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ITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETPEDRPVVGDVLLAVGAGSLDEAVRWAASARAAVV VLRDDETPMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETESGRGPTDLFALADSLADGIGNPV VIQDRHLGVLAYSRLAQADPALVETVLQRQTPEPLRALLEARGVFAHLQVADEPLFVAEDAERGLSGRMV VAVRAGAELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLERQVESELVIRLLEGTADAAT VASRLDLAHNGLRVVAVQAFVGADRDAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEASTARRW VGALRAALPERLTMIAGISGVAEVGDLAAARQEADECLALHEMSPAAPPPAYDESWDDILLQRLRAAARS GRAPTRGPVADLGRHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLDDSK KRLAMMIELAAIHTD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1987 | - | - | 100% (506) | putative DNA-binding protein |
| M. avium 104 | MAV_1330 | - | 9e-28 | 30.17% (484) | hypothetical protein MAV_1330 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 8e-30 | 29.53% (491) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_1946 | - | 1e-169 | 63.10% (504) | putative DNA-binding protein |
| M. tuberculosis H37Rv | Rv1186c | - | 1e-29 | 29.53% (491) | hypothetical protein Rv1186c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4202c | - | 7e-09 | 28.83% (163) | putative regulatory protein |
| M. marinum M | MMAR_4254 | - | 4e-27 | 27.85% (492) | hypothetical protein MMAR_4254 |
| M. smegmatis MC2 155 | MSMEG_6290 | - | 0.0 | 67.13% (505) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 1e-176 | 63.85% (520) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 2e-27 | 27.85% (492) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_4779 | - | 1e-170 | 64.19% (511) | putative DNA-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
Rv1186c|M.tuberculosis_H37Rv --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
MMAR_4254|M.marinum_M --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MUL_0931|M.ulcerans_Agy99 --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MSMEG_6290|M.smegmatis_MC2_155 ------------MVTLDRLINVLGGYGIHLKLCSTPRSTELRSVVMHEPG
TH_2137|M.thermoresistible__bu ------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENA
MAV_1987|M.avium_104 ------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETP
Mflv_1946|M.gilvum_PYR-GCK MHTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPEVV
Mvan_4779|M.vanbaalenii_PYR-1 ------------MITLDRLINVLGGYGARWHSGSADRQTELRSVVLPEVV
MAB_4202c|M.abscessus_ATCC_199 ----------------MRWVLDQPELKLTLKSGAAGVGREINLALTTELA
: : . : . :
Mb1218c|M.bovis_AF2122/97 DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
Rv1186c|M.tuberculosis_H37Rv DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
MMAR_4254|M.marinum_M DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MUL_0931|M.ulcerans_Agy99 DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MSMEG_6290|M.smegmatis_MC2_155 ---------PVVGDVLLAVGAASLADALEWAEAAHA----VVVLVRATDE
TH_2137|M.thermoresistible__bu GG------LRVTGDVLLAVGAESVAEAVRWAETAQA----VVVLTRAGPD
MAV_1987|M.avium_104 ED------RPVVGDVLLAVGAGSLDEAVRWAASARA----AVVVLRDDET
Mflv_1946|M.gilvum_PYR-GCK DG------RTVSGDVLLAIGATTTAEAVRWARAARA----VVVLTRGG-G
Mvan_4779|M.vanbaalenii_PYR-1 DG------RTVSGDVLLAVGAASPAEALQWARAARA----VVVLTRGEHA
MAB_4202c|M.abscessus_ATCC_199 DP----AQWLSGGELVLTTGIGLPKSSRDRRRYLRSLDENNVAALGFGTG
.::.: * .: .
Mb1218c|M.bovis_AF2122/97 SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
Rv1186c|M.tuberculosis_H37Rv SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
MMAR_4254|M.marinum_M AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MUL_0931|M.ulcerans_Agy99 AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MSMEG_6290|M.smegmatis_MC2_155 DLT-TAPDG-IAVMLVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
TH_2137|M.thermoresistible__bu ASR-SCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
MAV_1987|M.avium_104 PMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETE--SGRGPTDL
Mflv_1946|M.gilvum_PYR-GCK DPE--PDTAGVAVLVVDSAMPWSEFAAIVYGLVMEGRETE--SGRGPTDL
Mvan_4779|M.vanbaalenii_PYR-1 DPE--LDGAGVAVVVIDSAMPWSDFAAIVYGLVMEGRETE--SGRGPTDL
MAB_4202c|M.abscessus_ATCC_199 LTFDEVPPELVSTADELGMPLLEIPLRTPFAAVVKAVSTR--IAELEYDA
:. . : . . *
Mb1218c|M.bovis_AF2122/97 FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
Rv1186c|M.tuberculosis_H37Rv FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
MMAR_4254|M.marinum_M FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
MUL_0931|M.ulcerans_Agy99 FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
MSMEG_6290|M.smegmatis_MC2_155 FALADSLAETVGGSVTIEDRRSSVLAYSRLQHDADPARAETILSRQAPER
TH_2137|M.thermoresistible__bu FALADNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEP
MAV_1987|M.avium_104 FALADSLADGIGNPVVIQDRHLGVLAYSR-LAQADPALVETVLQRQTPEP
Mflv_1946|M.gilvum_PYR-GCK FALADNLSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPS
Mvan_4779|M.vanbaalenii_PYR-1 FALADSLAGAVGGAVVIEDRSSQVLAFSRGQQDADPGRIATILARQAPPE
MAB_4202c|M.abscessus_ATCC_199 VLRASRAQPRITRAIVNGGVQAVTAELGRSLRASVVVLDPGGTVVASHPR
. *. : : . . . :
Mb1218c|M.bovis_AF2122/97 HLQWIGQWGIFDALRAGREVVRVAE-------RPELGLRPRLAIGIHQPG
Rv1186c|M.tuberculosis_H37Rv HLQWIGQWGIFDALRPGREVVRVAE-------RPELGLRPRLAIGIHQPG
MMAR_4254|M.marinum_M HLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQPP
MUL_0931|M.ulcerans_Agy99 HLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQPP
MSMEG_6290|M.smegmatis_MC2_155 LRTLFAERGVFRHLAESDEPLFVAG-------DPEQGLTGRMVVAARAG-
TH_2137|M.thermoresistible__bu LRRLFEQLGVSEHLAAGDDPLFIAA-------RPGHDLTGRTVIAVRAG-
MAV_1987|M.avium_104 LRALLEARGVFAHLQVADEPLFVAE-------DAERGLSGRMVVAVRAG-
Mflv_1946|M.gilvum_PYR-GCK LRAVFDAHGVFAHLAVSDEPLFVPG-------DDAVGLTGRMVVAARAG-
Mvan_4779|M.vanbaalenii_PYR-1 LRAVYEAHGVFAHLAVSDDPVFVPGDAPDGMLDDAAGRTGRMVVAARAG-
MAB_4202c|M.abscessus_ATCC_199 NLDVATVNLVRGALSPGASAGVQQL-------DPGITVSQQAIGVGGTS-
: * . . :
Mb1218c|M.bovis_AF2122/97 VGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNT
Rv1186c|M.tuberculosis_H37Rv VGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNT
MMAR_4254|M.marinum_M VAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPST
MUL_0931|M.ulcerans_Agy99 VAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPST
MSMEG_6290|M.smegmatis_MC2_155 ------RELLGSVWVTCAQPLPEANRAALADGARMVAVHLLRSRASADLE
TH_2137|M.thermoresistible__bu ------RELLGSVWVVTPEPLDDGRRRALADGARTVALHLLRSRASADLE
MAV_1987|M.avium_104 ------AELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADLE
Mflv_1946|M.gilvum_PYR-GCK ------RELLGSVWVAVPKPLAGQQRQALADGARTVALHLLRSRASADLE
Mvan_4779|M.vanbaalenii_PYR-1 ------RELLGSVWVACASPLVGDRRRALADGAHTVALHLLRSRASADLE
MAB_4202c|M.abscessus_ATCC_199 ---------YGVLAVVSKTPLTFVDQVLLGHTNSLLALDFDKPSRLQEAQ
* : * : :. :
Mb1218c|M.bovis_AF2122/97 HALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD
Rv1186c|M.tuberculosis_H37Rv HALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD
MMAR_4254|M.marinum_M HARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD
MUL_0931|M.ulcerans_Agy99 HARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD
MSMEG_6290|M.smegmatis_MC2_155 RQVESDLVIRLLEG-----AADAATVASRLALPQTP-LRVIALRAHTADE
TH_2137|M.thermoresistible__bu RQVESDLVLRLLEG-----TSDAAGAAARLGLPQEA-LRIIAVRARSGVD
MAV_1987|M.avium_104 RQVESELVIRLLEG-----TADAATVASRLDLAHNG-LRVVAVQAFVGAD
Mflv_1946|M.gilvum_PYR-GCK RQVESEMVIRLLES-----PADAETVASRLGLPPSA-LRVIALRALDTTG
Mvan_4779|M.vanbaalenii_PYR-1 RQVESELVIRLLES-----PADAATVASRLGLPPAT-LRVIALRASDEGG
MAB_4202c|M.abscessus_ATCC_199 RRLNGQALGLLLGD-----ERNLGPVWAQLGQAADARGRIRVLVVDAESQ
: . : : * : .* . : . .
Mb1218c|M.bovis_AF2122/97 TAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSW
Rv1186c|M.tuberculosis_H37Rv TAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSW
MMAR_4254|M.marinum_M ---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSW
MUL_0931|M.ulcerans_Agy99 ---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSW
MSMEG_6290|M.smegmatis_MC2_155 ---GHSALLLAFERATAGFGWSRPGRSALADNTVYTVLPSPDPD-TATTW
TH_2137|M.thermoresistible__bu ---RQGPLLLAFEHATTGFGWSRAGRSALAGDTVYTVLPADHAA-TARRW
MAV_1987|M.avium_104 ---RDAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEAS-TARRW
Mflv_1946|M.gilvum_PYR-GCK ---RHSALLQMFERATAGFGWSRPSRSALADATVYTVLAAEPAA-VARDW
Mvan_4779|M.vanbaalenii_PYR-1 ---RHAALLQMFERATAGFGWSRPSRSALADTTVYTVLAAEAAA-VARDW
MAB_4202c|M.abscessus_ATCC_199 T--ALVRVLPAVTRDMESAGYPVFAHTGE--RQLTVVLPGAETADFARRL
: . .: .: . : .:*. .
Mb1218c|M.bovis_AF2122/97 VRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-
Rv1186c|M.tuberculosis_H37Rv VRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-
MMAR_4254|M.marinum_M VRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPIS
MUL_0931|M.ulcerans_Agy99 VRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPIS
MSMEG_6290|M.smegmatis_MC2_155 VAGLRAALPDPVSVVAGVSGPAVAA---ELVLARREADECLALHEVRHGG
TH_2137|M.thermoresistible__bu VEGLQAALPSEVTVSAGISGIADHT---ELPDARREADECLALHDALHDA
MAV_1987|M.avium_104 VGALRAALPERLTMIAGISGVAEVG---DLAAARQEADECLALHEMSPAA
Mflv_1946|M.gilvum_PYR-GCK VSALISTLPDQVTVKAGISAPAAAT---DLAVARTEADECLALQESTDAG
Mvan_4779|M.vanbaalenii_PYR-1 VSALVAALPEQLTVQAGISAPAAAT---ELAVARTEADECLALQEGTGAD
MAB_4202c|M.abscessus_ATCC_199 FGDVDARIKKGL--RAGLSGAHPVG---RLADAVQNARLAASVAERGGTP
. : : : : : * :. :
Mb1218c|M.bovis_AF2122/97 ------------LGQVTSLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLG
Rv1186c|M.tuberculosis_H37Rv ------------LGQVTSLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLG
MMAR_4254|M.marinum_M ------------IGRVTSLAEARTTVLLDEIVTLVGNDARLIDPRIPDLR
MUL_0931|M.ulcerans_Agy99 ------------IGRVTSLAEARTTVLLDEIVTLVGNDARLIDPRIPDLR
MSMEG_6290|M.smegmatis_MC2_155 --------------AVPVYDEAWDDILLQRLRVAAQSGRAPQRGPVAELR
TH_2137|M.thermoresistible__bu RPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAALH
MAV_1987|M.avium_104 --------------PPPAYDESWDDILLQRLRAAARSGRAPTRGPVADLG
Mflv_1946|M.gilvum_PYR-GCK --------------EPPAYDESWDDLLLRRLKTAARSGRTPTRGAVAELR
Mvan_4779|M.vanbaalenii_PYR-1 --------------APPAYDESWDDLLLRRLRAAARSGRTPPRGAVAELR
MAB_4202c|M.abscessus_ATCC_199 -----------------LEFTSLAGSALLSFGASREVLVAVANATLEPIV
: * : . : :
Mb1218c|M.bovis_AF2122/97 AQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLS
Rv1186c|M.tuberculosis_H37Rv AQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLS
MMAR_4254|M.marinum_M AKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLS
MUL_0931|M.ulcerans_Agy99 AKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLS
MSMEG_6290|M.smegmatis_MC2_155 RHDQAHGTHYAPTLQAWLQAQGDLAEAGRMLGVHENTVRYRLRRMAEVTN
TH_2137|M.thermoresistible__bu EHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQ
MAV_1987|M.avium_104 RHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITN
Mflv_1946|M.gilvum_PYR-GCK EHDSAHGTAYVPTLRAWLQERGDPVRTAAHLGVHENTVRYRMRRMAELTE
Mvan_4779|M.vanbaalenii_PYR-1 AHDSTHGTAYVPTLRAWLQERGDPGRTGTRLGVHENTVRYRMRRMAELTD
MAB_4202c|M.abscessus_ATCC_199 EHDAVHGSELMTSLRAYLEANGHWESAATVVGVHRHTLRKRIETVQSLLA
:* :*: :* *. :. : ** :*:* *:. : :
Mb1218c|M.bovis_AF2122/97 TSLGDPDVRLLFSLGLRAMERTA----
Rv1186c|M.tuberculosis_H37Rv TSLGDPDVRLLFSLGLRAMERTA----
MMAR_4254|M.marinum_M TSFADPDVRLVFSLGLRATDRSS----
MUL_0931|M.ulcerans_Agy99 TSFADPDVRLVFSLGLRATDHSS----
MSMEG_6290|M.smegmatis_MC2_155 LELTDPRKRLAMMIQLAASEHLS----
TH_2137|M.thermoresistible__bu LDLQDPDKRLAMMIELAAIEGPPILSG
MAV_1987|M.avium_104 LSLDDSKKRLAMMIELAAIHTD-----
Mflv_1946|M.gilvum_PYR-GCK LHLDDARKRFAMTIELAVLD-------
Mvan_4779|M.vanbaalenii_PYR-1 LRLDDADKRFAMMIELAVLD-------
MAB_4202c|M.abscessus_ATCC_199 CDLDIARVRAELLLAMLTGTPGTGN--
: . * : : : .