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TDHLDTAHLAALSAVVEFGSFDAAGAHLHITPSAVSQRIKALEQRVGQVLVLREKPCVATPAGAPLLRLA AQTALLQAEALAELRGGTADLPRIALAVNADSMATWFTEVLTRLPHVLFDVRIEDQDHSARLLREGVVMG AVTTERAPVAGCRVHALGVMRYVPVASRDYVARHFPDGFTREAASKAPSLAWNRDDALQDQLVRKVFRRS VQRPTHYVPTATGFGAAVHAGLGWGMYPIALLDGSFVPITEQHLDVPLYWQCWKLDSAVVAQVTAAVDAA AAGLLRDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0362 | - | - | 100% (289) | chromosome replication initiation inhibitor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2007c | - | 1e-112 | 70.41% (294) | chromosome replication initiation inhibitor protein |
| M. tuberculosis H37Rv | Rv1985c | - | 1e-112 | 70.41% (294) | chromosome replication initiation inhibitor protein |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-08 | 27.18% (195) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4381c | - | 9e-83 | 56.90% (290) | chromosome replication initiation inhibitor protein |
| M. marinum M | MMAR_4902 | - | 2e-07 | 35.94% (128) | putative regulatory protein |
| M. avium 104 | MAV_0094 | - | 3e-08 | 32.54% (169) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_0548 | - | 1e-123 | 76.16% (281) | chromosome replication initiation inhibitor protein |
| M. thermoresistible (build 8) | TH_3504 | - | 6e-06 | 28.11% (185) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2698 | - | 7e-06 | 23.95% (238) | LysR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0375 | - | 1e-143 | 86.51% (289) | chromosome replication initiation inhibitor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0362|M.gilvum_PYR-GCK ---MTDHLDTAHLAALSAVVEFGSFDAAGAHLHITPSAVSQRIKALEQRV
Mvan_0375|M.vanbaalenii_PYR-1 ---MVDQLDTGQLAALSAVVEFGSFDAAAERLHVTPSAISQRIKALEQRV
MSMEG_0548|M.smegmatis_MC2_155 -----MQIDGQQLAAFAAVIELGSFDAAAARLHVTPSAVSQRIKALEQRV
Mb2007c|M.bovis_AF2122/97 --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
Rv1985c|M.tuberculosis_H37Rv --MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSLEQQV
MAB_4381c|M.abscessus_ATCC_199 -----MSLDSQQLVAFAAVVDEGSFDAAARRLMITPSAVSQRVKALERSV
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
MAV_0094|M.avium_104 ---MGQVLDIAPLRSLVAVADCGGFHRAAAALHLSQSAVSQHLRRIEAVV
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
MMAR_4902|M.marinum_M ------MIDPHRLRILRAVVAEGSIGGAAAALGCTPSAVSQHIAVLQREI
MUL_2698|M.ulcerans_Agy99 MPLSPRMPELASFEIFLAIAQTGSLGAAARELGLTQQAVSKRLAAMEAHT
: : *: * : *. * .::*. : ::
Mflv_0362|M.gilvum_PYR-GCK GQVLVLRE-KPCVATPAGAPLLRLAAQTALLQAEALAELRG------GTA
Mvan_0375|M.vanbaalenii_PYR-1 GQVLVLRE-KPCVATPAGVPLLRLAAQTALLQAEALAEMRG------GSA
MSMEG_0548|M.smegmatis_MC2_155 GQVLVVRE-KPCTATPAGVPLLRLAAQTALLESEALAEMGG------GSS
Mb2007c|M.bovis_AF2122/97 GQVLVVRE-KPCRATTAGIPLLRLAAQTALLESEALAEMGGN-----ASL
Rv1985c|M.tuberculosis_H37Rv GQVLVVRE-KPCRATTAGIPLLRLAAQTALLESEALAEMGGN-----ASL
MAB_4381c|M.abscessus_ATCC_199 GQVLVRRE-KPCVATDAGTSLMRLAAQIGTLEREALQEMGG--------G
MLBr_02041|M.leprae_Br4923 GVQLIERS-TRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGG
MAV_0094|M.avium_104 GEPIVQRSGRGVVFTEVGQKALRHARTILAAHDTALDDLGAT----ENKV
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT-EAAAQAH
MMAR_4902|M.marinum_M GLTLVEKVGRGIAPTDAGATLAAES-AAVFDGLSRLDGLVADLRHGRAGT
MUL_2698|M.ulcerans_Agy99 GVTLAVRTTRGSQLTPAGLIVSEWAARLLEVAQEIDAGLGSLRKE-GRER
* : : . .
Mflv_0362|M.gilvum_PYR-GCK DLPRIALAVNADSMATWFTEVLTRLPH-----VLFDVRIEDQDHSARLLR
Mvan_0375|M.vanbaalenii_PYR-1 ELPRIAMAVNADSMATWFTEVFARLPH-----VLFDIRIEDQDHSAQLLR
MSMEG_0548|M.smegmatis_MC2_155 HRPRMALAVNADSMASWFTGVFRRLPD-----VLFDIRIEDQDLSARFLR
Mb2007c|M.bovis_AF2122/97 KRTRITIAVNADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLR
Rv1985c|M.tuberculosis_H37Rv KRTRITIAVNADSMATWFSAVFDGLGD-----VLLDVRIEDQDHSARLLR
MAB_4381c|M.abscessus_ATCC_199 VPIRVAIAVNADSFGTWMGSVVSQIPDG----VLIDIRIEDQDHSAELLR
MLBr_02041|M.leprae_Br4923 MRLGLIPTVAPYVLPTMLTGLTHRLPT-----LTLRVVEDQTEHLLTALR
MAV_0094|M.avium_104 LTIGATEHGADVMLAGLSGALRDRLPD-----LRVRFRLDRNVSLADSID
TH_3504|M.thermoresistible__bu YVIGHTPALSGAEAYALIEPAVTAYPS-----TSFTLRQLYPDALTDAVF
MMAR_4902|M.marinum_M LRVSYFASAGAAWMPAVIATISSEYPA-----VRLDLRLVELADADDAAP
MUL_2698|M.ulcerans_Agy99 IRVAASQTIAEQLMPHWLLALQDAAKRRGTTAPQVILTATNSDHAIAAVR
. .
Mflv_0362|M.gilvum_PYR-GCK EGVVMGAVTTERAPVAGCRVHALGVMRYVPVASRDYVARHFPDGFTR---
Mvan_0375|M.vanbaalenii_PYR-1 EGVVMGAVTTERAPVAGCRVQPLGVMRYVPVATEAYVQRHLPDGFTR---
MSMEG_0548|M.smegmatis_MC2_155 EGVVMGAVTTERTPVSGCRVHPLGAMRYIPVASAEYMARYLPDGFNR---
Mb2007c|M.bovis_AF2122/97 EGVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---
Rv1985c|M.tuberculosis_H37Rv EGVAMGAVTTERNPVPGCRVHPLGEMRYLPVASRPFVQRHLSDGFTA---
MAB_4381c|M.abscessus_ATCC_199 AGVVMAAVTTEPRPIAGCRSESLGAMRYFGMASPEYVERHLPDGLLDSGI
MLBr_02041|M.leprae_Br4923 EGALDAAMIALPVETAGIAEIPIYDEDFVLALPPG----HPLSGKRRVPT
MAV_0094|M.avium_104 RGLVDVAIMLDGAGLDRANASGLVRLQWVSARTLT--------------I
TH_3504|M.thermoresistible__bu DGTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDS----HPLAARESVDI
MMAR_4902|M.marinum_M DVEINVAGMPG-TELSNYDTAALVTEDYVVVVGAG----DSLAERDSVTL
MUL_2698|M.ulcerans_Agy99 DGTADLGFVENPGPPTGLGSRVVGHDDLVVVVPPG---HKWTRRPSPVTA
. :
Mflv_0362|M.gilvum_PYR-GCK EAASKAPSLAWNRD--DALQDQLVRKVFRR-----SVQRPTHYVPTATGF
Mvan_0375|M.vanbaalenii_PYR-1 EAAERAPSLAWNRA--DALQDQLVRKVFRR-----SVARPVHYVPTAAGF
MSMEG_0548|M.smegmatis_MC2_155 EAAAAAPSLAWNRD--DRLQDQLVRKVFRR-----DVTRPVHFIPTAEGF
Mb2007c|M.bovis_AF2122/97 AAAAKAPSLAWNRD--DGLQDMLVRKAFRR-----AITRPTHFVPTTEGF
Rv1985c|M.tuberculosis_H37Rv AAAAKAPSLAWNRD--DGLQDMLVRKAFRR-----AITRPTHFVPTTEGF
MAB_4381c|M.abscessus_ATCC_199 DKVRQAPLIRWDRR--DALQDQFLRKLFRR-----DVVVAGHCVPTTVGF
MLBr_02041|M.leprae_Br4923 TALAQLPLLLLDEG--HCLRDQTLDICRKSG---VQAELANTRAASLATA
MAV_0094|M.avium_104 APKDPLPLVIFSEP--CTLREPAFAILDSHR---IDYEIAAECG-DLSGL
TH_3504|M.thermoresistible__bu TELAREQVALWAPPGTSYYSDFLMGACRRAG---FEPDYVVSRVQGAATV
MMAR_4902|M.marinum_M RELAGEPWIDNDVAR-GNCRENLLRACTAAG----FTPCFRVETHDYVTA
MUL_2698|M.ulcerans_Agy99 RELAEMPLVTREPR--SGIRDSLTVALRQVLGEDMVQASPVLELSSAAAM
:
Mflv_0362|M.gilvum_PYR-GCK GAAVHAGLGWGMYPIA-------LLDGSFVPIT--EQHLDVPLYWQCWK-
Mvan_0375|M.vanbaalenii_PYR-1 GAAVHAGLGWGMYPIQ-------LLDASFVPIT--DQHLDVPLYWQCWK-
MSMEG_0548|M.smegmatis_MC2_155 GAAVRAGLGWGMYPED-------LVDASFVPIT--EHHLDVPLFWQCWK-
Mb2007c|M.bovis_AF2122/97 TAAARAGLGWGMFPEKLA--ASPLADGSFVRVC--DIHLDVPLYWQCWK-
Rv1985c|M.tuberculosis_H37Rv TAAARAGLGWGMFPEKLA--ASPLADGSFVRVC--DIHLDVPLYWQCWK-
MAB_4381c|M.abscessus_ATCC_199 TAALRAGLGWGMMPEQ-------LGREGLVELAP-GRYLDVPLYWQHWK-
MLBr_02041|M.leprae_Br4923 VQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRSAS-
MAV_0094|M.avium_104 YAAVRSGLGVALLPMIG------KFPDGLGPAEGLPPANNASILVRGRTG
TH_3504|M.thermoresistible__bu AAPLTTG-GIAFVTAAAG-----PTMNGRVQVVDLTPPLLVPVQALWQR-
MMAR_4902|M.marinum_M VRFVAAGVGLTVVPRLAL----IDLPAGVRTVAISEPTPRRTIVVRRHHR
MUL_2698|M.ulcerans_Agy99 RAAVLAGAGPAAMSRLAIADDLAVGRLRAISIPGLDLRRQLRAIWVGGRV
* * .
Mflv_0362|M.gilvum_PYR-GCK LDSAVVAQVTAAVDAAAAGLLRDR-------
Mvan_0375|M.vanbaalenii_PYR-1 LDSDTVRQVTAAVDSAASGLLRDR-------
MSMEG_0548|M.smegmatis_MC2_155 LDSPLVQAITDAVLAASARLRGRRTAAER--
Mb2007c|M.bovis_AF2122/97 LDSPIIARITDTVRAAASGLYRGQQRRRRPG
Rv1985c|M.tuberculosis_H37Rv LDSPIIARITDTVRAAASGLYRGQQRRRRPG
MAB_4381c|M.abscessus_ATCC_199 FESSTLSAITSAVREAATVLRRSR-------
MLBr_02041|M.leprae_Br4923 GRSASYRQIAKIIGELISTEHHVRLVA----
MAV_0094|M.avium_104 IDPALLSTVDTAVRDLLATAT----------
TH_3504|M.thermoresistible__bu ---HTLSAIRDRILEGLG-------------
MMAR_4902|M.marinum_M ARNNVVAGRVLELIHQQAVRTHGPAVGALA-
MUL_2698|M.ulcerans_Agy99 PPAGAIRELLSHITSGGE-------------
: