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VITARSLCQDENLGLTLVAGAQAADRPIAWAHAIELADPTPYLAGGELVMTTGINIGADAAAQADYVARL AAAGTAALAVDTGTTLTAVPAGVLAAGDEHGVPVLRVPASTPFIAIARVVIDAVKADQLESVQRVVDQQE VLARATLRGGIPGVVGALAECLSAVVVAVSTDGRDLAAGGTADPQLISALSEAVGQARNRGAAVIPDGDA LLTIQRLRAAQAVRGYLVVRSAGPLSDSGRLLVSHAVSLISIALEKPARVQDAEQRLRSAVTRELLGGRG AVDDGLLRYFGFTPDGDVVVSVLHGIGPVLAAEEELSRPLADTGPYLMAATGTEIVIVLPADGSRARIRT LLRGRGAPGGGSSRVVPMADVGTGLEQARVAAHSSVGEFTEYADLGPLAAVLDGRTSRELRFLAAVLDPL AGNDEDLIATLAAFLRHNGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQLWLALRAFQLLE NRRAPAGRCDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | - | 100% (501) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0042 | - | 1e-20 | 26.54% (486) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0861 | - | 7e-19 | 26.47% (476) | transcriptional regulator, CdaR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 8e-09 | 29.38% (177) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0801 | - | 8e-20 | 27.10% (465) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv1186c | - | 8e-09 | 29.38% (177) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 1e-05 | 35.87% (92) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 1e-124 | 52.81% (498) | peptidase |
| M. marinum M | MMAR_4254 | - | 5e-07 | 28.39% (236) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 1e-07 | 24.02% (333) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 1e-161 | 61.48% (501) | regulatory protein |
| M. thermoresistible (build 8) | TH_2938 | - | 1e-06 | 39.53% (86) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0931 | - | 3e-07 | 28.39% (236) | hypothetical protein MUL_0931 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1854|M.vanbaalenii_PYR-1 ---------MITARSLCQDENLGLT-LVAGAQAADRPIAWAHAIELADPT
MSMEG_6688|M.smegmatis_MC2_155 ---------MITARGLAQVESLGLS-LLAGAQGADREIAWAHANELRDPT
MAB_0825|M.abscessus_ATCC_1997 -MAEYRLTVPITVRDLTQRADLGLV-LSAGEAGAARAIKWAHAIELNDPT
Mb1218c|M.bovis_AF2122/97 ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
Rv1186c|M.tuberculosis_H37Rv ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
MMAR_4254|M.marinum_M ----MGVAGVGLGQLLLALDATLVS-LVEAPRGLDLPVASAALVDSDDVR
MUL_0931|M.ulcerans_Agy99 ----MGVAGVGLGQLLLALDATLVS-LVEAPRGLDLPVASAALVDSDDVR
MAV_1987|M.avium_104 --------MITLDRLVNVLGGYGVR-LRWSSVPRSTELRSVVIHETPEDR
Mflv_0801|M.gilvum_PYR-GCK MSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRDPS
TH_2938|M.thermoresistible__bu -------------------VGYG----PGSRQGSGCRQLLELLRDSVEGN
MLBr_01652|M.leprae_Br4923 ----------MNHNHFVPAPPRRLP-LELLDTVPDSLLRRLKQYSGRLAT
.
Mvan_1854|M.vanbaalenii_PYR-1 -----PYLAGGELVMTTGINIGADAAAQADYVARLAA-------------
MSMEG_6688|M.smegmatis_MC2_155 -----PYLAGGELVMTTGINIGAGAGEQRDYVARLSA-------------
MAB_0825|M.abscessus_ATCC_1997 -----PYLFGGELVMTTGLTVGLSHAEQYEYAARLSG-------------
Mb1218c|M.bovis_AF2122/97 -----LGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPS
Rv1186c|M.tuberculosis_H37Rv -----LGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPS
MMAR_4254|M.marinum_M -----LGLAAAAGSADIFFLLGVTDHEALRWIDGQAG--TPVAIFVKQPS
MUL_0931|M.ulcerans_Agy99 -----LGLAAAAGSADIFFLLGVTDHEALRWIDGQAG--TPVAIFVKQPS
MAV_1987|M.avium_104 PVVGDVLLAVGAGSLDEAVRWAASARAAVVVLRDDET-------------
Mflv_0801|M.gilvum_PYR-GCK -----RYLRGGELVCTVGISLHSAEDCS-TFVDALAG-------------
TH_2938|M.thermoresistible__bu -----IDTIFSAIQHDIPIEEVAPPTAALEYARRLAR-------------
MLBr_01652|M.leprae_Br4923 -----EAVTAMQERLPFFADLEASQRASVTLVVQTAV-------------
Mvan_1854|M.vanbaalenii_PYR-1 AGTAALAVDTGTTLTAVP------------AGVLAAG-------DEHGVP
MSMEG_6688|M.smegmatis_MC2_155 AGIAALAVDTGTTLQEVP------------AAVLAAG-------DELGLP
MAB_0825|M.abscessus_ATCC_1997 KNVAALAFDTGTTFSEVP------------PGILAAG-------DELGLP
Mb1218c|M.bovis_AF2122/97 DSVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTD
Rv1186c|M.tuberculosis_H37Rv DSVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTD
MMAR_4254|M.marinum_M DAVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTD
MUL_0931|M.ulcerans_Agy99 DAVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTD
MAV_1987|M.avium_104 PMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETES---GRGPTD
Mflv_0801|M.gilvum_PYR-GCK AGAAGVCFGVGDGHDDVP------------AALLDACR-------RAGLP
TH_2938|M.thermoresistible__bu ----------------------------------------------HGVE
MLBr_01652|M.leprae_Br4923 ------------------------------------------------VN
Mvan_1854|M.vanbaalenii_PYR-1 VLRVPASTPFIAIARVVIDAVKADQLESVQRVVDQQEVLARATL-RGGIP
MSMEG_6688|M.smegmatis_MC2_155 VLEVPASTPFIAIARVVIDAVKADELSAVQRMVDQQQVLARATL-RGGIP
MAB_0825|M.abscessus_ATCC_1997 ILQVPVSTPFIAITRAVIDELTADELRAVQRVVDQQDVLVRATL-RDGAP
Mb1218c|M.bovis_AF2122/97 LFGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPP
Rv1186c|M.tuberculosis_H37Rv LFGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPP
MMAR_4254|M.marinum_M LFGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPP
MUL_0931|M.ulcerans_Agy99 LFGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPP
MAV_1987|M.avium_104 LFALADSLADGIGNPVVIQDRHLGVLAYSR-LAQADPALVETVLQRQTPE
Mflv_0801|M.gilvum_PYR-GCK VLVAPPSVPFSVISRFVAESRLGTEIAVARATNALVPELLLSLRRHDSPR
TH_2938|M.thermoresistible__bu PHALLRAYRLGQQKLLDIVLHEIRSLDWER-----EVSLEFVVGVTNATF
MLBr_01652|M.leprae_Br4923 FVQWMQNPHSDVSYTAQAFELVPQDLARRIALRHTVDMVRVTMEFFEEVV
:
Mvan_1854|M.vanbaalenii_PYR-1 GVVGALAECLSAVVVAVSTDGRDLAAGGTADPQLISALSEAVGQARNRGA
MSMEG_6688|M.smegmatis_MC2_155 AVVNALAECLSATVVVADIEGRILATRGAADQQLVEVLEASRRAGARAQA
MAB_0825|M.abscessus_ATCC_1997 GVVSALSRSLAATVIVTATDGTLLAEAGHDAEHLAEITRGAFPNHSRKHA
Mb1218c|M.bovis_AF2122/97 EHLQWIGQWGIFDALRAGREVVRVAER----PELGLRPRLAIGIHQPGVG
Rv1186c|M.tuberculosis_H37Rv EHLQWIGQWGIFDALRPGREVVRVAER----PELGLRPRLAIGIHQPGVG
MMAR_4254|M.marinum_M EHLKWIGQWGIFDALRSGSEVVRVAER----PELGLRPRLAIGIHQPPVA
MUL_0931|M.ulcerans_Agy99 EHLKWIGQWGIFDALRSGSEVVRVAER----PELGLRPRLAIGIHQPPVA
MAV_1987|M.avium_104 PLRALLEARGVFAHLQVADEPLFVAED----AERGLSGRMVVAVRAG---
Mflv_0801|M.gilvum_PYR-GCK RLLDAAGQVLGCYFLLEPE---------------------GAAKGDEAAV
TH_2938|M.thermoresistible__bu GYIDGISQRVVEVYQ-----------------------------------
MLBr_01652|M.leprae_Br4923 PLLARSEEQLTALTVGILKYSRDLAFT-----------------------
Mvan_1854|M.vanbaalenii_PYR-1 A-VIPDGDALLTIQRLRAAQAVRGYLVVRSAGPLSDSGRLLVSHAVSLIS
MSMEG_6688|M.smegmatis_MC2_155 G-VVADADGYVTVQTLRAAQPVRGHLAVRTEQPMSNSQRLLVAHAVSLIS
MAB_0825|M.abscessus_ATCC_1997 SRVVADRDGYCTIQTVRAGKAERGYLAVRSEDALTAAQRLLVSHAMALIA
Mb1218c|M.bovis_AF2122/97 ALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHA
Rv1186c|M.tuberculosis_H37Rv ALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHA
MMAR_4254|M.marinum_M ARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHA
MUL_0931|M.ulcerans_Agy99 ARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTHA
MAV_1987|M.avium_104 ----AELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLERQ
Mflv_0801|M.gilvum_PYR-GCK TVPVPGLGALVWMGRGDRPEPALLDLIARFVRAAQGE----RDIEAALTR
TH_2938|M.thermoresistible__bu ------QERERWLENRNSLRAMRVRELLDGGEVDVDTASATVGYPLRRTH
MLBr_01652|M.leprae_Br4923 -----AATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAALNW
Mvan_1854|M.vanbaalenii_PYR-1 IALEKPARVQDAEQRLRSAVTRELLGGRGAVDDGLLRYFGFT----PDGD
MSMEG_6688|M.smegmatis_MC2_155 IELEKPARVVDAEDRLRSAVTRDILSGTGTTDSAVLRYLGFQ----PDDE
MAB_0825|M.abscessus_ATCC_1997 IELEKPARVADAEQRLRGAVTRALLADPAAADRSVLRYFGFD----PDTE
Mb1218c|M.bovis_AF2122/97 LRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTA
Rv1186c|M.tuberculosis_H37Rv LRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTA
MMAR_4254|M.marinum_M RRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD--
MUL_0931|M.ulcerans_Agy99 RRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD--
MAV_1987|M.avium_104 VESELVIRLLEGTADAATVASRLDLAHNGLRVVAVQAFVGADR-------
Mflv_0801|M.gilvum_PYR-GCK ERVGQLLSLVERRMLLPDALSQLVQWPG----------------------
TH_2938|M.thermoresistible__bu LAVCVWTPDGSAGDNELDRLQRYVRGLAEALG------------------
MLBr_01652|M.leprae_Br4923 DTTAPATVVVGTPTPNHDGPNGQVSSER----------------------
Mvan_1854|M.vanbaalenii_PYR-1 VVVSVLHGIGPVLAAEEELSRPLADTGP-YLMAATGTEIVIVLPADGSR-
MSMEG_6688|M.smegmatis_MC2_155 VVVLLLTGFTPLLTAQDDLGQRLAPAGS-YLMTSTGDEFAIIVHAARRRR
MAB_0825|M.abscessus_ATCC_1997 VVVVLLCNVGSVLPGELHIDRQLARGGP-YLMASVSGEIVVVLAAKNVGR
Mb1218c|M.bovis_AF2122/97 VRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGT
Rv1186c|M.tuberculosis_H37Rv VRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGT
MMAR_4254|M.marinum_M -KQSRLADVLALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGT
MUL_0931|M.ulcerans_Agy99 -KQSRLADVLALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGT
MAV_1987|M.avium_104 DAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEASTARR-WVGAL
Mflv_0801|M.gilvum_PYR-GCK ------------FAGEIACSAWPAGAGALLSISFPGALIGDAPDLCMMLT
TH_2938|M.thermoresistible__bu -------------APGDSLFIALDRLTGCGWIPLPG-DAATGAVAGVRRY
MLBr_01652|M.leprae_Br4923 --------------ASQEVREIAARHGRAALTDVHGTWLVAIISGQLAPT
Mvan_1854|M.vanbaalenii_PYR-1 --ARIRTLLRGRG-APGGGSSRVVPMADVGTGLEQARVAAHS-SVGEFTE
MSMEG_6688|M.smegmatis_MC2_155 VYAAVEEFGRVTGRTVRGGASQPVRLADAVVGAEQARIAAHSNSRRNITE
MAB_0825|M.abscessus_ATCC_1997 ASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIAE
Mb1218c|M.bovis_AF2122/97 ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQV
Rv1186c|M.tuberculosis_H37Rv ISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQV
MMAR_4254|M.marinum_M ISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRV
MUL_0931|M.ulcerans_Agy99 ISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGRV
MAV_1987|M.avium_104 RAALPERLTMIAG---ISGVAEVGDLAAARQEADECLALHEMSPAAPPPA
Mflv_0801|M.gilvum_PYR-GCK AGAVEMPDDLALPTGHSAPVT-LADLGSAIAQARIALTLAEHRGGRVGPD
TH_2938|M.thermoresistible__bu AAEHPDGPHLALGDPLPGLDGFRRSYRQALRTRAVAVAAGASAPRVTAAA
MLBr_01652|M.leprae_Br4923 DKFFSDLLHAFSDGPVVIGPT--APMLTAAYHSASEAVSGMNAVAGWSGA
.
Mvan_1854|M.vanbaalenii_PYR-1 YADLGPLAAVLDGRTSRELR--FLAAVLDPLAG--NDED--LIATLAAFL
MSMEG_6688|M.smegmatis_MC2_155 FTEVKVFGTLLGGRSTAELR--VLAQPIEPLLA--GGDE--LIDALTAFL
MAB_0825|M.abscessus_ATCC_1997 FDELDIYGVLLGGRDRGELA--VLAQSVAPLLG--TGADTTLLDTLESFL
Mb1218c|M.bovis_AF2122/97 TSLAEARTTVLLDEIVTLVG--TDQRLVDPRIRDLGAQDPVLAQTLRAYL
Rv1186c|M.tuberculosis_H37Rv TSLAEARTTVLLDEIVTLVG--TDQRLVDPRIRDLGAQDPVLAQTLRAYL
MMAR_4254|M.marinum_M TSLAEARTTVLLDEIVTLVG--NDARLIDPRIPDLRAKDPVLADTLRVYL
MUL_0931|M.ulcerans_Agy99 TSLAEARTTVLLDEIVTLVG--NDARLIDPRIPDLRAKDPVLADTLRVYL
MAV_1987|M.avium_104 YDESWDDILLQRLRAAARSGRAPTRGPVADLGRHDRANGTDYLATLRAWL
Mflv_0801|M.gilvum_PYR-GCK --QLSTLESLLEQLPLAQLAP-FRQLLIDPLTELDTSRGTQHVRTLRTFV
TH_2938|M.thermoresistible__bu DPGLSAAALLTGDLAEARTW---VQEVLGPLSAD-TKNDARLRETLGVFL
MLBr_01652|M.leprae_Br4923 PRPVQARELLPERALMGDAS--AIVALHTDVMLPLADAGPTLIETLDAYL
: :* ::
Mvan_1854|M.vanbaalenii_PYR-1 RHNGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQLWLALRA
MSMEG_6688|M.smegmatis_MC2_155 RHNGQLEAAASELQIHRHTMRNRMRRISDLLADDLGTADTRAQLWLAIRA
MAB_0825|M.abscessus_ATCC_1997 ACNGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAALWIAIRA
Mb1218c|M.bovis_AF2122/97 DAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRA
Rv1186c|M.tuberculosis_H37Rv DAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRA
MMAR_4254|M.marinum_M DSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGLRA
MUL_0931|M.ulcerans_Agy99 DSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGLRA
MAV_1987|M.avium_104 QAQGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLDDSKKRLAMMIELAA
Mflv_0801|M.gilvum_PYR-GCK ACNGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQHNDLTTFVIGMWA
TH_2938|M.thermoresistible__bu RHGSSYTAAADELNLHFNTVKYRVQRAVERRGRPIVPDRLDVELALLICQ
MLBr_01652|M.leprae_Br4923 DCGGAIEACARKLFVHPNTVRYRLKRITDFTGHDPTLPRDAYVLRVAATV
. . .* :* :*:: *: : : :
Mvan_1854|M.vanbaalenii_PYR-1 FQLLENRRAPAGRCDS
MSMEG_6688|M.smegmatis_MC2_155 WQLLVSRERPGLS---
MAB_0825|M.abscessus_ATCC_1997 RALLG-----------
Mb1218c|M.bovis_AF2122/97 MERTA-----------
Rv1186c|M.tuberculosis_H37Rv MERTA-----------
MMAR_4254|M.marinum_M TDRSS-----------
MUL_0931|M.ulcerans_Agy99 TDHSS-----------
MAV_1987|M.avium_104 IHTD------------
Mflv_0801|M.gilvum_PYR-GCK ADRGE-----------
TH_2938|M.thermoresistible__bu WFGAAVLRPQR-----
MLBr_01652|M.leprae_Br4923 GKLNYPTHH-------