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TPVLACRSCGTQPLENARFCHGCGAPVAAAADAHAEYKQVTVLFADVVHSMDIAAALGAERLREIMTELV NRAAVVVQRYGGTVDKFTGDGIMAVFGAPAALEDHALRACLAALGVQDEAKRLAGEVDRRDGVVLQLRVG LNSGQVVAGEIGTGALGYTAVGEQVGLAQRMEAVAAPETVMLGESTARLVEGAAVLGEPQLVHIKGVEAA VPAWQLLGVVDQYWQSGPAPATLVGREWELDTLTTMLDRSIAGRGSVVTLVGRAGIGKTRLAREAAQVAK NLGVTVFSTFCESHATDIPFRAVTRLLRAAAQVSRLDDATARVRVRAIVPDGDPQDLLLLYDLLGIADPQ VELPKIAPEARRRRLTALINAVQLARAQPAVYVIEDAHWMDEASESMVAEFLTVIPQTHSMVLVTYRPDY RGALRGVRGAQSIALGPLSDAETSALIAELLGPAPSVAQIAEIIATRAAGNPFFAEEIIRELAERRVLVG ERGRYTCTAEADDAIVPATLQATIGARIDRLSPAAKQTLSAAAVIGSRFSTELLIGLGIDPPIEELISAE LVDQVRFTEPAEYVFRHPLIHTVAYESQLKSARAQMHRRLAAVIEARVPESADQYAALIAEHLEAAGESH AAYGWQVRAAAWATNRDIAAAHLSWERARKIADALPVDDPNRAAMRIAPRTMLCGIAFRIHIDVAGARFE ELRELCAAAGDKASLSIGMAGLVIDHLQHARMREASQLATEAMTLIESVGDPALTVALSIALIYAKSECA EWSDALRWSQRVIALADGDPTMGALIIGCPLAVAFATRANARYCLGRPGWAEDLQHGLAMARSADPMSYA TVVAYVYSAGISTGVLASDDCALGEIEDALQIAERSGDDVALAIARMTLGIALVHRREDPMRDRGQAALA DVSDMFQRRVYFLADLPFVEVYLAREWARCGDLDGAIAHMRAAVEHLFREGRLLGWSTPATGVLVQTLLD RGTEGDLVEAAAAIERLAAAPADDGLAVREILLLRLRALLARAHGDDTTYARLRDRYRDTASAMGFAGHI AQAESMP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5257 | - | - | 100% (1058) | membrane-anchored adenylyl cyclase |
| M. marinum M | MMAR_5254 | - | 0.0 | 62.54% (1057) | membrane-anchored adenylyl cyclase |
| M. marinum M | MMAR_3043 | - | 5e-40 | 30.24% (615) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 7e-14 | 33.10% (142) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4653 | - | 6e-20 | 26.38% (671) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv3645 | - | 7e-14 | 33.10% (142) | transmembrane protein |
| M. leprae Br4923 | MLBr_02341 | - | 0.0 | 68.76% (733) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_1459c | - | 2e-14 | 35.71% (154) | hypothetical protein MAB_1459c |
| M. avium 104 | MAV_4804 | - | 1e-13 | 23.82% (638) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0228 | - | 0.0 | 52.94% (1054) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_0858 | - | 1e-13 | 33.10% (142) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4617 | - | 1e-17 | 34.59% (185) | hypothetical protein MUL_4617 |
| M. vanbaalenii PYR-1 | Mvan_1904 | - | 0.0 | 41.43% (1021) | adenylyl cyclase class-3/4/guanylyl cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAF
Mflv_4653|M.gilvum_PYR-GCK --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 GVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERDRWR
Mflv_4653|M.gilvum_PYR-GCK --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 ADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAATRL
Mflv_4653|M.gilvum_PYR-GCK -----------------MRYRLLGPLQVVHGEAAVDIGPRKQRSVLAALL
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --------------------------MTPVLACRSCGTQPLENARFCHGC
MLBr_02341|M.leprae_Br4923 --------------------------MTTALVCVACGAELRSIAKFCDEC
MSMEG_0228|M.smegmatis_MC2_155 -----------------------------MVACGTCGTELRQGARFCDSC
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 LSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRAGGF
Mflv_4653|M.gilvum_PYR-GCK LAQGRVVSTDRLVDVVWGDDVPASATASLQVYISNLRRALRSGAGDRTVS
Mb3669|M.bovis_AF2122/97 -------------------MDAEAFVGFRQVPAARYGGLMATTAALPRRI
Rv3645|M.tuberculosis_H37Rv -------------------MDAEAFVGFRQVPAARYGGLMATTAALPRRI
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 -------------------MANESIRAVSRRVGRALGAITGQTGNIN-TG
MMAR_5257|M.marinum_M GAPVAAAADAHAEYKQVTVLFADVVHSMDIAAALGAERLREIMTELVNRA
MLBr_02341|M.leprae_Br4923 GSPVVEAETP-AEYKQVTVLFADVVGSMDIAAAVGLERLREIMTELVSRA
MSMEG_0228|M.smegmatis_MC2_155 GTAIVDGSKH-AEYKQVTVLFADVVDSMRLAAAVGAERLREILSALVSRC
Mvan_1904|M.vanbaalenii_PYR-1 ----------------MTVLFADVVGSMRLAAELDPERLREIMNDLFNRS
MUL_4617|M.ulcerans_Agy99 ------------------------MERVWQWAWDRCGARYSWAICVVTFA
MAV_4804|M.avium_104 DPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEFHHRT
Mflv_4653|M.gilvum_PYR-GCK SVAQPIVRQPPGYFLDAGPDESDIAVFTAACARAAAAIDGERWDEALAEA
Mb3669|M.bovis_AF2122/97 HAFVRWVVRTPWP----------------------------------LFS
Rv3645|M.tuberculosis_H37Rv HAFVRWVVRTPWP----------------------------------LFS
TH_0858|M.thermoresistible__bu -----------------------------------------------VFA
MAB_1459c|M.abscessus_ATCC_199 NGYGSWLLGTADESTFI-----------------------QRIRIQLILT
MMAR_5257|M.marinum_M AVVVQRYGGTVDKFTG-----------------------------DGIMA
MLBr_02341|M.leprae_Br4923 AGVIERYGGTVDKFTG-----------------------------DGIMA
MSMEG_0228|M.smegmatis_MC2_155 SGVVGHYGGTVDKFTG-----------------------------DGIMA
Mvan_1904|M.vanbaalenii_PYR-1 ATVVQRYHGTMDKFTG-----------------------------DGLMA
MUL_4617|M.ulcerans_Agy99 VVLPVYL----------------------------------------LLS
MAV_4804|M.avium_104 GGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAAEFLG
Mflv_4653|M.gilvum_PYR-GCK DTALSLVRGELLEDIG----------------------------DADWIR
:
Mb3669|M.bovis_AF2122/97 LSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLP-------PVNLLIFVS
Rv3645|M.tuberculosis_H37Rv LSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLP-------PVNLLIFVS
TH_0858|M.thermoresistible__bu LGMVQADIIGALFVLGFLRFGLPPGDRLELQDLP-------AFNLALFLG
MAB_1459c|M.abscessus_ATCC_199 VFVVAANLIGIGVVILLVTVAFPTPN--VFDAPA-------WVNFVIVPV
MMAR_5257|M.marinum_M VFGAPAALEDHALRACLAALGVQDEAKRLAGEVDRRDGVVLQLRVGLNSG
MLBr_02341|M.leprae_Br4923 IFGAPTALEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSG
MSMEG_0228|M.smegmatis_MC2_155 LFGAPLALEDHALRACLAALDLQYESHRLADELDLPAGVGLQIRVGLNSG
Mvan_1904|M.vanbaalenii_PYR-1 LFGAPMALEDHALRACIAALEIQAVVGELADEVEQRDGVRLQLRVGLNSG
MUL_4617|M.ulcerans_Agy99 FWVVAFENSGHYIEAAVVTVAV--------------------VSLGLWVI
MAV_4804|M.avium_104 RYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWACLEL
Mflv_4653|M.gilvum_PYR-GCK EDAARFAEMRTECLAGKVMSLLALGKIPAALTAASQLGALDPLADRGCRL
Mb3669|M.bovis_AF2122/97 TVIILFLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPL
Rv3645|M.tuberculosis_H37Rv TVIILFLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPL
TH_0858|M.thermoresistible__bu YLVVSFTVGAYVTLRLLLPVIRWQRRDTLLADPDPAATELARARALRMPF
MAB_1459c|M.abscessus_ATCC_199 YIALAVLIGAVWGTRRIFKAVRWALDERPPTKAD-------QRNAFAVPW
MMAR_5257|M.marinum_M QVVAGEIGTGALGYTAVGEQVGLAQRMEAVAAPETVMLGESTARLVEGAA
MLBr_02341|M.leprae_Br4923 QVIVGEIGSSALGYTAVGVQVGMAQRMESVAPPGVVMLSESTARLVEQTA
MSMEG_0228|M.smegmatis_MC2_155 QVIAGEMSAGGFGYTAIGEQVGMAQRMESVAPHGGIMCSDTTARLVEDSV
Mvan_1904|M.vanbaalenii_PYR-1 DVVVGDIGSGPGRYTAIGHAVGMAQRMEAAASAGAVVCSLSTADLVEHAT
MUL_4617|M.ulcerans_Agy99 FLPSVVRRRLPEKWAADHDVDRLSALEATYVYGRDAVVRGLGSNVVLGAF
MAV_4804|M.avium_104 RLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRAVHLRI
Mflv_4653|M.gilvum_PYR-GCK QMLALYRAGRTADALEVYTRYARRLDAELGLEPGPELRDLQTAVLRQAPE
:
Mb3669|M.bovis_AF2122/97 YRTLI----------------SLAVWATG----GGVFILASWSVAKHAAP
Rv3645|M.tuberculosis_H37Rv YRTLI----------------SLAVWATG----GGVFILASWSVAKHAAP
TH_0858|M.thermoresistible__bu YRTLI----------------SGTNWFLG----TIVFIVASWPVAGHSAP
MAB_1459c|M.abscessus_ATCC_199 RLTVI----------------QSVLWAGG----VALFTLLYGLYDPMYIP
MMAR_5257|M.marinum_M VLGEP----------------QLVHIKGVEAAVPAWQLLGVVDQYWQSGP
MLBr_02341|M.leprae_Br4923 VLGAP----------------QTVRIKGAEDAVPARRLLRVAEPRQPTWF
MSMEG_0228|M.smegmatis_MC2_155 LLGAP----------------EMLRVKGCDRPVAARRLLAATNAAHG-GR
Mvan_1904|M.vanbaalenii_PYR-1 RLGAV----------------QTVRIKGSDEPAPARRLVAVEAARMVVGR
MUL_4617|M.ulcerans_Agy99 NLVAV----------------GAVAGASG--------------SRLVQYG
MAV_4804|M.avium_104 GRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQARAQA
Mflv_4653|M.gilvum_PYR-GCK LSGWP-----------------RSPGWTGAAAVTATEAVPVRLDTVESAS
Mb3669|M.bovis_AF2122/97 VVAVATALGATATAIIG-------YLQSER--------VLRPVAVAAL-R
Rv3645|M.tuberculosis_H37Rv VVAVATALGATATAIIG-------YLQSER--------VLRPVAVAAL-R
TH_0858|M.thermoresistible__bu VIAVATGLGATATAIIG-------YLQAER--------VLRPVAVAAL-R
MAB_1459c|M.abscessus_ATCC_199 KIFFAVGFSGAVVCAAN-------YLFTEF--------AMRPVAARAL-E
MMAR_5257|M.marinum_M APATLVGREWELDTLTT-------MLDRSIAGRGSVVTLVGRAGIGKT-R
MLBr_02341|M.leprae_Br4923 SESTLVGREWELATLAA-------MLDRSIGGRGSVVGLVGPAGIGKT-R
MSMEG_0228|M.smegmatis_MC2_155 SDPTLVGRSWELNTIAG-------LLDEAVEGRGGIVSVVGPPGIGKS-R
Mvan_1904|M.vanbaalenii_PYR-1 NEGLMLGRDGELHQLCD-------SLDRRR--RRHLVSVVGAPGVGKS-R
MUL_4617|M.ulcerans_Agy99 IVGAATGIGIQLIAIHS-------FVEAAL----------RPVRVAII-G
MAV_4804|M.avium_104 SFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVPVLNT
Mflv_4653|M.gilvum_PYR-GCK HRAPLVGRRRELAAAAD-------VLDRVTAGAARWLVLSGPPGIGKT-R
. :
Mb3669|M.bovis_AF2122/97 SGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHATPEAL
Rv3645|M.tuberculosis_H37Rv SGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIALLHATPEAL
TH_0858|M.thermoresistible__bu GGVPENFRAPGVVLRQVLTWVLSTGVPVLAIVLALVASKVGILTAPAEQL
MAB_1459c|M.abscessus_ATCC_199 AGYRRRRLASGVMVRTVLAWMLGSGVPAAGIVITGIG-ALVLHNLTVSQL
MMAR_5257|M.marinum_M LAREAAQVAKNLGVTVFSTFCESHATDIPFRAVTRLLRAAAQVSRLDDAT
MLBr_02341|M.leprae_Br4923 LVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLDDRS
MSMEG_0228|M.smegmatis_MC2_155 MVRESIELARRRGVAVFYTYCESHASDVPFHVVVPLLREGFGVAGLDPAA
Mvan_1904|M.vanbaalenii_PYR-1 LVEEFCRRLRGAGTEVVLAGCDAHAMPIAFRALSRLLRAMFSADDLGDDD
MUL_4617|M.ulcerans_Agy99 DTAIGDSLPRSRPTFAAWSNLSVFGVAFNFAIVGAMLAGLISQAHTVP-L
MAV_4804|M.avium_104 LLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDELGERV
Mflv_4653|M.gilvum_PYR-GCK LAEEIAGLVAAGDGDVVWVNCPDERGTPPWWPMRQLVRALGADADEVLEI
Mb3669|M.bovis_AF2122/97 FNPI-------------LMMALAALGIGSVSTLLVAMSIADPLRQLRWAL
Rv3645|M.tuberculosis_H37Rv FNPI-------------LMMALAALGIGSVSTLLVAMSIADPLRQLRWAL
TH_0858|M.thermoresistible__bu TTPL-------------LVLAIATLVIGLSGTVLVAMSIADPLRQLRWAL
MAB_1459c|M.abscessus_ATCC_199 AVAV-------------IIIAGAIPSFGLILIWIASWLMATPVKEVQTAI
MMAR_5257|M.marinum_M ARVR-------------VRAIVPDGDPQDLLLLYDLLGIADPQVELPKIA
MLBr_02341|M.leprae_Br4923 ARAR-------------VREQIPDADTQDLLLLDDLLGIADPAVELPRLD
MSMEG_0228|M.smegmatis_MC2_155 ARVR-------------VRSLVPDADPEDLLLLDDVLGIADPDVPMPDLD
Mvan_1904|M.vanbaalenii_PYR-1 AREL-------------VLSQVPMG-STDAQIIFEAMGIADGAAPPLHVG
MUL_4617|M.ulcerans_Agy99 VSLV-------------IGAGMAVVFGVPVIVAPSFSPSMQPSRDLAAGT
MAV_4804|M.avium_104 ATQAGKPRM----GNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPIL
Mflv_4653|M.gilvum_PYR-GCK PPHADPDTARFLVYERIQRLLESAPRLLAVVVDDVQWADTTSAACLAYIA
.
Mb3669|M.bovis_AF2122/97 SEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELS---------------
Rv3645|M.tuberculosis_H37Rv SEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELS---------------
TH_0858|M.thermoresistible__bu GEVQRGNFNAHMQIYDASELGLLQAGFNDMVRDLA---------------
MAB_1459c|M.abscessus_ATCC_199 KRVAQNDLDIDLVVYDGTELGELQAGFNTMVEGLR---------------
MMAR_5257|M.marinum_M PEARRRRLTALINAVQLARAQPAVYVIEDAHWMDE---------------
MLBr_02341|M.leprae_Br4923 PDARRRRLTALINVAQLALSRPAVFVVEDVHWIDE---------------
MSMEG_0228|M.smegmatis_MC2_155 ADARRRRVAALVNAASLARREPGLYVLEDAHWIDE---------------
Mvan_1904|M.vanbaalenii_PYR-1 ADGRRHRLVETMAQFVRLRSTPMVLVLEDAHWIDA---------------
MUL_4617|M.ulcerans_Agy99 ERVAAGDYSRRLPVVQDDDLGALAASFNHMQAGLV---------------
MAV_4804|M.avium_104 AELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLG
Mflv_4653|M.gilvum_PYR-GCK GTLRDRPVLVVVTVRDGEHPAEVSRLLSTVARGEAN-------------R
.
Mb3669|M.bovis_AF2122/97 --ERQRLRDLFGRYVGEDVARRAL-------------ERGTELGG-----
Rv3645|M.tuberculosis_H37Rv --ERQRLRDLFGRYVGEDVARRAL-------------ERGTELGG-----
TH_0858|M.thermoresistible__bu --ERQRLRDLFGRYVGEDVARRAL-------------ERGTELGG-----
MAB_1459c|M.abscessus_ATCC_199 --ERERVRDLFGKHVGREVAAAAE-------------QQQPELGG-----
MMAR_5257|M.marinum_M --ASESMVAEFLTVIPQTHSMVLV-------------TYRPDYRGALRGV
MLBr_02341|M.leprae_Br4923 --VSDSMLADFLAVIPQTRSMALV-------------TYRPEYHGALRHV
MSMEG_0228|M.smegmatis_MC2_155 --VSESMLAEFLTVVTHTHSVMLI-------------TYRPEYTGVLARV
Mvan_1904|M.vanbaalenii_PYR-1 --ASEAVLCEFATVLERTSTVLVT-------------TCRPEYRGGLRKR
MUL_4617|M.ulcerans_Agy99 --ERQRLQAAFGTYVDPGLAARLL-------------EQGDDVFTG----
MAV_4804|M.avium_104 DHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGEL
Mflv_4653|M.gilvum_PYR-GCK LIEVPALSSEDVATLANEVAEEVVT-----------AAEAAELADRTG--
:
Mb3669|M.bovis_AF2122/97 -----------QERDVAVLFVDLVG-STQLAATRPPAEVVQ---------
Rv3645|M.tuberculosis_H37Rv -----------QERDVAVLFVDLVG-STQLAATRPPAEVVQ---------
TH_0858|M.thermoresistible__bu -----------QERDVAVLFVDLVG-STRLAATTPPADVVN---------
MAB_1459c|M.abscessus_ATCC_199 -----------EERHIAVLFADIVG-STRLAATRPAVEVVA---------
MMAR_5257|M.marinum_M RGAQSIALGPLSDAETSALIAELLGPAPSVAQIAEIIATRA---------
MLBr_02341|M.leprae_Br4923 VGAQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERA---------
MSMEG_0228|M.smegmatis_MC2_155 SGAQTIALRPLTDGQTSTLLTELLGPDAAAHQLAGLIADRA---------
Mvan_1904|M.vanbaalenii_PYR-1 S-AHTVTVAPLNDSLTMDLVLNLLGGDGAMGGLASRIVGVA---------
MUL_4617|M.ulcerans_Agy99 -----------ERRQVTVMFVDVRD-FTPFAEAHAAEDTVS---------
MAV_4804|M.avium_104 RDAVEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRS
Mflv_4653|M.gilvum_PYR-GCK -----------GNPFFVSEYARLPREERAGNEIPRAVRSVLD--------
:
Mb3669|M.bovis_AF2122/97 --------------------LLNEFFRVVVETVARHGGFVNKFQGDAALA
Rv3645|M.tuberculosis_H37Rv --------------------LLNEFFRVVVETVARHGGFVNKFQGDAALA
TH_0858|M.thermoresistible__bu --------------------LLNEFFRVVVDTVNRHGGFVNKFQGDAALA
MAB_1459c|M.abscessus_ATCC_199 --------------------LLNRFFTVVVEEIDRYEGMVNKFEGDATLA
MMAR_5257|M.marinum_M --------------------AGNPFFAEEIIRELAERRVLVGERGRYTCT
MLBr_02341|M.leprae_Br4923 --------------------AGNPFFAQEITRELAERGVLTGERGRYACS
MSMEG_0228|M.smegmatis_MC2_155 --------------------AGNPFFTQEIVRDLAERGVLRGERGAYRFH
Mvan_1904|M.vanbaalenii_PYR-1 --------------------AGNPYFVEEIVRDLVGRGVLAGSRGDYRLI
MUL_4617|M.ulcerans_Agy99 --------------------RLNELFEIVVPTVVDAGGHVNKFLGDGALA
MAV_4804|M.avium_104 QPVPSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEV
Mflv_4653|M.gilvum_PYR-GCK --------------------RRLAALDPAVMQVLRAAAVIADVLDSVTVP
: :
Mb3669|M.bovis_AF2122/97 IFGAPIEHPDGAGAALSAARELHDELIPVL--GSAEFGIGVSAGRAIAGH
Rv3645|M.tuberculosis_H37Rv IFGAPIEHPDGAGAALSAARELHDELIPVL--GSAEFGIGVSAGRAIAGH
TH_0858|M.thermoresistible__bu IFGAPIEHPDACGAALAAARELHDELIAVL--GETEFGIGVSAGRAIAGH
MAB_1459c|M.abscessus_ATCC_199 VFGAPVRQDRPESQALAAARAIARRLRTEV--PECQAGIGVASGQAVAGN
MMAR_5257|M.marinum_M AEADDAIVPATLQATIGARIDRLSPAAKQT--LSAAAVIGSRFSTELLIG
MLBr_02341|M.leprae_Br4923 TDVAEVCVPATLQATIAARIDRLSPPAKQL--LVAAAVIGFRFGSDLLAS
MSMEG_0228|M.smegmatis_MC2_155 GADVEIGVPATLQATIAARIDRLEVEAKRT--LSAAAVIGLRFGPDMLAA
Mvan_1904|M.vanbaalenii_PYR-1 RDVDDIGVPVTVQAVLAARIDRLAPATKAV--LNAAAVIGNRFDAETLQV
MUL_4617|M.ulcerans_Agy99 VFGTPNDLADHADAAVAAAVLIHRRVVERFG-EEFRIGIGINTGVVIAGT
MAV_4804|M.avium_104 ALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGA
Mflv_4653|M.gilvum_PYR-GCK LLARTTALDLDTLADYLDEAADERIIVNSHTGDGYVFAHGLLREQLLTGM
.
Mb3669|M.bovis_AF2122/97 IGAQAR--FEYTVIGDPVNEAARLTELAKLEDGHVLASAIAVSGALDAEA
Rv3645|M.tuberculosis_H37Rv IGAQAR--FEYTVIGDPVNEAARLTELAKLEDGHVLASAIAVSGALDAEA
TH_0858|M.thermoresistible__bu IGAQAR--FEYTVIGDPVNEAARLTELAKLEEGHVLASAMAVSGALDAEA
MAB_1459c|M.abscessus_ATCC_199 IGAHDR--FEYTVIGDPVNEAARLCELSKTVPGHLVASLDTVLRAHHREA
MMAR_5257|M.marinum_M LGIDPP---IEELISAELVDQVRFTEPAEYVFRHPLIHTVAYESQLKSAR
MLBr_02341|M.leprae_Br4923 LGIDLS---VDELIDANLVDQVRFTAPVEYAFRHPLIRTVAYESQLKSDR
MSMEG_0228|M.smegmatis_MC2_155 LGADVS---MQALIDAELVDQVMFAPRPEYAFRHPLIRMVALESQLKSDR
Mvan_1904|M.vanbaalenii_PYR-1 LTPNARSGELAELVATELIDQMEFAPRQRYCFRHPLVRAVAYDSQISANR
MUL_4617|M.ulcerans_Agy99 IGGGKL---EFTLIGDTVNVAARVEQLTKATGDAILLTQQCVDAQGSRPA
MAV_4804|M.avium_104 LSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARAR
Mflv_4653|M.gilvum_PYR-GCK PALRRQ---RVHAKVADVLADSALPDAPTWRAQHLVAAQPLVEPTVVVPA
Mb3669|M.bovis_AF2122/97 LCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSSEVRG--------
Rv3645|M.tuberculosis_H37Rv LCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSSEVRG--------
TH_0858|M.thermoresistible__bu LCWDVGETVELRGRTVPTQLARPVKLAFSNGPGPSNNSDAPGTRT-----
MAB_1459c|M.abscessus_ATCC_199 LHWRSGDTVTLRGRTEPTELAVPV--------------------------
MMAR_5257|M.marinum_M AQMHRRLAAVIEARVPESADQYAALIAEHLEAAGESHAAYGWQVR-----
MLBr_02341|M.leprae_Br4923 ARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMR-----
MSMEG_0228|M.smegmatis_MC2_155 AELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFTWHMR-----
Mvan_1904|M.vanbaalenii_PYR-1 ARAHRLLAGAIETRDPAAKDENAALIATHLEGAGDFETACRWHLR-----
MUL_4617|M.ulcerans_Agy99 GLIDRG-LHVLKGKSAAIQVFGLHQESDMRADLTH---------------
MAV_4804|M.avium_104 GQHGKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHML
Mflv_4653|M.gilvum_PYR-GCK CRLAAEQATQQWSSDIAAGWWQAALDAYDRLPASERDDADRDALT-----
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------TGSVSRADAETTAPES--------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --------------AAAWATNRDIAAAHLSWERARKIADALPVDDPNRAA
MLBr_02341|M.leprae_Br4923 --------------AAAWATNQDVRAARVSWEHATKIADALTAEDPHRAA
MSMEG_0228|M.smegmatis_MC2_155 --------------AGTWLTNRDIDAARLSWQRARHVADQLPHDAEDRAA
Mvan_1904|M.vanbaalenii_PYR-1 --------------AADWLRMRDLLAARNQWEIAMRVADGLPGADDAVTA
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 RSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHAL
Mflv_4653|M.gilvum_PYR-GCK --------------VELLEAHSRAGRGQLVLDSVTRYLGEALRTGRAASA
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M MRIAPRTMLCGIAFRIHIDVAG-ARFEELRELCAAAGDKASLSIGMAGLV
MLBr_02341|M.leprae_Br4923 MCIAPRTRLCGIAWRGRFNSS--SGFDEVRQLCNATGDKAPLAVATVGPA
MSMEG_0228|M.smegmatis_MC2_155 MTIAPRTLLCLSTWRAGGHLSD-TGFDELCALAAAADDKVSLATAMAGQV
Mvan_1904|M.vanbaalenii_PYR-1 LRIAPRTMLVSTELFVGADPDNDQRLVELRELTARVDDSHSLALALAGRI
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 SGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIV
Mflv_4653|M.gilvum_PYR-GCK GRVASALLRASGGWPWLAPGNDPGELLTLLSRAATLSEGEPASAARVLPA
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M IDHLQHA-RMREASQLATEAMTLIESVGDP--ALTVALSIALIYAKSECA
MLBr_02341|M.leprae_Br4923 IDHVYQD-RLH---------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 SALLVHA-HYRESSSLASELTSLLESVGDR--RLTVALLFAALGAKFQTG
Mvan_1904|M.vanbaalenii_PYR-1 VTFIVNSNRVPEALPLAAELAELVDTLGPTPAAELEIIYTAMSFAHLASC
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 EGPWTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLG
Mflv_4653|M.gilvum_PYR-GCK LAVGHCYHPDPTIAPELLDRAERLAEATGDPDVIADVLIGRLITFSGVAT
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M EWSDALRWSQRVIALADGDPTMGALIIGCPLAVAFATRANARYCLGRPGW
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 EANEVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLGDPDW
Mvan_1904|M.vanbaalenii_PYR-1 EFDAALEVIGRSIALEPEYP-------STDRALAYAIGGLCEVCLGSRER
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 VIYAEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQS
Mflv_4653|M.gilvum_PYR-GCK LSAQSLEWVQRLNALRHSRSREDAVIAHSVATMAAMNLGDVDGARRHVQA
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M AED-LQHGLA---------------MARSADPMSYATVVAYVYSAGISTG
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 RTG-LDRATP---------------LVRDFGITTRALMLTYKCIG-LPTG
Mvan_1904|M.vanbaalenii_PYR-1 GIGHIRLATE---------------LARAMSPVSFSAVS--LYWGILAAM
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 LIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIE
Mflv_4653|M.gilvum_PYR-GCK GIAGSEELQLP--------------VLRAQLRWMEAVLAVWHGDFAEAGR
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M VLASDDCALGEIEDALQIAERSGDDVALAIARMTLGIALVHRREDPMRDR
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 LLLPSPELLEESCEVLEVAQRSADDLALAGAQVSRGLLLLWQG-GPYRDE
Mvan_1904|M.vanbaalenii_PYR-1 GMHVAEDLVDDMREWLARAESFGDRFGIIAAQWTYATLLLQAG-SPRRDE
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 DMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRA
Mflv_4653|M.gilvum_PYR-GCK HHAIAAHVHEQTELYEAGSGLLARATLLRERGGPVDPSWTDLNAQQAGGL
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M GQAALADVSDMFQRRVYFLADLPFVEVYLAREWARCGDLDGAIAHMRAAV
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 ALELLSLGREASVREQFTMAAVPAVDTELARDMAARGDLDGAIELARDVV
Mvan_1904|M.vanbaalenii_PYR-1 AFVLLRRAEVGITTHNLQSFALAITGMQLAREAARNGHRDEAIDSIRHLV
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 GLGMLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTII
Mflv_4653|M.gilvum_PYR-GCK GMVGVVRTGVLTLLSGPKARAEALATLRHWAQHTDRAHIWTTLGHHTLLA
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M --EHLFREGRLLGWSTPATGVLVQTLLDRGTEGDLVEAAAAIERLAAAPA
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --DTSIDSGEAINMSASVT-VLVQSLIARGDRDDLDHAQRVIDRFAALPT
Mvan_1904|M.vanbaalenii_PYR-1 --TLHTRDAPLLHLG-CPAESLCEMLIDRGGTRDLLEVEEVLEQWCSR--
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 GDAVNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNR
Mflv_4653|M.gilvum_PYR-GCK HLAVDHDLPDFAEPLLAQLDPYRDRIAVIGQVGMAGPVALATARLHALRG
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_5257|M.marinum_M DDGLAVREILLLRLRALLARAHGDDTTYARLRDRYRDTASAMGFAGHIAQ
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 DPGFVLYDVQLMRLRALLARARGDEERYRECSDRYRELATAYRYEGHMAL
Mvan_1904|M.vanbaalenii_PYR-1 SPGTAPMDLWTIRIRALLASARGERQRYAQLADEYAAACEFTGYRHHWGG
MUL_4617|M.ulcerans_Agy99 --------------------------------------------------
MAV_4804|M.avium_104 RRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRC
Mflv_4653|M.gilvum_PYR-GCK DKAAALADLALARSIAERSAGVPTLLRCRLLECELTEESPGRSTAASTLA
Mb3669|M.bovis_AF2122/97 ------------------------------------
Rv3645|M.tuberculosis_H37Rv ------------------------------------
TH_0858|M.thermoresistible__bu ------------------------------------
MAB_1459c|M.abscessus_ATCC_199 ------------------------------------
MMAR_5257|M.marinum_M AESMP-------------------------------
MLBr_02341|M.leprae_Br4923 ------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 AARMA-------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 PYPVLSDRRG--------------------------
MUL_4617|M.ulcerans_Agy99 ------------------------------------
MAV_4804|M.avium_104 RDMLPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK
Mflv_4653|M.gilvum_PYR-GCK AEAADLGMAAVAEAASRLL-----------------