H37Rv NVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAKA
MMAR_0405|M.marinum_M NVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAEA
MAV_5022|M.avium_104 NVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARR
MAB_0983c|M.abscessus_ATCC_199 HTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALE
MLBr_01784|M.leprae_Br4923 NTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWART
MUL_1292|M.ulcerans_Agy99 NTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARA
Mflv_4588|M.gilvum_PYR-GCK RTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALTIVAVDPVEFKREQAGG
Mvan_5270|M.vanbaalenii_PYR-1 NTADVSPGDTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFR
... .: * ::* **:* . * :. :: * *
MSMEG_0127|M.smegmatis_MC2_155 LGVHETFTP--------EQAAD--LRAEVVIEAAGHPA--ALETAIGLTG
TH_3466|M.thermoresistible__bu LGAHEAYTP--------DQAVDANLKAQVVIEAAGHPD--ALATAIQLTA
Mb0167c|M.bovis_AF2122/97 LGAHEIYTP--------QQATAGGVKAAVVVEAVGHPA--ALHTAIGLTA
Rv0162c|M.tuberculosis_H37Rv LGAHEIYTP--------QQATAGGVKAAVVVEAVGHPA--ALHTAIGLTA
MMAR_0405|M.marinum_M LGASATYTP--------QQAAAAGVKADVVIEAAGHPA--ALETAIGLTA
MAV_5022|M.avium_104 LGAHQAYTP--------QQAVEARVKAAVVIEAVGHPA--ALQTAIDLTA
MAB_0983c|M.abscessus_ATCC_199 LGATSACAP--------DEAPGG---HDWVFEVVGSAA--VLEQAYALTG
MLBr_01784|M.leprae_Br4923 FGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARD
MUL_1292|M.ulcerans_Agy99 FGATHTVNARELDVVETIQDLTGGFGVDVVIDAVGRPE--TWKQAFYARD
Mflv_4588|M.gilvum_PYR-GCK FGATHAVAT-IDEAWSLISDITRGKLADVCVLTTDVAEGAYTAEALSLVG
Mvan_5270|M.vanbaalenii_PYR-1 FGATHFVTS-MEEATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIR
:*. . . ... *
MSMEG_0127|M.smegmatis_MC2_155 PGGRTITVGLPRPD-ARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
TH_3466|M.thermoresistible__bu PGGRTITVGLPPPD-ARLTVSPLGLVAEGRSLIGSYLGSAVPARDIPRFV
Mb0167c|M.bovis_AF2122/97 PGGRTITVGLPPPD-VRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFV
Rv0162c|M.tuberculosis_H37Rv PGGRTITVGLPPPD-VRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFV
MMAR_0405|M.marinum_M PGGRTITVGLPPPD-ARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
MAV_5022|M.avium_104 PGGRTITVGLPPPD-ARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
MAB_0983c|M.abscessus_ATCC_199 RGGGTVSVGLPHPD-ARISLPALNIVAEGRSILGSYMGSAQPQQDIPAML
MLBr_01784|M.leprae_Br4923 LAGTVVLVGVPTPD-MRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLV
MUL_1292|M.ulcerans_Agy99 LAGTVVLVGVPTPD-MRLDMPLVDFFSRGGALKSSWYGDCLPERDFPTLI
Mflv_4588|M.gilvum_PYR-GCK KRGRVVITAIGHPEDTSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLV
Mvan_5270|M.vanbaalenii_PYR-1 KGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLL
* .: ..: : : : .: *.. . *:* ::
MSMEG_0127|M.smegmatis_MC2_155 ELWRAGRLPVESLVSSTIALDDINAGMDELAEGRAVRQVIDFA---
TH_3466|M.thermoresistible__bu DLWRSGRLPVEQLVSSTITLDELNEGLDRLADGAAVRQLITLPG--
Mb0167c|M.bovis_AF2122/97 SLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
Rv0162c|M.tuberculosis_H37Rv SLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
MMAR_0405|M.marinum_M SLWQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF----
MAV_5022|M.avium_104 ELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA--
MAB_0983c|M.abscessus_ATCC_199 ALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA
MLBr_01784|M.leprae_Br4923 DLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML----
MUL_1292|M.ulcerans_Agy99 DLYLQGRLPLDKFVSEQIGLGGIEEAFEKMHAGKVLRSVVVL----
Mflv_4588|M.gilvum_PYR-GCK ELYNSGQLKLDELITREYTLDEINEGYDDMRSGRNIRGLIRF----
Mvan_5270|M.vanbaalenii_PYR-1 SLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH--
*: *:* : . : * :: . . : * :* ::