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VTVLFADVVGSMRLAAELDPERLREIMNDLFNRSATVVQRYHGTMDKFTGDGLMALFGAPMALEDHALRA CIAALEIQAVVGELADEVEQRDGVRLQLRVGLNSGDVVVGDIGSGPGRYTAIGHAVGMAQRMEAAASAGA VVCSLSTADLVEHATRLGAVQTVRIKGSDEPAPARRLVAVEAARMVVGRNEGLMLGRDGELHQLCDSLDR RRRRHLVSVVGAPGVGKSRLVEEFCRRLRGAGTEVVLAGCDAHAMPIAFRALSRLLRAMFSADDLGDDDA RELVLSQVPMGSTDAQIIFEAMGIADGAAPPLHVGADGRRHRLVETMAQFVRLRSTPMVLVLEDAHWIDA ASEAVLCEFATVLERTSTVLVTTCRPEYRGGLRKRSAHTVTVAPLNDSLTMDLVLNLLGGDGAMGGLASR IVGVAAGNPYFVEEIVRDLVGRGVLAGSRGDYRLIRDVDDIGVPVTVQAVLAARIDRLAPATKAVLNAAA VIGNRFDAETLQVLTPNARSGELAELVATELIDQMEFAPRQRYCFRHPLVRAVAYDSQISANRARAHRLL AGAIETRDPAAKDENAALIATHLEGAGDFETACRWHLRAADWLRMRDLLAARNQWEIAMRVADGLPGADD AVTALRIAPRTMLVSTELFVGADPDNDQRLVELRELTARVDDSHSLALALAGRIVTFIVNSNRVPEALPL AAELAELVDTLGPTPAAELEIIYTAMSFAHLASCEFDAALEVIGRSIALEPEYPSTDRALAYAIGGLCEV CLGSRERGIGHIRLATELARAMSPVSFSAVSLYWGILAAMGMHVAEDLVDDMREWLARAESFGDRFGIIA AQWTYATLLLQAGSPRRDEAFVLLRRAEVGITTHNLQSFALAITGMQLAREAARNGHRDEAIDSIRHLVT LHTRDAPLLHLGCPAESLCEMLIDRGGTRDLLEVEEVLEQWCSRSPGTAPMDLWTIRIRALLASARGERQ RYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1904 | - | - | 100% (1014) | adenylyl cyclase class-3/4/guanylyl cyclase |
| M. vanbaalenii PYR-1 | Mvan_1815 | - | 4e-21 | 23.84% (692) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4265 | - | 3e-16 | 33.90% (177) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1352c | - | 3e-15 | 29.69% (192) | adenylate cyclase |
| M. gilvum PYR-GCK | Mflv_4653 | - | 6e-17 | 22.92% (759) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1318c | - | 3e-15 | 29.69% (192) | adenylate cyclase |
| M. leprae Br4923 | MLBr_02341 | - | 1e-159 | 46.97% (692) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_1459c | - | 1e-15 | 34.09% (176) | hypothetical protein MAB_1459c |
| M. marinum M | MMAR_5257 | - | 0.0 | 41.43% (1021) | membrane-anchored adenylyl cyclase |
| M. avium 104 | MAV_1220 | - | 7e-15 | 29.94% (157) | adenylate cyclase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_0228 | - | 0.0 | 41.32% (1014) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_3295 | - | 3e-15 | 34.27% (178) | PUTATIVE putative putative adenylate/guanylate cyclase |
| M. ulcerans Agy99 | MUL_3594 | - | 3e-23 | 39.08% (174) | adenylylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1352c|M.bovis_AF2122/97 -----------------------------------------MS--AKKST
Rv1318c|M.tuberculosis_H37Rv -----------------------------------------MS--AKKST
MAB_1459c|M.abscessus_ATCC_199 -----------------------------------------MANESIRAV
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 MTTALVCVACGAELRSIAKFCDECGSPVVEAETP-AEYKQVTVLFADVVG
MMAR_5257|M.marinum_M MTPVLACRSCGTQPLENARFCHGCGAPVAAAADAHAEYKQVTVLFADVVH
MSMEG_0228|M.smegmatis_MC2_155 ---MVACGTCGTELRQGARFCDSCGTAIVDGSKH-AEYKQVTVLFADVVD
Mvan_1904|M.vanbaalenii_PYR-1 ----------------------------------------MTVLFADVVG
Mflv_4653|M.gilvum_PYR-GCK ------------MRYRLLGPLQVVHGEAAVDIGPRKQRSVLAALLLAQGR
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 AQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTAL
Rv1318c|M.tuberculosis_H37Rv AQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTAL
MAB_1459c|M.abscessus_ATCC_199 SRRVGRALGAITGQTGNINTGNGYGSWLLGTADESTFIQRIRIQLILTVF
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu ----------VTG----------------ARRARADQVGANRIGVTYAAR
MLBr_02341|M.leprae_Br4923 SMDIAAAVGLERLREIMTELVSRAAGVIERYGGTVDKFTGDGIMAIFGAP
MMAR_5257|M.marinum_M SMDIAAALGAERLREIMTELVNRAAVVVQRYGGTVDKFTGDGIMAVFGAP
MSMEG_0228|M.smegmatis_MC2_155 SMRLAAAVGAERLREILSALVSRCSGVVGHYGGTVDKFTGDGIMALFGAP
Mvan_1904|M.vanbaalenii_PYR-1 SMRLAAELDPERLREIMNDLFNRSATVVQRYHGTMDKFTGDGLMALFGAP
Mflv_4653|M.gilvum_PYR-GCK VVSTDRLVDVVWGDDVPASATASLQVYISNLRRALRSGAGDRTVSSVAQP
MUL_3594|M.ulcerans_Agy99 --------------------------------MHVNGFGGLAAQQVAASP
Mb1352c|M.bovis_AF2122/97 VVTAN----LLGIG-VALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLA
Rv1318c|M.tuberculosis_H37Rv VVTAN----LLGIG-VALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLA
MAB_1459c|M.abscessus_ATCC_199 VVAAN----LIGIG-VVILLVTVAFPTPNVF-DAPAWVNFVIVPVYIALA
MAV_1220|M.avium_104 MSLSY----VLAVGEAAAILIPLRGHTSVGVNADFARQNTGPVLALIALG
TH_3295|M.thermoresistible__bu LTAAH----LTAAAAVLAVIVVLADNTVGDVRRLLTRENLIAFVVLVVLS
MLBr_02341|M.leprae_Br4923 TALED----HALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQ
MMAR_5257|M.marinum_M AALED----HALRACLAALGVQDEAKRLAGEVDRRDGVVLQLRVGLNSGQ
MSMEG_0228|M.smegmatis_MC2_155 LALED----HALRACLAALDLQYESHRLADELDLPAGVGLQIRVGLNSGQ
Mvan_1904|M.vanbaalenii_PYR-1 MALED----HALRACIAALEIQAVVGELADEVEQRDGVRLQLRVGLNSGD
Mflv_4653|M.gilvum_PYR-GCK IVRQPPGYFLDAGPDESDIAVFTAACARAAAAIDGERWDEALAEADTALS
MUL_3594|M.ulcerans_Agy99 ICCAPLDERSAIPGPQPPVRLLVVDDADGVETLFGARFRTELRCDEYDLS
: :
Mb1352c|M.bovis_AF2122/97 LALGSYALTRQTVQALRWAIEGRKPTREEERR-TFLAPWRV---AVGHLM
Rv1318c|M.tuberculosis_H37Rv LALGSYALTRQTVQALRWAIEGRKPTREEERR-TFLAPWRV---AVGHLM
MAB_1459c|M.abscessus_ATCC_199 VLIGAVWGTRRIFKAVRWALDERPPTKADQRN-AFAVPWRL---TVIQSV
MAV_1220|M.avium_104 IVGVAVAGALSLAPTLRWYVAGEEPTPQQRDA-VMKLAGRQ---SAILVT
TH_3295|M.thermoresistible__bu AAVDSAVGILTMRPTFRWFAGGAGPTPEQQRA-ALRIPLRQ---TGIEFA
MLBr_02341|M.leprae_Br4923 VIVGEIGSSALGYTAVGVQVGMAQRMESVAPPGVVMLSEST---ARLVEQ
MMAR_5257|M.marinum_M VVAGEIGTGALGYTAVGEQVGLAQRMEAVAAPETVMLGEST---ARLVEG
MSMEG_0228|M.smegmatis_MC2_155 VIAGEMSAGGFGYTAIGEQVGMAQRMESVAPHGGIMCSDTT---ARLVED
Mvan_1904|M.vanbaalenii_PYR-1 VVVGDIGSGPGRYTAIGHAVGMAQRMEAAASAGAVVCSLST---ADLVEH
Mflv_4653|M.gilvum_PYR-GCK LVRGELLEDIGDADWIREDAARFAEMRTECLAGKVMSLLALGKIPAALTA
MUL_3594|M.ulcerans_Agy99 FSNDPVQALKMVGDSPDIEVLVTNLNMPQMNGLDLLTEVAKLGRPLKTIV
. .
Mb1352c|M.bovis_AF2122/97 FWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPF
Rv1318c|M.tuberculosis_H37Rv FWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPF
MAB_1459c|M.abscessus_ATCC_199 LWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAVVCAANYLFTEFAMRPV
MAV_1220|M.avium_104 AWAVSGGIFLLLNLAGGARLLLPIALGALLGGSAAAGTGMLLAQRTLRPI
TH_3295|M.thermoresistible__bu VWIVSGTVFMVLNLQAPGGVAFVIGGAILFGAMTTACIGYLITTRTLRPI
MLBr_02341|M.leprae_Br4923 TAVLGAPQTVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWELAT
MMAR_5257|M.marinum_M AAVLGEPQLVHIKGVEAAVPAWQLLGVVDQYWQSGPAPATLVGREWELDT
MSMEG_0228|M.smegmatis_MC2_155 SVLLGAPEMLRVKGCDRPVAARRLLAATNAAHG-GRSDPTLVGRSWELNT
Mvan_1904|M.vanbaalenii_PYR-1 ATRLGAVQTVRIKGSDEPAPARRLVAVEAARMVVGRNEGLMLGRDGELHQ
Mflv_4653|M.gilvum_PYR-GCK ASQLGALDPLADRGCRLQMLALYRAGRTADALEVYTRYARRLDAELGLEP
MUL_3594|M.ulcerans_Agy99 LTACNDLANIRAAMMRGAFDFQLTPLDLEDLRVTISKAVTIVRELQAGEA
.
Mb1352c|M.bovis_AF2122/97 AAQALEAGPPPRRLAPGILGR----------------------TMVVWLL
Rv1318c|M.tuberculosis_H37Rv AAQALEAGPPPRRLAPGILGR----------------------TMVVWLL
MAB_1459c|M.abscessus_ATCC_199 AARALEAGYRRRRLASGVMVR----------------------TVLAWML
MAV_1220|M.avium_104 MRAATLG-AEPRLAVPSVYAR----------------------LVLLWFL
TH_3295|M.thermoresistible__bu IAAAMTN-STARIQLPGPLGR----------------------LLYVWIL
MLBr_02341|M.leprae_Br4923 LAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQLAKGLEVEVFSVFCE
MMAR_5257|M.marinum_M LTTMLDRSIAGRGSVVTLVGRAGIGKTRLAREAAQVAKNLGVTVFSTFCE
MSMEG_0228|M.smegmatis_MC2_155 IAGLLDEAVEGRGGIVSVVGPPGIGKSRMVRESIELARRRGVAVFYTYCE
Mvan_1904|M.vanbaalenii_PYR-1 LCDSLDRRR--RRHLVSVVGAPGVGKSRLVEEFCRRLRGAGTEVVLAGCD
Mflv_4653|M.gilvum_PYR-GCK GPELRDLQTAVLRQAPELSGWP---RSPGWTGAAAVTATEAVPVRLDTVE
MUL_3594|M.ulcerans_Agy99 ARQRALELADQNRRVENIFGR--------------------------YVS
Mb1352c|M.bovis_AF2122/97 GSGVPVVGIALMAMFEMVLLNLTR-MQFATGVLIISMVTLVFGFILMWIL
Rv1318c|M.tuberculosis_H37Rv GSGVPVVGIALMAMFEMVLLNLTR-MQFATGVLIISMVTLVFGFILMWIL
MAB_1459c|M.abscessus_ATCC_199 GSGVPAAGIVITGIGALVLHNLTV-SQLAVAVIIIAGAIPSFGLILIWIA
MAV_1220|M.avium_104 CSAFPIAVIAALVVLRSYGWLVEKSASLDVPILVVSLAALVLGLPTMILT
TH_3295|M.thermoresistible__bu FSVLPALGVVTIVLARSRGWFLQASAPIERPILVMMGVSVVLGISAAVLV
MLBr_02341|M.leprae_Br4923 SHATDVAFDVVAQLVRAVAQISGLDDRSARARVREQIPDADTQDLLLLDD
MMAR_5257|M.marinum_M SHATDIPFRAVTRLLRAAAQVSRLDDATARVRVRAIVPDGDPQDLLLLYD
MSMEG_0228|M.smegmatis_MC2_155 SHASDVPFHVVVPLLREGFGVAGLDPAAARVRVRSLVPDADPEDLLLLDD
Mvan_1904|M.vanbaalenii_PYR-1 AHAMPIAFRALSRLLRAMFSADDLGDDDARELVLSQVPMG-STDAQIIFE
Mflv_4653|M.gilvum_PYR-GCK SASHRAPLVGRRRELAAAADVLDRVTAGAARWLVLSGPPGIGKTRLAEEI
MUL_3594|M.ulcerans_Agy99 EEVKTHLLACPEGHQNSERRTLTMLMADIRGFTRLSEILSPERALQVLNA
Mb1352c|M.bovis_AF2122/97 AWLTATP-----------------------------------VRVVRAAL
Rv1318c|M.tuberculosis_H37Rv AWLTATP-----------------------------------VRVVRAAL
MAB_1459c|M.abscessus_ATCC_199 SWLMATP-----------------------------------VKEVQTAI
MAV_1220|M.avium_104 SRSISDP-----------------------------------IGEVVDAM
TH_3295|M.thermoresistible__bu ARSISDP-----------------------------------VHEVVLAM
MLBr_02341|M.leprae_Br4923 LLGIADP-----------------------------------AVELPRLD
MMAR_5257|M.marinum_M LLGIADP-----------------------------------QVELPKIA
MSMEG_0228|M.smegmatis_MC2_155 VLGIADP-----------------------------------DVPMPDLD
Mvan_1904|M.vanbaalenii_PYR-1 AMGIADG-----------------------------------AAPPLHVG
Mflv_4653|M.gilvum_PYR-GCK AGLVAAGDGDVVWVNCPDERGTPPWWPMRQLVRALGADADEVLEIPPHAD
MUL_3594|M.ulcerans_Agy99 YLERATD----------------------------------VVIRWNGTI
:
Mb1352c|M.bovis_AF2122/97 RRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGR
Rv1318c|M.tuberculosis_H37Rv RRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGR
MAB_1459c|M.abscessus_ATCC_199 KRVAQNDLDIDLVVYDGTELGELQAGFNTMVEGLRERERVRDLFGKHVGR
MAV_1220|M.avium_104 AEIEHGRMETYVGAYERSQIGRLQTGFNRMVAGLAERDRLRDLFGRHVGA
TH_3295|M.thermoresistible__bu REVERGR-PAAVDVYEPSEIGRLQAGFNSMVAGLAERERLRDLFGRYVGT
MLBr_02341|M.leprae_Br4923 PDARRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLAVIPQ
MMAR_5257|M.marinum_M PEARRRRLTALINAVQLARAQPAVYVIEDAHWMDEASESMVAEFLTVIPQ
MSMEG_0228|M.smegmatis_MC2_155 ADARRRRVAALVNAASLARREPGLYVLEDAHWIDEVSESMLAEFLTVVTH
Mvan_1904|M.vanbaalenii_PYR-1 ADGRRHRLVETMAQFVRLRSTPMVLVLEDAHWIDAASEAVLCEFATVLER
Mflv_4653|M.gilvum_PYR-GCK PDTARFLVYERIQRLLESAPRLLAVVVDDVQWADTTSAACLAYIAGTLRD
MUL_3594|M.ulcerans_Agy99 NEILGDGLLVFFGVPNTDGEAAEHAVAAALELQLAMGELNVSHREQGLPE
. :
Mb1352c|M.bovis_AF2122/97 EVAAAAERERSKLGGEE-----------------------RHVAVVFIDI
Rv1318c|M.tuberculosis_H37Rv EVAAAAERERSKLGGEE-----------------------RHVAVVFIDI
MAB_1459c|M.abscessus_ATCC_199 EVAAAAEQQQPELGGEE-----------------------RHIAVLFADI
MAV_1220|M.avium_104 DVAQRAIEEGASLSGDV-----------------------VEAAVLFIDL
TH_3295|M.thermoresistible__bu DVAREAVEHGEALRGDV-----------------------REVGVLFVDL
MLBr_02341|M.leprae_Br4923 TRSMALVTYRPEYHGALRHVVG-------AQIIAVAPLSDVETSTLVAEL
MMAR_5257|M.marinum_M THSMVLVTYRPDYRGALRGVRG-------AQSIALGPLSDAETSALIAEL
MSMEG_0228|M.smegmatis_MC2_155 THSVMLITYRPEYTGVLARVSG-------AQTIALRPLTDGQTSTLLTEL
Mvan_1904|M.vanbaalenii_PYR-1 TSTVLVTTCRPEYRGGLRKRS--------AHTVTVAPLNDSLTMDLVLNL
Mflv_4653|M.gilvum_PYR-GCK RPVLVVVTVRDGEHPAEVSRLLSTVARGEANRLIEVPALSSEDVATLANE
MUL_3594|M.ulcerans_Agy99 LGIGIGVHTGEAVVGTIGSPR-------------------RQKYTAIGKN
. .
Mb1352c|M.bovis_AF2122/97 VG-STQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIF
Rv1318c|M.tuberculosis_H37Rv VG-STQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIF
MAB_1459c|M.abscessus_ATCC_199 VG-STRLAATRPAVEVVALLNRFFTVVVEEIDRYEGMVNKFEGDATLAVF
MAV_1220|M.avium_104 VG-STQLAESRPPQEVAEVLNDFFRIVVNAVDEHHGLVNKFAGDAALAVF
TH_3295|M.thermoresistible__bu VG-STTLAASRPPEDVARILNDFFQIVVTAVEDGAGLVNKFQGDAVLAVF
MLBr_02341|M.leprae_Br4923 LGLDQSVTQIGELITERAAGNPFFAQEITRELAERGVLTGERGRYACSTD
MMAR_5257|M.marinum_M LGPAPSVAQIAEIIATRAAGNPFFAEEIIRELAERRVLVGERGRYTCTAE
MSMEG_0228|M.smegmatis_MC2_155 LGPDAAAHQLAGLIADRAAGNPFFTQEIVRDLAERGVLRGERGAYRFHGA
Mvan_1904|M.vanbaalenii_PYR-1 LGGDGAMGGLASRIVGVAAGNPYFVEEIVRDLVGRGVLAGSRGDYRLIRD
Mflv_4653|M.gilvum_PYR-GCK VAEEVVTAAEAAELADRTGGNPFFVSEYARLPREERAGNEIPRAVRSVLD
MUL_3594|M.ulcerans_Agy99 VNLVARIESNTVGGQVLVSESTYHEICAIADTSGSTQVRVKGLTEPITVH
: . :.
Mb1352c|M.bovis_AF2122/97 GAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGAR
Rv1318c|M.tuberculosis_H37Rv GAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGAR
MAB_1459c|M.abscessus_ATCC_199 GAPVRQDRPESQALAAARAIARRLRTEVPECQAGIGVASGQAVAGNIGAH
MAV_1220|M.avium_104 GVPLPTNEPASAALATARTLGTQLR-QLP-VDFGIGVSAGRVFAGNVGAE
TH_3295|M.thermoresistible__bu GAPLRIDDPAAAALRTARRLASRLR-DLPGLDFGIGVSCGRVFAGTIGGE
MLBr_02341|M.leprae_Br4923 VAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGID
MMAR_5257|M.marinum_M ADDAIVPATLQATIGARIDRLSPAAKQTLSAAAVIGSRFSTELLIGLGID
MSMEG_0228|M.smegmatis_MC2_155 DVEIGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGAD
Mvan_1904|M.vanbaalenii_PYR-1 VDDIGVPVTVQAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQVLTPN
Mflv_4653|M.gilvum_PYR-GCK RRLAALDPAVMQVLRAAAVIADVLDSVTVPLLARTTALDLDTLADYLDEA
MUL_3594|M.ulcerans_Agy99 DITGLAGRYNLRLPSIDRKVIPLVVPRPTGIAVIENKIIGAAHPAEVVGS
:
Mb1352c|M.bovis_AF2122/97 ER--------------------------------------------FEYT
Rv1318c|M.tuberculosis_H37Rv ER--------------------------------------------FEYT
MAB_1459c|M.abscessus_ATCC_199 DR--------------------------------------------FEYT
MAV_1220|M.avium_104 NR--------------------------------------------YEYT
TH_3295|M.thermoresistible__bu HR--------------------------------------------YEYT
MLBr_02341|M.leprae_Br4923 LS---VDELIDAN---------LVDQVRFTAPVEYAFRHPLIRTVAYESQ
MMAR_5257|M.marinum_M PP---IEELISAE---------LVDQVRFTEPAEYVFRHPLIHTVAYESQ
MSMEG_0228|M.smegmatis_MC2_155 VS---MQALIDAE---------LVDQVMFAPRPEYAFRHPLIRMVALESQ
Mvan_1904|M.vanbaalenii_PYR-1 ARSGELAELVATE---------LIDQMEFAPRQRYCFRHPLVRAVAYDSQ
Mflv_4653|M.gilvum_PYR-GCK ADERIIVNSHTGDGYVFAHGLLREQLLTGMPALRRQRVHAKVADVLADSA
MUL_3594|M.ulcerans_Agy99 GD------------------------------------------------
Mb1352c|M.bovis_AF2122/97 VIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLR
Rv1318c|M.tuberculosis_H37Rv VIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLR
MAB_1459c|M.abscessus_ATCC_199 VIGDPVNEAARLCELSKTVPGHLVASLDTVLRAHHREALHWRSGDTVTLR
MAV_1220|M.avium_104 VIGDAVNEAARLADLAKTADRRILCSAAAIEAAGEAERGHWAECYSTVLR
TH_3295|M.thermoresistible__bu VIGDPVNEASRLADRAKHVATRVLASGAALAAAQPEEHTRWVGRGSALLR
MLBr_02341|M.leprae_Br4923 LKSDRARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMR
MMAR_5257|M.marinum_M LKSARAQMHRRLAAVIEARVPESADQYAALIAEHLEAAGESHAAYGWQVR
MSMEG_0228|M.smegmatis_MC2_155 LKSDRAELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFTWHMR
Mvan_1904|M.vanbaalenii_PYR-1 ISANRARAHRLLAGAIETRDPAAKDENAALIATHLEGAGDFETACRWHLR
Mflv_4653|M.gilvum_PYR-GCK LPDAPTWRAQHLVAAQPLVEPTVVVPACRLAAEQATQQWSSDIAAGWWQA
MUL_3594|M.ulcerans_Agy99 -GAVRVRTGLQVAPFCDLVLDVAGAQVFAKVVDCGVDGGICELMAVFTSV
. :
Mb1352c|M.bovis_AF2122/97 GHDQPVRLAKPVGLTKPRR-------------------------------
Rv1318c|M.tuberculosis_H37Rv GHDQPVRLAKPVGLTKPRR-------------------------------
MAB_1459c|M.abscessus_ATCC_199 GRTEPTELAVPV--------------------------------------
MAV_1220|M.avium_104 GRSETTHVSAPTG-------------------------------------
TH_3295|M.thermoresistible__bu GRAEPTELAEPAGPDDPAAG------------------------------
MLBr_02341|M.leprae_Br4923 AAAWATNQDVRAARVSWEHATKIADALTAEDPHRAAMCIAPRTRLCGIAW
MMAR_5257|M.marinum_M AAAWATNRDIAAAHLSWERARKIADALPVDDPNRAAMRIAPRTMLCGIAF
MSMEG_0228|M.smegmatis_MC2_155 AGTWLTNRDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTW
Mvan_1904|M.vanbaalenii_PYR-1 AADWLRMRDLLAARNQWEIAMRVADGLPGADDAVTALRIAPRTMLVSTEL
Mflv_4653|M.gilvum_PYR-GCK ALDAYDRLPASERDDADRDALTVELLEAHSRAGRGQLVLDSVTRYLGEAL
MUL_3594|M.ulcerans_Agy99 SDDVRRALAAPSTANSLS--------------------------------
.
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 RGR-------------------FNSS--SGFDEVRQLCNATGDKAPLAVA
MMAR_5257|M.marinum_M RIH-------------------IDVAG-ARFEELRELCAAAGDKASLSIG
MSMEG_0228|M.smegmatis_MC2_155 RAG-------------------GHLSD-TGFDELCALAAAADDKVSLATA
Mvan_1904|M.vanbaalenii_PYR-1 FVG-------------------ADPDNDQRLVELRELTARVDDSHSLALA
Mflv_4653|M.gilvum_PYR-GCK RTGRAASAGRVASALLRASGGWPWLAPGNDPGELLTLLSRAATLSEGEPA
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 TVGPAIDHVYQD-RLH----------------------------------
MMAR_5257|M.marinum_M MAGLVIDHLQHA-RMREASQLATEAMTLIESVGDP--ALTVALSIAL---
MSMEG_0228|M.smegmatis_MC2_155 MAGQVSALLVHA-HYRESSSLASELTSLLESVGDR--RLTVALLFAA---
Mvan_1904|M.vanbaalenii_PYR-1 LAGRIVTFIVNSNRVPEALPLAAELAELVDTLGPTPAAELEIIYTAM---
Mflv_4653|M.gilvum_PYR-GCK SAARVLPALAVGHCYHPDPTIAPELLDRAERLAEATGDPDVIADVLIGRL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M IYAKSECAEWSDALRWSQRVIALADGDPTMGALIIGCPLAVAFATRANAR
MSMEG_0228|M.smegmatis_MC2_155 LGAKFQTGEANEVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMAR
Mvan_1904|M.vanbaalenii_PYR-1 SFAHLASCEFDAALEVIGRSIALEPEYP-------STDRALAYAIGGLCE
Mflv_4653|M.gilvum_PYR-GCK ITFSGVATLSAQSLEWVQRLNALRHSRSREDAVIAHSVATMAAMNLGDVD
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M YCLGRPGWAED-LQHGLAMARSADPMSYATVVAYVYSAGISTGVLASDDC
MSMEG_0228|M.smegmatis_MC2_155 ACLGDPDWRTG-LDRATPLVRDFGITTRALMLTYKCIG-LPTGLLLPSPE
Mvan_1904|M.vanbaalenii_PYR-1 VCLGSRERGIGHIRLATELARAMSPVSFSAVS--LYWGILAAMGMHVAED
Mflv_4653|M.gilvum_PYR-GCK GARRHVQAGIAGSEELQLPVLRAQLRWMEAVLAVWHGDFAEAGRHHAIAA
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M ALGEIEDALQIAERSGDDVALAIAR---MTLGIALVHRREDPMRDRGQAA
MSMEG_0228|M.smegmatis_MC2_155 LLEESCEVLEVAQRSADDLALAGAQ---VSRGLLLLWQG-GPYRDEALEL
Mvan_1904|M.vanbaalenii_PYR-1 LVDDMREWLARAESFGDRFGIIAAQ---WTYATLLLQAG-SPRRDEAFVL
Mflv_4653|M.gilvum_PYR-GCK HVHEQTELYEAGSGLLARATLLRERGGPVDPSWTDLNAQQAGGLGMVGVV
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M LADVSDMFQRRVYFLADLPFVEVYLAREWARCGDLDGAIAHMRAAVEHLF
MSMEG_0228|M.smegmatis_MC2_155 LSLGREASVREQFTMAAVPAVDTELARDMAARGDLDGAIELARDVVDTSI
Mvan_1904|M.vanbaalenii_PYR-1 LRRAEVGITTHNLQSFALAITGMQLAREAARNGHRDEAIDSIRHLVTLHT
Mflv_4653|M.gilvum_PYR-GCK RTGVLTLLSGPKARAEALATLRHWAQHTDRAHIWTTLGHHTLLAHLAVDH
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M REGRLLGWSTPATGVLVQTLLDRGTEGDLVEAAAAIERLAAAPADDGLAV
MSMEG_0228|M.smegmatis_MC2_155 DSGEAINMSASVT-VLVQSLIARGDRDDLDHAQRVIDRFAALPTDPGFVL
Mvan_1904|M.vanbaalenii_PYR-1 RDAPLLHLG-CPAESLCEMLIDRGGTRDLLEVEEVLEQWCSR--SPGTAP
Mflv_4653|M.gilvum_PYR-GCK DLPDFAEPLLAQLDPYRDRIAVIGQVGMAGPVALATARLHALRGDKAAAL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 --------------------------------------------------
Rv1318c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1220|M.avium_104 --------------------------------------------------
TH_3295|M.thermoresistible__bu --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MMAR_5257|M.marinum_M REILLLR--------LRALLARAHGDDTTYARLRDRYRDTASAMGFAGHI
MSMEG_0228|M.smegmatis_MC2_155 YDVQLMR--------LRALLARARGDEERYRECSDRYRELATAYRYEGHM
Mvan_1904|M.vanbaalenii_PYR-1 MDLWTIR--------IRALLASARGERQRYAQLADEYAAACEFTGYRHHW
Mflv_4653|M.gilvum_PYR-GCK ADLALARSIAERSAGVPTLLRCRLLECELTEESPGRSTAASTLAAEAADL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb1352c|M.bovis_AF2122/97 -------------
Rv1318c|M.tuberculosis_H37Rv -------------
MAB_1459c|M.abscessus_ATCC_199 -------------
MAV_1220|M.avium_104 -------------
TH_3295|M.thermoresistible__bu -------------
MLBr_02341|M.leprae_Br4923 -------------
MMAR_5257|M.marinum_M AQAESMP------
MSMEG_0228|M.smegmatis_MC2_155 ALAARMA------
Mvan_1904|M.vanbaalenii_PYR-1 GGPYPVLSDRRG-
Mflv_4653|M.gilvum_PYR-GCK GMAAVAEAASRLL
MUL_3594|M.ulcerans_Agy99 -------------