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MAEYRLTVPITVRDLTQRADLGLVLSAGEAGAARAIKWAHAIELNDPTPYLFGGELVMTTGLTVGLSHAE QYEYAARLSGKNVAALAFDTGTTFSEVPPGILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAV QRVVDQQDVLVRATLRDGAPGVVSALSRSLAATVIVTATDGTLLAEAGHDAEHLAEITRGAFPNHSRKHA SRVVADRDGYCTIQTVRAGKAERGYLAVRSEDALTAAQRLLVSHAMALIAIELEKPARVADAEQRLRGAV TRALLADPAAADRSVLRYFGFDPDTEVVVVLLCNVGSVLPGELHIDRQLARGGPYLMASVSGEIVVVLAA KNVGRASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIAEFDELDIYGVLLGGRD RGELAVLAQSVAPLLGTGADTTLLDTLESFLACNGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSAD TRAALWIAIRARALLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0825 | - | - | 100% (506) | peptidase |
| M. abscessus ATCC 19977 | MAB_4202c | - | 3e-58 | 32.94% (510) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_4347 | - | 7e-14 | 21.43% (532) | putative regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 1e-07 | 26.20% (229) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0801 | - | 2e-14 | 34.56% (136) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv1186c | - | 1e-07 | 26.20% (229) | hypothetical protein Rv1186c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4254 | - | 6e-06 | 30.86% (162) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 9e-07 | 23.24% (512) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 1e-135 | 53.43% (496) | regulatory protein |
| M. thermoresistible (build 8) | TH_2137 | - | 4e-09 | 25.54% (325) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 4e-06 | 30.86% (162) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 1e-123 | 52.81% (498) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4254|M.marinum_M ----MGVAGVGLGQLLLALDATLVS-LVEAPRGLDLPVASAALVDSDDVR
MUL_0931|M.ulcerans_Agy99 ----MGVAGVGLGQLLLALDATLVS-LVEAPRGLDLPVASAALVDSDDVR
Mb1218c|M.bovis_AF2122/97 ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
Rv1186c|M.tuberculosis_H37Rv ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
MAV_1987|M.avium_104 --------MITLDRLVNVLGGYGVR-LRWSSVPRSTELRSVVIHETPEDR
TH_2137|M.thermoresistible__bu --------VVTLDRLVNVLGSYGVR-LQFCPVPRSTEVRSVALHENAGGL
MSMEG_6688|M.smegmatis_MC2_155 ---------MITARGLAQVESLGLS-LLAGAQGADREIAWAHANELRDPT
Mvan_1854|M.vanbaalenii_PYR-1 ---------MITARSLCQDENLGLT-LVAGAQAADRPIAWAHAIELADPT
MAB_0825|M.abscessus_ATCC_1997 -MAEYRLTVPITVRDLTQRADLGLV-LSAGEAGAARAIKWAHAIELNDPT
Mflv_0801|M.gilvum_PYR-GCK MSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRDPS
: : : : . :
MMAR_4254|M.marinum_M LGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSDAVV
MUL_0931|M.ulcerans_Agy99 LGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSDAVV
Mb1218c|M.bovis_AF2122/97 LGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVV
Rv1186c|M.tuberculosis_H37Rv LGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSDSVV
MAV_1987|M.avium_104 P------VVGDVLLAVGAGSLDEAVRWAASARA----AVVVLRDDETPMT
TH_2137|M.thermoresistible__bu R------VTGDVLLAVGAESVAEAVRWAETAQA----VVVLTRAG-PDAS
MSMEG_6688|M.smegmatis_MC2_155 PYLAGGELVMTTGINIGAGAGEQRDYVARLSAAGIAALAVDTGTTLQEVP
Mvan_1854|M.vanbaalenii_PYR-1 PYLAGGELVMTTGINIGADAAAQADYVARLAAAGTAALAVDTGTTLTAVP
MAB_0825|M.abscessus_ATCC_1997 PYLFGGELVMTTGLTVGLSHAEQYEYAARLSGKNVAALAFDTGTTFSEVP
Mflv_0801|M.gilvum_PYR-GCK RYLRGGELVCTVGISLHSA-EDCSTFVDALAGAGAAGVCFGVGDGHDDVP
: : .
MMAR_4254|M.marinum_M AKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGL
MUL_0931|M.ulcerans_Agy99 AKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDLFGL
Mb1218c|M.bovis_AF2122/97 AGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGL
Rv1186c|M.tuberculosis_H37Rv AGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGL
MAV_1987|M.avium_104 FDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETE--SGRGPTDLFAL
TH_2137|M.thermoresistible__bu RSCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDLFAL
MSMEG_6688|M.smegmatis_MC2_155 AAVLAAGDELGLPVLEVPASTPFIAIARVVIDAVKADELSAVQRMVDQQQ
Mvan_1854|M.vanbaalenii_PYR-1 AGVLAAGDEHGVPVLRVPASTPFIAIARVVIDAVKADQLESVQRVVDQQE
MAB_0825|M.abscessus_ATCC_1997 PGILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAVQRVVDQQD
Mflv_0801|M.gilvum_PYR-GCK AALLDACRRAGLPVLVAPPSVPFSVISRFVAESRLGTEIAVARATNALVP
. . : : .
MMAR_4254|M.marinum_M AQSLADRIHGMVS-IEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHL
MUL_0931|M.ulcerans_Agy99 AQSLADRIHGMVS-IEDAQSHVLAYSASSDEADELRRLSILGRAGPPEHL
Mb1218c|M.bovis_AF2122/97 AQSLADRIHGMIS-IEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHL
Rv1186c|M.tuberculosis_H37Rv AQSLADRIHGMIS-IEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHL
MAV_1987|M.avium_104 ADSLADGIGNPVV-IQDRHLGVLAYS-RLAQADPALVETVLQRQTPEPLR
TH_2137|M.thermoresistible__bu ADNLADAVGGPVT-IEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLR
MSMEG_6688|M.smegmatis_MC2_155 VLARATLRGGIPA-VVNALAECLSATVVVADIEGR----ILATRGAADQQ
Mvan_1854|M.vanbaalenii_PYR-1 VLARATLRGGIPG-VVGALAECLSAVVVAVSTDGR----DLAAGGTADPQ
MAB_0825|M.abscessus_ATCC_1997 VLVRATLRDGAPG-VVSALSRSLAATVIVTATDGT----LLAEAGHDAEH
Mflv_0801|M.gilvum_PYR-GCK ELLLSLRRHDSPRRLLDAAGQVLGCYFLLEP-------------------
: . : . *.
MMAR_4254|M.marinum_M KWIGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVF
MUL_0931|M.ulcerans_Agy99 KWIGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPPVF
Mb1218c|M.bovis_AF2122/97 QWIGQWGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVF
Rv1186c|M.tuberculosis_H37Rv QWIGQWGIFDALRPGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVF
MAV_1987|M.avium_104 ALLEARGVFAHLQVADEPLFVAEDAERGLSGRMVVAVRAG-------AEL
TH_2137|M.thermoresistible__bu RLFEQLGVSEHLAAGDDPLFIAARPGHDLTGRTVIAVRAG-------REL
MSMEG_6688|M.smegmatis_MC2_155 LVEVLEASRRAGARAQAG-VVADADGYVTVQTLRAAQPVR----------
Mvan_1854|M.vanbaalenii_PYR-1 LISALSEAVGQARNRGAA-VIPDGDALLTIQRLRAAQAVR----------
MAB_0825|M.abscessus_ATCC_1997 LAEITRGAFPNHSRKHASRVVADRDGYCTIQTVRAGKAER----------
Mflv_0801|M.gilvum_PYR-GCK ---------EGAAKGDEAAVTVPVPGLGALVWMGRGDRPE----------
.
MMAR_4254|M.marinum_M AGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLL
MUL_0931|M.ulcerans_Agy99 AGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHARRVQQLL
Mb1218c|M.bovis_AF2122/97 AGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLL
Rv1186c|M.tuberculosis_H37Rv AGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLL
MAV_1987|M.avium_104 IGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLERQVESELVI
TH_2137|M.thermoresistible__bu LGSVWVVTPEPLDDGRRRALADGARTVALHLLRSRASADLERQVESDLVL
MSMEG_6688|M.smegmatis_MC2_155 -GHLAVRTEQPMSNSQRLLVAHAVSLISIELEKPARVVDAEDRLRSAVTR
Mvan_1854|M.vanbaalenii_PYR-1 -GYLVVRSAGPLSDSGRLLVSHAVSLISIALEKPARVQDAEQRLRSAVTR
MAB_0825|M.abscessus_ATCC_1997 -GYLAVRSEDALTAAQRLLVSHAMALIAIELEKPARVADAEQRLRGAVTR
Mflv_0801|M.gilvum_PYR-GCK -----------------PALLDLIARFVRAAQGERDIEAALTRERVGQLL
: . .
MMAR_4254|M.marinum_M GLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQSRLA
MUL_0931|M.ulcerans_Agy99 GLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQSRLA
Mb1218c|M.bovis_AF2122/97 GLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHVRLV
Rv1186c|M.tuberculosis_H37Rv GLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHVRLV
MAV_1987|M.avium_104 RLLEGTADAATVASRLDLAHNGLRVVAVQAFVGADRD-------APLLLA
TH_2137|M.thermoresistible__bu RLLEGTSDAAGAAARLGLPQEALRIIAVRARSGVDRQ-------GPLLLA
MSMEG_6688|M.smegmatis_MC2_155 DILSGTGTTDSAVLRYLGFQPDDEVVVLLLTG-----------FTPLLTA
Mvan_1854|M.vanbaalenii_PYR-1 ELLGGRGAVDDGLLRYFGFTPDGDVVVSVLHG-----------IGPVLAA
MAB_0825|M.abscessus_ATCC_1997 ALLADPAAADRSVLRYFGFDPDTEVVVVLLCN-----------VGSVLPG
Mflv_0801|M.gilvum_PYR-GCK SLVERRMLLPDALSQLVQWPGFAGEIACSAWP------------------
:
MMAR_4254|M.marinum_M DVLALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTISALRSE
MUL_0931|M.ulcerans_Agy99 DVLALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTISALRSE
Mb1218c|M.bovis_AF2122/97 DVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAE
Rv1186c|M.tuberculosis_H37Rv DVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAE
MAV_1987|M.avium_104 FERATTGFGWSRPGRSALAGNSVYAVLPADEASTARR-WVGALRAALPER
TH_2137|M.thermoresistible__bu FEHATTGFGWSRAGRSALAGDTVYTVLPADHAATARR-WVEGLQAALPSE
MSMEG_6688|M.smegmatis_MC2_155 QDDLGQRLAPAGSYLMTSTGDEFAIIVHAA---------RRRRVYAAVEE
Mvan_1854|M.vanbaalenii_PYR-1 EEELSRPLADTGPYLMAATGTEIVIVLPAD---------GSR---ARIRT
MAB_0825|M.abscessus_ATCC_1997 ELHIDRQLARGGPYLMASVSGEIVVVLAAK---------NVGRASELHRS
Mflv_0801|M.gilvum_PYR-GCK -AGAGALLSISFPGALIGDAPDLCMMLTAG-------------------A
. . . ::
MMAR_4254|M.marinum_M LGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVT------
MUL_0931|M.ulcerans_Agy99 LGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRVT------
Mb1218c|M.bovis_AF2122/97 LGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVT------
Rv1186c|M.tuberculosis_H37Rv LGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQVT------
MAV_1987|M.avium_104 L--TMIAGISG-VAEVGDLAAARQEADECLALHEMSPAAPPP--------
TH_2137|M.thermoresistible__bu V--TVSAGISG-IADHTELPDARREADECLALHDALHDARPDTGSPDSDS
MSMEG_6688|M.smegmatis_MC2_155 FGRVTGRTVRGGASQPVRLADAVVGAEQARIAAHSNSRRNITEF------
Mvan_1854|M.vanbaalenii_PYR-1 LLRGRG-APGGGSSRVVPMADVGTGLEQARVAAHS-SVGEFTEY------
MAB_0825|M.abscessus_ATCC_1997 LGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIAEF------
Mflv_0801|M.gilvum_PYR-GCK VEMPDDLALPTGHSAPVTLADLGSAIAQARIALTLAEHRGGRVGP-----
. : : .
MMAR_4254|M.marinum_M ------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKDP----VLA
MUL_0931|M.ulcerans_Agy99 ------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKDP----VLA
Mb1218c|M.bovis_AF2122/97 ------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQDP----VLA
Rv1186c|M.tuberculosis_H37Rv ------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQDP----VLA
MAV_1987|M.avium_104 ------AYDESWDDILLQRLRAAARSGRAPTRGPVADLGRHDRANGTDYL
TH_2137|M.thermoresistible__bu DALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAALHEHDLRHATQYV
MSMEG_6688|M.smegmatis_MC2_155 ------TEVKVFGTLLGGRSTAELRVLAQPIEPLLAGGDE--------LI
Mvan_1854|M.vanbaalenii_PYR-1 ------ADLGPLAAVLDGRTSRELRFLAAVLDPLAGNDED--------LI
MAB_0825|M.abscessus_ATCC_1997 ------DELDIYGVLLGGRDRGELAVLAQSVAPLLGTGADT------TLL
Mflv_0801|M.gilvum_PYR-GCK ------DQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSRG---TQHV
:*
MMAR_4254|M.marinum_M DTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLV
MUL_0931|M.ulcerans_Agy99 DTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLV
Mb1218c|M.bovis_AF2122/97 QTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLL
Rv1186c|M.tuberculosis_H37Rv QTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLL
MAV_1987|M.avium_104 ATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLDDSKKRLA
TH_2137|M.thermoresistible__bu ATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQLDLQDPDKRLA
MSMEG_6688|M.smegmatis_MC2_155 DALTAFLRHNGQLEAAASELQIHRHTMRNRMRRISDLLADDLGTADTRAQ
Mvan_1854|M.vanbaalenii_PYR-1 ATLAAFLRHNGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQ
MAB_0825|M.abscessus_ATCC_1997 DTLESFLACNGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAA
Mflv_0801|M.gilvum_PYR-GCK RTLRTFVACNGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQHNDLTT
:* :: *. :. * :* :*:* *: :: : . .
MMAR_4254|M.marinum_M FSLGLRATDRSS-----------
MUL_0931|M.ulcerans_Agy99 FSLGLRATDHSS-----------
Mb1218c|M.bovis_AF2122/97 FSLGLRAMERTA-----------
Rv1186c|M.tuberculosis_H37Rv FSLGLRAMERTA-----------
MAV_1987|M.avium_104 MMIELAAIHTD------------
TH_2137|M.thermoresistible__bu MMIELAAIEGPPILSG-------
MSMEG_6688|M.smegmatis_MC2_155 LWLAIRAWQLLVSRERPGLS---
Mvan_1854|M.vanbaalenii_PYR-1 LWLALRAFQLLENRRAPAGRCDS
MAB_0825|M.abscessus_ATCC_1997 LWIAIRARALLG-----------
Mflv_0801|M.gilvum_PYR-GCK FVIGMWAADRGE-----------
: : : *