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DLREMRAFVAVVETGRFAAAAERLRLSQPAVSHTIRGLEQRWGVRLLERTRAGVRTTAAGELLLTEAKAV LSRYDQAMDVLSSGKRTSTLLRLGIPFGLPAGMPATALAALTQAWRSTVIAIHQMSSVDQIELLERRELD IGLLRHRPVTSDLDATLVADEPLGAIVSAARAEQLCLPATDVDLEALGTLRWQGFARDSSPPWYDEVTAT LRGFGVHVEPTPARPQETSAEFAYATVSLGNTFTLAPACCRQTLPSALTWRRIAGDPLRRRTWAVWPATS RRRDVGELVALLEGAHDVEHDTACVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4025 | - | - | 100% (307) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_1799 | - | 1e-17 | 27.24% (301) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1909 | - | 1e-15 | 36.42% (173) | putative HTH-type transcriptional regulator YnfL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 5e-10 | 25.78% (256) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1356 | - | 5e-18 | 38.15% (173) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 5e-10 | 25.78% (256) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 4e-11 | 26.60% (312) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0993c | - | 7e-14 | 30.92% (207) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0317 | oxyS | 6e-08 | 36.84% (95) | oxidative stress response regulatory protein OxyS |
| M. avium 104 | MAV_2789 | - | 1e-15 | 31.36% (169) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 9e-10 | 30.67% (163) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4805 | oxyS | 7e-08 | 36.84% (95) | oxidative stress response regulatory protein OxyS |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 1e-11 | 32.09% (187) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0121|M.bovis_AF2122/97 --------------------------------------------------
Rv0117|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0317|M.marinum_M MKLLGAPKINPELTLAQIPGSDSLVVIPIPRTSGLARRAAPAVQPRCGVT
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1356|M.gilvum_PYR-GCK --------------------------------------------------
MAV_2789|M.avium_104 --------------------------------------------------
Mvan_3362|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4025|M.smegmatis_MC2_155 --------------------------------------------------
TH_3504|M.thermoresistible__bu --------------------------------------------------
MAB_0993c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02041|M.leprae_Br4923 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 ---------------------------------------------MLFRQ
Rv0117|M.tuberculosis_H37Rv ---------------------------------------------MLFRQ
MMAR_0317|M.marinum_M RTAQWRADLVATVQDLAAQSGTGGRQRSGGGGSLSESVPMTEEVSVLFRQ
MUL_4805|M.ulcerans_Agy99 ---------------------------------------------MLFRQ
Mflv_1356|M.gilvum_PYR-GCK -------------------MVSAVTGRPTNDPPHTWRHRTIKEPPMELRH
MAV_2789|M.avium_104 -----------------------------MKDLCSSGMDVVQAGRVELRH
Mvan_3362|M.vanbaalenii_PYR-1 ---------------------------------------------MELRQ
MSMEG_4025|M.smegmatis_MC2_155 ---------------------------------------------MDLRE
TH_3504|M.thermoresistible__bu ----------------------------------------VPSPKIDLRR
MAB_0993c|M.abscessus_ATCC_199 -------------------------------------MAETAPLDLDLRL
MLBr_02041|M.leprae_Br4923 --------------------------------------MSDKSYQPTIAG
:
Mb0121|M.bovis_AF2122/97 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
Rv0117|M.tuberculosis_H37Rv LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MMAR_0317|M.marinum_M LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MUL_4805|M.ulcerans_Agy99 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELHVTLINRGHSFE
Mflv_1356|M.gilvum_PYR-GCK LRYFLAVAETCHFGQAAEQLHIAQPALSYAIRQLENSLDATLFTRTTRHV
MAV_2789|M.avium_104 LRAFEAVARLESFTLAAQELSITQPALSRTIKQLEDALEASLLDRTSRHV
Mvan_3362|M.vanbaalenii_PYR-1 LEYLVAVVEERSFTKAAQRERVAQPAVSAQIRRLERQVGQPLLTRSHRGV
MSMEG_4025|M.smegmatis_MC2_155 MRAFVAVVETGRFAAAAERLRLSQPAVSHTIRGLEQRWGVRLLERTRAGV
TH_3504|M.thermoresistible__bu LAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDVGADLFTRDGRRI
MAB_0993c|M.abscessus_ATCC_199 VRYFTVVAEQRHFGRASTELRVAQPSLSRQISRLEQQLGVRLLDRTPQGT
MLBr_02041|M.leprae_Br4923 LRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGLGVQLIERSTRRV
: : .*.. * *: : * ::* : ** *: *
Mb0121|M.bovis_AF2122/97 GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
Rv0117|M.tuberculosis_H37Rv GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
MMAR_0317|M.marinum_M GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVPSASTTA
MUL_4805|M.ulcerans_Agy99 GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVRSASTTA
Mflv_1356|M.gilvum_PYR-GCK ALTPAGEFLRVEATRILNGVDAAQRGVRRIAAGRSGLLRLGLTGTAAFSH
MAV_2789|M.avium_104 ATTPAGRVFLGHVERILTELGRGVDAVRQQASIRLGFSWLLPDPWAQDTV
Mvan_3362|M.vanbaalenii_PYR-1 RVTPAGAALLPHARAALAAVRDAQAAVDDVANLVRGAVAIGTVTLHPVDV
MSMEG_4025|M.smegmatis_MC2_155 RTTAAGELLLTEAKAVLSRYDQAMDVLSSGKR-TSTLLRLG-IPFGLPAG
TH_3504|M.thermoresistible__bu SLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHYVIGHTPALSGAE
MAB_0993c|M.abscessus_ATCC_199 TLTEAGEVFLPKAKTLLRSADQAAAHARAAAQPSHLTVGYSMGIIVTPAV
MLBr_02041|M.leprae_Br4923 FVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGMRLGLIPTVAPYV
* * : :
Mb0121|M.bovis_AF2122/97 SLVLSAFC-SAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQ-DS
Rv0117|M.tuberculosis_H37Rv SLVLSAFC-SAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQ-DS
MMAR_0317|M.marinum_M SLVLSDFC-SAHPLVKAQICSRLAVTELYRRLRDFELDAAIVYTSSD-DG
MUL_4805|M.ulcerans_Agy99 SLVLSDFC-SAHPLVKAQICSRLAVTELYRRLRDFERDAAIVYTSSD-DG
Mflv_1356|M.gilvum_PYR-GCK LPKIARIVRQELPAVALDIHADLLTPDQCEGLRTGALDVGVLRPPAV-GG
MAV_2789|M.avium_104 ARFERTTR---------TTVSLIRTDDALGAVQQGRVDIALVRG-HV-TS
Mvan_3362|M.vanbaalenii_PYR-1 ARLMADFH-AEHPGVEITLGTDT-SDVLLAKLEDGRLDAAIVSIGADEDP
MSMEG_4025|M.smegmatis_MC2_155 MPATALAALTQAWRSTVIAIHQMSSVDQIELLERRELDIGLLRHRPV--T
TH_3504|M.thermoresistible__bu AYALIEPAVTAYPSTS-FTLRQLYPDALTDAVFDGTVQLGLRRGVVP--T
MAB_0993c|M.abscessus_ATCC_199 LQMRQKHP------DADIRATHLKWDEARAALLDHRVDAVVARLPFS--T
MLBr_02041|M.leprae_Br4923 LPTMLTGLTHRLPTLTLRVVEDQ-TEHLLTALREGALDAAMIALPVE--T
: : :
Mb0121|M.bovis_AF2122/97 DDVDLVPLYEEQY---VLLSPADMLPPGTSTLVWRDAAQLPLALLT--AD
Rv0117|M.tuberculosis_H37Rv DDVDLVPLYEEQY---VLLSPADMLPPGTSTLVWRDAAQLPLALLT--AD
MMAR_0317|M.marinum_M HDVDLVPLYEERY---VLLAPPEMLPPGVSTLSWLDAAQLPLALLS--SD
MUL_4805|M.ulcerans_Agy99 HDVDLVPLYEERY---VLLAPPEMLPPGVSTLSWLDAAQLPLALLS--SD
Mflv_1356|M.gilvum_PYR-GCK -DVATRTIAAEPL---VLAVSADHRLAAEPVVSLADLRSEPFIGYTG-QD
MAV_2789|M.avium_104 TAVRIVHLFDEPR---VAVCSVHSPLAKRAKLDWAEVPRWPLVINT----
Mvan_3362|M.vanbaalenii_PYR-1 AGLEYEVITDEAL---EAAVTAQHRLARRKSLSLKQLCEYPVISLP--AG
MSMEG_4025|M.smegmatis_MC2_155 SDLDATLVADEPLGAIVSAARAEQLCLPATDVDLEALGTLRWQGFARDSS
TH_3504|M.thermoresistible__bu PELATAVIGYHRVR---VAFVDSHPLAARESVDITELAREQVALWAPPGT
MAB_0993c|M.abscessus_ATCC_199 DQLHVTILYDEPR---VVLLPSDHPLAQHDSLTLADIANEPMPRIRN-AD
MLBr_02041|M.leprae_Br4923 AGIAEIPIYDEDF---VLALPPGHPLSGKRRVPTTALAQLPLLLLD--EG
: : . :
Mb0121|M.bovis_AF2122/97 MRDRQVIDAAFADHAVSAI---PQVETDSVASLFAQVATGNWASIVPHTW
Rv0117|M.tuberculosis_H37Rv MRDRQVIDAAFADHAVSAI---PQVETDSVASLFAQVATGNWASIVPHTW
MMAR_0317|M.marinum_M MRDRQIIDAAFADHAITVS---PQVETDSVASLFAQVATGNSASIVPHTW
MUL_4805|M.ulcerans_Agy99 MRDRQIIDAAFADHAITVS---PQVETDSVASLFAQVATGNSASIVPHTW
Mflv_1356|M.gilvum_PYR-GCK SAVNDAVTRSCRAAGFVPH---REHSAPGTAVLLALVAADLGVSVVPAS-
MAV_2789|M.avium_104 --ASGTTGPWSWPAGDGPE---TIVETTNFDEWIESVAADRGIGVIPDVA
Mvan_3362|M.vanbaalenii_PYR-1 TGLRSRLDDACAAAGLRPR---IAFEATSPLELADLARHGLGVAILPRSM
MSMEG_4025|M.smegmatis_MC2_155 PPWYDEVTATLRGFGVHVEPTPARPQETSAEFAYATVSLGNTFTLAPACC
TH_3504|M.thermoresistible__bu SYYSDFLMGACRRAGFEPD--YVVSRVQGAATVAAPLTTG-GIAFVTAAA
MAB_0993c|M.abscessus_ATCC_199 PSWSAYWRVEPRPDGSLAP---DGPVIDAIEDKFEVIASGQAISLSAGAH
MLBr_02041|M.leprae_Br4923 HCLRDQTLDICRKSGVQAEL--ANTRAASLATAVQCVTGGLGVTLLPQSA
. . . .
Mb0121|M.bovis_AF2122/97 LWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQ
Rv0117|M.tuberculosis_H37Rv LWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQ
MMAR_0317|M.marinum_M LWTTPAGG----EIRPVQLVSPVVKAQVALATSSTGPGSPVARALMTSAQ
MUL_4805|M.ulcerans_Agy99 LWTTPGR-------------------------------------------
Mflv_1356|M.gilvum_PYR-GCK VRALPLHGVVFRDLVDGGTVDLALAWRDGVDNPVVDAVVAVLAGALTSLD
MAV_2789|M.avium_104 IRRNVHPGVRFVALRDAPDIPVALAFVKRASG-------PVLRRFIEAAV
Mvan_3362|M.vanbaalenii_PYR-1 ARGS--AGLHPLRLSPELRGRLVWAWRTDISGPAARLLNARARAMIAATG
MSMEG_4025|M.smegmatis_MC2_155 RQTLPSALTWRRIAGDPLRRRTWAVWPATSRRRDVGELVALLEGAHDVEH
TH_3504|M.thermoresistible__bu GPTMN-GRVQVVDLTPPLLVPVQALWQRHTLS-------AIRDRILEGLG
MAB_0993c|M.abscessus_ATCC_199 GSTMR-PDIVAVPLEGVEPSHVAIATRADDRGRLVAAFRKVAQAVLTGPG
MLBr_02041|M.leprae_Br4923 APVESVRSKLGLAQFAAPCPGRRIGLAFRSASGRSASYRQIAKIIGELIS
Mb0121|M.bovis_AF2122/97 ALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv ALALNEFFDTQLRGITRRR
MMAR_0317|M.marinum_M GLALDEFFQTRLMEISRRR
MUL_4805|M.ulcerans_Agy99 -------------------
Mflv_1356|M.gilvum_PYR-GCK HPALQEQS-----------
MAV_2789|M.avium_104 DAAANQ-------------
Mvan_3362|M.vanbaalenii_PYR-1 TPAVIPGA-----------
MSMEG_4025|M.smegmatis_MC2_155 DTACVG-------------
TH_3504|M.thermoresistible__bu -------------------
MAB_0993c|M.abscessus_ATCC_199 -------------------
MLBr_02041|M.leprae_Br4923 TEHHVRLVA----------