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VDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQVGQVLVVREKPCRATTAGIPLLRL AAQTALLESEALAEMGGNASLKRTRITIAVNADSMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVA MGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFR RAITRPTHFVPTTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSPIIARI TDTVRAAASGLYRGQQRRRRPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1985c | - | - | 100% (303) | chromosome replication initiation inhibitor protein |
| M. tuberculosis H37Rv | Rv2282c | - | 2e-07 | 25.19% (270) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2007c | - | 1e-173 | 100.00% (303) | chromosome replication initiation inhibitor protein |
| M. gilvum PYR-GCK | Mflv_0362 | - | 1e-112 | 70.41% (294) | chromosome replication initiation inhibitor protein |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-05 | 30.71% (140) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4381c | - | 7e-83 | 56.61% (295) | chromosome replication initiation inhibitor protein |
| M. marinum M | MMAR_3419 | - | 1e-07 | 25.40% (248) | LysR family transcriptional regulator |
| M. avium 104 | MAV_2151 | - | 2e-08 | 26.15% (260) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0548 | - | 1e-116 | 72.35% (293) | chromosome replication initiation inhibitor protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-07 | 27.44% (277) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2698 | - | 4e-08 | 25.58% (258) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0375 | - | 1e-112 | 71.13% (291) | chromosome replication initiation inhibitor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1985c|M.tuberculosis_H37Rv --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
Mb2007c|M.bovis_AF2122/97 --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
Mflv_0362|M.gilvum_PYR-GCK ---MTDHLDTAHLAALSAVVEFGSFDAAGAHLHITPSAVSQRIKALEQRV
Mvan_0375|M.vanbaalenii_PYR-1 ---MVDQLDTGQLAALSAVVEFGSFDAAAERLHVTPSAISQRIKALEQRV
MSMEG_0548|M.smegmatis_MC2_155 -----MQIDGQQLAAFAAVIELGSFDAAAARLHVTPSAVSQRIKALEQRV
MAB_4381c|M.abscessus_ATCC_199 -----MSLDSQQLVAFAAVVDEGSFDAAARRLMITPSAVSQRVKALERSV
MMAR_3419|M.marinum_M MPLSPRMPELGSFEIFLAIAQTGSLGAAARELGLTQQAVSKRLAAMEAHT
MUL_2698|M.ulcerans_Agy99 MPLSPRMPELASFEIFLAIAQTGSLGAAARELGLTQQAVSKRLAAMEAHT
MAV_2151|M.avium_104 MPLSPRMPELASFEAFLAIAETGSLGRAARELGLTQQAISRRLATMEAQI
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
: : *: : * : *. * : .::* : ::*
Rv1985c|M.tuberculosis_H37Rv GQVLVVREKP-CRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRI
Mb2007c|M.bovis_AF2122/97 GQVLVVREKP-CRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRI
Mflv_0362|M.gilvum_PYR-GCK GQVLVLREKP-CVATPAGAPLLRLAAQTALLQAEALAELRG-GTADLPRI
Mvan_0375|M.vanbaalenii_PYR-1 GQVLVLREKP-CVATPAGVPLLRLAAQTALLQAEALAEMRG-GSAELPRI
MSMEG_0548|M.smegmatis_MC2_155 GQVLVVREKP-CTATPAGVPLLRLAAQTALLESEALAEMGG-GSSHRPRM
MAB_4381c|M.abscessus_ATCC_199 GQVLVRREKP-CVATDAGTSLMRLAAQIGTLEREALQEMGG---GVPIRV
MMAR_3419|M.marinum_M GVTLAVRTTRGSQLTPAGLIVSEWAARLLEVAQEIDAGLGSLRKEGRERI
MUL_2698|M.ulcerans_Agy99 GVTLAVRTTRGSQLTPAGLIVSEWAARLLEVAQEIDAGLGSLRKEGRERI
MAV_2151|M.avium_104 GVTLAVRTTRGSQLTPAGLIVADWAARLLEVAHEIDAGLGSLRKEGRERI
MLBr_02041|M.leprae_Br4923 GVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGM
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHY
* * * * * : .
Rv1985c|M.tuberculosis_H37Rv TIAVN----ADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLRE
Mb2007c|M.bovis_AF2122/97 TIAVN----ADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLRE
Mflv_0362|M.gilvum_PYR-GCK ALAVN----ADSMATWFTEVLTRLPH-----VLFDVRIEDQDHSARLLRE
Mvan_0375|M.vanbaalenii_PYR-1 AMAVN----ADSMATWFTEVFARLPH-----VLFDIRIEDQDHSAQLLRE
MSMEG_0548|M.smegmatis_MC2_155 ALAVN----ADSMASWFTGVFRRLPD-----VLFDIRIEDQDLSARFLRE
MAB_4381c|M.abscessus_ATCC_199 AIAVN----ADSFGTWMGSVVSQIPDG----VLIDIRIEDQDHSAELLRA
MMAR_3419|M.marinum_M RVAASQTIAEQLMPHWLLALQDAAKRRGTTAPQVILTATNSDHAIAAVRD
MUL_2698|M.ulcerans_Agy99 RVAASQTIAEQLMPHWLLALQDAAKRRGTTAPQVILTATNSDHAIAAVRD
MAV_2151|M.avium_104 RVAASQTISEQLMPHWLLSLQAEATRRGEAAPQVILTATNSEHAIASVRD
MLBr_02041|M.leprae_Br4923 RLGLIPTVAPYVLPTMLTGLTHRLPT-----LTLRVVEDQTEHLLTALRE
TH_3504|M.thermoresistible__bu VIGHTPALSGAEAYALIEPAVTAYPS-----TSFTLRQLYPDALTDAVFD
:. : . : : :
Rv1985c|M.tuberculosis_H37Rv GVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---A
Mb2007c|M.bovis_AF2122/97 GVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---A
Mflv_0362|M.gilvum_PYR-GCK GVVMGAVTTERAPVAGCRVHALGVMRYVPVASRDYVARHFPDGFTR---E
Mvan_0375|M.vanbaalenii_PYR-1 GVVMGAVTTERAPVAGCRVQPLGVMRYVPVATEAYVQRHLPDGFTR---E
MSMEG_0548|M.smegmatis_MC2_155 GVVMGAVTTERTPVSGCRVHPLGAMRYIPVASAEYMARYLPDGFNR---E
MAB_4381c|M.abscessus_ATCC_199 GVVMAAVTTEPRPIAGCRSESLGAMRYFGMASPEYVERHLPDGLLDSGID
MMAR_3419|M.marinum_M GTADLGFVENPGPPTGLGSRVVGHDDLVVVVPPGHKWTRRPSPVTA---R
MUL_2698|M.ulcerans_Agy99 GTADLGFVENPGPPTGLGSRVVGHDDLVVVVPPGHKWTRRPSPVTA---R
MAV_2151|M.avium_104 GSADLGFVENPGTPKGLGSCVVGEDELVIVVPPTHKWARRSRVVTA---R
MLBr_02041|M.leprae_Br4923 GALDAAMIALPVETAGIAEIPIYDEDFVLALPPGHPLSGKRRVPTT----
TH_3504|M.thermoresistible__bu GTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDSHPLAARESVDIT--EL
* .. : .
Rv1985c|M.tuberculosis_H37Rv AAAKAPSLAWNRDDGLQDML---VRKAFRRAITRPTHFVPTTEGFTAAAR
Mb2007c|M.bovis_AF2122/97 AAAKAPSLAWNRDDGLQDML---VRKAFRRAITRPTHFVPTTEGFTAAAR
Mflv_0362|M.gilvum_PYR-GCK AASKAPSLAWNRDDALQDQL---VRKVFRRSVQRPTHYVPTATGFGAAVH
Mvan_0375|M.vanbaalenii_PYR-1 AAERAPSLAWNRADALQDQL---VRKVFRRSVARPVHYVPTAAGFGAAVH
MSMEG_0548|M.smegmatis_MC2_155 AAAAAPSLAWNRDDRLQDQL---VRKVFRRDVTRPVHFIPTAEGFGAAVR
MAB_4381c|M.abscessus_ATCC_199 KVRQAPLIRWDRRDALQDQF---LRKLFRRDVVVAGHCVPTTVGFTAALR
MMAR_3419|M.marinum_M ELAETPLVTREPRSGIRDSLTVALRQVLGEDMVQASPVLELSS--AAAMR
MUL_2698|M.ulcerans_Agy99 ELAEMPLVTREPRSGIRDSLTVALRQVLGEDMVQASPVLELSS--AAAMR
MAV_2151|M.avium_104 ELAQTPLVAREPHSGIRDSLTVALRKVLGEDMQQAAPVLELTS--AAAMR
MLBr_02041|M.leprae_Br4923 ALAQLPLLLLDEGHCLRDQTLDICRKSGVQAELANTRAASLAT-AVQCVT
TH_3504|M.thermoresistible__bu AREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTT
. * *: . :
Rv1985c|M.tuberculosis_H37Rv AGLGWGMFPEKLAASPLADGSFVRVC-DIHLDVPLYWQCWKLDSPIIARI
Mb2007c|M.bovis_AF2122/97 AGLGWGMFPEKLAASPLADGSFVRVC-DIHLDVPLYWQCWKLDSPIIARI
Mflv_0362|M.gilvum_PYR-GCK AGLGWGMYPIA-----LLDGSFVPIT-EQHLDVPLYWQCWKLDSAVVAQV
Mvan_0375|M.vanbaalenii_PYR-1 AGLGWGMYPIQ-----LLDASFVPIT-DQHLDVPLYWQCWKLDSDTVRQV
MSMEG_0548|M.smegmatis_MC2_155 AGLGWGMYPED-----LVDASFVPIT-EHHLDVPLFWQCWKLDSPLVQAI
MAB_4381c|M.abscessus_ATCC_199 AGLGWGMMPEQ-----LGREGLVELAPGRYLDVPLYWQHWKFESSTLSAI
MMAR_3419|M.marinum_M AAVLAGAGPAAMSR--LAIADDLAVGRLRAISIPGLDLRRQLRAIWVGGR
MUL_2698|M.ulcerans_Agy99 AAVLAGAGPAAMSR--LAIADDLAVGRLRAISIPGLDLRRQLRAIWVGGR
MAV_2151|M.avium_104 AAVLAGAGPAAMSR--LAVADDLAVGRLHAVEIPKLDLRRKFRAIWIGGR
MLBr_02041|M.leprae_Br4923 GGLGVTLLPQSAAP---VESVRSKLG-LAQFAAPCPGRRIGLAFRSASGR
TH_3504|M.thermoresistible__bu GGIAFVTAAAGPTMN--GRVQVVDLTPPLLVPVQALWQRHTLSAIRDR--
..: . : . :
Rv1985c|M.tuberculosis_H37Rv TDTVRAAASGLYRGQQRRRRPG---
Mb2007c|M.bovis_AF2122/97 TDTVRAAASGLYRGQQRRRRPG---
Mflv_0362|M.gilvum_PYR-GCK TAAVDAAAAGLLRDR----------
Mvan_0375|M.vanbaalenii_PYR-1 TAAVDSAASGLLRDR----------
MSMEG_0548|M.smegmatis_MC2_155 TDAVLAASARLRGRRTAAER-----
MAB_4381c|M.abscessus_ATCC_199 TSAVREAATVLRRSR----------
MMAR_3419|M.marinum_M VPPAGAIRELLSHITSGGE------
MUL_2698|M.ulcerans_Agy99 VPPAGAIRELLSHITSGGE------
MAV_2151|M.avium_104 TPPAGAIRDLLSHIIARTAASK---
MLBr_02041|M.leprae_Br4923 SASYRQIAKIIGELISTEHHVRLVA
TH_3504|M.thermoresistible__bu ------ILEGLG-------------
: