For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VQIDGQQLAAFAAVIELGSFDAAAARLHVTPSAVSQRIKALEQRVGQVLVVREKPCTATPAGVPLLRLAA QTALLESEALAEMGGGSSHRPRMALAVNADSMASWFTGVFRRLPDVLFDIRIEDQDLSARFLREGVVMGA VTTERTPVSGCRVHPLGAMRYIPVASAEYMARYLPDGFNREAAAAAPSLAWNRDDRLQDQLVRKVFRRDV TRPVHFIPTAEGFGAAVRAGLGWGMYPEDLVDASFVPITEHHLDVPLFWQCWKLDSPLVQAITDAVLAAS ARLRGRRTAAER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0548 | - | - | 100% (292) | chromosome replication initiation inhibitor protein |
| M. smegmatis MC2 155 | MSMEG_4025 | - | 3e-07 | 41.67% (72) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_0471 | - | 5e-07 | 41.03% (78) | transcriptional regulator LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2007c | - | 1e-117 | 72.35% (293) | chromosome replication initiation inhibitor protein |
| M. gilvum PYR-GCK | Mflv_0362 | - | 1e-123 | 76.16% (281) | chromosome replication initiation inhibitor protein |
| M. tuberculosis H37Rv | Rv1985c | - | 1e-117 | 72.35% (293) | chromosome replication initiation inhibitor protein |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-07 | 27.23% (191) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4381c | - | 5e-85 | 58.22% (292) | chromosome replication initiation inhibitor protein |
| M. marinum M | MMAR_3419 | - | 8e-07 | 25.42% (240) | LysR family transcriptional regulator |
| M. avium 104 | MAV_0094 | - | 2e-08 | 25.51% (243) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-09 | 31.34% (201) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2698 | - | 7e-07 | 25.42% (240) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0375 | - | 1e-124 | 77.27% (286) | chromosome replication initiation inhibitor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0362|M.gilvum_PYR-GCK ---MTDHLDTAHLAALSAVVEFGSFDAAGAHLHITPSAVSQRIKALEQRV
Mvan_0375|M.vanbaalenii_PYR-1 ---MVDQLDTGQLAALSAVVEFGSFDAAAERLHVTPSAISQRIKALEQRV
MSMEG_0548|M.smegmatis_MC2_155 -----MQIDGQQLAAFAAVIELGSFDAAAARLHVTPSAVSQRIKALEQRV
Mb2007c|M.bovis_AF2122/97 --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
Rv1985c|M.tuberculosis_H37Rv --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
MAB_4381c|M.abscessus_ATCC_199 -----MSLDSQQLVAFAAVVDEGSFDAAARRLMITPSAVSQRVKALERSV
MMAR_3419|M.marinum_M MPLSPRMPELGSFEIFLAIAQTGSLGAAARELGLTQQAVSKRLAAMEAHT
MUL_2698|M.ulcerans_Agy99 MPLSPRMPELASFEIFLAIAQTGSLGAAARELGLTQQAVSKRLAAMEAHT
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
MAV_0094|M.avium_104 ---MGQVLDIAPLRSLVAVADCGGFHRAAAALHLSQSAVSQHLRRIEAVV
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
: : *: : * : *. * : .::*. : :*
Mflv_0362|M.gilvum_PYR-GCK GQVLVLREKP-CVATPAGAPLLRLAAQTALLQAEALAELRG-GTADLPRI
Mvan_0375|M.vanbaalenii_PYR-1 GQVLVLREKP-CVATPAGVPLLRLAAQTALLQAEALAEMRG-GSAELPRI
MSMEG_0548|M.smegmatis_MC2_155 GQVLVVREKP-CTATPAGVPLLRLAAQTALLESEALAEMGG-GSSHRPRM
Mb2007c|M.bovis_AF2122/97 GQVLVVREKP-CRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRI
Rv1985c|M.tuberculosis_H37Rv GQVLVVREKP-CRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRI
MAB_4381c|M.abscessus_ATCC_199 GQVLVRREKP-CVATDAGTSLMRLAAQIGTLEREALQEMGG---GVPIRV
MMAR_3419|M.marinum_M GVTLAVRTTRGSQLTPAGLIVSEWAARLLEVAQEIDAGLGSLRKEGRERI
MUL_2698|M.ulcerans_Agy99 GVTLAVRTTRGSQLTPAGLIVSEWAARLLEVAQEIDAGLGSLRKEGRERI
MLBr_02041|M.leprae_Br4923 GVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGM
MAV_0094|M.avium_104 GEPIVQRSGRGVVFTEVGQKALRHARTILAAHDTALDDLGA---TENKVL
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHY
* : * * * .
Mflv_0362|M.gilvum_PYR-GCK ALAVN----ADSMATWFTEVLTRLPH-----VLFDVRIEDQDHSARLLRE
Mvan_0375|M.vanbaalenii_PYR-1 AMAVN----ADSMATWFTEVFARLPH-----VLFDIRIEDQDHSAQLLRE
MSMEG_0548|M.smegmatis_MC2_155 ALAVN----ADSMASWFTGVFRRLPD-----VLFDIRIEDQDLSARFLRE
Mb2007c|M.bovis_AF2122/97 TIAVN----ADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLRE
Rv1985c|M.tuberculosis_H37Rv TIAVN----ADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLRE
MAB_4381c|M.abscessus_ATCC_199 AIAVN----ADSFGTWMGSVVSQIPDG----VLIDIRIEDQDHSAELLRA
MMAR_3419|M.marinum_M RVAASQTIAEQLMPHWLLALQDAAKRRGTTAPQVILTATNSDHAIAAVRD
MUL_2698|M.ulcerans_Agy99 RVAASQTIAEQLMPHWLLALQDAAKRRGTTAPQVILTATNSDHAIAAVRD
MLBr_02041|M.leprae_Br4923 RLGLIPTVAPYVLPTMLTGLTHRLPT-----LTLRVVEDQTEHLLTALRE
MAV_0094|M.avium_104 TIGATEHGADVMLAGLSGALRDRLPD-----LRVRFRLDRNVSLADSIDR
TH_3504|M.thermoresistible__bu VIGHTPALSGAEAYALIEPAVTAYPS-----TSFTLRQLYPDALTDAVFD
:. . . :
Mflv_0362|M.gilvum_PYR-GCK GVVMGAVTTERAPVAGCRVHALGVMRYVPVASRDYVARHFPDGFTR---E
Mvan_0375|M.vanbaalenii_PYR-1 GVVMGAVTTERAPVAGCRVQPLGVMRYVPVATEAYVQRHLPDGFTR---E
MSMEG_0548|M.smegmatis_MC2_155 GVVMGAVTTERTPVSGCRVHPLGAMRYIPVASAEYMARYLPDGFNR---E
Mb2007c|M.bovis_AF2122/97 GVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---A
Rv1985c|M.tuberculosis_H37Rv GVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---A
MAB_4381c|M.abscessus_ATCC_199 GVVMAAVTTEPRPIAGCRSESLGAMRYFGMASPEYVERHLPDGLLDSGID
MMAR_3419|M.marinum_M GTADLGFVENPGPPTGLGSRVVGHDDLVVVVPPGHKWTRRPSPVTA---R
MUL_2698|M.ulcerans_Agy99 GTADLGFVENPGPPTGLGSRVVGHDDLVVVVPPGHKWTRRPSPVTA---R
MLBr_02041|M.leprae_Br4923 GALDAAMIALPVETAGIAEIPIYDEDFVLALPPGHPLSGKRRVPTT----
MAV_0094|M.avium_104 GLVDVAIMLDGAGLDRANASGLVRLQWVSARTLTIAPK------------
TH_3504|M.thermoresistible__bu GTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDSHPLAARESVDIT----
* .. :
Mflv_0362|M.gilvum_PYR-GCK AASKAPSLAWNRDDALQDQL---VRKVFRRSVQR--PTHYVPTATGFGAA
Mvan_0375|M.vanbaalenii_PYR-1 AAERAPSLAWNRADALQDQL---VRKVFRRSVAR--PVHYVPTAAGFGAA
MSMEG_0548|M.smegmatis_MC2_155 AAAAAPSLAWNRDDRLQDQL---VRKVFRRDVTR--PVHFIPTAEGFGAA
Mb2007c|M.bovis_AF2122/97 AAAKAPSLAWNRDDGLQDML---VRKAFRRAITR--PTHFVPTTEGFTAA
Rv1985c|M.tuberculosis_H37Rv AAAKAPSLAWNRDDGLQDML---VRKAFRRAITR--PTHFVPTTEGFTAA
MAB_4381c|M.abscessus_ATCC_199 KVRQAPLIRWDRRDALQDQF---LRKLFRRDVVV--AGHCVPTTVGFTAA
MMAR_3419|M.marinum_M ELAETPLVTREPRSGIRDSLTVALRQVLGEDMVQASPVLELSSAAAMRAA
MUL_2698|M.ulcerans_Agy99 ELAEMPLVTREPRSGIRDSLTVALRQVLGEDMVQASPVLELSSAAAMRAA
MLBr_02041|M.leprae_Br4923 ALAQLPLLLLDEGHCLRDQT---LDICRKSGVQAELANTRAASLATAVQC
MAV_0094|M.avium_104 --DPLPLVIFSEPCTLREPA----FAILDSHRIDYEIAAECGDLSGLYAA
TH_3504|M.thermoresistible__bu ELAREQVALWAPPGTSYYSD-FLMGACRRAGFEPDYVVSRVQGAATVAAP
Mflv_0362|M.gilvum_PYR-GCK VHAGLGWGMYPIA-----LLDGSFVPIT----EQHLDVPLYWQCWK-LDS
Mvan_0375|M.vanbaalenii_PYR-1 VHAGLGWGMYPIQ-----LLDASFVPIT----DQHLDVPLYWQCWK-LDS
MSMEG_0548|M.smegmatis_MC2_155 VRAGLGWGMYPED-----LVDASFVPIT----EHHLDVPLFWQCWK-LDS
Mb2007c|M.bovis_AF2122/97 ARAGLGWGMFPEKLAASPLADGSFVRVC----DIHLDVPLYWQCWK-LDS
Rv1985c|M.tuberculosis_H37Rv ARAGLGWGMFPEKLAASPLADGSFVRVC----DIHLDVPLYWQCWK-LDS
MAB_4381c|M.abscessus_ATCC_199 LRAGLGWGMMPEQ-----LGREGLVELAP---GRYLDVPLYWQHWK-FES
MMAR_3419|M.marinum_M VLAGAGPAAMSRLAIADDLAVGRLRAIS------IPGLDLRRQLRA-IWV
MUL_2698|M.ulcerans_Agy99 VLAGAGPAAMSRLAIADDLAVGRLRAIS------IPGLDLRRQLRA-IWV
MLBr_02041|M.leprae_Br4923 VTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRSAS-GRS
MAV_0094|M.avium_104 VRSGLGVALLPMIG----KFPDGLGPAEG--LPPANNASILVRGRTGIDP
TH_3504|M.thermoresistible__bu LTTG-GIAFVTAAAG--PTMNGRVQVVD-------LTPPLLVPVQALWQR
* * . . :
Mflv_0362|M.gilvum_PYR-GCK AVVAQVTAAVDAAAAGLLRDR-------
Mvan_0375|M.vanbaalenii_PYR-1 DTVRQVTAAVDSAASGLLRDR-------
MSMEG_0548|M.smegmatis_MC2_155 PLVQAITDAVLAASARLRGRRTAAER--
Mb2007c|M.bovis_AF2122/97 PIIARITDTVRAAASGLYRGQQRRRRPG
Rv1985c|M.tuberculosis_H37Rv PIIARITDTVRAAASGLYRGQQRRRRPG
MAB_4381c|M.abscessus_ATCC_199 STLSAITSAVREAATVLRRSR-------
MMAR_3419|M.marinum_M GGRVPPAGAIRELLSHITSGGE------
MUL_2698|M.ulcerans_Agy99 GGRVPPAGAIRELLSHITSGGE------
MLBr_02041|M.leprae_Br4923 ASYRQIAKIIGELISTEHHVRLVA----
MAV_0094|M.avium_104 ALLSTVDTAVRDLLATAT----------
TH_3504|M.thermoresistible__bu HTLSAIRDRILEGLG-------------
: