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VSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRDPSRYLRGGELVCTVGISLHSAE DCSTFVDALAGAGAAGVCFGVGDGHDDVPAALLDACRRAGLPVLVAPPSVPFSVISRFVAESRLGTEIAV ARATNALVPELLLSLRRHDSPRRLLDAAGQVLGCYFLLEPEGAAKGDEAAVTVPVPGLGALVWMGRGDRP EPALLDLIARFVRAAQGERDIEAALTRERVGQLLSLVERRMLLPDALSQLVQWPGFAGEIACSAWPAGAG ALLSISFPGALIGDAPDLCMMLTAGAVEMPDDLALPTGHSAPVTLADLGSAIAQARIALTLAEHRGGRVG PDQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSRGTQHVRTLRTFVACNGSLSETAKELFLHTNTVR HRLGRIQEITGRDPLQHNDLTTFVIGMWAADRGE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0801 | - | - | 100% (454) | transcriptional regulator, CdaR |
| M. gilvum PYR-GCK | Mflv_0356 | - | 6e-10 | 27.22% (169) | purine catabolism PurC domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1946 | - | 1e-08 | 33.33% (126) | putative DNA-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 2e-09 | 30.41% (148) | hypothetical protein Mb2266 |
| M. tuberculosis H37Rv | Rv2242 | - | 2e-09 | 30.41% (148) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 8e-08 | 30.33% (122) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 1e-14 | 34.56% (136) | peptidase |
| M. marinum M | MMAR_3335 | - | 6e-09 | 34.04% (94) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_4933 | - | 1e-09 | 33.07% (127) | hypothetical protein MAV_4933 |
| M. smegmatis MC2 155 | MSMEG_1068 | - | 1e-162 | 64.35% (460) | regulatory protein |
| M. thermoresistible (build 8) | TH_1338 | - | 5e-08 | 40.00% (85) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 1e-08 | 28.57% (147) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_0042 | - | 0.0 | 83.74% (455) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3335|M.marinum_M MNDNQFSAIARLGSARSPLELLETVPDSLLRRLKQYSGR-LATEAVSAMQ
MUL_1307|M.ulcerans_Agy99 MNNNQFSAIARLGSARSPLELLETVPDSLLRRLKQYSGR-LATEAVSAMQ
MLBr_01652|M.leprae_Br4923 MNHNHFVPAP---PRRLPLELLDTVPDSLLRRLKQYSGR-LATEAVTAMQ
Mb2266|M.bovis_AF2122/97 MNDNQLAPVAR---PRSPLELLDTVPDSLLRRLKQYSGR-LATEAVSAMQ
Rv2242|M.tuberculosis_H37Rv MNDNQLAPVAR---PRSPLELLDTVPDSLLRRLKQYSGR-LATEAVSAMQ
TH_1338|M.thermoresistible__bu VPDNRFVPPQ------STLEVLESVPESVLRRLKQYSGR-LATEAVHTME
Mflv_0801|M.gilvum_PYR-GCK MSEDRAESAAPTLRDLLEAAQ---LSLSGPDPADRNLDREVSWVHTTEMR
Mvan_0042|M.vanbaalenii_PYR-1 MSEVHAEPAAPTLRDLATAG----LGLSVPDGTAQELDRPVSWVHTTEMR
MSMEG_1068|M.smegmatis_MC2_155 MPD--RDDVAPTLRDLLNSHLGVVAAQNLTDDLSAELDRTITWAHTTELR
MAB_0825|M.abscessus_ATCC_1997 MAEYRLTVPITVRDLTQRADLGLVLSAG-----EAGAARAIKWAHAIELN
MAV_4933|M.avium_104 MKDFRAPVNG-----VDGDSASALVAVPKSQGAQTIRPDSVSRLVGALLD
: . : :
MMAR_3335|M.marinum_M ERLPFFADLEASQRASVAL-VVQTAVVNFAEWMQNPRSD--VSYTAQAFE
MUL_1307|M.ulcerans_Agy99 ERLPFFADLEASQRASVAL-VVQTAVVNFAEWMQNPRSD--VSYTAQAFE
MLBr_01652|M.leprae_Br4923 ERLPFFADLEASQRASVTL-VVQTAVVNFVQWMQNPHSD--VSYTAQAFE
Mb2266|M.bovis_AF2122/97 ERLPFFADLEASQRASVAL-VVQTAVVNFVEWMHDPHSD--VGYTAQAFE
Rv2242|M.tuberculosis_H37Rv ERLPFFADLEASQRASVAL-VVQTAVVNFVEWMHDPHSD--VGYTAQAFE
TH_1338|M.thermoresistible__bu ERLPFFADLEASQRASVHL-VVQTAVVNFVEWMRDPRSN--VTYTMQAFE
Mflv_0801|M.gilvum_PYR-GCK DPSRYLRGGELVCTVGISL-HSAEDCSTFVDALAGAGAAGVCFGVGDGHD
Mvan_0042|M.vanbaalenii_PYR-1 DPSRYLRGGELVCTVGISL-HTDQDCATFVDALSRARAAGVCFGVGDEHD
MSMEG_1068|M.smegmatis_MC2_155 DPSRYLRGGELVCTVGISL-QTPDDCEAFVAALCESGAAGLCFGTGDAHD
MAB_0825|M.abscessus_ATCC_1997 DPTPYLFGGELVMTTGLTVGLSHAEQYEYAARLSGKNVAALAFDTGTTFS
MAV_4933|M.avium_104 DHAAVVGRVRSVIRSRLPVYRSVADEALEAELEWVLRSAVGGREALHEPQ
: . . : : . . .
MMAR_3335|M.marinum_M LVPQDLTRRIALR--------------------------HTVDMVRVTME
MUL_1307|M.ulcerans_Agy99 LVPQDLTRRIALR--------------------------HTVDMVRVTME
MLBr_01652|M.leprae_Br4923 LVPQDLARRIALR--------------------------HTVDMVRVTME
Mb2266|M.bovis_AF2122/97 LVPQDLTRRIALR--------------------------QTVDMVRVTME
Rv2242|M.tuberculosis_H37Rv LVPQDLTRRIALR--------------------------QTVDMVRVTME
TH_1338|M.thermoresistible__bu VVPQDLTRRIALR--------------------------QTVEMVRTTME
Mflv_0801|M.gilvum_PYR-GCK DVPAALLDACRRAGLPVLVAPPSVPFSVISRFVAESRLGTEIAVARATNA
Mvan_0042|M.vanbaalenii_PYR-1 AVPEALLAQCRLHGLPLLVAPPSVPFSVVSRFVAEYWLGSEIAVARATNA
MSMEG_1068|M.smegmatis_MC2_155 AVPDALVAACTRRRLPLLIAPPNVLFATVSRYVADFQVGGELAVARATNT
MAB_0825|M.abscessus_ATCC_1997 EVPPGILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAVQRVVD
MAV_4933|M.avium_104 IAGLAAIGEARAR------------------------DGVPVDDMLRAWR
. : .
MMAR_3335|M.marinum_M FFEEVVPLLARSEEQ--------------------LTALTVGILKYSRDL
MUL_1307|M.ulcerans_Agy99 FFEEVVPLLARSEEQ--------------------LTALTVGILKYSRDL
MLBr_01652|M.leprae_Br4923 FFEEVVPLLARSEEQ--------------------LTALTVGILKYSRDL
Mb2266|M.bovis_AF2122/97 FFEEVVPLLARSEEQ--------------------LTALTVGILKYSRDL
Rv2242|M.tuberculosis_H37Rv FFEEVVPLLARSEEQ--------------------LTALTVGILKYSRDL
TH_1338|M.thermoresistible__bu FFEQVVPLLARSEEQ--------------------VTALTAGILRYSRDL
Mflv_0801|M.gilvum_PYR-GCK LVPELLLSLRRHDSP--------------------RRLLDAAGQVLGCYF
Mvan_0042|M.vanbaalenii_PYR-1 LVPELLSSLRRHDSP--------------------RQLLDSAGQLLGCYF
MSMEG_1068|M.smegmatis_MC2_155 LVPELLASARRRESP--------------------RQLLDRAGEVLGCYF
MAB_0825|M.abscessus_ATCC_1997 QQDVLVRATLRDGAPGVVSALSRSLAATVIVTATDGTLLAEAGHDAEHLA
MAV_4933|M.avium_104 IGVEVVVECAREAAR------------------------RLGVDDARVLE
:: * .
MMAR_3335|M.marinum_M AFTAASAYADAAEARGTWDSRMEASVVDAVVRG----------DTGPELL
MUL_1307|M.ulcerans_Agy99 AFTAASAYADAAEARGTWDSRMEASVVDAVVRG----------DTGPELL
MLBr_01652|M.leprae_Br4923 AFTAATAYADAAEARGTWDSRMEASVVDAVVRG----------DTGPELL
Mb2266|M.bovis_AF2122/97 AFTAATAYADAAEARGTWDSRMEASVVDAVVRG----------DTGPELL
Rv2242|M.tuberculosis_H37Rv AFTAATAYADAAEARGTWDSRMEASVVDAVVRG----------DTGPELL
TH_1338|M.thermoresistible__bu AFAAATAYADAAEARGAWDTRMEANVVDAVVRG----------AVGPELQ
Mflv_0801|M.gilvum_PYR-GCK LLEPEGAAK-GDEAAVTVPVPGLGALVWMGRGD----------RPEPALL
Mvan_0042|M.vanbaalenii_PYR-1 LLEPEGGAD-SDDDAVTVPVPGLGTLVWVGRGD----------HPEPALL
MSMEG_1068|M.smegmatis_MC2_155 LLEPGAPADTGGPAAHTVTIDGLGTLVWVGSGT----------PPDDAVL
MAB_0825|M.abscessus_ATCC_1997 EITRGAFPNHSRKHASRVVADRDGYCTIQTVRAGKAERGYLAVRSEDALT
MAV_4933|M.avium_104 LVQSALAWSDIAMATSAKAHRRTERALALEAEE------------SDAEF
.
MMAR_3335|M.marinum_M SRAAALNWDTTAPATVVVGTPA--SARDGSDG---SERAIQDVR------
MUL_1307|M.ulcerans_Agy99 SRAAALNWDTTAPATVVVGTPA--SARDGSDG---SERAIQDVR------
MLBr_01652|M.leprae_Br4923 SRAAALNWDTTAPATVVVGTPT--PNHDGPNGQVSSERASQEVR------
Mb2266|M.bovis_AF2122/97 SRAAALNWDTTAPATVLVGTPA--PGPNGSNSDGDSERASQDVR------
Rv2242|M.tuberculosis_H37Rv SRAAALNWDTTAPATVLVGTPA--PGPNGSNSDGDSERASQDVR------
TH_1338|M.thermoresistible__bu SQAAALNWDATAPATVVVGLPR--PDR--------LEVVSQDVH------
Mflv_0801|M.gilvum_PYR-GCK DLIARFVRAAQGERDIEAALTR--ERVGQLLSLVERRMLLPDALSQLVQW
Mvan_0042|M.vanbaalenii_PYR-1 DLIARFVRAAQGERDIEAALAR--ERVGQLLSLVERRMLLPDALSQLLEW
MSMEG_1068|M.smegmatis_MC2_155 DVIVRFVHAAQGERDIEAALAR--ERVGQLLSLVERRMLLPDALNQLLDW
MAB_0825|M.abscessus_ATCC_1997 AAQRLLVSHAMALIAIELEKPARVADAEQRLRGAVTRALLADPAAADRSV
MAV_4933|M.avium_104 VRGALMGSLPAAELRMHAELRG--LDPGAEYVAVRARLGGDGP-------
: . . : .
MMAR_3335|M.marinum_M --------------DAAAQHGRAALTDVHG--------TWLVAIVSGHLS
MUL_1307|M.ulcerans_Agy99 --------------DAAAQHGRAALTDVHG--------TWLVAIVSGHLS
MLBr_01652|M.leprae_Br4923 --------------EIAARHGRAALTDVHG--------TWLVAIISGQLA
Mb2266|M.bovis_AF2122/97 --------------DTAARHGRAALTDVHG--------TWLVAIVSGQLS
Rv2242|M.tuberculosis_H37Rv --------------DTAARHGRAALTDVHG--------TWLVAIVSGQLS
TH_1338|M.thermoresistible__bu --------------HVANRHGRTALSDVHG--------TWLVTIVSGALS
Mflv_0801|M.gilvum_PYR-GCK PGF---------AGEIACSAWPAGAGALLS--------ISFPGALIGDAP
Mvan_0042|M.vanbaalenii_PYR-1 PGFS--------AGEIACSAWPAGAGALVS--------MAFPDALIGDAP
MSMEG_1068|M.smegmatis_MC2_155 PGLA--------AREVACSAWPAGAGALLS--------MAFPTALVGDAP
MAB_0825|M.abscessus_ATCC_1997 LRYFGFDPDTEVVVVLLCNVGSVLPGELHIDRQLARGGPYLMASVSGEIV
MAV_4933|M.avium_104 --------------HLRLEQSLGFQDPAHSR-------RGLCALLDGDLA
: : *
MMAR_3335|M.marinum_M PTDKVFKDLLEAFSDGP--------VVIGPTAPMLTAAYHSASEAISGMN
MUL_1307|M.ulcerans_Agy99 PTDKVFKDLLEAFSDGP--------VVIGPTAPMLTAAYHSASEAISGMN
MLBr_01652|M.leprae_Br4923 PTDKFFSDLLHAFSDGP--------VVIGPTAPMLTAAYHSASEAVSGMN
Mb2266|M.bovis_AF2122/97 PTEKFLKDLLAAFADAP--------VVIGPTAPMLTAAHRSASEAISGMN
Rv2242|M.tuberculosis_H37Rv PTEKFLKDLLAAFADAP--------VVIGPTAPMLTAAHRSASEAISGMN
TH_1338|M.thermoresistible__bu PTDRFLTDLLDVFADGP--------VVLGPTAPTLSAAYRSATEAIAGMN
Mflv_0801|M.gilvum_PYR-GCK DLCMMLTAGAVEMPDDL-------ALPTGHSAPVTLADLGSAIAQARIAL
Mvan_0042|M.vanbaalenii_PYR-1 DLCLMLTVGALEVTDDL-------ALPTGHSAPVPLTDIGSAIAQARIAL
MSMEG_1068|M.smegmatis_MC2_155 EVCLVLTDPATSATADLPAIAAELSLPSGHSATAPLAELGSAITQARIAL
MAB_0825|M.abscessus_ATCC_1997 VVLAAKNVGRASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQAR-SV
MAV_4933|M.avium_104 GFLIEPPRDVEG--------------VVGFGPPRPLTRLSESYRMAARAL
* .
MMAR_3335|M.marinum_M AVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-AGP
MUL_1307|M.ulcerans_Agy99 AVAGWRG---ASRPVLARELLPERALMGDASAIVALHTDVMRPLAD-AGP
MLBr_01652|M.leprae_Br4923 AVAGWSG---APRPVQARELLPERALMGDASAIVALHTDVMLPLAD-AGP
Mb2266|M.bovis_AF2122/97 AVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-AGP
Rv2242|M.tuberculosis_H37Rv AVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-AGP
TH_1338|M.thermoresistible__bu AVAGWSG---APRPVPARELLPERALLGDQTAIAALESEVMRPLAD-AGP
Mflv_0801|M.gilvum_PYR-GCK TLAEHRGGRVGPDQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSRGT
Mvan_0042|M.vanbaalenii_PYR-1 TLAEHRGGRVGPDQLSTLESLLEQLPLAQLAPFKQLLIAPLAELDSQRGT
MSMEG_1068|M.smegmatis_MC2_155 DLARQHGGSIGPDQLSTFDSLLEGLPLSRLTPFKQQLIDPLAESDHERGT
MAB_0825|M.abscessus_ATCC_1997 ARAHPDGRIAEFDELDIYGVLLGGRDRGELAVLAQSVAPLLGTGAD---T
MAV_4933|M.avium_104 VTAEACGLRGAYDIAALGLRTAVAIDADVGELLRKRYLEPLSVGGS--SR
* * : :
MMAR_3335|M.marinum_M TLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGRDPTQPRD
MUL_1307|M.ulcerans_Agy99 TLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGRDPTQPRD
MLBr_01652|M.leprae_Br4923 TLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGHDPTLPRD
Mb2266|M.bovis_AF2122/97 TLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRD
Rv2242|M.tuberculosis_H37Rv TLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRD
TH_1338|M.thermoresistible__bu TLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRRIAEITGRDPAVPRD
Mflv_0801|M.gilvum_PYR-GCK QHVRTLRTFVACNGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQHND
Mvan_0042|M.vanbaalenii_PYR-1 QHVRTLRVFLACNGSLSETAKELFLHTNTVRHRLSRIQEITGRDPLQHND
MSMEG_1068|M.smegmatis_MC2_155 QHVRTLRVFLATNGSLIDTARELFLHTNTVRHRLARIHEITGRNPLHFED
MAB_0825|M.abscessus_ATCC_1997 TLLDTLESFLACNGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADT
MAV_4933|M.avium_104 ELIATVRTYLACGMHVERTATRLFVHQNTVRYRLARFEELTGASLRDTEV
*: :: . : * .* :* :*:* *: *: : . .
MMAR_3335|M.marinum_M AYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRRGTEGP---
MUL_1307|M.ulcerans_Agy99 AYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRRGTEGP---
MLBr_01652|M.leprae_Br4923 AYVLRVAATVGKLNYPTHH-------------------------
Mb2266|M.bovis_AF2122/97 AYVLRVAATVGQLNYPTPH-------------------------
Rv2242|M.tuberculosis_H37Rv AYVLRVAATVGQLNYPTPH-------------------------
TH_1338|M.thermoresistible__bu AYVLRVAVSVSRLTRQSYQSSTVNPDLGSTAGWRGQAAGGHRAM
Mflv_0801|M.gilvum_PYR-GCK LTTFVIGMWAADRGE-----------------------------
Mvan_0042|M.vanbaalenii_PYR-1 LTAFVIGLWAADRAERPAGL------------------------
MSMEG_1068|M.smegmatis_MC2_155 QAAFAIGLRASDRHSRMTRRPN----------------------
MAB_0825|M.abscessus_ATCC_1997 RAALWIAIRARALLG-----------------------------
MAV_4933|M.avium_104 VTEVWWVLELAAMRL-----------------------------
.