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M. smegmatis MC2 155 MSMEG_0228 (-)

annotation: adenylate and guanylate cyclase catalytic domain-containing protein
coordinates: 254330 - 257482
length: 1050

MVACGTCGTELRQGARFCDSCGTAIVDGSKHAEYKQVTVLFADVVDSMRLAAAVGAERLREILSALVSRC
SGVVGHYGGTVDKFTGDGIMALFGAPLALEDHALRACLAALDLQYESHRLADELDLPAGVGLQIRVGLNS
GQVIAGEMSAGGFGYTAIGEQVGMAQRMESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDRPVAA
RRLLAATNAAHGGRSDPTLVGRSWELNTIAGLLDEAVEGRGGIVSVVGPPGIGKSRMVRESIELARRRGV
AVFYTYCESHASDVPFHVVVPLLREGFGVAGLDPAAARVRVRSLVPDADPEDLLLLDDVLGIADPDVPMP
DLDADARRRRVAALVNAASLARREPGLYVLEDAHWIDEVSESMLAEFLTVVTHTHSVMLITYRPEYTGVL
ARVSGAQTIALRPLTDGQTSTLLTELLGPDAAAHQLAGLIADRAAGNPFFTQEIVRDLAERGVLRGERGA
YRFHGADVEIGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGADVSMQALIDAELVDQ
VMFAPRPEYAFRHPLIRMVALESQLKSDRAELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFT
WHMRAGTWLTNRDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTWRAGGHLSDTGFDELCA
LAAAADDKVSLATAMAGQVSALLVHAHYRESSSLASELTSLLESVGDRRLTVALLFAALGAKFQTGEANE
VVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLGDPDWRTGLDRATPLVRDFGITTRALMLT
YKCIGLPTGLLLPSPELLEESCEVLEVAQRSADDLALAGAQVSRGLLLLWQGGPYRDEALELLSLGREAS
VREQFTMAAVPAVDTELARDMAARGDLDGAIELARDVVDTSIDSGEAINMSASVTVLVQSLIARGDRDDL
DHAQRVIDRFAALPTDPGFVLYDVQLMRLRALLARARGDEERYRECSDRYRELATAYRYEGHMALAARMA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_0228--100% (1050)adenylate and guanylate cyclase catalytic domain-containing protein
M. smegmatis MC2 155MSMEG_4431-2e-2227.53% (385) putative regulatory protein
M. smegmatis MC2 155MSMEG_1963-9e-2024.79% (605) putative transcriptional regulatory protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1651ccya6e-1531.58% (171) membrane-anchored adenylyl cyclase Cya (ATP
M. gilvum PYR-GCKMflv_1156-5e-1421.89% (804) regulatory protein, LuxR
M. tuberculosis H37RvRv1625ccya6e-1531.58% (171) membrane-anchored adenylyl cyclase Cya (ATP
M. leprae Br4923MLBr_02341-0.060.95% (717) putative regulatory protein
M. abscessus ATCC 19977MAB_3361-2e-1323.87% (750) LuxR family transcriptional regulator
M. marinum MMMAR_5257-0.052.94% (1054) membrane-anchored adenylyl cyclase
M. avium 104MAV_4804-4e-1527.64% (351) GAF domain-containing protein
M. thermoresistible (build 8)TH_3225-1e-1425.92% (490) PUTATIVE regulatory protein, LuxR
M. ulcerans Agy99MUL_3594-6e-1831.25% (192) adenylylate/guanylate cyclase
M. vanbaalenii PYR-1Mvan_1904-0.041.32% (1014) adenylyl cyclase class-3/4/guanylyl cyclase

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_02341|M.leprae_Br4923          --------MTTALVCVACGAELRSIAKFCDECGSPVVEAETP-AEYKQVT
MMAR_5257|M.marinum_M               --------MTPVLACRSCGTQPLENARFCHGCGAPVAAAADAHAEYKQVT
MSMEG_0228|M.smegmatis_MC2_155      -----------MVACGTCGTELRQGARFCDSCGTAIVDGSKH-AEYKQVT
Mvan_1904|M.vanbaalenii_PYR-1       ------------------------------------------------MT
MAB_3361|M.abscessus_ATCC_1997      -----------------------------------MLRGQAGVGKTALLR
TH_3225|M.thermoresistible__bu      MSSRDGDVVLHGRAAEIATLRDVMSTARAGSSRVLVLHGEAGVGKTALLG
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          ----------------MKAVDDFLAGLQQLQPAGLLIEGEAGIGKTTMLA
MAV_4804|M.avium_104                --MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMK
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          -VLFADVVGSMDIAAAVGLERLREIMTELVSRAAG-VIERYGGTVDKFTG
MMAR_5257|M.marinum_M               -VLFADVVHSMDIAAALGAERLREIMTELVNRAAV-VVQRYGGTVDKFTG
MSMEG_0228|M.smegmatis_MC2_155      -VLFADVVDSMRLAAAVGAERLREILSALVSRCSG-VVGHYGGTVDKFTG
Mvan_1904|M.vanbaalenii_PYR-1       -VLFADVVGSMRLAAELDPERLREIMNDLFNRSAT-VVQRYHGTMDKFTG
MAB_3361|M.abscessus_ATCC_1997      -YVLGKASG-QLIAQASGIQSEMELAFAGLQQFCA-PLTKYSGAIPDPQR
TH_3225|M.thermoresistible__bu      -QLLGDAAG-MRCVQVAGVESDMELAYAGLHQLCA-PLLDRLDDLPSPQR
Mb1651c|M.bovis_AF2122/97           ----------------------------MRTQARA-PTQHYAESVAR---
Rv1625c|M.tuberculosis_H37Rv        ---MAARKCGAPPIAADGSTRRPDCVTAVRTQARA-PTQHYAESVAR---
Mflv_1156|M.gilvum_PYR-GCK          GVVDAARQAGFRVLSAHGDQSGSGLAHAAIADLFAGVQTDILDGLPELQR
MAV_4804|M.avium_104                -AFGVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERD
MUL_3594|M.ulcerans_Agy99           -------------MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ---
                                                                                      

MLBr_02341|M.leprae_Br4923          DGIMAIF--------------------------GAPTALEDHALRACLAA
MMAR_5257|M.marinum_M               DGIMAVF--------------------------GAPAALEDHALRACLAA
MSMEG_0228|M.smegmatis_MC2_155      DGIMALF--------------------------GAPLALEDHALRACLAA
Mvan_1904|M.vanbaalenii_PYR-1       DGLMALF--------------------------GAPMALEDHALRACIAA
MAB_3361|M.abscessus_ATCC_1997      EALTIAF--------------------------GTRSGPPPDRFLIGLAV
TH_3225|M.thermoresistible__bu      DVLNVAF--------------------------GRGAGPAPGRFLVGLAV
Mb1651c|M.bovis_AF2122/97           ----------------------------------------RQRVLTITAW
Rv1625c|M.tuberculosis_H37Rv        ----------------------------------------RQRVLTITAW
Mflv_1156|M.gilvum_PYR-GCK          RAADGVLR------------------------RGDGTGGPTDERVIAAAL
MAV_4804|M.avium_104                RWRADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAA
MUL_3594|M.ulcerans_Agy99           ---------------------------------------PPVRLLVVDDA
                                                                                      

MLBr_02341|M.leprae_Br4923          LGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGV
MMAR_5257|M.marinum_M               LGVQDEAKRLAGEVDRRDGVVLQLRVGLNSGQVVAGEIGTGALGYTAVGE
MSMEG_0228|M.smegmatis_MC2_155      LDLQYESHRLADELDLPAGVGLQIRVGLNSGQVIAGEMSAGGFGYTAIGE
Mvan_1904|M.vanbaalenii_PYR-1       LEIQAVVGELADEVEQRDGVRLQLRVGLNSGDVVVGDIGSGPGRYTAIGH
MAB_3361|M.abscessus_ATCC_1997      LSLLAAAAEHQPVLCVIDDAQWLDRVSLQTLAFVTRRLGSEP-VAMLFAV
TH_3225|M.thermoresistible__bu      LNLLAAAGADQPLLCVIDDAQWLDRVSLQTLGFVARRLMAEP-VAMVFAL
Mb1651c|M.bovis_AF2122/97           LAVVVTGSFALMQLATGAGGWYIALINVFT--------------------
Rv1625c|M.tuberculosis_H37Rv        LAVVVTGSFALMQLATGAGGWYIALINVFT--------------------
Mflv_1156|M.gilvum_PYR-GCK          LGAVHGSATRTPVLVAVDDVQWLDPSSVAVLAFVARRVKGR--VGFVVAE
MAV_4804|M.avium_104                TRLLSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRA
MUL_3594|M.ulcerans_Agy99           DGVETLFGARFRTELRCDEYDLSFSN------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          ----QVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAED
MMAR_5257|M.marinum_M               ----QVGLAQRMEAVAAPETVMLGESTARLVEGAAVLGEPQLVHIKGVEA
MSMEG_0228|M.smegmatis_MC2_155      ----QVGMAQRMESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDR
Mvan_1904|M.vanbaalenii_PYR-1       ----AVGMAQRMEAAASAGAVVCSLSTADLVEHATRLGAVQTVRIKGSDE
MAB_3361|M.abscessus_ATCC_1997      ----RDGTDSELAGLPELTVHGLRAADAGTLLDSVIPG---LLDERVRDR
TH_3225|M.thermoresistible__bu      ----RDDIHEALVGVPALAVPGLADADARTLLEHMFPG---AIDANVRDR
Mb1651c|M.bovis_AF2122/97           --------------AVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWD
Rv1625c|M.tuberculosis_H37Rv        --------------AVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWD
Mflv_1156|M.gilvum_PYR-GCK          ----RPGVGPGLPAATWLQVG--TGALTRLPVAPMSLGALHTMLSSRLGR
MAV_4804|M.avium_104                GGFDPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEFH
MUL_3594|M.ulcerans_Agy99           ---------------DPVQALKMVGDSPDIEVLVTNLNMPQMNGLDLLTE
                                                                                      

MLBr_02341|M.leprae_Br4923          AVPARRLLRVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVG
MMAR_5257|M.marinum_M               AVPAWQLLGVVDQYWQSGPAPATLVGREWELDTLTTMLDRSIAGRGSVVT
MSMEG_0228|M.smegmatis_MC2_155      PVAARRLLAATNAAHG-GRSDPTLVGRSWELNTIAGLLDEAVEGRGGIVS
Mvan_1904|M.vanbaalenii_PYR-1       PAPARRLVAVEAARMVVGRNEGLMLGRDGELHQLCDSLDRRR--RRHLVS
MAB_3361|M.abscessus_ATCC_1997      IVAETQGNPLALLELPRDMTAEELAG------------GFGWPDGGRLAG
TH_3225|M.thermoresistible__bu      LVAESRGNPLALLEVPRTYAVGELAG------------GFVSPGAGSAPS
Mb1651c|M.bovis_AF2122/97           VGTDAG--------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        VGTDAG--------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          RFSRPQIVRIAEVSGGNPLYALELAR---------VADGAGSRPGQRLPE
MAV_4804|M.avium_104                HRTGGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAAE
MUL_3594|M.ulcerans_Agy99           VAKLGR--------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          LVGPAGIGKTRLVAEAVQLAKGLE----------VEVFSVFCESHATDVA
MMAR_5257|M.marinum_M               LVGRAGIGKTRLAREAAQVAKNLG----------VTVFSTFCESHATDIP
MSMEG_0228|M.smegmatis_MC2_155      VVGPPGIGKSRMVRESIELARRRG----------VAVFYTYCESHASDVP
Mvan_1904|M.vanbaalenii_PYR-1       VVGAPGVGKSRLVEEFCRRLRGAG----------TEVVLAGCDAHAMPIA
MAB_3361|M.abscessus_ATCC_1997      QIEQTFLRRVQQLPAHTQTLLLAA----------ATDPLGDVTLLARAAQ
TH_3225|M.thermoresistible__bu      RIEENYVHRIRALPAQTRRLLLIA----------AAEPIGDSALFLRAAA
Mb1651c|M.bovis_AF2122/97           -------AQFFFLVAAALVVLLVG----------IEHTALAVGLAAVAAG
Rv1625c|M.tuberculosis_H37Rv        -------AQFFFLVAAALVVLLVG----------IEHTALAVGLAAVAAG
Mflv_1156|M.gilvum_PYR-GCK          SLSELVRLRVDGLAEDVRDVLLVA----------ASATSPTVDLLAKAVG
MAV_4804|M.avium_104                FLGRYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWAC
MUL_3594|M.ulcerans_Agy99           -------PLKTIVLTACNDLANIR----------AAMMRGAFDFQLTPLD
                                                                                      

MLBr_02341|M.leprae_Br4923          FDVVAQLVRAVAQISG--LDDRSARARVREQIPDADTQDLLL-LDDLLGI
MMAR_5257|M.marinum_M               FRAVTRLLRAAAQVSR--LDDATARVRVRAIVPDGDPQDLLL-LYDLLGI
MSMEG_0228|M.smegmatis_MC2_155      FHVVVPLLREGFGVAG--LDPAAARVRVRSLVPDADPEDLLL-LDDVLGI
Mvan_1904|M.vanbaalenii_PYR-1       FRALSRLLRAMFSADD--LGDDDARELVLSQVPMG-STDAQI-IFEAMGI
MAB_3361|M.abscessus_ATCC_1997      QLGIPMHAIAPAEAAD--LVELSTRVRFRHPLVRSAVYISAN-PLERRRI
TH_3225|M.thermoresistible__bu      LMGIAVDALAPAEAAR--VIQFGPRMRFFHPLMRSAAYRAAD-PRDRRAV
Mb1651c|M.bovis_AF2122/97           LVIALEFLVPPDTGLQ--PPWAMSVSFVLTTVSACGVAVATV-WFALRDT
Rv1625c|M.tuberculosis_H37Rv        LVIALEFLVPPDTGLQ--PPWAMSVSFVLTTVSACGVAVATV-WFALRDT
Mflv_1156|M.gilvum_PYR-GCK          VTPAAVTGLVEAAEVEGIVVIDGNRIRFTHPVLANGIYAGAD-PQRRREV
MAV_4804|M.avium_104                LELRLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLS-PDEMRAV
MUL_3594|M.ulcerans_Agy99           LEDLRVTISKAVTIVRELQAGEAARQRALELADQNRRVENIFGRYVSEEV
                                                                                      

MLBr_02341|M.leprae_Br4923          ADPAVELPRLDPDARRRRLTALINVAQLALSRPAV-------FVVEDVHW
MMAR_5257|M.marinum_M               ADPQVELPKIAPEARRRRLTALINAVQLARAQPAV-------YVIEDAHW
MSMEG_0228|M.smegmatis_MC2_155      ADPDVPMPDLDADARRRRVAALVNAASLARREPGL-------YVLEDAHW
Mvan_1904|M.vanbaalenii_PYR-1       ADGAAPPLHVGADGRRHRLVETMAQFVRLRSTPMV-------LVLEDAHW
MAB_3361|M.abscessus_ATCC_1997      HGVLAGATDPGADPDRRAWHRAHAAAGTDEAIAWE-------LEQSAGRA
TH_3225|M.thermoresistible__bu      HRALAEATDPGADPDRRAWHAANGVTGTDDAVAAE-------LEKSAARA
Mb1651c|M.bovis_AF2122/97           ARAEAVMEAEHDRSEALLANMLPASIAERLKEPER-------NIIADKYD
Rv1625c|M.tuberculosis_H37Rv        ARAEAVMEAEHDRSEALLANMLPASIAERLKEPER-------NIIADKYD
Mflv_1156|M.gilvum_PYR-GCK          HR---RLADLKTDPELRARHLALASTVADETTLTT-------LDAAADAA
MAV_4804|M.avium_104                HLRIGRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQA
MUL_3594|M.ulcerans_Agy99           KTHLLACPEGHQNSERRTLTMLMADIRGFTRLSEILS---PERALQVLNA
                                                                                      

MLBr_02341|M.leprae_Br4923          IDEVSDSMLADFLAVIPQTRSMA------LVTYRPEYHGALRHVVGAQII
MMAR_5257|M.marinum_M               MDEASESMVAEFLTVIPQTHSMV------LVTYRPDYRGALRGVRGAQSI
MSMEG_0228|M.smegmatis_MC2_155      IDEVSESMLAEFLTVVTHTHSVM------LITYRPEYTGVLARVSGAQTI
Mvan_1904|M.vanbaalenii_PYR-1       IDAASEAVLCEFATVLERTSTVL------VTTCRPEYRGGLRKRS-AHTV
MAB_3361|M.abscessus_ATCC_1997      QAKGGVLAAAAFLQRATELTADP------AARGRRALAAAQSKYDAAAFD
TH_3225|M.thermoresistible__bu      QQRGGIAATATFLERAVVLTADP------GLRGRRALAAAQAKRDAADSA
Mb1651c|M.bovis_AF2122/97           EASVLFADIVGFTERASSTAPAD------LVRFLDRLYSAFDELVDQHGL
Rv1625c|M.tuberculosis_H37Rv        EASVLFADIVGFTERASSTAPAD------LVRFLDRLYSAFDELVDQHGL
Mflv_1156|M.gilvum_PYR-GCK          RARGAPAAAAELLEWAMQLGGDS------VSR---RIRAAEHHVVAGDMR
MAV_4804|M.avium_104                RAQASFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVP
MUL_3594|M.ulcerans_Agy99           YLERATDVVIRWNGTINEILGDG------LLVFFGVPNTDGEAAEHAVAA
                                                                                      

MLBr_02341|M.leprae_Br4923          AVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITRELA
MMAR_5257|M.marinum_M               ALGPLSDAETSALIAELLGPAPSVAQIAEIIATRAAGNPFFAEEIIRELA
MSMEG_0228|M.smegmatis_MC2_155      ALRPLTDGQTSTLLTELLGPDAAAHQLAGLIADRAAGNPFFTQEIVRDLA
Mvan_1904|M.vanbaalenii_PYR-1       TVAPLNDSLTMDLVLNLLGGDGAMGGLASRIVGVAAGNPYFVEEIVRDLV
MAB_3361|M.abscessus_ATCC_1997      AARELLGVADMTPLDPLARARATRLRAKIAFAESRVG------AFGSVTV
TH_3225|M.thermoresistible__bu      AAHDLLAIAERAPLSALEWARAVHLRAQLEFARSRAG------DAGGPPV
Mb1651c|M.bovis_AF2122/97           EKIKVS--------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        EKIKVS--------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          RAATLLEQALVDLRPGVLCAIALNLLAGVRMVEDDYIR------------
MAV_4804|M.avium_104                VLNTLLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDEL
MUL_3594|M.ulcerans_Agy99           ALELQLAMGELNVSHREQGLPELGIGIGVHTGEAVVG-------------
                                                                                      

MLBr_02341|M.leprae_Br4923          ERGVLTGERGRYACSTDVAE------------------------------
MMAR_5257|M.marinum_M               ERRVLVGERGRYTCTAEADD------------------------------
MSMEG_0228|M.smegmatis_MC2_155      ERGVLRGERGAYRFHGADVE------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       GRGVLAGSRGDYRLIRDVDD------------------------------
MAB_3361|M.abscessus_ATCC_1997      SEAAIGLVEAARCLENLDDN------------------------------
TH_3225|M.thermoresistible__bu      GQTAAALLTAAQLLQDVDAP------------------------------
Mb1651c|M.bovis_AF2122/97           ---------GDSYMVVSGVP------------------------------
Rv1625c|M.tuberculosis_H37Rv        ---------GDSYMVVSGVP------------------------------
Mflv_1156|M.gilvum_PYR-GCK          ----AVELLERARADADNDA------------------------------
MAV_4804|M.avium_104                GERVATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPIL
MUL_3594|M.ulcerans_Agy99           ----TIGSPRRQKYTAIGKN------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------VCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLA
MMAR_5257|M.marinum_M               --------AIVPATLQATIGARIDRLSPAAKQTLSAAAVIGSRFSTELLI
MSMEG_0228|M.smegmatis_MC2_155      --------IGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLA
Mvan_1904|M.vanbaalenii_PYR-1       --------IGVPVTVQAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQ
MAB_3361|M.abscessus_ATCC_1997      --------LARETYLDAVGAAMYGGRLCPRGGAVEVAEPARLAPAGAQP-
TH_3225|M.thermoresistible__bu      --------AARESYLEAFAALMYAGRLAPSGALLEAADAVQAAFARAPEG
Mb1651c|M.bovis_AF2122/97           --------RPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG-----
Rv1625c|M.tuberculosis_H37Rv        --------RPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG-----
Mflv_1156|M.gilvum_PYR-GCK          --------VLVTTLLSLGFCLGMTGSFTAQLATVREAVAVAERAGVPALT
MAV_4804|M.avium_104                AELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLG
MUL_3594|M.ulcerans_Agy99           -----------VNLVARIESNTVGGQVLVSESTYHEICAIADTSG-----
                                                                                      

MLBr_02341|M.leprae_Br4923          SLGIDLS---------------------------------------VDEL
MMAR_5257|M.marinum_M               GLGIDPP---------------------------------------IEEL
MSMEG_0228|M.smegmatis_MC2_155      ALGADVS---------------------------------------MQAL
Mvan_1904|M.vanbaalenii_PYR-1       VLTPNARS------------------------------------GELAEL
MAB_3361|M.abscessus_ATCC_1997      ARPSDLLL------------------------------------DGLARR
TH_3225|M.thermoresistible__bu      SRAVDAFC------------------------------------QGMTQR
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          SRALAMWV------------------------------------H-----
MAV_4804|M.avium_104                DHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGEL
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          IDANLVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEA
MMAR_5257|M.marinum_M               ISAELVDQVRFTEPAEYVFRHPLIHTVAYESQLKSARAQMHRRLAAVIEA
MSMEG_0228|M.smegmatis_MC2_155      IDAELVDQVMFAPRPEYAFRHPLIRMVALESQLKSDRAELHRRLAVDIER
Mvan_1904|M.vanbaalenii_PYR-1       VATELIDQMEFAPRQRYCFRHPLVRAVAYDSQISANRARAHRLLAGAIET
MAB_3361|M.abscessus_ATCC_1997      ITHGAAASAQTLGEALTLIRCEAD-RPANTS-WMEQAFPIALESATHEVW
TH_3225|M.thermoresistible__bu      IVGGISAAAAPLRVALTAMCELARSRPAEVVHWLVPAFPVLQESAGHELW
Mb1651c|M.bovis_AF2122/97           -----------------LATGPVVAGVVGSRRFFYDVWGDAVNVASRMES
Rv1625c|M.tuberculosis_H37Rv        -----------------LATGPVVAGVVGSRRFFYDVWGDAVNVASRMES
Mflv_1156|M.gilvum_PYR-GCK          -----VSFQAGNGLDSAALLRAVDLEDPEDNTPIPFRASAARGLSLALTG
MAV_4804|M.avium_104                RDAVEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRS
MUL_3594|M.ulcerans_Agy99           -----------------------STQVRVKGLTEPITVHDITGLAGRYNL
                                                                                      

MLBr_02341|M.leprae_Br4923          R---------------------------APHSVDQHAVLIAEHLEAAGDL
MMAR_5257|M.marinum_M               R---------------------------VPESADQYAALIAEHLEAAGES
MSMEG_0228|M.smegmatis_MC2_155      R---------------------------APHAADEHAALIADHYEEAGDL
Mvan_1904|M.vanbaalenii_PYR-1       R---------------------------DPAAKDENAALIATHLEGAGDF
MAB_3361|M.abscessus_ATCC_1997      D---------------------------DDMWHHLATRAVHIAREVGALS
TH_3225|M.thermoresistible__bu      D---------------------------ENLVDALSEAVVRQARDAGALA
Mb1651c|M.bovis_AF2122/97           T---------------------------DSVGQIQVPDEVYERLKDD---
Rv1625c|M.tuberculosis_H37Rv        T---------------------------DSVGQIQVPDEVYERLKDD---
Mflv_1156|M.gilvum_PYR-GCK          R---------------------------LAEADGQLAAVAQRSAQRGAEQ
MAV_4804|M.avium_104                QPVPSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEV
MUL_3594|M.ulcerans_Agy99           R---------------------------LPSIDRKVIPLVVPRPTGIAVI
                                                                                      

MLBr_02341|M.leprae_Br4923          HAAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTAEDPHR-AAMCIA
MMAR_5257|M.marinum_M               HAAYGWQVRAAAWATNRDIAAAHLSWERARKIADALPVDDPNR-AAMRIA
MSMEG_0228|M.smegmatis_MC2_155      RAAFTWHMRAGTWLTNRDIDAARLSWQRARHVADQLPHDAEDR-AAMTIA
Mvan_1904|M.vanbaalenii_PYR-1       ETACRWHLRAADWLRMRDLLAARNQWEIAMRVADGLPGADDAV-TALRIA
MAB_3361|M.abscessus_ATCC_1997      LLPAALIYRAGMHVHAGELDAAAELVQEADAISAATGH-APIRYHSLILA
TH_3225|M.thermoresistible__bu      GLPQALVYRAGVHLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIA
Mb1651c|M.bovis_AF2122/97           -----FVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV-
Rv1625c|M.tuberculosis_H37Rv        -----FVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV-
Mflv_1156|M.gilvum_PYR-GCK          DVMAVLGYRTLVAIWRGRYAEADAYAADTMERAEQLGGSMVIAFSICAAV
MAV_4804|M.avium_104                ALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGA
MUL_3594|M.ulcerans_Agy99           ENKIIGAAHPAEVVGSGDGAVRVRTGLQVAPFCDLVLDVAGAQVFAKVVD
                                            :                                         

MLBr_02341|M.leprae_Br4923          PRTRLCG----------IAWRGRFNSS--SGFDEVRQLCNATGDKAPLAV
MMAR_5257|M.marinum_M               PRTMLCG----------IAFRIHIDVAG-ARFEELRELCAAAGDKASLSI
MSMEG_0228|M.smegmatis_MC2_155      PRTLLCL----------STWRAGGHLSD-TGFDELCALAAAADDKVSLAT
Mvan_1904|M.vanbaalenii_PYR-1       PRTMLVS----------TELFVGADPDNDQRLVELRELTARVDDSHSLAL
MAB_3361|M.abscessus_ATCC_1997      AWRGSEP----------TAIRLIDEAMRDGAARGEGRLLGAMGYAAGVLN
TH_3225|M.thermoresistible__bu      AWRGDAV----------EAARLIEAAAADGEARGEGRLMGLTGYAAALLY
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          AAYRGRE----------DQAR-DQAAGALAQGGDYVALTVWASATLAFLE
MAV_4804|M.avium_104                LSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARAR
MUL_3594|M.ulcerans_Agy99           CG-------------------------VDGGICELMAVFTSVSDDVRRAL
                                                                                      

MLBr_02341|M.leprae_Br4923          ATVGPAIDHVYQD-RLH---------------------------------
MMAR_5257|M.marinum_M               GMAGLVIDHLQHA-RMREASQLATEAMTLIESVGDP--ALTVALS-----
MSMEG_0228|M.smegmatis_MC2_155      AMAGQVSALLVHA-HYRESSSLASELTSLLESVGDR--RLTVALL-----
Mvan_1904|M.vanbaalenii_PYR-1       ALAGRIVTFIVNSNRVPEALPLAAELAELVDTLGPTPAAELEIIY-----
MAB_3361|M.abscessus_ATCC_1997      NSLGRYELAFMAARRACEHEDLG----------------LYSWCL-----
TH_3225|M.thermoresistible__bu      NGIGRYREALAAARTTCEYEDLG----------------FYSWCL-----
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          VSRGNYEQALEAAEPLVDLYRDFPG-----------TELMSACFM-----
MAV_4804|M.avium_104                GQHGKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHML
MUL_3594|M.ulcerans_Agy99           AAPSTANSLS----------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               -------------------------------------------IALIYAK
MSMEG_0228|M.smegmatis_MC2_155      -------------------------------------------FAALGAK
Mvan_1904|M.vanbaalenii_PYR-1       -------------------------------------------TAMSFAH
MAB_3361|M.abscessus_ATCC_1997      -------------------------------------------IELIEAA
TH_3225|M.thermoresistible__bu      -------------------------------------------HELVEAA
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          -------------------------------------------PDAIESL
MAV_4804|M.avium_104                RSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHAL
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               SECAEWSDALRWSQRVIALADGDPTMGALIIGCPLAVAFATRANARYCLG
MSMEG_0228|M.smegmatis_MC2_155      FQTGEANEVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLG
Mvan_1904|M.vanbaalenii_PYR-1       LASCEFDAALEVIGRSIALEPEYP-------STDRALAYAIGGLCEVCLG
MAB_3361|M.abscessus_ATCC_1997      VRCGEHDTAVKAFG---------------------------QLEERALAA
TH_3225|M.thermoresistible__bu      ARVGETDTAHRALG---------------------------DIEERAGAS
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          IAVGRLDEAEPLIA---------------------------AFERNGAEL
MAV_4804|M.avium_104                SGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIV
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               RPGWAED-LQHGLAMARSADPMSYATVVAYVYSAGISTGVLASDDCALG-
MSMEG_0228|M.smegmatis_MC2_155      DPDWRTG-LDRATPLVRDFGITTRALMLTYKCIG-LPTGLLLPSPELLE-
Mvan_1904|M.vanbaalenii_PYR-1       SRERGIGHIRLATELARAMSPVSFSAVS--LYWGILAAMGMHVAEDLVD-
MAB_3361|M.abscessus_ATCC_1997      QSDWSQGMVARSRALITVG-------------------------HDAEP-
TH_3225|M.thermoresistible__bu      GTPWGLGALAGARALLADG-------------------------DEADR-
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          DRPWQLAIGNRCRAMLLSATG---------------------DLDGALA-
MAV_4804|M.avium_104                EGPWTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLG
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               -----------------------------------EIEDALQIAERSGDD
MSMEG_0228|M.smegmatis_MC2_155      -----------------------------------ESCEVLEVAQRSADD
Mvan_1904|M.vanbaalenii_PYR-1       -----------------------------------DMREWLARAESFGDR
MAB_3361|M.abscessus_ATCC_1997      -----------------------------------HYREAIQRLTNTRIS
TH_3225|M.thermoresistible__bu      -----------------------------------LFREALDHLSRSRVV
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          -----------------------------------AAERAMAEHARLPMP
MAV_4804|M.avium_104                VIYAEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQS
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               VALAIARMTLGIALVHRREDPMRDRGQAALADVSDMFQRRVYFLADLPFV
MSMEG_0228|M.smegmatis_MC2_155      LALAGAQVSRGLLLLWQG-GPYRDEALELLSLGREASVREQFTMAAVPAV
Mvan_1904|M.vanbaalenii_PYR-1       FGIIAAQWTYATLLLQAG-SPRRDEAFVLLRRAEVGITTHNLQSFALAIT
MAB_3361|M.abscessus_ATCC_1997      AHLARAHLIYGEWLRRCN---RRSDARTELTAAHGSFVN-----------
TH_3225|M.thermoresistible__bu      VHRARVHLTYGEWLRREH---RRGEARRELNEAHGMFTR-----------
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          FERARSALTLGEVLRRLR----RRDAAAAVRDALAQFEELG---------
MAV_4804|M.avium_104                LIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIE
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               EVYLAREWARCGDLDGAIAHMRAAVEHLFREG---------RLLGWSTPA
MSMEG_0228|M.smegmatis_MC2_155      DTELARDMAARGDLDGAIELARDVVDTSIDSG---------EAINMSASV
Mvan_1904|M.vanbaalenii_PYR-1       GMQLAREAARNGHRDEAIDSIRHLVTLHTRDA---------PLLHLG-CP
MAB_3361|M.abscessus_ATCC_1997      -------MGTAAFAERAERELRATGAKVRKRS---------ASSEKALTA
TH_3225|M.thermoresistible__bu      -------MGAQGFAERSRRELIAVGEKVRRQP---------LTSGDELTA
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          -------------VPLWVARARIALSGLAVSG---------SAVGSELTD
MAV_4804|M.avium_104                DMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRA
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               TGVLVQTLLDRGTEGDLVEAAAAIERLAAAPADDGLAVREILLLRLRALL
MSMEG_0228|M.smegmatis_MC2_155      T-VLVQSLIARGDRDDLDHAQRVIDRFAALPTDPGFVLYDVQLMRLRALL
Mvan_1904|M.vanbaalenii_PYR-1       AESLCEMLIDRGGTRDLLEVEEVLEQWCSR--SPGTAPMDLWTIRIRALL
MAB_3361|M.abscessus_ATCC_1997      QEAQIARMAGQGLTNQEIAAQLFIS-------------SHTVEWHLRKVF
TH_3225|M.thermoresistible__bu      QEAQIAGLAADGLTNQEIGAQLFLS-------------VHTVEWHLRKVF
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          SERRIAELAASGMSNRDVAETLFVS-------------VKTIETNLSRVY
MAV_4804|M.avium_104                GLGMLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTII
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               ARAHGDDTTYARLRDRYRDTASAMGFAGHIAQAESMP-------------
MSMEG_0228|M.smegmatis_MC2_155      ARARGDEERYRECSDRYRELATAYRYEGHMALAARMA-------------
Mvan_1904|M.vanbaalenii_PYR-1       ASARGERQRYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG--------
MAB_3361|M.abscessus_ATCC_1997      AKRGITSRRQLRSGR-----------------------------------
TH_3225|M.thermoresistible__bu      VKLGITSRRQLRAAPRVTATW-----------------------------
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          RKLGIRSRAQLGRMLR----------------------------------
MAV_4804|M.avium_104                GDAVNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNR
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          --------------------------------------------------
MMAR_5257|M.marinum_M               --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      --------------------------------------------------
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_4804|M.avium_104                RRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRC
MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

MLBr_02341|M.leprae_Br4923          ------------------------------------
MMAR_5257|M.marinum_M               ------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      ------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       ------------------------------------
MAB_3361|M.abscessus_ATCC_1997      ------------------------------------
TH_3225|M.thermoresistible__bu      ------------------------------------
Mb1651c|M.bovis_AF2122/97           ------------------------------------
Rv1625c|M.tuberculosis_H37Rv        ------------------------------------
Mflv_1156|M.gilvum_PYR-GCK          ------------------------------------
MAV_4804|M.avium_104                RDMLPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK
MUL_3594|M.ulcerans_Agy99           ------------------------------------