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MSVSMISDSARTAAGARPGGEWWAREIELVDQLRGLRERAARELRGAVTLPAVEWDVPGRSAEAISALTH LCIDSLRRLSGGEVERAQRLCDLVLDLQRLAMDWYLHDTAMRSQRLAECAAGLSRLRGVPSSAALLDNAC QELVLRCGFHRAVLSKVESHGWKPLMLHDRSADAGDSWFSDWINQTVPLVRDAPEAEMMSRRRPSLVHDT DTAPVYRPLIVHAGRSRSYVVAPVLHGRDVVGFLHTDHHPLARRVDEADREVAWVFADGFSHLYERAVLL ERLRAQRESVRELFFGAVDRIDELCESGLDTPRGAEADRCGDTDGQTGRPPVTLTEREADVFDLMVTGAS NQEIADRLVITEGTVKSHVKHILRKYGAVNRAQAIAWALNGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0349 | - | - | 100% (392) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | 6e-47 | 38.72% (328) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_0348 | - | 1e-36 | 36.09% (327) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 3e-06 | 40.00% (55) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_5014 | - | 1e-08 | 45.76% (59) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3133c | devR | 3e-06 | 40.00% (55) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 5e-09 | 50.85% (59) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 3e-43 | 37.20% (328) | putative regulatory protein |
| M. avium 104 | MAV_5280 | - | 6e-08 | 45.59% (68) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0330 | - | 1e-121 | 57.22% (395) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 5e-43 | 37.50% (304) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 7e-43 | 37.42% (310) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0349|M.vanbaalenii_PYR-1 ------------------MSVSMISDSARTAAGARPGGEWWAREIELVDQ
MSMEG_0330|M.smegmatis_MC2_155 ------------------MSVLIGAESSRTAGTGRVRSDRLSKRTEFDER
MMAR_2876|M.marinum_M ----------------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
TH_4501|M.thermoresistible__bu ----------------MTIAGDVPDSGSDETLAG--HPGWASRPAAESDA
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_5014|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0349|M.vanbaalenii_PYR-1 LRGLRERAARELRGAVTLPAVEWDVPGRSAEAISALTHLCIDSLRRLSGG
MSMEG_0330|M.smegmatis_MC2_155 FSALRDRAAAVL-GTERPPALESGSPIRVGEVISDFSQLCVRRLQAVRSS
MMAR_2876|M.marinum_M TRHYREAFGDCNVDPTDDPMA------VVAEAIDVNAAAVRHALESLGD-
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMA------VVAEAIDVNAAAVRHALESQGD-
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMS------VVSEAIDTRANEVRNALETCGD-
MAB_1522|M.abscessus_ATCC_1997 -------------------------------------------MTD--TE
MAV_5280|M.avium_104 -------------------------------------------MTDPAPE
Mb3157c|M.bovis_AF2122/97 -------------------------------------------------M
Rv3133c|M.tuberculosis_H37Rv -------------------------------------------------M
Mflv_5014|M.gilvum_PYR-GCK ---------------------------------------------MSSEP
Mvan_0349|M.vanbaalenii_PYR-1 EVERAQRLCDLVLDLQRLAMDWYLHDTAMRSQRLAECAAGLSRLRGVPSS
MSMEG_0330|M.smegmatis_MC2_155 DTEAERQLGSLLLELQQLALDWYLFETGVRSQRLADCAVSLNRLRAMPTT
MMAR_2876|M.marinum_M --VHAVNALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDV
MUL_2876|M.ulcerans_Agy99 --VHAVNALETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDV
TH_4501|M.thermoresistible__bu --EEAIAALESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDDV
MAB_1522|M.abscessus_ATCC_1997 VGVLLVDDQELVRTG--LRRILRRKD------GFAIVGECADGSE-----
MAV_5280|M.avium_104 ITVLLVDDQDLVRSG--LRRILRRKD------GFVIVAECADGDE-----
Mb3157c|M.bovis_AF2122/97 VKVFLVDDHEVVRRG--LVDLLGADP------ELDVVGEAGSVAE-----
Rv3133c|M.tuberculosis_H37Rv VKVFLVDDHEVVRRG--LVDLLGADP------ELDVVGEAGSVAE-----
Mflv_5014|M.gilvum_PYR-GCK VRIVLVDDHEMVIEG--LKAMLAAFAD-----RVCVVGQSVGADQ-----
Mvan_0349|M.vanbaalenii_PYR-1 AALLDNACQELVLRCGFHRAVLSKVES-HGWKPLMLHDRSADAGDSWFSD
MSMEG_0330|M.smegmatis_MC2_155 AALLDNACHELVFRLGFRRAVLSTVDT-RGWTPMILLDRTEPADRGWFSN
MMAR_2876|M.marinum_M AMIVDRAPRELVESCGFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAF
MUL_2876|M.ulcerans_Agy99 AMIVDRAPRELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAF
TH_4501|M.thermoresistible__bu ATIVDRAPRELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAF
:. :::* :* .
MAB_1522|M.abscessus_ATCC_1997 ---VAAAVSRARPDVVIMDLR----MKQMSGIEAIRLLHAAQ-GPPALAL
MAV_5280|M.avium_104 ---VPAAVAAHRPDVVVMDLR----MRRVDGIEATRRLGGR---PPVLAL
Mb3157c|M.bovis_AF2122/97 ---AMARVPAARPDVAVLDVR----LPDGNGIELCRDLLSRMPDLRCLIL
Rv3133c|M.tuberculosis_H37Rv ---AMARVPAARPDVAVLDVR----LPDGNGIELCRDLLSRMPDLRCLIL
Mflv_5014|M.gilvum_PYR-GCK ---VMGVVTDLDPDIVLCDVR----MQGSSGLDVCQQLRRRDPDRKIVML
Mvan_0349|M.vanbaalenii_PYR-1 WINQTVPLVRDAPEAEMMSRRRPSLVHDTDTAPVYRPLIVHAGRSRSYVV
MSMEG_0330|M.smegmatis_MC2_155 WQNQTVPLVQTTPEALSLSRRRPCLIEDTTDAPVYRPLIVHAGQSRSYVV
MMAR_2876|M.marinum_M AQSVAPLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVA
MUL_2876|M.ulcerans_Agy99 AQSVAPLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVA
TH_4501|M.thermoresistible__bu AQSVAPPLDHMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVA
: : : : .
MAB_1522|M.abscessus_ATCC_1997 TTFDDDELLSGALRAG---------------------AAGFILKDSPAEE
MAV_5280|M.avium_104 TTFNEDELLSGALRAG---------------------AAGFVLKDSSAEE
Mb3157c|M.bovis_AF2122/97 TSYTSDEAMLDAILAG---------------------ASGYVVKDIKGME
Rv3133c|M.tuberculosis_H37Rv TSYTSDEAMLDAILAG---------------------ASGYVVKDIKGME
Mflv_5014|M.gilvum_PYR-GCK SVYDDEQYLFQAMRVG---------------------ASGYLLKSISSED
Mvan_0349|M.vanbaalenii_PYR-1 APVLHGRDVVGFLHTDHHPLARRVDEADREVAWVFADGFSHLYERAVLLE
MSMEG_0330|M.smegmatis_MC2_155 APLVQSGDVMGFLHTDHYPENTPVDEADRDVLWAFADGFSHIYQRAALLE
MMAR_2876|M.marinum_M APVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLE
MUL_2876|M.ulcerans_Agy99 APVMPTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLE
TH_4501|M.thermoresistible__bu APVMPTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLE
: : : .. . .. : :
MAB_1522|M.abscessus_ATCC_1997 LVRAVHAVARGEAYLDPAVTSRVLNAYRRAPAAVSGD-------------
MAV_5280|M.avium_104 LIRAVRAVARGEGYLDPAVTSRVLTTYRKAAPGPHGA-------------
Mb3157c|M.bovis_AF2122/97 LARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQD---------------
Rv3133c|M.tuberculosis_H37Rv LARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQD---------------
Mflv_5014|M.gilvum_PYR-GCK LVEQLESVHSGKTAIDPTMAAR-------AVEWPG---------------
Mvan_0349|M.vanbaalenii_PYR-1 RLRAQRESVRELFFGAVDRIDELCESGLDTPRGAEAD-RCGDTDGQTG-R
MSMEG_0330|M.smegmatis_MC2_155 NLRRQRDHIRDLLISTVDQIDELCDVSVEATAWADENGQTADDDATTGAR
MMAR_2876|M.marinum_M RMRRQHAEVRSALASADEAARALQDADLDLRKIEPVE-RSPAARSLAEVQ
MUL_2876|M.ulcerans_Agy99 RMRRQHAEVRSALASADEAARALQDADLDLRKIEPVE-RSPAARSLAEVQ
TH_4501|M.thermoresistible__bu RMRRLQAEVRNALASADEAARALQDADLDLRKIEPQE-RSPAARSLAEVH
. .
MAB_1522|M.abscessus_ATCC_1997 --AQDKLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIGRIFVKLD
MAV_5280|M.avium_104 --AIAELTTRERDVLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLD
Mb3157c|M.bovis_AF2122/97 --PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLG
Rv3133c|M.tuberculosis_H37Rv --PLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLG
Mflv_5014|M.gilvum_PYR-GCK --ARQGLTQRESEILALVVNGLSNRAIAAKLIIGDETVKTHLSSIYRKLG
Mvan_0349|M.vanbaalenii_PYR-1 PP--VTLTEREADVFDLMVTGASNQEIADRLVITEGTVKSHVKHILRKYG
MSMEG_0330|M.smegmatis_MC2_155 PPHRVELTERESEVLRLMVTGASNHEIAEQLVITEGTVKSHVKHILRKYG
MMAR_2876|M.marinum_M TRAMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLH
MUL_2876|M.ulcerans_Agy99 TRVMAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLH
TH_4501|M.thermoresistible__bu TRVMAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVKRVLRKLH
** :* :: *: * :* ** .: : ***.:: : *
MAB_1522|M.abscessus_ATCC_1997 LRDRAAAIVYAYDHGIVTPK----
MAV_5280|M.avium_104 LRDRAAAIVYAYDNGIVAPR----
Mb3157c|M.bovis_AF2122/97 MERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv MERRTQAAVFATELKRSRPPGDGP
Mflv_5014|M.gilvum_PYR-GCK VSDRTAAVATALREGIFQ------
Mvan_0349|M.vanbaalenii_PYR-1 AVNRAQAIAWALNGG---------
MSMEG_0330|M.smegmatis_MC2_155 AVNRAQAIAWALQGT---------
MMAR_2876|M.marinum_M ATNRAEAASAYVRLASVPEVG---
MUL_2876|M.ulcerans_Agy99 ATNRAEAASAYVRLASVSEVG---
TH_4501|M.thermoresistible__bu ATNRAEAASAYVRLASVPEVG---
*: *