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MAKSFTLVQLRYFTAVARHENMRAAALDLNVTQSTLSAAIHQLEREVGAELFQRLSSRGLRLTAEGRRLL IGAKTVLEDADQLYQSVRAEREELVGDLVVGIFSPIAPFHAPNILTAVEKRHPGIKLTFLEGDQETLMRA VRDGICEIAVMYDLGVGTEFDYRSLERIPPHVLVSADHPRAAHPEQPVHLRDFEDEPFVLLDLKHSREYY LDIFKRLGVRPRIRHFVSGYETVRSYVGLGQGYSVLNRRLVHDLTYAGRRIVALELADDVPPIEVVLVRL RDARLTRKALAVEQVCVDLHATAPQHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0817 | - | - | 100% (307) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1678 | - | 2e-50 | 35.10% (302) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 3e-17 | 27.40% (281) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 4e-10 | 37.82% (119) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1356 | - | 4e-17 | 29.93% (294) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 4e-10 | 37.82% (119) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-19 | 31.86% (226) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4409 | - | 2e-21 | 29.90% (311) | hydrogen peroxide-inducible genes activator |
| M. marinum M | MMAR_2756 | oxyR | 5e-21 | 32.14% (224) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_2838 | - | 3e-20 | 30.36% (224) | hydrogen peroxide-inducible genes activator |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-10 | 29.86% (144) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 4e-21 | 32.58% (221) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_4734 | - | 8e-15 | 35.42% (144) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02041|M.leprae_Br4923 -------------------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASF
MAV_2838|M.avium_104 -------------------MPDKTYQPTIAGLRAFVAVAEKRQFSGAATA
MMAR_2756|M.marinum_M -----------MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MUL_2998|M.ulcerans_Agy99 ----------------MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MAB_4409|M.abscessus_ATCC_1997 -------------------MSDRSYQPTVVGLRAFVAIARKRHFGSAAGE
Mb0121|M.bovis_AF2122/97 --------------------------MLFRQLEYFVAVAQERHFARAAEK
Rv0117|M.tuberculosis_H37Rv --------------------------MLFRQLEYFVAVAQERHFARAAEK
Mflv_1356|M.gilvum_PYR-GCK MVSAVTGRPTNDPPHTWRHRTIKEPPMELRHLRYFLAVAETCHFGQAAEQ
Mvan_4734|M.vanbaalenii_PYR-1 --------------------------MELRQLEAFVAVAGELHFGRAAEK
TH_3504|M.thermoresistible__bu ---------------------VPSPKIDLRRLAQFVAVAELGSFTRAAAT
MSMEG_0817|M.smegmatis_MC2_155 ----------------------MAKSFTLVQLRYFTAVARHENMRAAALD
. * * *:. : **
MLBr_02041|M.leprae_Br4923 LGVRQSTLSQALAALESGLGVQLIERSTRR-VFVTTQGRHLLPRAQAAIE
MAV_2838|M.avium_104 LGVSQSTLSQALAALEAGLGTQLVERSTRR-VFLTPQGAELLPHAQAVVE
MMAR_2756|M.marinum_M LGVSQSTLSQALAALEAGLDLHLVERSTRR-VFLTTEGRSLLPHAQAAVE
MUL_2998|M.ulcerans_Agy99 LGVSQSTLSQALAALEAGLDLHLVERSTRR-VFLTTEGRSLLPHAQAAVE
MAB_4409|M.abscessus_ATCC_1997 LGVSQPSLSQALSMLEEGLGVRLVERNTRK-VLLTPEGDALLEKAISALN
Mb0121|M.bovis_AF2122/97 CYVSQPALSSAIAKLERELNVTLINRGHSF-EGLTREGERLVVWAKRILA
Rv0117|M.tuberculosis_H37Rv CYVSQPALSSAIAKLERELNVTLINRGHSF-EGLTREGERLVVWAKRILA
Mflv_1356|M.gilvum_PYR-GCK LHIAQPALSYAIRQLENSLDATLFTRTTRH-VALTPAGEFLRVEATRILN
Mvan_4734|M.vanbaalenii_PYR-1 LHIGQPTLSELIRRLEREVGTPLLTRTTRR-VALTQAGVELFGRAKVILD
TH_3504|M.thermoresistible__bu LHLSQQALSSAVRALENDVGADLFTRDGRR-ISLTTAGRTLLAEGKPLLA
MSMEG_0817|M.smegmatis_MC2_155 LNVTQSTLSAAIHQLEREVGAELFQRLSSRGLRLTAEGRRLLIGAKTVLE
: * :** : ** :. *. * :* * * . :
MLBr_02041|M.leprae_Br4923 AMDAFTAAAAGESDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLR
MAV_2838|M.avium_104 AADAFTAAAAGSADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRPGLTLR
MMAR_2756|M.marinum_M AVEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVR
MUL_2998|M.ulcerans_Agy99 AVEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVR
MAB_4409|M.abscessus_ATCC_1997 AVDEFTSAASGVRDPFAQTLRLGLIPTVAPYVLPMVLSGLSREFPEMSLR
Mb0121|M.bovis_AF2122/97 EHAAFKAEVDAVRSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQ
Rv0117|M.tuberculosis_H37Rv EHAAFKAEVDAVRSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQ
Mflv_1356|M.gilvum_PYR-GCK GVDAAQRGVRRIAAGRSGLLRLGLTGTAAFSHLPKIARIVRQELPAVALD
Mvan_4734|M.vanbaalenii_PYR-1 DVEGAAAAVRRLADGEAGTVRLGITPPVAPVLAPHLSQALHSAAPDVQL-
TH_3504|M.thermoresistible__bu AARTVAEHVRQTEAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFT
MSMEG_0817|M.smegmatis_MC2_155 DADQLYQSVRAEREELVGDLVVGIFSPIAPFHAPNILTAVEKRHPGIKLT
. .* . : : * .
MLBr_02041|M.leprae_Br4923 VVEDQT-EHLLTALREGALDAAMIALPVETAG-IAEIPIYDEDFVLALPP
MAV_2838|M.avium_104 VTEDQT-ERLLAVLREGALDAALIALPAETAG-VTAIPIYDEDFVLALPP
MMAR_2756|M.marinum_M VIEDQT-ERLLTALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPP
MUL_2998|M.ulcerans_Agy99 VIEDQT-ERLLTALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPP
MAB_4409|M.abscessus_ATCC_1997 VTEDQT-HRLLRSLSDGTLDVAVMALPVQTQG-MAEIPMYREDFVLALPS
Mb0121|M.bovis_AF2122/97 VCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPA
Rv0117|M.tuberculosis_H37Rv VCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPA
Mflv_1356|M.gilvum_PYR-GCK IHADLLTPDQCEGLRTGALDVGVLRPPAVGGD-VATRTIAAEPLVLAVSA
Mvan_4734|M.vanbaalenii_PYR-1 VVQRMWLPDLQRAIGDGELDVAITCGPVADPPGILSEVFCAEPVMVGLRA
TH_3504|M.thermoresistible__bu LRQLYP-DALTDAVFDGTVQLGLRRGVVPTPE-LATAVIGYHRVRVAFVD
MSMEG_0817|M.smegmatis_MC2_155 FLEGDQ-ETLMRAVRDGICEIAVMYDLGVGTE-FDYRSLERIPPHVLVSA
. : : : . : :
MLBr_02041|M.leprae_Br4923 GHPLSGKRR--VPTTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAEL
MAV_2838|M.avium_104 GHPLAGKRR--VPATALADLPLLLLDEG--HCLRDQALDVCHKAGVRAEL
MMAR_2756|M.marinum_M GHPMADRHG--VPVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEL
MUL_2998|M.ulcerans_Agy99 GHPMADRHG--VPVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEH
MAB_4409|M.abscessus_ATCC_1997 GHPLAGSKN--VEPADLADMPLLLLDEG--HCLRDQALEVCQLAGVRPDL
Mb0121|M.bovis_AF2122/97 DMLPPGTST--LVWRDAAQLPLALLTAD--MRDR-QVIDAAFADHAVSAI
Rv0117|M.tuberculosis_H37Rv DMLPPGTST--LVWRDAAQLPLALLTAD--MRDR-QVIDAAFADHAVSAI
Mflv_1356|M.gilvum_PYR-GCK DHRLAAEPV--VSLADLRSEPFIGYTGQ--DSAVNDAVTRSCRAAGFVPH
Mvan_4734|M.vanbaalenii_PYR-1 DHHLAGRDA--VELRNLSTETIGVHSEA--LFPAWSLALRQVLDDTGIRP
TH_3504|M.thermoresistible__bu SHPLAARES--VDITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDY
MSMEG_0817|M.smegmatis_MC2_155 DHPRAAHPEQPVHLRDFEDEPFVLLDLK---HSREYYLDIFKRLGVRPRI
. . : .
MLBr_02041|M.leprae_Br4923 ANTRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLG----LAQFAAP
MAV_2838|M.avium_104 ANTRAASLATAVQCVTGGLGVTLIPQSAVPVEASRSRLG----LAQFAAP
MMAR_2756|M.marinum_M ADTRAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVG----LAHFAAP
MUL_2998|M.ulcerans_Agy99 ADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVG----LTHFAAP
MAB_4409|M.abscessus_ATCC_1997 GHTRAASLATAVQCVEGGLGVTLIPGTAVTAETASGGLA----TATFAAP
Mb0121|M.bovis_AF2122/97 PQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDP
Rv0117|M.tuberculosis_H37Rv PQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDP
Mflv_1356|M.gilvum_PYR-GCK REHSAPGTAVLLALVAADLGVSVVPASVRALPLHGVVFR------DLVDG
Mvan_4734|M.vanbaalenii_PYR-1 PAVEFTDTDLAAYRWPIQSEVDWVLTTAAVAGDSAGVVLRPTSPAHFVPY
TH_3504|M.thermoresistible__bu VVSRVQGAATVAAPLTTG-GIAFVTAAAGPTMNG-----------RVQVV
MSMEG_0817|M.smegmatis_MC2_155 RHFVSG-YETVRSYVGLGQGYSVLNRRLVHDLTYAGRRIV---ALELADD
: .
MLBr_02041|M.leprae_Br4923 CPGRRIGLAFRSASGRSASYRQIAKIIGELISTEHHVRLVA------
MAV_2838|M.avium_104 RPGRRIGLVFRSSSGRDDSYRELAGLIGELISSQHQVRLVK------
MMAR_2756|M.marinum_M TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 TPGRRIGLVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MAB_4409|M.abscessus_ATCC_1997 VPGRRIGLVYRAISAREDAYRRLAELLTRLVSAVHPVTADAA-----
Mb0121|M.bovis_AF2122/97 VLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv VLKAQIALATNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR
Mflv_1356|M.gilvum_PYR-GCK G-TVDLALAWRDGVDNPVVDAVVAVLAGALTSLDHPALQEQS-----
Mvan_4734|M.vanbaalenii_PYR-1 TLQWCPIRATTVAVGRFVRLALSVDVPPGWVSQPDHLRHGAGSLLED
TH_3504|M.thermoresistible__bu DLTPPLLVPVQALWQRHTLSAIRDRILEGLG----------------
MSMEG_0817|M.smegmatis_MC2_155 VPPIEVVLVRLRDARLTRKALAVEQVCVDLHATAPQHR---------