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ITARGLAQVESLGLSLLAGAQGADREIAWAHANELRDPTPYLAGGELVMTTGINIGAGAGEQRDYVARLS AAGIAALAVDTGTTLQEVPAAVLAAGDELGLPVLEVPASTPFIAIARVVIDAVKADELSAVQRMVDQQQV LARATLRGGIPAVVNALAECLSATVVVADIEGRILATRGAADQQLVEVLEASRRAGARAQAGVVADADGY VTVQTLRAAQPVRGHLAVRTEQPMSNSQRLLVAHAVSLISIELEKPARVVDAEDRLRSAVTRDILSGTGT TDSAVLRYLGFQPDDEVVVLLLTGFTPLLTAQDDLGQRLAPAGSYLMTSTGDEFAIIVHAARRRRVYAAV EEFGRVTGRTVRGGASQPVRLADAVVGAEQARIAAHSNSRRNITEFTEVKVFGTLLGGRSTAELRVLAQP IEPLLAGGDELIDALTAFLRHNGQLEAAASELQIHRHTMRNRMRRISDLLADDLGTADTRAQLWLAIRAW QLLVSRERPGLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6688 | - | - | 100% (503) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0579 | - | 1e-33 | 27.45% (521) | helix-turn-helix, Fis-type |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 2e-24 | 24.50% (498) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 6e-07 | 37.50% (88) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0356 | - | 4e-18 | 24.15% (501) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv1186c | - | 6e-07 | 37.50% (88) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 1e-05 | 35.29% (68) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 1e-135 | 53.43% (496) | peptidase |
| M. marinum M | MMAR_4254 | - | 2e-05 | 33.72% (86) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_2195 | - | 8e-06 | 36.76% (68) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 4e-06 | 36.36% (66) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0931 | - | 1e-05 | 33.72% (86) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 1e-161 | 61.48% (501) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6688|M.smegmatis_MC2_155 --------MITARGLAQVESLGLSLLAGAQGADREIAWAHANELRDPTPY
Mvan_1854|M.vanbaalenii_PYR-1 --------MITARSLCQDENLGLTLVAGAQAADRPIAWAHAIELADPTPY
MAB_0825|M.abscessus_ATCC_1997 MAEYRLTVPITVRDLTQRADLGLVLSAGEAGAARAIKWAHAIELNDPTPY
MLBr_01652|M.leprae_Br4923 ---------------MNHNHFVP--APPRRLPLELLDTVPDSLLRRLKQY
MAV_2195|M.avium_104 ---------------MNDNPFAGPFAKHPRSPLETLDTVPESVLRRLKQY
TH_1338|M.thermoresistible__bu ---------------VPDNRFVP-----PQSTLEVLESVPESVLRRLKQY
Mb1218c|M.bovis_AF2122/97 ---MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVRLG
Rv1186c|M.tuberculosis_H37Rv ---MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVRLG
MMAR_4254|M.marinum_M ---MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSDDVRLG
MUL_0931|M.ulcerans_Agy99 ---MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSDDVRLG
Mflv_0356|M.gilvum_PYR-GCK -----MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTL
: .
MSMEG_6688|M.smegmatis_MC2_155 LAGGELVMTTGINIGAGAGEQRDYVARLSA--------AGIAALAVDTGT
Mvan_1854|M.vanbaalenii_PYR-1 LAGGELVMTTGINIGADAAAQADYVARLAA--------AGTAALAVDTGT
MAB_0825|M.abscessus_ATCC_1997 LFGGELVMTTGLTVGLSHAEQYEYAARLSG--------KNVAALAFDTGT
MLBr_01652|M.leprae_Br4923 SG------RLATEAVTAMQERLPFFADLEA--------SQRASVTLVVQT
MAV_2195|M.avium_104 SG------RLATEAVSVMQDRLPFFADLEA--------SQRASVSLVVQT
TH_1338|M.thermoresistible__bu SG------RLATEAVHTMEERLPFFADLEA--------SQRASVHLVVQT
Mb1218c|M.bovis_AF2122/97 LAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGA
Rv1186c|M.tuberculosis_H37Rv LAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGA
MMAR_4254|M.marinum_M LAAAAGSADIFFLLGVTDHEALRWIDGQAG--TPVAIFVKQPSDAVVAKA
MUL_0931|M.ulcerans_Agy99 LAAAAGSADIFFLLGVTDHEALRWIDGQAG--TPVAIFVKQPSDAVVAKA
Mflv_0356|M.gilvum_PYR-GCK LQGGELVLTTGAAMARSPRTYLRGLAEAGA-----------VGVVVEVGA
. . . :
MSMEG_6688|M.smegmatis_MC2_155 TLQEVPAAVLAAGDELGLPVLEVPASTPFIAIARVVIDAVKADELSAVQR
Mvan_1854|M.vanbaalenii_PYR-1 TLTAVPAGVLAAGDEHGVPVLRVPASTPFIAIARVVIDAVKADQLESVQR
MAB_0825|M.abscessus_ATCC_1997 TFSEVPPGILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAVQR
MLBr_01652|M.leprae_Br4923 AVVNFVQWMQNPHSDVSYTAQAFELVP--QDLARRIALRHTVDMVRVTME
MAV_2195|M.avium_104 AVVNFAEWMQDPKSNVRHTAQAFELVP--QDLARRIALRHSVEMVRVTME
TH_1338|M.thermoresistible__bu AVVNFVEWMRDPRSNVTYTMQAFEVVP--QDLTRRIALRQTVEMVRTTME
Mb1218c|M.bovis_AF2122/97 VRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQS
Rv1186c|M.tuberculosis_H37Rv VRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQS
MMAR_4254|M.marinum_M VRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGLAQS
MUL_0931|M.ulcerans_Agy99 VRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGLAQS
Mflv_0356|M.gilvum_PYR-GCK VVPEVPPGVGGIAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEF
. . .: .
MSMEG_6688|M.smegmatis_MC2_155 MVDQQQVLARATLRG-------GIPAVVNALAECLSATVVVADIEGRILA
Mvan_1854|M.vanbaalenii_PYR-1 VVDQQEVLARATLRG-------GIPGVVGALAECLSAVVVAVSTDGRDLA
MAB_0825|M.abscessus_ATCC_1997 VVDQQDVLVRATLRD-------GAPGVVSALSRSLAATVIVTATDGTLLA
MLBr_01652|M.leprae_Br4923 FFEEVVPLLARSEEQ-------LTALTVGILKYSRDLAFTAATAYADAAE
MAV_2195|M.avium_104 FFEEVVPLLARSEEQ-------LTALTVGVLKYSRDLAFTAATAYADAAE
TH_1338|M.thermoresistible__bu FFEQVVPLLARSEEQ-------VTALTAGILRYSRDLAFAAATAYADAAE
Mb1218c|M.bovis_AF2122/97 LADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIG
Rv1186c|M.tuberculosis_H37Rv LADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIG
MMAR_4254|M.marinum_M LADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHLKWIG
MUL_0931|M.ulcerans_Agy99 LADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHLKWIG
Mflv_0356|M.gilvum_PYR-GCK DRRVHETFTDLSMKR------ASLSGIVDAAAKLLGEHVVLEDLSHQALV
: ..
MSMEG_6688|M.smegmatis_MC2_155 TRGAADQQLVEVLEASRRAGARAQAG-VVADADGYVTVQTLRAAQPVRGH
Mvan_1854|M.vanbaalenii_PYR-1 AGGTADPQLISALSEAVGQARNRGAA-VIPDGDALLTIQRLRAAQAVRGY
MAB_0825|M.abscessus_ATCC_1997 EAGHDAEHLAEITRGAFPNHSRKHASRVVADRDGYCTIQTVRAGKAERGY
MLBr_01652|M.leprae_Br4923 ARGTWDSRMEASVVDAVVRG---DTGPELLSRAAALNWDTTAPATVVVGT
MAV_2195|M.avium_104 ARGTWDSRMEASVVDAVVRG---DTGPELLSRAAALNWDTTAPATVVVGT
TH_1338|M.thermoresistible__bu ARGAWDTRMEANVVDAVVRG---AVGPELQSQAAALNWDATAPATVVVGL
Mb1218c|M.bovis_AF2122/97 QWGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAGTI
Rv1186c|M.tuberculosis_H37Rv QWGIFDALRPGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAGTI
MMAR_4254|M.marinum_M QWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVFAGSI
MUL_0931|M.ulcerans_Agy99 QWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVFAGSI
Mflv_0356|M.gilvum_PYR-GCK ASTGIPADLLTDWARRSRRSPGGGAGAEPWSATDVGPRFEQWGRLVVPYA
MSMEG_6688|M.smegmatis_MC2_155 LAVRTEQPMSNSQRLLVAHAVSLISIELEKPARVVDAEDR---LRSAVTR
Mvan_1854|M.vanbaalenii_PYR-1 LVVRSAGPLSDSGRLLVSHAVSLISIALEKPARVQDAEQR---LRSAVTR
MAB_0825|M.abscessus_ATCC_1997 LAVRSEDALTAAQRLLVSHAMALIAIELEKPARVADAEQR---LRGAVTR
MLBr_01652|M.leprae_Br4923 PTPNHDGPNGQVSSERASQEVREIAARHGR-AALTDVHGT---WLVAIIS
MAV_2195|M.avium_104 PAPGRDGSTGPGDSERASQHVRDIAAQHGR-AALTDVHGT---WLVAIVS
TH_1338|M.thermoresistible__bu PRPDR--------LEVVSQDVHHVANRHGR-TALSDVHGT---WLVTIVS
Mb1218c|M.bovis_AF2122/97 WVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGLAE
Rv1186c|M.tuberculosis_H37Rv WVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGLAE
MMAR_4254|M.marinum_M WVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLLGLAD
MUL_0931|M.ulcerans_Agy99 WVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLLGLAD
Mflv_0356|M.gilvum_PYR-GCK PADATRAATVLERAAAALAMHRMVEQNRTGLQHQAQSGLIDDVLRGRVVD
. :
MSMEG_6688|M.smegmatis_MC2_155 DILSGTGTTDSAVLRYLGFQPDD----------------EVVVLLLTGFT
Mvan_1854|M.vanbaalenii_PYR-1 ELLGGRGAVDDGLLRYFGFTPDG----------------DVVVSVLHGIG
MAB_0825|M.abscessus_ATCC_1997 ALLADPAAADRSVLRYFGFDPDT----------------EVVVVLLCNVG
MLBr_01652|M.leprae_Br4923 GQLAPTDKFFSDLLHAFSDGP----------------------VVIGPTA
MAV_2195|M.avium_104 GQLSPTDKFLGDLLEAFSDGP----------------------VVVGPTA
TH_1338|M.thermoresistible__bu GALSPTDRFLTDLLDVFADGP----------------------VVLGPTA
Mb1218c|M.bovis_AF2122/97 LNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD-TAVRHVRLVDVM
Rv1186c|M.tuberculosis_H37Rv LNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD-TAVRHVRLVDVM
MMAR_4254|M.marinum_M PDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD----KQSRLADVL
MUL_0931|M.ulcerans_Agy99 PDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD----KQSRLADVL
Mflv_0356|M.gilvum_PYR-GCK DRDAAARAQALGLRSNAQYLPVVVRVARPAEIDDPVAGHRRNVAVLDAVA
: . :
MSMEG_6688|M.smegmatis_MC2_155 PLLTAQDDLGQRLAPAGSYL---MTSTGDEFAIIVHAARRR-RVYAAVEE
Mvan_1854|M.vanbaalenii_PYR-1 PVLAAEEELSRPLADTGPYL---MAATGTEIVIVLPADGSR----ARIRT
MAB_0825|M.abscessus_ATCC_1997 SVLPGELHIDRQLARGGPYL---MASVSGEIVVVLAAKNVG-RASELHRS
MLBr_01652|M.leprae_Br4923 PMLTAAYHSASEAVSG-------MNAVAG---------------------
MAV_2195|M.avium_104 PMLTAAYHSASEAISG-------MNAVGG---------------------
TH_1338|M.thermoresistible__bu PTLSAAYRSATEAIAG-------MNAVAG---------------------
Mb1218c|M.bovis_AF2122/97 ALSASAFRHDAQVAANGSRI---YVLLPQTTTGRAVTSWVRGTISALRAE
Rv1186c|M.tuberculosis_H37Rv ALSASAFRHDAQVAANGSRI---YVLLPQTTTGRAVTSWVRGTISALRAE
MMAR_4254|M.marinum_M ALSASAFRRDAQVGTNGSRI---YVVLPQTATARSLTSWVRGTISALRSE
MUL_0931|M.ulcerans_Agy99 ALSASAFRRDAQVGTNGSRI---YVVLPQTATARSLTSWVRGTISALRSE
Mflv_0356|M.gilvum_PYR-GCK HTVNACGHTGLFSLRGDGEVGAVLSLKDSRTRSVDQALGALARRIHTEIR
.
MSMEG_6688|M.smegmatis_MC2_155 FGRVTGRTVRGGASQPVRLADAVVGAEQARIAAHSNSRRNITEFTEVKVF
Mvan_1854|M.vanbaalenii_PYR-1 LLRGRG-APGGGSSRVVPMADVGTGLEQARVAAHS-SVGEFTEYADLGPL
MAB_0825|M.abscessus_ATCC_1997 LGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIAEFDELDIY
MLBr_01652|M.leprae_Br4923 ---------WSGAPRPVQARELLP--------------------------
MAV_2195|M.avium_104 ---------WRGAPRPVLARELLP--------------------------
TH_1338|M.thermoresistible__bu ---------WSGAPRPVPARELLP--------------------------
Mb1218c|M.bovis_AF2122/97 LGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVTSLAEAR
Rv1186c|M.tuberculosis_H37Rv LGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVTSLAEAR
MMAR_4254|M.marinum_M LGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVTSLAEAR
MUL_0931|M.ulcerans_Agy99 LGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVTSLAEAR
Mflv_0356|M.gilvum_PYR-GCK RVDGSDRVVVTLGPSARNVTDAIAGLAEAIDTAEVALSLRGDVRDFYRTS
.
MSMEG_6688|M.smegmatis_MC2_155 GTLLG------GRSTAELRVLAQPIEPLLA--GGDE--LIDALTAFLRHN
Mvan_1854|M.vanbaalenii_PYR-1 AAVLD------GRTSRELRFLAAVLDPLAG--NDED--LIATLAAFLRHN
MAB_0825|M.abscessus_ATCC_1997 GVLLG------GRDRGELAVLAQSVAPLLG--TGADTTLLDTLESFLACN
MLBr_01652|M.leprae_Br4923 ERALM------GDASAIVALHTDVMLPLAD--AGPT--LIETLDAYLDCG
MAV_2195|M.avium_104 ERALM------GDASAIVALHTDVMGPLAD--AGPT--LIETLDAFLDSG
TH_1338|M.thermoresistible__bu ERALL------GDQTAIAALESEVMRPLAD--AGPT--LTETLDAFLESG
Mb1218c|M.bovis_AF2122/97 TTVLL------DEIVTLVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDAF
Rv1186c|M.tuberculosis_H37Rv TTVLL------DEIVTLVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDAF
MMAR_4254|M.marinum_M TTVLL------DEIVTLVGNDARLIDPRIPDLRAKDPVLADTLRVYLDSF
MUL_0931|M.ulcerans_Agy99 TTVLL------DEIVTLVGNDARLIDPRIPDLRAKDPVLADTLRVYLDSF
Mflv_0356|M.gilvum_PYR-GCK DIRLRGLISLLRDDPRIRRFAETELRALLAHDAGAEPSNISVLREYLRLA
* : . .* :*
MSMEG_6688|M.smegmatis_MC2_155 GQLEAAASELQIHRHTMRNRMRRISDLLADDLGTADTRAQLWLAIRAWQL
Mvan_1854|M.vanbaalenii_PYR-1 GQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQLWLALRAFQL
MAB_0825|M.abscessus_ATCC_1997 GQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAALWIAIRARAL
MLBr_01652|M.leprae_Br4923 GAIEACARKLFVHPNTVRYRLKRITDFTGHDPTLPRDAYVLRVAATVGKL
MAV_2195|M.avium_104 GAIEACARKLFVHPNTVRYRLKRITDFTGRDPMQPRDAYVLRVAATVGQL
TH_1338|M.thermoresistible__bu GAIEACARRLFVHPNTVRYRLRRIAEITGRDPAVPRDAYVLRVAVSVSRL
Mb1218c|M.bovis_AF2122/97 GDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRAMER
Rv1186c|M.tuberculosis_H37Rv GDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRAMER
MMAR_4254|M.marinum_M GDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGLRATDR
MUL_0931|M.ulcerans_Agy99 GDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGLRATDH
Mflv_0356|M.gilvum_PYR-GCK GNKSALAERLHMSRPALYKRLRGIEDALGVDLDDGESMTSLHVAVMVLDS
* * * : :: *: : . : :. .
MSMEG_6688|M.smegmatis_MC2_155 LVSRERPGLS---------------------
Mvan_1854|M.vanbaalenii_PYR-1 LENRRAPAGRCDS------------------
MAB_0825|M.abscessus_ATCC_1997 LG-----------------------------
MLBr_01652|M.leprae_Br4923 NYPTHH-------------------------
MAV_2195|M.avium_104 NYPTHPPSAAGAAMPAVPLPVNGAARGQSGG
TH_1338|M.thermoresistible__bu TRQSYQSSTVNPDLGSTAGWRGQAAGGHRAM
Mb1218c|M.bovis_AF2122/97 TA-----------------------------
Rv1186c|M.tuberculosis_H37Rv TA-----------------------------
MMAR_4254|M.marinum_M SS-----------------------------
MUL_0931|M.ulcerans_Agy99 SS-----------------------------
Mflv_0356|M.gilvum_PYR-GCK LTGSG--------------------------