For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTTKERPIGTELLSRSSSAVATTLLSEKAFAAGRATHRDLASPGEQISAALDALLASLDEVRQATSPAET LECAPRALATSAVFQRVMLSRVSGSTWLPDAVYGVDGQRRRDVRFECYPDERLEDLQIPLASPLVEAEVV RRRLPALVSDAHHETRVHPPLIERMQAGEYVVAPITAGSTVLGLLHASRPTDGRPLTTAHRDLLRMFADG VGLSYEHALLVERIERQRRYVLDACDSAVRSAAGTDLTTPIPLRPRPFRTNTVVSTQTSFTQTSQRRESS RLTILTSREREVLALLASGATNAQLADQLTVAESTVKSHVKHILHKLGASNRAAAISFYLRETRGRSRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0331 | - | - | 100% (350) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_0330 | - | 7e-32 | 31.88% (298) | transcriptional regulator, LuxR family protein |
| M. smegmatis MC2 155 | MSMEG_1082 | - | 4e-11 | 40.51% (79) | putative response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0867c | narL | 4e-09 | 42.65% (68) | nitrate/nitrite response transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0730 | - | 2e-09 | 44.78% (67) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0844c | narL | 4e-09 | 42.65% (68) | nitrate/nitrite response transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 4e-11 | 57.41% (54) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 9e-37 | 35.12% (299) | putative regulatory protein |
| M. avium 104 | MAV_5280 | - | 3e-09 | 38.03% (71) | two-component system response regulator |
| M. thermoresistible (build 8) | TH_4501 | - | 5e-38 | 34.73% (311) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 1e-36 | 34.78% (299) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0348 | - | 3e-73 | 50.30% (334) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0331|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0348|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2876|M.marinum_M ----------------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
TH_4501|M.thermoresistible__bu ----------------MTIAGDVPDSGSDETLAG--HPGWASRPAAESDA
Mb0867c|M.bovis_AF2122/97 --------------------------------------------------
Rv0844c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
MSMEG_0331|M.smegmatis_MC2_155 -----------------------MMTTKERPIGTELLSRSSSAVATTLLS
Mvan_0348|M.vanbaalenii_PYR-1 -----------------------MVPGN---------------VGFAEMA
MMAR_2876|M.marinum_M TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESLGDVHAVNAL
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESQGDVHAVNAL
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMSVVSEAIDTRANEVRNALETCGDEEAIAAL
Mb0867c|M.bovis_AF2122/97 --------------------------------------------MSNPQP
Rv0844c|M.tuberculosis_H37Rv --------------------------------------------MSNPQP
Mflv_0730|M.gilvum_PYR-GCK --------------------------------------------MTGPG-
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------MTD---
MAV_5280|M.avium_104 --------------------------------------------MTDPA-
MSMEG_0331|M.smegmatis_MC2_155 EKAFAAGRATHRDLASPGEQISAALDALLASLDEVRQATSPAETLECAPR
Mvan_0348|M.vanbaalenii_PYR-1 DRLADASAASQRMMTATAERAGRDLGGVLNALALLRENTAVPDVLQQAGL
MMAR_2876|M.marinum_M ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
MUL_2876|M.ulcerans_Agy99 ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
TH_4501|M.thermoresistible__bu ESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDDVATIVDRAPR
Mb0867c|M.bovis_AF2122/97 EKVRVVVGDDHPLFREGVVR----ALSLSGSVNVVGEADDGAAALELIKA
Rv0844c|M.tuberculosis_H37Rv EKVRVVVGDDHPLFREGVVR----ALSLSGSVNVVGEADDGAAALELIKA
Mflv_0730|M.gilvum_PYR-GCK -RVRVVVGDDHPMFRDGVVR----ALQSSGAIDVVAEADDGTAALAAIRE
MAB_1522|M.abscessus_ATCC_1997 TEVGVLLVDDQELVRTGLRR----ILRRKDGFAIVGECADGSEVAAAVSR
MAV_5280|M.avium_104 PEITVLLVDDQDLVRSGLRR----ILRRKDGFVIVAECADGDEVPAAVAA
: . : .. :
MSMEG_0331|M.smegmatis_MC2_155 ALATSAVFQRVMLSRVSGSTWLPDAVYGVDGQRRRDVRFECYPDERLEDL
Mvan_0348|M.vanbaalenii_PYR-1 EVCRTAVFDWVMVSRVAGSTWRPVVRYEMGADGRVTVDVDES-GCGVDTS
MMAR_2876|M.marinum_M ELVESCGFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFA-----QSV
MUL_2876|M.ulcerans_Agy99 ELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFA-----QSV
TH_4501|M.thermoresistible__bu ELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFA-----QSV
Mb0867c|M.bovis_AF2122/97 HLPDVALLDYRMPGMDGAQVPAAVRSYELPTRVLLISAHDEP--------
Rv0844c|M.tuberculosis_H37Rv HLPDVALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEP--------
Mflv_0730|M.gilvum_PYR-GCK HRPAVALLDYRMPGMDGAEVAAAVQRGALPTRVLLISAHDES--------
MAB_1522|M.abscessus_ATCC_1997 ARPDVVIMDLRMKQMSGIEAIRLLHAAQGPPALALTTFDDD---------
MAV_5280|M.avium_104 HRPDVVVMDLRMRRVDGIEATRRLGGR--PPVLALTTFNED---------
:: :
MSMEG_0331|M.smegmatis_MC2_155 QIPLASPLVEAEVVRRRLPALVSDAHHETRVHPPLIERMQAGEYVVAPIT
Mvan_0348|M.vanbaalenii_PYR-1 DIPLMSPLVEAEVVRRRLPALVLDAGHEPRVHRPLVDRAGTTQYVVAPVV
MMAR_2876|M.marinum_M APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
MUL_2876|M.ulcerans_Agy99 APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
TH_4501|M.thermoresistible__bu APPLDHMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVM
Mb0867c|M.bovis_AF2122/97 -------AIVYQALQQGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLV
Rv0844c|M.tuberculosis_H37Rv -------AIVYQALQQGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLV
Mflv_0730|M.gilvum_PYR-GCK -------AIVYRALADGAAGFLPKESTRNELITAVLDCAKGRDVVAPSLA
MAB_1522|M.abscessus_ATCC_1997 -------ELLSGALRAGAAGFILKDSPAEELVRAVHAVARGEAYLDPAVT
MAV_5280|M.avium_104 -------ELLSGALRAGAAGFVLKDSSAEELIRAVRAVARGEGYLDPAVT
: : ..:: . .: .: : ..:
MSMEG_0331|M.smegmatis_MC2_155 AGSTVLGLLHASRPTDGRPLTTAHRDLLRMFADGVGLSYEHALLVERIER
Mvan_0348|M.vanbaalenii_PYR-1 VEGAVIGLIHASSAAPGRVLTDLDRDLLRMFADGVGLVYERAALAERSER
MMAR_2876|M.marinum_M PTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
MUL_2876|M.ulcerans_Agy99 PTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
TH_4501|M.thermoresistible__bu PTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
Mb0867c|M.bovis_AF2122/97 GG-----------------------------------------LAGEIRQ
Rv0844c|M.tuberculosis_H37Rv GG-----------------------------------------LAGEIRQ
Mflv_0730|M.gilvum_PYR-GCK AG-----------------------------------------LAGEIRR
MAB_1522|M.abscessus_ATCC_1997 SR-----------------------------------------VLNAYRR
MAV_5280|M.avium_104 SR-----------------------------------------VLTTYRK
: .:
MSMEG_0331|M.smegmatis_MC2_155 QRRYVLDACDSAVRSAAGTDLTTPIPLRPRP-FRTNTVVSTQTSFTQTSQ
Mvan_0348|M.vanbaalenii_PYR-1 QRCAVTEVCDAAVRSFDEVNPIAAFGLGSEPGLVSPDGDSVPAPFAGICE
MMAR_2876|M.marinum_M QHAEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRA--
MUL_2876|M.ulcerans_Agy99 QHAEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRV--
TH_4501|M.thermoresistible__bu LQAEVRNALASADEAARALQDADLDLRKIEPQERSPAARSLAEVHTRV--
Mb0867c|M.bovis_AF2122/97 RAAPVA--------------------------------------------
Rv0844c|M.tuberculosis_H37Rv RAAPVA--------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK RAEPEG--------------------------------------------
MAB_1522|M.abscessus_ATCC_1997 APAAVSGDAQ----------------------------------------
MAV_5280|M.avium_104 AAPGPHGAAI----------------------------------------
MSMEG_0331|M.smegmatis_MC2_155 RRES----SRLTILTSREREVLALLASGATNAQLADQLTVAESTVKSHVK
Mvan_0348|M.vanbaalenii_PYR-1 SRGAGRGGTRLARLTAREREVLALLASGATNAQLADRLTVAESTVKSHVK
MMAR_2876|M.marinum_M ----------MAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVK
MUL_2876|M.ulcerans_Agy99 ----------MAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVK
TH_4501|M.thermoresistible__bu ----------MAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVK
Mb0867c|M.bovis_AF2122/97 -----------PVLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQ
Rv0844c|M.tuberculosis_H37Rv -----------PVLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQ
Mflv_0730|M.gilvum_PYR-GCK -----------PALSPREREVLVLIAAGSTIPAMARELFLAPSTVKTHVQ
MAB_1522|M.abscessus_ATCC_1997 -----------DKLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIG
MAV_5280|M.avium_104 -----------AELTTRERDVLTLIGKGLSNSEIADELCISGVTVKSHIG
*: ** :** :. * : :* .* :: ***:*:
MSMEG_0331|M.smegmatis_MC2_155 HILHKLGASNRAAAISFYLRETRGRSRS--
Mvan_0348|M.vanbaalenii_PYR-1 HILHKLGAGNRAAAIACYLRESPDRERQRR
MMAR_2876|M.marinum_M RVLRKLHATNRAEAASAYVRLASVPEVG--
MUL_2876|M.ulcerans_Agy99 RVLRKLHATNRAEAASAYVRLASVSEVG--
TH_4501|M.thermoresistible__bu RVLRKLHATNRAEAASAYVRLASVPEVG--
Mb0867c|M.bovis_AF2122/97 RLYEKLGVSDRAAAVAEAMRQRLLD-----
Rv0844c|M.tuberculosis_H37Rv RLYEKLGVSDRAAAVAEAMRQRLLD-----
Mflv_0730|M.gilvum_PYR-GCK RLYEKLGVSDRGAAVAEAMRRKLLD-----
MAB_1522|M.abscessus_ATCC_1997 RIFVKLDLRDRAAAIVYAYDHGIVTPK---
MAV_5280|M.avium_104 RIFGKLDLRDRAAAIVYAYDNGIVAPR---
:: ** :*. *