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VSVSEVVGVRALGLRGVLMGRGDADIRWVATSELPDPTPFLEGGEILLTTGIETRTWGREWDDYVRRLAG AAVAAVGFGIGLTHERTPTALIAACREHDVNLFEVPRRTTFVAISREVARLLSEQESAATQAALQTQRKL ISAATKRHPATAVITALAQALDGAACLMSPDGRALTGPVGPRRGEFPFDDAAADVRRLQTQAGRSAATQS RPALSLSVQPIGLRGRPAAYLATMGPVRLSDAERDALTTSVAVLGLVDEQRRSRSTTRQHLHSRAIELLA GNDSRTAQLILEVDAPALVIPERIRFLRATGGDSEITDAVTALERRGILAGTYADELCTVAVPERAEAAG ESMVDAGLQVGVGAAVPSDDGASGYRTAGLALAQTTPTAALVVWDRVVNDGPLGLIDPQRAAAFAESWLS GLDSEQLETLRCFLRHHGSRLKVAEELGLHRNTVRNRLDAIEALLPGRLDDPQTRVSAWIALQSLPPENR PVSP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0579 | - | - | 100% (495) | helix-turn-helix, Fis-type |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 1e-33 | 27.45% (521) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 3e-20 | 24.20% (500) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 7e-05 | 25.88% (371) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0801 | - | 2e-20 | 26.03% (461) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv1186c | - | 9e-05 | 25.88% (371) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01052 | - | 9e-05 | 29.92% (127) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 2e-31 | 26.60% (500) | peptidase |
| M. marinum M | MMAR_4242 | - | 9e-07 | 28.57% (189) | transcriptional regulatory protein |
| M. avium 104 | MAV_1987 | - | 3e-05 | 26.73% (217) | putative DNA-binding protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0944 | - | 5e-06 | 28.04% (189) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 1e-33 | 27.10% (476) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 ----MRIAGVGLGQLLLALDATVVSLVD-APRGLDLPVASTALIDSDDVR
Rv1186c|M.tuberculosis_H37Rv ----MRIAGVGLGQLLLALDATVVSLVD-APRGLDLPVASTALIDSDDVR
MAB_0825|M.abscessus_ATCC_1997 -MAEYRLTVPITVRDLTQRADLGLVLSA-GEAGAARAIKWAHAIELNDPT
Mvan_1854|M.vanbaalenii_PYR-1 ---------MITARSLCQDENLGLTLVA-GAQAADRPIAWAHAIELADPT
MMAR_4242|M.marinum_M -----------MPWQRPSSRIRELIREG-ARRALNAGPEWIEELDRETVS
MUL_0944|M.ulcerans_Agy99 -----------MPWQRPSSRIRELIREG-ARRALNAGPEWIEELDRETVS
MLBr_01052|M.leprae_Br4923 -----------MARQHPSPRVRELIREG-ARIALNPTQEWIDQLDRATFA
MSMEG_0579|M.smegmatis_MC2_155 ---------MVSVSEVVGVRALGLRGVL-MGRG-DADIRWVATSELPDPT
MAV_1987|M.avium_104 ------MITLDRLVNVLGGYGVRLRWSS-VPRSTELRSVVIHETPEDRPV
Mflv_0801|M.gilvum_PYR-GCK MSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRDPS
:
Mb1218c|M.bovis_AF2122/97 L---GLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDS
Rv1186c|M.tuberculosis_H37Rv L---GLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDS
MAB_0825|M.abscessus_ATCC_1997 P---YLFGGELVMTTGLTVGLSHAEQYEYAARLSGKNVAALAFDTGTTFS
Mvan_1854|M.vanbaalenii_PYR-1 P---YLAGGELVMTTGINIGADAAAQADYVARLAAAGTAALAVDTGTTLT
MMAR_4242|M.marinum_M A---NPTIANDPVLAKVVKRANRANLVHWAAANVRHPGAPVPANLGGEP-
MUL_0944|M.ulcerans_Agy99 A---NPTIANDPVLAKVVKRVNRANLVHWAAANVRHPGAPVPANLGGEP-
MLBr_01052|M.leprae_Br4923 A---NPAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPEP-
MSMEG_0579|M.smegmatis_MC2_155 P---FLEGGEILLTTGIETRTWGREWDDYVRRLAGAAVAAVGFGIGLTHE
MAV_1987|M.avium_104 VGDVLLAVGAGSLDEAVRWAASARAAVVVLRDDETPMTFDGVTDVGAVLV
Mflv_0801|M.gilvum_PYR-GCK R---YLRGGELVCTVGISLHS-AEDCSTFVDALAGAGAAGVCFGVGDGHD
. .
Mb1218c|M.bovis_AF2122/97 VVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLF
Rv1186c|M.tuberculosis_H37Rv VVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLF
MAB_0825|M.abscessus_ATCC_1997 EVPPGILAAGDELGLP--------------ILQVP---------VSTPFI
Mvan_1854|M.vanbaalenii_PYR-1 AVPAGVLAAGDEHGVP--------------VLRVP---------ASTPFI
MMAR_4242|M.marinum_M -------------------------------------------------L
MUL_0944|M.ulcerans_Agy99 -------------------------------------------------L
MLBr_01052|M.leprae_Br4923 -------------------------------------------------L
MSMEG_0579|M.smegmatis_MC2_155 RTPTALIAACREHDVN--------------LFEVP---------RRTTFV
MAV_1987|M.avium_104 IDPTVSWSAVAAVVYG----------------LVLEGRETESGRGPTDLF
Mflv_0801|M.gilvum_PYR-GCK DVPAALLDACRRAGLP--------------VLVAP---------PSVPFS
Mb1218c|M.bovis_AF2122/97 GLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILG-RAGPPE
Rv1186c|M.tuberculosis_H37Rv GLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILG-RAGPPE
MAB_0825|M.abscessus_ATCC_1997 AITRAVIDELT--------ADELRAVQRVVDQQDVLVRATLRDGAPGVVS
Mvan_1854|M.vanbaalenii_PYR-1 AIARVVIDAVK--------ADQLESVQRVVDQQEVLARATLRGGIPGVVG
MMAR_4242|M.marinum_M RMARDLVRRGL--------ETLTLDIYRIGQYIAWRLWINIAFDLTSDPQ
MUL_0944|M.ulcerans_Agy99 RMARDLVRRGL--------EALTLDIYRIGQYIAWRLWINIAFDLTSDPQ
MLBr_01052|M.leprae_Br4923 TMARDLVRRGR--------DVLALDIYRVGQYTAWRRWMEIAFTLTSDPQ
MSMEG_0579|M.smegmatis_MC2_155 AISREVARLLS-------EQESAATQAALQTQRKLISAATKRHPATAVIT
MAV_1987|M.avium_104 ALADSLADGIGNPVVIQDRHLGVLAYSRLAQADPALVETVLQRQTPEPLR
Mflv_0801|M.gilvum_PYR-GCK VISRFVAESRLG-------TEIAVARATNALVPELLLSLRRHDSPRRLLD
:: :
Mb1218c|M.bovis_AF2122/97 HLQWIGQWGIFDALRAGREVVR-VAERPELGLRPRLAIGI----HQPGVG
Rv1186c|M.tuberculosis_H37Rv HLQWIGQWGIFDALRPGREVVR-VAERPELGLRPRLAIGI----HQPGVG
MAB_0825|M.abscessus_ATCC_1997 ALSRSLAATVIVTATDGTLLAEAGHDAEHLAEITRGAFPN----HSRKHA
Mvan_1854|M.vanbaalenii_PYR-1 ALAECLSAVVVAVSTDGRDLAAGGTADPQLISALSEAVG-----QARNRG
MMAR_4242|M.marinum_M ELRELLDVSAKSVNEFIEATLAGIAAQVQLEHDE----------------
MUL_0944|M.ulcerans_Agy99 ELHELLDVSAKSVNEFIEATLAGIAAQVQLEHDE----------------
MLBr_01052|M.leprae_Br4923 ELREILNVSAQSINEYVAATLEAIATHMQLERDE----------------
MSMEG_0579|M.smegmatis_MC2_155 ALAQALDGAACLMSPDGRALTGPVGPRRGEFPFDDAAADVRRLQTQAGRS
MAV_1987|M.avium_104 ALLEARGVFAHLQVADEPLFVAEDAERGLSGRMVVAVRAG----------
Mflv_0801|M.gilvum_PYR-GCK AAGQVLGCYFLLEPEGAAKGDEAAVTVPVPGLGALVWMGR----------
Mb1218c|M.bovis_AF2122/97 ALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHA
Rv1186c|M.tuberculosis_H37Rv ALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHA
MAB_0825|M.abscessus_ATCC_1997 SRVVADRDGYCTIQTVRAGKAERGYLAVRSEDALTAAQRLLVSHAMALIA
Mvan_1854|M.vanbaalenii_PYR-1 AAVIPDGDALLTIQRLRAAQAVRGYLVVRSAGPLSDSGRLLVSHAVSLIS
MMAR_4242|M.marinum_M -----------LTRGNHADRLEVVGHLLEGAPISRERAETRLGYSLIRAH
MUL_0944|M.ulcerans_Agy99 -----------LTRGNHADRLEVVGHLLEGAPISRERAETRLGYSLIRAH
MLBr_01052|M.leprae_Br4923 -----------LTRSTHAERLEVVDLILEGAPVTQERAEARLGYRLGLTH
MSMEG_0579|M.smegmatis_MC2_155 AATQSRPALSLSVQPIGLRGRPAAYLATMGPVRLSDAERDALTTSVAVLG
MAV_1987|M.avium_104 ----AELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLERQ
Mflv_0801|M.gilvum_PYR-GCK ---------GDRPEPALLDLIARFVRAAQGERDIEAALTRERVGQLLSLV
.
Mb1218c|M.bovis_AF2122/97 LRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTA
Rv1186c|M.tuberculosis_H37Rv LRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTA
MAB_0825|M.abscessus_ATCC_1997 IELEKPARVADAEQRLRGAVTRALLADPAAADRSVLRYFGFDP----DTE
Mvan_1854|M.vanbaalenii_PYR-1 IALEKPARVQDAEQRLRSAVTRELLGGRGAVDDGLLRYFGFTP----DGD
MMAR_4242|M.marinum_M TAAIIWSDDFDGDHSNLDRAADAFCHAVGSSQD-----------------
MUL_0944|M.ulcerans_Agy99 TAAIIWSDDFDGDHSNLDRAADAFCHAVGSSQD-----------------
MLBr_01052|M.leprae_Br4923 TAAVIWSDDLDGDHGYLDQAAEAFSHVVESTQQ-----------------
MSMEG_0579|M.smegmatis_MC2_155 LVDEQRRSRSTTRQHLHSRAIELLAGNDSRTAQ-----------------
MAV_1987|M.avium_104 VESELVIRLLEGTADAATVASRLDLAHNGLRVVAVQAFVGADR-------
Mflv_0801|M.gilvum_PYR-GCK ERRMLLPDALSQLVQWPGFAGEIACSAWPAGAG-----------------
Mb1218c|M.bovis_AF2122/97 VRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGT
Rv1186c|M.tuberculosis_H37Rv VRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGT
MAB_0825|M.abscessus_ATCC_1997 VVVVLLCNVGSVLPGELHIDRQLARGGPYLMASVSGEIVVVLAAKN-VGR
Mvan_1854|M.vanbaalenii_PYR-1 VVVSVLHGIGPVLAAEEELSRPLADTGPYLMAATGTEIVIVLPADGSRAR
MMAR_4242|M.marinum_M -----LTVVANAATRWVWLAEATNLDIDTIEQAVDNASDARIAIGTKASG
MUL_0944|M.ulcerans_Agy99 -----LTVVANAATRWVWLAEATNLDIDTIEQAVDNASDARIAIGTKASG
MLBr_01052|M.leprae_Br4923 -----LIVVASAATRWVWLADALALDVPEVQKALLNLSKARVAIGTSSAG
MSMEG_0579|M.smegmatis_MC2_155 -LILEVDAPALVIPERIRFLRATGGDSEITDAVTALERRGILAGTYADEL
MAV_1987|M.avium_104 -DAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEASTARRWVGAL
Mflv_0801|M.gilvum_PYR-GCK -------ALLSISFPGALIGDAPDLCMMLTAGAVEMPDDLALPTGHSAPV
Mb1218c|M.bovis_AF2122/97 ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVT
Rv1186c|M.tuberculosis_H37Rv ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVT
MAB_0825|M.abscessus_ATCC_1997 ASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIAE
Mvan_1854|M.vanbaalenii_PYR-1 IRTLLRGRGAPGG-----GSSRVVPMADVGTGLEQAR-VAAHSSVGEFTE
MMAR_4242|M.marinum_M IEGFRRS---------------------HLEALTTQRTLARLKSDQRVAF
MUL_0944|M.ulcerans_Agy99 IEGFRRS---------------------HLEALTTQRTLARLKSDQRVAF
MLBr_01052|M.leprae_Br4923 IEGFRRS---------------------HLEALTAQRTLARLKSHQQVAF
MSMEG_0579|M.smegmatis_MC2_155 CTVAVPERAEAAGESMVDAGLQVGVGAAVPSDDGASGYRTAGLALAQTTP
MAV_1987|M.avium_104 RAALPERLTMIAGISGVAEVGDLAAARQEADECLALHEMSPAAPPPAYDE
Mflv_0801|M.gilvum_PYR-GCK TLADLGS----------------------AIAQARIALTLAEHRGGRVGP
Mb1218c|M.bovis_AF2122/97 SLAEARTTVLLDEIVT-LVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDA
Rv1186c|M.tuberculosis_H37Rv SLAEARTTVLLDEIVT-LVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDA
MAB_0825|M.abscessus_ATCC_1997 FDELDIYGVLLGGRDRGELAVLAQSVAPLLGTG--ADTTLLDTLESFLAC
Mvan_1854|M.vanbaalenii_PYR-1 YADLGPLAAVLDGRTSRELRFLAAVLDPLAGN----DEDLIATLAAFLRH
MMAR_4242|M.marinum_M FSDVQIVALITQNPQA-----ADEFITSTLGELESAAPELQATLLMFINE
MUL_0944|M.ulcerans_Agy99 FSDVQIVALITQNTQA-----ANEFITSTLGELESAAPELQATLLMFINE
MLBr_01052|M.leprae_Br4923 FADVQLVSLITQNPED-----AKEFITSTLGDFESASPALQQTLLTFINE
MSMEG_0579|M.smegmatis_MC2_155 TAALVVWDRVVNDGPLGLID-PQRAAAFAESWLSGLDSEQLETLRCFLRH
MAV_1987|M.avium_104 SWDDILLQRLRAAARS-GRAPTRGPVADLGRHDRANGTDYLATLRAWLQA
Mflv_0801|M.gilvum_PYR-GCK DQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSRGTQHVRTLRTFVAC
: ** ::
Mb1218c|M.bovis_AF2122/97 FGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRAME
Rv1186c|M.tuberculosis_H37Rv FGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRAME
MAB_0825|M.abscessus_ATCC_1997 NGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAALWIAIRARA
Mvan_1854|M.vanbaalenii_PYR-1 NGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQLWLALRAFQ
MMAR_4242|M.marinum_M QCNASRAAKRLYTHRNTLLRRIEAAQRLLPRPLAHTSVHVAVALEALQWR
MUL_0944|M.ulcerans_Agy99 QCNASRAAKRLYTHRNTLLRRIEAAQRLLPRPLAHTSVHVAVALEALQWR
MLBr_01052|M.leprae_Br4923 QCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVALEALQWR
MSMEG_0579|M.smegmatis_MC2_155 HGSRLKVAEELGLHRNTVRNRLDAIEALLPGRLDDPQTRVSAWIALQSLP
MAV_1987|M.avium_104 QGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLDDSKKRLAMMIELAAIH
Mflv_0801|M.gilvum_PYR-GCK NGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQHNDLTTFVIGMWAAD
. .. * * :*: *: : . :
Mb1218c|M.bovis_AF2122/97 RTA----------------
Rv1186c|M.tuberculosis_H37Rv RTA----------------
MAB_0825|M.abscessus_ATCC_1997 LLG----------------
Mvan_1854|M.vanbaalenii_PYR-1 LLENRRAPAGRCDS-----
MMAR_4242|M.marinum_M GDNIAKLPTPTSQDDEVPA
MUL_0944|M.ulcerans_Agy99 GDNIAKLPTPTSQDDEVPA
MLBr_01052|M.leprae_Br4923 GDQTNTSGPRAGRNDGVPA
MSMEG_0579|M.smegmatis_MC2_155 PENRPVSP-----------
MAV_1987|M.avium_104 TD-----------------
Mflv_0801|M.gilvum_PYR-GCK RGE----------------