For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MVACGTCGTELRQGARFCDSCGTAIVDGSKHAEYKQVTVLFADVVDSMRLAAAVGAERLREILSALVSRC SGVVGHYGGTVDKFTGDGIMALFGAPLALEDHALRACLAALDLQYESHRLADELDLPAGVGLQIRVGLNS GQVIAGEMSAGGFGYTAIGEQVGMAQRMESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDRPVAA RRLLAATNAAHGGRSDPTLVGRSWELNTIAGLLDEAVEGRGGIVSVVGPPGIGKSRMVRESIELARRRGV AVFYTYCESHASDVPFHVVVPLLREGFGVAGLDPAAARVRVRSLVPDADPEDLLLLDDVLGIADPDVPMP DLDADARRRRVAALVNAASLARREPGLYVLEDAHWIDEVSESMLAEFLTVVTHTHSVMLITYRPEYTGVL ARVSGAQTIALRPLTDGQTSTLLTELLGPDAAAHQLAGLIADRAAGNPFFTQEIVRDLAERGVLRGERGA YRFHGADVEIGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGADVSMQALIDAELVDQ VMFAPRPEYAFRHPLIRMVALESQLKSDRAELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFT WHMRAGTWLTNRDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTWRAGGHLSDTGFDELCA LAAAADDKVSLATAMAGQVSALLVHAHYRESSSLASELTSLLESVGDRRLTVALLFAALGAKFQTGEANE VVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLGDPDWRTGLDRATPLVRDFGITTRALMLT YKCIGLPTGLLLPSPELLEESCEVLEVAQRSADDLALAGAQVSRGLLLLWQGGPYRDEALELLSLGREAS VREQFTMAAVPAVDTELARDMAARGDLDGAIELARDVVDTSIDSGEAINMSASVTVLVQSLIARGDRDDL DHAQRVIDRFAALPTDPGFVLYDVQLMRLRALLARARGDEERYRECSDRYRELATAYRYEGHMALAARMA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0228 | - | - | 100% (1050) | adenylate and guanylate cyclase catalytic domain-containing protein |
M. smegmatis MC2 155 | MSMEG_4431 | - | 2e-22 | 27.53% (385) | putative regulatory protein |
M. smegmatis MC2 155 | MSMEG_1963 | - | 9e-20 | 24.79% (605) | putative transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1651c | cya | 6e-15 | 31.58% (171) | membrane-anchored adenylyl cyclase Cya (ATP |
M. gilvum PYR-GCK | Mflv_1156 | - | 5e-14 | 21.89% (804) | regulatory protein, LuxR |
M. tuberculosis H37Rv | Rv1625c | cya | 6e-15 | 31.58% (171) | membrane-anchored adenylyl cyclase Cya (ATP |
M. leprae Br4923 | MLBr_02341 | - | 0.0 | 60.95% (717) | putative regulatory protein |
M. abscessus ATCC 19977 | MAB_3361 | - | 2e-13 | 23.87% (750) | LuxR family transcriptional regulator |
M. marinum M | MMAR_5257 | - | 0.0 | 52.94% (1054) | membrane-anchored adenylyl cyclase |
M. avium 104 | MAV_4804 | - | 4e-15 | 27.64% (351) | GAF domain-containing protein |
M. thermoresistible (build 8) | TH_3225 | - | 1e-14 | 25.92% (490) | PUTATIVE regulatory protein, LuxR |
M. ulcerans Agy99 | MUL_3594 | - | 6e-18 | 31.25% (192) | adenylylate/guanylate cyclase |
M. vanbaalenii PYR-1 | Mvan_1904 | - | 0.0 | 41.32% (1014) | adenylyl cyclase class-3/4/guanylyl cyclase |
CLUSTAL 2.0.9 multiple sequence alignment MLBr_02341|M.leprae_Br4923 --------MTTALVCVACGAELRSIAKFCDECGSPVVEAETP-AEYKQVT MMAR_5257|M.marinum_M --------MTPVLACRSCGTQPLENARFCHGCGAPVAAAADAHAEYKQVT MSMEG_0228|M.smegmatis_MC2_155 -----------MVACGTCGTELRQGARFCDSCGTAIVDGSKH-AEYKQVT Mvan_1904|M.vanbaalenii_PYR-1 ------------------------------------------------MT MAB_3361|M.abscessus_ATCC_1997 -----------------------------------MLRGQAGVGKTALLR TH_3225|M.thermoresistible__bu MSSRDGDVVLHGRAAEIATLRDVMSTARAGSSRVLVLHGEAGVGKTALLG Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK ----------------MKAVDDFLAGLQQLQPAGLLIEGEAGIGKTTMLA MAV_4804|M.avium_104 --MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMK MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -VLFADVVGSMDIAAAVGLERLREIMTELVSRAAG-VIERYGGTVDKFTG MMAR_5257|M.marinum_M -VLFADVVHSMDIAAALGAERLREIMTELVNRAAV-VVQRYGGTVDKFTG MSMEG_0228|M.smegmatis_MC2_155 -VLFADVVDSMRLAAAVGAERLREILSALVSRCSG-VVGHYGGTVDKFTG Mvan_1904|M.vanbaalenii_PYR-1 -VLFADVVGSMRLAAELDPERLREIMNDLFNRSAT-VVQRYHGTMDKFTG MAB_3361|M.abscessus_ATCC_1997 -YVLGKASG-QLIAQASGIQSEMELAFAGLQQFCA-PLTKYSGAIPDPQR TH_3225|M.thermoresistible__bu -QLLGDAAG-MRCVQVAGVESDMELAYAGLHQLCA-PLLDRLDDLPSPQR Mb1651c|M.bovis_AF2122/97 ----------------------------MRTQARA-PTQHYAESVAR--- Rv1625c|M.tuberculosis_H37Rv ---MAARKCGAPPIAADGSTRRPDCVTAVRTQARA-PTQHYAESVAR--- Mflv_1156|M.gilvum_PYR-GCK GVVDAARQAGFRVLSAHGDQSGSGLAHAAIADLFAGVQTDILDGLPELQR MAV_4804|M.avium_104 -AFGVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERD MUL_3594|M.ulcerans_Agy99 -------------MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ--- MLBr_02341|M.leprae_Br4923 DGIMAIF--------------------------GAPTALEDHALRACLAA MMAR_5257|M.marinum_M DGIMAVF--------------------------GAPAALEDHALRACLAA MSMEG_0228|M.smegmatis_MC2_155 DGIMALF--------------------------GAPLALEDHALRACLAA Mvan_1904|M.vanbaalenii_PYR-1 DGLMALF--------------------------GAPMALEDHALRACIAA MAB_3361|M.abscessus_ATCC_1997 EALTIAF--------------------------GTRSGPPPDRFLIGLAV TH_3225|M.thermoresistible__bu DVLNVAF--------------------------GRGAGPAPGRFLVGLAV Mb1651c|M.bovis_AF2122/97 ----------------------------------------RQRVLTITAW Rv1625c|M.tuberculosis_H37Rv ----------------------------------------RQRVLTITAW Mflv_1156|M.gilvum_PYR-GCK RAADGVLR------------------------RGDGTGGPTDERVIAAAL MAV_4804|M.avium_104 RWRADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAA MUL_3594|M.ulcerans_Agy99 ---------------------------------------PPVRLLVVDDA MLBr_02341|M.leprae_Br4923 LGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGEIGSSALGYTAVGV MMAR_5257|M.marinum_M LGVQDEAKRLAGEVDRRDGVVLQLRVGLNSGQVVAGEIGTGALGYTAVGE MSMEG_0228|M.smegmatis_MC2_155 LDLQYESHRLADELDLPAGVGLQIRVGLNSGQVIAGEMSAGGFGYTAIGE Mvan_1904|M.vanbaalenii_PYR-1 LEIQAVVGELADEVEQRDGVRLQLRVGLNSGDVVVGDIGSGPGRYTAIGH MAB_3361|M.abscessus_ATCC_1997 LSLLAAAAEHQPVLCVIDDAQWLDRVSLQTLAFVTRRLGSEP-VAMLFAV TH_3225|M.thermoresistible__bu LNLLAAAGADQPLLCVIDDAQWLDRVSLQTLGFVARRLMAEP-VAMVFAL Mb1651c|M.bovis_AF2122/97 LAVVVTGSFALMQLATGAGGWYIALINVFT-------------------- Rv1625c|M.tuberculosis_H37Rv LAVVVTGSFALMQLATGAGGWYIALINVFT-------------------- Mflv_1156|M.gilvum_PYR-GCK LGAVHGSATRTPVLVAVDDVQWLDPSSVAVLAFVARRVKGR--VGFVVAE MAV_4804|M.avium_104 TRLLSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRA MUL_3594|M.ulcerans_Agy99 DGVETLFGARFRTELRCDEYDLSFSN------------------------ MLBr_02341|M.leprae_Br4923 ----QVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAED MMAR_5257|M.marinum_M ----QVGLAQRMEAVAAPETVMLGESTARLVEGAAVLGEPQLVHIKGVEA MSMEG_0228|M.smegmatis_MC2_155 ----QVGMAQRMESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDR Mvan_1904|M.vanbaalenii_PYR-1 ----AVGMAQRMEAAASAGAVVCSLSTADLVEHATRLGAVQTVRIKGSDE MAB_3361|M.abscessus_ATCC_1997 ----RDGTDSELAGLPELTVHGLRAADAGTLLDSVIPG---LLDERVRDR TH_3225|M.thermoresistible__bu ----RDDIHEALVGVPALAVPGLADADARTLLEHMFPG---AIDANVRDR Mb1651c|M.bovis_AF2122/97 --------------AVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWD Rv1625c|M.tuberculosis_H37Rv --------------AVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWD Mflv_1156|M.gilvum_PYR-GCK ----RPGVGPGLPAATWLQVG--TGALTRLPVAPMSLGALHTMLSSRLGR MAV_4804|M.avium_104 GGFDPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEFH MUL_3594|M.ulcerans_Agy99 ---------------DPVQALKMVGDSPDIEVLVTNLNMPQMNGLDLLTE MLBr_02341|M.leprae_Br4923 AVPARRLLRVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVG MMAR_5257|M.marinum_M AVPAWQLLGVVDQYWQSGPAPATLVGREWELDTLTTMLDRSIAGRGSVVT MSMEG_0228|M.smegmatis_MC2_155 PVAARRLLAATNAAHG-GRSDPTLVGRSWELNTIAGLLDEAVEGRGGIVS Mvan_1904|M.vanbaalenii_PYR-1 PAPARRLVAVEAARMVVGRNEGLMLGRDGELHQLCDSLDRRR--RRHLVS MAB_3361|M.abscessus_ATCC_1997 IVAETQGNPLALLELPRDMTAEELAG------------GFGWPDGGRLAG TH_3225|M.thermoresistible__bu LVAESRGNPLALLEVPRTYAVGELAG------------GFVSPGAGSAPS Mb1651c|M.bovis_AF2122/97 VGTDAG-------------------------------------------- Rv1625c|M.tuberculosis_H37Rv VGTDAG-------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK RFSRPQIVRIAEVSGGNPLYALELAR---------VADGAGSRPGQRLPE MAV_4804|M.avium_104 HRTGGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAAE MUL_3594|M.ulcerans_Agy99 VAKLGR-------------------------------------------- MLBr_02341|M.leprae_Br4923 LVGPAGIGKTRLVAEAVQLAKGLE----------VEVFSVFCESHATDVA MMAR_5257|M.marinum_M LVGRAGIGKTRLAREAAQVAKNLG----------VTVFSTFCESHATDIP MSMEG_0228|M.smegmatis_MC2_155 VVGPPGIGKSRMVRESIELARRRG----------VAVFYTYCESHASDVP Mvan_1904|M.vanbaalenii_PYR-1 VVGAPGVGKSRLVEEFCRRLRGAG----------TEVVLAGCDAHAMPIA MAB_3361|M.abscessus_ATCC_1997 QIEQTFLRRVQQLPAHTQTLLLAA----------ATDPLGDVTLLARAAQ TH_3225|M.thermoresistible__bu RIEENYVHRIRALPAQTRRLLLIA----------AAEPIGDSALFLRAAA Mb1651c|M.bovis_AF2122/97 -------AQFFFLVAAALVVLLVG----------IEHTALAVGLAAVAAG Rv1625c|M.tuberculosis_H37Rv -------AQFFFLVAAALVVLLVG----------IEHTALAVGLAAVAAG Mflv_1156|M.gilvum_PYR-GCK SLSELVRLRVDGLAEDVRDVLLVA----------ASATSPTVDLLAKAVG MAV_4804|M.avium_104 FLGRYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWAC MUL_3594|M.ulcerans_Agy99 -------PLKTIVLTACNDLANIR----------AAMMRGAFDFQLTPLD MLBr_02341|M.leprae_Br4923 FDVVAQLVRAVAQISG--LDDRSARARVREQIPDADTQDLLL-LDDLLGI MMAR_5257|M.marinum_M FRAVTRLLRAAAQVSR--LDDATARVRVRAIVPDGDPQDLLL-LYDLLGI MSMEG_0228|M.smegmatis_MC2_155 FHVVVPLLREGFGVAG--LDPAAARVRVRSLVPDADPEDLLL-LDDVLGI Mvan_1904|M.vanbaalenii_PYR-1 FRALSRLLRAMFSADD--LGDDDARELVLSQVPMG-STDAQI-IFEAMGI MAB_3361|M.abscessus_ATCC_1997 QLGIPMHAIAPAEAAD--LVELSTRVRFRHPLVRSAVYISAN-PLERRRI TH_3225|M.thermoresistible__bu LMGIAVDALAPAEAAR--VIQFGPRMRFFHPLMRSAAYRAAD-PRDRRAV Mb1651c|M.bovis_AF2122/97 LVIALEFLVPPDTGLQ--PPWAMSVSFVLTTVSACGVAVATV-WFALRDT Rv1625c|M.tuberculosis_H37Rv LVIALEFLVPPDTGLQ--PPWAMSVSFVLTTVSACGVAVATV-WFALRDT Mflv_1156|M.gilvum_PYR-GCK VTPAAVTGLVEAAEVEGIVVIDGNRIRFTHPVLANGIYAGAD-PQRRREV MAV_4804|M.avium_104 LELRLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLS-PDEMRAV MUL_3594|M.ulcerans_Agy99 LEDLRVTISKAVTIVRELQAGEAARQRALELADQNRRVENIFGRYVSEEV MLBr_02341|M.leprae_Br4923 ADPAVELPRLDPDARRRRLTALINVAQLALSRPAV-------FVVEDVHW MMAR_5257|M.marinum_M ADPQVELPKIAPEARRRRLTALINAVQLARAQPAV-------YVIEDAHW MSMEG_0228|M.smegmatis_MC2_155 ADPDVPMPDLDADARRRRVAALVNAASLARREPGL-------YVLEDAHW Mvan_1904|M.vanbaalenii_PYR-1 ADGAAPPLHVGADGRRHRLVETMAQFVRLRSTPMV-------LVLEDAHW MAB_3361|M.abscessus_ATCC_1997 HGVLAGATDPGADPDRRAWHRAHAAAGTDEAIAWE-------LEQSAGRA TH_3225|M.thermoresistible__bu HRALAEATDPGADPDRRAWHAANGVTGTDDAVAAE-------LEKSAARA Mb1651c|M.bovis_AF2122/97 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPER-------NIIADKYD Rv1625c|M.tuberculosis_H37Rv ARAEAVMEAEHDRSEALLANMLPASIAERLKEPER-------NIIADKYD Mflv_1156|M.gilvum_PYR-GCK HR---RLADLKTDPELRARHLALASTVADETTLTT-------LDAAADAA MAV_4804|M.avium_104 HLRIGRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQA MUL_3594|M.ulcerans_Agy99 KTHLLACPEGHQNSERRTLTMLMADIRGFTRLSEILS---PERALQVLNA MLBr_02341|M.leprae_Br4923 IDEVSDSMLADFLAVIPQTRSMA------LVTYRPEYHGALRHVVGAQII MMAR_5257|M.marinum_M MDEASESMVAEFLTVIPQTHSMV------LVTYRPDYRGALRGVRGAQSI MSMEG_0228|M.smegmatis_MC2_155 IDEVSESMLAEFLTVVTHTHSVM------LITYRPEYTGVLARVSGAQTI Mvan_1904|M.vanbaalenii_PYR-1 IDAASEAVLCEFATVLERTSTVL------VTTCRPEYRGGLRKRS-AHTV MAB_3361|M.abscessus_ATCC_1997 QAKGGVLAAAAFLQRATELTADP------AARGRRALAAAQSKYDAAAFD TH_3225|M.thermoresistible__bu QQRGGIAATATFLERAVVLTADP------GLRGRRALAAAQAKRDAADSA Mb1651c|M.bovis_AF2122/97 EASVLFADIVGFTERASSTAPAD------LVRFLDRLYSAFDELVDQHGL Rv1625c|M.tuberculosis_H37Rv EASVLFADIVGFTERASSTAPAD------LVRFLDRLYSAFDELVDQHGL Mflv_1156|M.gilvum_PYR-GCK RARGAPAAAAELLEWAMQLGGDS------VSR---RIRAAEHHVVAGDMR MAV_4804|M.avium_104 RAQASFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVP MUL_3594|M.ulcerans_Agy99 YLERATDVVIRWNGTINEILGDG------LLVFFGVPNTDGEAAEHAVAA MLBr_02341|M.leprae_Br4923 AVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQEITRELA MMAR_5257|M.marinum_M ALGPLSDAETSALIAELLGPAPSVAQIAEIIATRAAGNPFFAEEIIRELA MSMEG_0228|M.smegmatis_MC2_155 ALRPLTDGQTSTLLTELLGPDAAAHQLAGLIADRAAGNPFFTQEIVRDLA Mvan_1904|M.vanbaalenii_PYR-1 TVAPLNDSLTMDLVLNLLGGDGAMGGLASRIVGVAAGNPYFVEEIVRDLV MAB_3361|M.abscessus_ATCC_1997 AARELLGVADMTPLDPLARARATRLRAKIAFAESRVG------AFGSVTV TH_3225|M.thermoresistible__bu AAHDLLAIAERAPLSALEWARAVHLRAQLEFARSRAG------DAGGPPV Mb1651c|M.bovis_AF2122/97 EKIKVS-------------------------------------------- Rv1625c|M.tuberculosis_H37Rv EKIKVS-------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK RAATLLEQALVDLRPGVLCAIALNLLAGVRMVEDDYIR------------ MAV_4804|M.avium_104 VLNTLLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDEL MUL_3594|M.ulcerans_Agy99 ALELQLAMGELNVSHREQGLPELGIGIGVHTGEAVVG------------- MLBr_02341|M.leprae_Br4923 ERGVLTGERGRYACSTDVAE------------------------------ MMAR_5257|M.marinum_M ERRVLVGERGRYTCTAEADD------------------------------ MSMEG_0228|M.smegmatis_MC2_155 ERGVLRGERGAYRFHGADVE------------------------------ Mvan_1904|M.vanbaalenii_PYR-1 GRGVLAGSRGDYRLIRDVDD------------------------------ MAB_3361|M.abscessus_ATCC_1997 SEAAIGLVEAARCLENLDDN------------------------------ TH_3225|M.thermoresistible__bu GQTAAALLTAAQLLQDVDAP------------------------------ Mb1651c|M.bovis_AF2122/97 ---------GDSYMVVSGVP------------------------------ Rv1625c|M.tuberculosis_H37Rv ---------GDSYMVVSGVP------------------------------ Mflv_1156|M.gilvum_PYR-GCK ----AVELLERARADADNDA------------------------------ MAV_4804|M.avium_104 GERVATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPIL MUL_3594|M.ulcerans_Agy99 ----TIGSPRRQKYTAIGKN------------------------------ MLBr_02341|M.leprae_Br4923 --------VCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLA MMAR_5257|M.marinum_M --------AIVPATLQATIGARIDRLSPAAKQTLSAAAVIGSRFSTELLI MSMEG_0228|M.smegmatis_MC2_155 --------IGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLA Mvan_1904|M.vanbaalenii_PYR-1 --------IGVPVTVQAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQ MAB_3361|M.abscessus_ATCC_1997 --------LARETYLDAVGAAMYGGRLCPRGGAVEVAEPARLAPAGAQP- TH_3225|M.thermoresistible__bu --------AARESYLEAFAALMYAGRLAPSGALLEAADAVQAAFARAPEG Mb1651c|M.bovis_AF2122/97 --------RPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG----- Rv1625c|M.tuberculosis_H37Rv --------RPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG----- Mflv_1156|M.gilvum_PYR-GCK --------VLVTTLLSLGFCLGMTGSFTAQLATVREAVAVAERAGVPALT MAV_4804|M.avium_104 AELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLG MUL_3594|M.ulcerans_Agy99 -----------VNLVARIESNTVGGQVLVSESTYHEICAIADTSG----- MLBr_02341|M.leprae_Br4923 SLGIDLS---------------------------------------VDEL MMAR_5257|M.marinum_M GLGIDPP---------------------------------------IEEL MSMEG_0228|M.smegmatis_MC2_155 ALGADVS---------------------------------------MQAL Mvan_1904|M.vanbaalenii_PYR-1 VLTPNARS------------------------------------GELAEL MAB_3361|M.abscessus_ATCC_1997 ARPSDLLL------------------------------------DGLARR TH_3225|M.thermoresistible__bu SRAVDAFC------------------------------------QGMTQR Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK SRALAMWV------------------------------------H----- MAV_4804|M.avium_104 DHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGEL MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 IDANLVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEA MMAR_5257|M.marinum_M ISAELVDQVRFTEPAEYVFRHPLIHTVAYESQLKSARAQMHRRLAAVIEA MSMEG_0228|M.smegmatis_MC2_155 IDAELVDQVMFAPRPEYAFRHPLIRMVALESQLKSDRAELHRRLAVDIER Mvan_1904|M.vanbaalenii_PYR-1 VATELIDQMEFAPRQRYCFRHPLVRAVAYDSQISANRARAHRLLAGAIET MAB_3361|M.abscessus_ATCC_1997 ITHGAAASAQTLGEALTLIRCEAD-RPANTS-WMEQAFPIALESATHEVW TH_3225|M.thermoresistible__bu IVGGISAAAAPLRVALTAMCELARSRPAEVVHWLVPAFPVLQESAGHELW Mb1651c|M.bovis_AF2122/97 -----------------LATGPVVAGVVGSRRFFYDVWGDAVNVASRMES Rv1625c|M.tuberculosis_H37Rv -----------------LATGPVVAGVVGSRRFFYDVWGDAVNVASRMES Mflv_1156|M.gilvum_PYR-GCK -----VSFQAGNGLDSAALLRAVDLEDPEDNTPIPFRASAARGLSLALTG MAV_4804|M.avium_104 RDAVEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRS MUL_3594|M.ulcerans_Agy99 -----------------------STQVRVKGLTEPITVHDITGLAGRYNL MLBr_02341|M.leprae_Br4923 R---------------------------APHSVDQHAVLIAEHLEAAGDL MMAR_5257|M.marinum_M R---------------------------VPESADQYAALIAEHLEAAGES MSMEG_0228|M.smegmatis_MC2_155 R---------------------------APHAADEHAALIADHYEEAGDL Mvan_1904|M.vanbaalenii_PYR-1 R---------------------------DPAAKDENAALIATHLEGAGDF MAB_3361|M.abscessus_ATCC_1997 D---------------------------DDMWHHLATRAVHIAREVGALS TH_3225|M.thermoresistible__bu D---------------------------ENLVDALSEAVVRQARDAGALA Mb1651c|M.bovis_AF2122/97 T---------------------------DSVGQIQVPDEVYERLKDD--- Rv1625c|M.tuberculosis_H37Rv T---------------------------DSVGQIQVPDEVYERLKDD--- Mflv_1156|M.gilvum_PYR-GCK R---------------------------LAEADGQLAAVAQRSAQRGAEQ MAV_4804|M.avium_104 QPVPSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEV MUL_3594|M.ulcerans_Agy99 R---------------------------LPSIDRKVIPLVVPRPTGIAVI MLBr_02341|M.leprae_Br4923 HAAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTAEDPHR-AAMCIA MMAR_5257|M.marinum_M HAAYGWQVRAAAWATNRDIAAAHLSWERARKIADALPVDDPNR-AAMRIA MSMEG_0228|M.smegmatis_MC2_155 RAAFTWHMRAGTWLTNRDIDAARLSWQRARHVADQLPHDAEDR-AAMTIA Mvan_1904|M.vanbaalenii_PYR-1 ETACRWHLRAADWLRMRDLLAARNQWEIAMRVADGLPGADDAV-TALRIA MAB_3361|M.abscessus_ATCC_1997 LLPAALIYRAGMHVHAGELDAAAELVQEADAISAATGH-APIRYHSLILA TH_3225|M.thermoresistible__bu GLPQALVYRAGVHLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIA Mb1651c|M.bovis_AF2122/97 -----FVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV- Rv1625c|M.tuberculosis_H37Rv -----FVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV- Mflv_1156|M.gilvum_PYR-GCK DVMAVLGYRTLVAIWRGRYAEADAYAADTMERAEQLGGSMVIAFSICAAV MAV_4804|M.avium_104 ALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGA MUL_3594|M.ulcerans_Agy99 ENKIIGAAHPAEVVGSGDGAVRVRTGLQVAPFCDLVLDVAGAQVFAKVVD : MLBr_02341|M.leprae_Br4923 PRTRLCG----------IAWRGRFNSS--SGFDEVRQLCNATGDKAPLAV MMAR_5257|M.marinum_M PRTMLCG----------IAFRIHIDVAG-ARFEELRELCAAAGDKASLSI MSMEG_0228|M.smegmatis_MC2_155 PRTLLCL----------STWRAGGHLSD-TGFDELCALAAAADDKVSLAT Mvan_1904|M.vanbaalenii_PYR-1 PRTMLVS----------TELFVGADPDNDQRLVELRELTARVDDSHSLAL MAB_3361|M.abscessus_ATCC_1997 AWRGSEP----------TAIRLIDEAMRDGAARGEGRLLGAMGYAAGVLN TH_3225|M.thermoresistible__bu AWRGDAV----------EAARLIEAAAADGEARGEGRLMGLTGYAAALLY Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK AAYRGRE----------DQAR-DQAAGALAQGGDYVALTVWASATLAFLE MAV_4804|M.avium_104 LSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARAR MUL_3594|M.ulcerans_Agy99 CG-------------------------VDGGICELMAVFTSVSDDVRRAL MLBr_02341|M.leprae_Br4923 ATVGPAIDHVYQD-RLH--------------------------------- MMAR_5257|M.marinum_M GMAGLVIDHLQHA-RMREASQLATEAMTLIESVGDP--ALTVALS----- MSMEG_0228|M.smegmatis_MC2_155 AMAGQVSALLVHA-HYRESSSLASELTSLLESVGDR--RLTVALL----- Mvan_1904|M.vanbaalenii_PYR-1 ALAGRIVTFIVNSNRVPEALPLAAELAELVDTLGPTPAAELEIIY----- MAB_3361|M.abscessus_ATCC_1997 NSLGRYELAFMAARRACEHEDLG----------------LYSWCL----- TH_3225|M.thermoresistible__bu NGIGRYREALAAARTTCEYEDLG----------------FYSWCL----- Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK VSRGNYEQALEAAEPLVDLYRDFPG-----------TELMSACFM----- MAV_4804|M.avium_104 GQHGKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHML MUL_3594|M.ulcerans_Agy99 AAPSTANSLS---------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M -------------------------------------------IALIYAK MSMEG_0228|M.smegmatis_MC2_155 -------------------------------------------FAALGAK Mvan_1904|M.vanbaalenii_PYR-1 -------------------------------------------TAMSFAH MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------IELIEAA TH_3225|M.thermoresistible__bu -------------------------------------------HELVEAA Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK -------------------------------------------PDAIESL MAV_4804|M.avium_104 RSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHAL MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M SECAEWSDALRWSQRVIALADGDPTMGALIIGCPLAVAFATRANARYCLG MSMEG_0228|M.smegmatis_MC2_155 FQTGEANEVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLG Mvan_1904|M.vanbaalenii_PYR-1 LASCEFDAALEVIGRSIALEPEYP-------STDRALAYAIGGLCEVCLG MAB_3361|M.abscessus_ATCC_1997 VRCGEHDTAVKAFG---------------------------QLEERALAA TH_3225|M.thermoresistible__bu ARVGETDTAHRALG---------------------------DIEERAGAS Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK IAVGRLDEAEPLIA---------------------------AFERNGAEL MAV_4804|M.avium_104 SGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIV MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M RPGWAED-LQHGLAMARSADPMSYATVVAYVYSAGISTGVLASDDCALG- MSMEG_0228|M.smegmatis_MC2_155 DPDWRTG-LDRATPLVRDFGITTRALMLTYKCIG-LPTGLLLPSPELLE- Mvan_1904|M.vanbaalenii_PYR-1 SRERGIGHIRLATELARAMSPVSFSAVS--LYWGILAAMGMHVAEDLVD- MAB_3361|M.abscessus_ATCC_1997 QSDWSQGMVARSRALITVG-------------------------HDAEP- TH_3225|M.thermoresistible__bu GTPWGLGALAGARALLADG-------------------------DEADR- Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK DRPWQLAIGNRCRAMLLSATG---------------------DLDGALA- MAV_4804|M.avium_104 EGPWTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLG MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M -----------------------------------EIEDALQIAERSGDD MSMEG_0228|M.smegmatis_MC2_155 -----------------------------------ESCEVLEVAQRSADD Mvan_1904|M.vanbaalenii_PYR-1 -----------------------------------DMREWLARAESFGDR MAB_3361|M.abscessus_ATCC_1997 -----------------------------------HYREAIQRLTNTRIS TH_3225|M.thermoresistible__bu -----------------------------------LFREALDHLSRSRVV Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK -----------------------------------AAERAMAEHARLPMP MAV_4804|M.avium_104 VIYAEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQS MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M VALAIARMTLGIALVHRREDPMRDRGQAALADVSDMFQRRVYFLADLPFV MSMEG_0228|M.smegmatis_MC2_155 LALAGAQVSRGLLLLWQG-GPYRDEALELLSLGREASVREQFTMAAVPAV Mvan_1904|M.vanbaalenii_PYR-1 FGIIAAQWTYATLLLQAG-SPRRDEAFVLLRRAEVGITTHNLQSFALAIT MAB_3361|M.abscessus_ATCC_1997 AHLARAHLIYGEWLRRCN---RRSDARTELTAAHGSFVN----------- TH_3225|M.thermoresistible__bu VHRARVHLTYGEWLRREH---RRGEARRELNEAHGMFTR----------- Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK FERARSALTLGEVLRRLR----RRDAAAAVRDALAQFEELG--------- MAV_4804|M.avium_104 LIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIE MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M EVYLAREWARCGDLDGAIAHMRAAVEHLFREG---------RLLGWSTPA MSMEG_0228|M.smegmatis_MC2_155 DTELARDMAARGDLDGAIELARDVVDTSIDSG---------EAINMSASV Mvan_1904|M.vanbaalenii_PYR-1 GMQLAREAARNGHRDEAIDSIRHLVTLHTRDA---------PLLHLG-CP MAB_3361|M.abscessus_ATCC_1997 -------MGTAAFAERAERELRATGAKVRKRS---------ASSEKALTA TH_3225|M.thermoresistible__bu -------MGAQGFAERSRRELIAVGEKVRRQP---------LTSGDELTA Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK -------------VPLWVARARIALSGLAVSG---------SAVGSELTD MAV_4804|M.avium_104 DMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRA MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M TGVLVQTLLDRGTEGDLVEAAAAIERLAAAPADDGLAVREILLLRLRALL MSMEG_0228|M.smegmatis_MC2_155 T-VLVQSLIARGDRDDLDHAQRVIDRFAALPTDPGFVLYDVQLMRLRALL Mvan_1904|M.vanbaalenii_PYR-1 AESLCEMLIDRGGTRDLLEVEEVLEQWCSR--SPGTAPMDLWTIRIRALL MAB_3361|M.abscessus_ATCC_1997 QEAQIARMAGQGLTNQEIAAQLFIS-------------SHTVEWHLRKVF TH_3225|M.thermoresistible__bu QEAQIAGLAADGLTNQEIGAQLFLS-------------VHTVEWHLRKVF Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK SERRIAELAASGMSNRDVAETLFVS-------------VKTIETNLSRVY MAV_4804|M.avium_104 GLGMLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTII MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M ARAHGDDTTYARLRDRYRDTASAMGFAGHIAQAESMP------------- MSMEG_0228|M.smegmatis_MC2_155 ARARGDEERYRECSDRYRELATAYRYEGHMALAARMA------------- Mvan_1904|M.vanbaalenii_PYR-1 ASARGERQRYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG-------- MAB_3361|M.abscessus_ATCC_1997 AKRGITSRRQLRSGR----------------------------------- TH_3225|M.thermoresistible__bu VKLGITSRRQLRAAPRVTATW----------------------------- Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK RKLGIRSRAQLGRMLR---------------------------------- MAV_4804|M.avium_104 GDAVNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNR MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 -------------------------------------------------- MMAR_5257|M.marinum_M -------------------------------------------------- MSMEG_0228|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1904|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu -------------------------------------------------- Mb1651c|M.bovis_AF2122/97 -------------------------------------------------- Rv1625c|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_1156|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4804|M.avium_104 RRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRC MUL_3594|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02341|M.leprae_Br4923 ------------------------------------ MMAR_5257|M.marinum_M ------------------------------------ MSMEG_0228|M.smegmatis_MC2_155 ------------------------------------ Mvan_1904|M.vanbaalenii_PYR-1 ------------------------------------ MAB_3361|M.abscessus_ATCC_1997 ------------------------------------ TH_3225|M.thermoresistible__bu ------------------------------------ Mb1651c|M.bovis_AF2122/97 ------------------------------------ Rv1625c|M.tuberculosis_H37Rv ------------------------------------ Mflv_1156|M.gilvum_PYR-GCK ------------------------------------ MAV_4804|M.avium_104 RDMLPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK MUL_3594|M.ulcerans_Agy99 ------------------------------------