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M. ulcerans Agy99 MUL_3594 (-)

annotation: adenylylate/guanylate cyclase
coordinates: 3989272 - 3990798
length: 508

MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQPPVRLLVVDDADGVETLFGARFRTELRCDEYDLSFS
NDPVQALKMVGDSPDIEVLVTNLNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRGAFDFQ
LTPLDLEDLRVTISKAVTIVRELQAGEAARQRALELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNSE
RRTLTMLMADIRGFTRLSEILSPERALQVLNAYLERATDVVIRWNGTINEILGDGLLVFFGVPNTDGEAA
EHAVAAALELQLAMGELNVSHREQGLPELGIGIGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARIESNT
VGGQVLVSESTYHEICAIADTSGSTQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKVIPLVVPRPTGI
AVIENKIIGAAHPAEVVGSGDGAVRVRTGLQVAPFCDLVLDVAGAQVFAKVVDCGVDGGICELMAVFTSV
SDDVRRALAAPSTANSLS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3594--100% (508)adenylylate/guanylate cyclase
M. ulcerans Agy99MUL_4617-6e-2133.87% (186) hypothetical protein MUL_4617
M. ulcerans Agy99MUL_3986-5e-2033.01% (209) adenylate cyclase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3669-2e-1928.69% (251) transmembrane protein
M. gilvum PYR-GCKMflv_1395-5e-1932.05% (259) putative adenylate/guanylate cyclase
M. tuberculosis H37RvRv3645-2e-1928.69% (251) transmembrane protein
M. leprae Br4923MLBr_00201-2e-2029.48% (251) hypothetical protein MLBr_00201
M. abscessus ATCC 19977MAB_1459c-1e-2033.47% (236) hypothetical protein MAB_1459c
M. marinum MMMAR_0730-0.099.41% (508) adenylylate/guanylate cyclase
M. avium 104MAV_4804-2e-1930.04% (233) GAF domain-containing protein
M. smegmatis MC2 155MSMEG_0228-4e-1831.25% (192) adenylate and guanylate cyclase catalytic domain-containing
M. thermoresistible (build 8)TH_0858-4e-1929.49% (234) PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
M. vanbaalenii PYR-1Mvan_1904-2e-2339.08% (174) adenylyl cyclase class-3/4/guanylyl cyclase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_4804|M.avium_104                MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAF
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_4804|M.avium_104                GVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERDRWR
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_4804|M.avium_104                ADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAATRL
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      ------------------------------MVACGTCGTELRQGARFCDS
Mvan_1904|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_4804|M.avium_104                LSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRAGGF
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      CGTAIVDGSKHAEYKQVTVLFADVVDSMRLAAAVGAERLREILSALVSRC
Mvan_1904|M.vanbaalenii_PYR-1       ----------------MTVLFADVVGSMRLAAELDPERLREIMNDLFNRS
MAV_4804|M.avium_104                DPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEFHHRT
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      SGVVGHYGGTVDKFTGDGIMALFG--APLALEDHALRACLAALDLQYESH
Mvan_1904|M.vanbaalenii_PYR-1       ATVVQRYHGTMDKFTGDGLMALFG--APMALEDHALRACIAALEIQAVVG
MAV_4804|M.avium_104                GGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAAEFLG
                                                                                      

MUL_3594|M.ulcerans_Agy99           ----------------MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ
MMAR_0730|M.marinum_M               ---------------MMHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQ
Mflv_1395|M.gilvum_PYR-GCK          -------------------------MAADPT-ETGRISAFVR--WVARTP
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            -----MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR--WVVRTP
Rv3645|M.tuberculosis_H37Rv         -----MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR--WVVRTP
MLBr_00201|M.leprae_Br4923          -------------------------MATQAAGLPGRIGAFVR--WGIRTP
MAB_1459c|M.abscessus_ATCC_199      -----MANESIRAVSRRVGRALG--AITGQTGNINTGNGYGS--WLLGTA
MSMEG_0228|M.smegmatis_MC2_155      RLADELDLPAGVGLQIRVGLNSGQVIAGEMSAGGFGYTAIGEQVGMAQRM
Mvan_1904|M.vanbaalenii_PYR-1       ELADEVEQRDGVRLQLRVGLNSGDVVVGDIGSGPGRYTAIGHAVGMAQRM
MAV_4804|M.avium_104                RYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWACLEL
                                                                                      

MUL_3594|M.ulcerans_Agy99           PPVRLLVVDDADGVETLFGARFRTELRCDEYDLSFSNDPVQALKMVGDSP
MMAR_0730|M.marinum_M               PPVRLLVVDDADGVETLFGARFRTELRCDEYDLSFSNDPVQALKMVGDSP
Mflv_1395|M.gilvum_PYR-GCK          WPVFTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGY-
TH_0858|M.thermoresistible__bu      --VFALGMVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGY-
Mb3669|M.bovis_AF2122/97            WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVST-
Rv3645|M.tuberculosis_H37Rv         WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVST-
MLBr_00201|M.leprae_Br4923          WPLFSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLS-
MAB_1459c|M.abscessus_ATCC_199      DESTFIQRIRIQLILTVFVVAANLIGIGVVILLVTVAFPTPN--VFDAP-
MSMEG_0228|M.smegmatis_MC2_155      ESVAPHGGIMCSDTTARLVEDSVLLGAPEMLRVKGCDRPVAARRLLAATN
Mvan_1904|M.vanbaalenii_PYR-1       EAAASAGAVVCSLSTADLVEHATRLGAVQTVRIKGSDEPAPARRLVAVEA
MAV_4804|M.avium_104                RLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRAVHLRI
                                                   :                      .           

MUL_3594|M.ulcerans_Agy99           D------------------------------------------IEVLVTN
MMAR_0730|M.marinum_M               D------------------------------------------IEVLVTN
Mflv_1395|M.gilvum_PYR-GCK          ---------------------------------------------LFVSF
TH_0858|M.thermoresistible__bu      ---------------------------------------------LVVSF
Mb3669|M.bovis_AF2122/97            ---------------------------------------------VIILF
Rv3645|M.tuberculosis_H37Rv         ---------------------------------------------VIILF
MLBr_00201|M.leprae_Br4923          ---------------------------------------------VVVAF
MAB_1459c|M.abscessus_ATCC_199      ---------------------------------------------AWVNF
MSMEG_0228|M.smegmatis_MC2_155      A-AHGGRSDPTLVGRSWELNTIAGLLDEAVE-----------GRGGIVSV
Mvan_1904|M.vanbaalenii_PYR-1       ARMVVGRNEGLMLGRDGELHQLCDSLDRRR-------------RRHLVSV
MAV_4804|M.avium_104                GRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQARAQA
                                                                                      

MUL_3594|M.ulcerans_Agy99           LNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRG-------
MMAR_0730|M.marinum_M               LNMPQMNGLDLLTEVAKLGRPLKTIVLTACNDLANIRAAMMRG-------
Mflv_1395|M.gilvum_PYR-GCK          TVA-SYLTLRMLIPVMRWQR---RDMLLGDRDPSDTEVARMR--------
TH_0858|M.thermoresistible__bu      TVG-AYVTLRLLLPVIRWQR---RDTLLADPDPAATELARAR--------
Mb3669|M.bovis_AF2122/97            LAG-AVVNLKLLMPVFRWQR---RDNLLTEPDPAATELARSR--------
Rv3645|M.tuberculosis_H37Rv         LAG-AVVNLKLLMPVFRWQR---RDNLLTEPDPAATELARSR--------
MLBr_00201|M.leprae_Br4923          STG-FAVNLKLLMPVFRWQR---RDNRLAEADPAATELARSR--------
MAB_1459c|M.abscessus_ATCC_199      VIVPVYIALAVLIGAVWGTRRIFKAVRWALDERPPTKADQRN--------
MSMEG_0228|M.smegmatis_MC2_155      VGPPGIGKSRMVRESIELARRRGVAVFYTYCESHASDVPFHVVVPLLR--
Mvan_1904|M.vanbaalenii_PYR-1       VGAPGVGKSRLVEEFCRRLRGAGTEVVLAGCDAHAMPIAFRALSRLLR--
MAV_4804|M.avium_104                SFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVPVLNT
                                                       *                              

MUL_3594|M.ulcerans_Agy99           ------------AFDFQLTPLDLEDLRVTISKAVTIVRELQAGEAARQRA
MMAR_0730|M.marinum_M               ------------AFDFQLTPLDLEDLRVTISKAVTIVRELQAGEAARQRA
Mflv_1395|M.gilvum_PYR-GCK          ------------ALKMPFYRSLISATNWLLGSVVFIVASWPVASKSAPVV
TH_0858|M.thermoresistible__bu      ------------ALRMPFYRTLISGTNWFLGTIVFIVASWPVAGHSAPVI
Mb3669|M.bovis_AF2122/97            ------------ALRMPLYRTLISLAVWATGGGVFILASWSVAKHAAPVV
Rv3645|M.tuberculosis_H37Rv         ------------ALRMPLYRTLISLAVWATGGGVFILASWSVAKHAAPVV
MLBr_00201|M.leprae_Br4923          ------------ALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSAPIV
MAB_1459c|M.abscessus_ATCC_199      ------------AFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKI
MSMEG_0228|M.smegmatis_MC2_155      ------EGFGVAGLDPAAARVRVRSLVPDADPEDLLLLDDVLGIADPDVP
Mvan_1904|M.vanbaalenii_PYR-1       ------AMFSADDLGDDDARELVLSQVPMG-STDAQIIFEAMGIADGAAP
MAV_4804|M.avium_104                LLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDELGERV
                                                          :                           

MUL_3594|M.ulcerans_Agy99           LELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNSER--------RTLT
MMAR_0730|M.marinum_M               VELADQNRRVENIFGRYVSEEVKTHLLACPEGHQNSER--------RTLT
Mflv_1395|M.gilvum_PYR-GCK          AVATGLGATATAIIGYLQSERVLRPVAVAALRGGVPENFRAPGVILRQVL
TH_0858|M.thermoresistible__bu      AVATGLGATATAIIGYLQAERVLRPVAVAALRGGVPENFRAPGVVLRQVL
Mb3669|M.bovis_AF2122/97            AVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVILRLML
Rv3645|M.tuberculosis_H37Rv         AVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVILRLML
MLBr_00201|M.leprae_Br4923          ALATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLRLML
MAB_1459c|M.abscessus_ATCC_199      FFAVGFSGAVVCAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVL
MSMEG_0228|M.smegmatis_MC2_155      MPDLDADARRRRVAALVNAASLARREPGLYVLEDAHWIDEVSESMLAEFL
Mvan_1904|M.vanbaalenii_PYR-1       PLHVGADGRRHRLVETMAQFVRLRSTPMVLVLEDAHWIDAASEAVLCEFA
MAV_4804|M.avium_104                ATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPILAELC
                                                                                    . 

MUL_3594|M.ulcerans_Agy99           MLMADIR---------GFTRLSEILSPERALQVLNAYLERATDVVIRWNG
MMAR_0730|M.marinum_M               MLMADIR---------GFTRLSEILSPERALQVLNAYLERATDVVIRWNG
Mflv_1395|M.gilvum_PYR-GCK          TWVLSTG---------VPVLAIVLALVASKFEVLTAPADRLITTILLLAI
TH_0858|M.thermoresistible__bu      TWVLSTG---------VPVLAIVLALVASKVGILTAPAEQLTTPLLVLAI
Mb3669|M.bovis_AF2122/97            AWIPSTG---------VPLLAIVLAVAADKIALLHATPEALFNPILMMAL
Rv3645|M.tuberculosis_H37Rv         AWIPSTG---------VPLLAIVLAVAADKIALLHATPEALFNPILMMAL
MLBr_00201|M.leprae_Br4923          TWVPSTG---------VPVLAIVLAVVADKIALLHAVPEQLFSPILLLAL
MAB_1459c|M.abscessus_ATCC_199      AWMLGSG---------VPAAGIVITGIG-ALVLHNLTVSQLAVAVIIIAG
MSMEG_0228|M.smegmatis_MC2_155      TVVTHTHSVMLITYRPEYTGVLARVSGAQTIALRPLTDGQTSTLLTELLG
Mvan_1904|M.vanbaalenii_PYR-1       TVLERTSTVLVTTCRPEYRGGLRKRS-AHTVTVAPLNDSLTMDLVLNLLG
MAV_4804|M.avium_104                NMAVLVRPN-LLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLGDHA
                                                                                :     

MUL_3594|M.ulcerans_Agy99           TINEILGDGLLVFFGV-----------------------PNTDGEAAEHA
MMAR_0730|M.marinum_M               TINEILGDGLLVFFGV-----------------------PNTDGEAAEHA
Mflv_1395|M.gilvum_PYR-GCK          VALIIGLSSTVLVAMS-----------------------IADPLRQLRWA
TH_0858|M.thermoresistible__bu      ATLVIGLSGTVLVAMS-----------------------IADPLRQLRWA
Mb3669|M.bovis_AF2122/97            AALGIGSVSTLLVAMS-----------------------IADPLRQLRWA
Rv3645|M.tuberculosis_H37Rv         AALGIGSVSTLLVAMS-----------------------IADPLRQLRWA
MLBr_00201|M.leprae_Br4923          AVLVVGLVSTWLVAMS-----------------------IADPLRQLRWA
MAB_1459c|M.abscessus_ATCC_199      AIPSFGLILIWIASWL-----------------------MATPVKEVQTA
MSMEG_0228|M.smegmatis_MC2_155      PDAAAHQLAGLIADRA-----------------------AGNPFFTQEIV
Mvan_1904|M.vanbaalenii_PYR-1       GDGAMGGLASRIVGVA-----------------------AGNPYFVEEIV
MAV_4804|M.avium_104                GSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGELRDA
                                               :                                   . .

MUL_3594|M.ulcerans_Agy99           VAAALE-------LQLAMGELNVSHRE-------------------QGLP
MMAR_0730|M.marinum_M               VAAALE-------LQLAMGELNVSHRE-------------------QGLP
Mflv_1395|M.gilvum_PYR-GCK          LGEVQR-------GNYNAHMQIYDASE-------------------LGLL
TH_0858|M.thermoresistible__bu      LGEVQR-------GNFNAHMQIYDASE-------------------LGLL
Mb3669|M.bovis_AF2122/97            LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
Rv3645|M.tuberculosis_H37Rv         LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
MLBr_00201|M.leprae_Br4923          LSEVQR-------GNYNAHMQIYDASE-------------------LGLL
MAB_1459c|M.abscessus_ATCC_199      IKRVAQ-------NDLDIDLVVYDGTE-------------------LGEL
MSMEG_0228|M.smegmatis_MC2_155      RDLAERGVLRGERGAYRFHGADVEIGV-------------------PATL
Mvan_1904|M.vanbaalenii_PYR-1       RDLVGRGVLAGSRGDYRLIRDVDDIGV-------------------PVTV
MAV_4804|M.avium_104                VEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRSQPV
                                       .                   .                          

MUL_3594|M.ulcerans_Agy99           ELGIG-----------IGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARI
MMAR_0730|M.marinum_M               ELGIG-----------IGVHTGEAVVGTIGSPRRQKYTAIGKNVNLVARI
Mflv_1395|M.gilvum_PYR-GCK          QAGFNDMVRDLAERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
TH_0858|M.thermoresistible__bu      QAGFNDMVRDLAERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
Mb3669|M.bovis_AF2122/97            QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
Rv3645|M.tuberculosis_H37Rv         QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVL
MLBr_00201|M.leprae_Br4923          QAGFNDMVRELSERQRLRDLFGRYVGEDVARRALEHGTELGGQERDVAVL
MAB_1459c|M.abscessus_ATCC_199      QAGFNTMVEGLRERERVRDLFGKHVGREVAAAAEQQQPELGGEERHIAVL
MSMEG_0228|M.smegmatis_MC2_155      QATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGADVS---MQALI
Mvan_1904|M.vanbaalenii_PYR-1       QAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQVLTPNARSGELAELV
MAV_4804|M.avium_104                PSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEVALG
                                       :                    :                         

MUL_3594|M.ulcerans_Agy99           ESNTVGG----------------QVLVSES------TYHEICAIADTSGS
MMAR_0730|M.marinum_M               ESNTVGG----------------QVLVSES------TYHEICAIADTSGS
Mflv_1395|M.gilvum_PYR-GCK          FVDLVGS----------------THLAATI------PASEVVSLLNEFFR
TH_0858|M.thermoresistible__bu      FVDLVGS----------------TRLAATT------PPADVVNLLNEFFR
Mb3669|M.bovis_AF2122/97            FVDLVGS----------------TQLAATR------PPAEVVQLLNEFFR
Rv3645|M.tuberculosis_H37Rv         FVDLVGS----------------TQLAATR------PPAEVVQLLNEFFR
MLBr_00201|M.leprae_Br4923          FVDLIGS----------------TQLAETK------PPTKVVHLLNEFFR
MAB_1459c|M.abscessus_ATCC_199      FADIVGS----------------TRLAATR------PAVEVVALLNRFFT
MSMEG_0228|M.smegmatis_MC2_155      DAELVDQ----------------VMFAPRPEYAFRHPLIRMVALESQLKS
Mvan_1904|M.vanbaalenii_PYR-1       ATELIDQ----------------MEFAPRQRYCFRHPLVRAVAYDSQISA
MAV_4804|M.avium_104                AAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGALSM
                                        :                               .        .    

MUL_3594|M.ulcerans_Agy99           TQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKV-----------IPLV
MMAR_0730|M.marinum_M               TQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKV-----------IPLV
Mflv_1395|M.gilvum_PYR-GCK          VVVDTVNRHG-GFVNKFQGDAALAIFGAPIEHPDA-----------SGAA
TH_0858|M.thermoresistible__bu      VVVDTVNRHG-GFVNKFQGDAALAIFGAPIEHPDA-----------CGAA
Mb3669|M.bovis_AF2122/97            VVVETVARHG-GFVNKFQGDAALAIFGAPIEHPDG-----------AGAA
Rv3645|M.tuberculosis_H37Rv         VVVETVARHG-GFVNKFQGDAALAIFGAPIEHPDG-----------AGAA
MLBr_00201|M.leprae_Br4923          VVVDTVGRHG-GFVNKFQGDAALAIFGAPIEHPDS-----------AGAA
MAB_1459c|M.abscessus_ATCC_199      VVVEEIDRYE-GMVNKFEGDATLAVFGAPVRQDRP-----------ESQA
MSMEG_0228|M.smegmatis_MC2_155      DRAELHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFTWHMRAGT
Mvan_1904|M.vanbaalenii_PYR-1       NRARAHRLLAGAIETRDPAAKDENAALIATHLEGAGDFETACRWHLRAAD
MAV_4804|M.avium_104                IHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARARGQH
                                                                .                     

MUL_3594|M.ulcerans_Agy99           VPRPTGIAVIENKIIGAAHPAEVVGSG---DGAVRVRTG-----------
MMAR_0730|M.marinum_M               VPKPIGIAVIENKIIGAAHPAEVVGSG---DGAVRVRTG-----------
Mflv_1395|M.gilvum_PYR-GCK          LAASRELHDELINVLGETEFGIGVSAGRAIAGHIGAQAR-----------
TH_0858|M.thermoresistible__bu      LAAARELHDELIAVLGETEFGIGVSAGRAIAGHIGAQAR-----------
Mb3669|M.bovis_AF2122/97            LSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
Rv3645|M.tuberculosis_H37Rv         LSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
MLBr_00201|M.leprae_Br4923          LSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQAR-----------
MAB_1459c|M.abscessus_ATCC_199      LAAARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDR-----------
MSMEG_0228|M.smegmatis_MC2_155      WLTNRDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTWRAG
Mvan_1904|M.vanbaalenii_PYR-1       WLRMRDLLAARNQWEIAMRVADGLPGADDAVTALRIAPRTMLVSTELFVG
MAV_4804|M.avium_104                GKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHMLRSA
                                          :             .                             

MUL_3594|M.ulcerans_Agy99           -------------------------------------LQVAPFCDLVLDV
MMAR_0730|M.marinum_M               -------------------------------------LQVAPFCDLVLDV
Mflv_1395|M.gilvum_PYR-GCK          -------------------------------------FEYTVIGDPVNEA
TH_0858|M.thermoresistible__bu      -------------------------------------FEYTVIGDPVNEA
Mb3669|M.bovis_AF2122/97            -------------------------------------FEYTVIGDPVNEA
Rv3645|M.tuberculosis_H37Rv         -------------------------------------FEYTVIGDPVNEA
MLBr_00201|M.leprae_Br4923          -------------------------------------FEYTVIGDPVNEA
MAB_1459c|M.abscessus_ATCC_199      -------------------------------------FEYTVIGDPVNEA
MSMEG_0228|M.smegmatis_MC2_155      GHLS--------------------------------DTGFDELCALAAAA
Mvan_1904|M.vanbaalenii_PYR-1       ADPDN-------------------------------DQRLVELRELTARV
MAV_4804|M.avium_104                YQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHALSGA
                                                                              :      .

MUL_3594|M.ulcerans_Agy99           AGAQVFAKVVDCGVDGGICE------------------------------
MMAR_0730|M.marinum_M               AGAQVFAKVVDCGVDGGICE------------------------------
Mflv_1395|M.gilvum_PYR-GCK          ARLTELAKLEPGHVLASSLA------------------------------
TH_0858|M.thermoresistible__bu      ARLTELAKLEEGHVLASAMA------------------------------
Mb3669|M.bovis_AF2122/97            ARLTELAKLEDGHVLASAIA------------------------------
Rv3645|M.tuberculosis_H37Rv         ARLTELAKLEDGHVLASAIA------------------------------
MLBr_00201|M.leprae_Br4923          ARLTELAKLEDGHVLASAIA------------------------------
MAB_1459c|M.abscessus_ATCC_199      ARLCELSKTVPGHLVASLDT------------------------------
MSMEG_0228|M.smegmatis_MC2_155      DDKVSLATAMAGQVSALLVH------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       DDSHSLALALAGRIVTFIVN------------------------------
MAV_4804|M.avium_104                RTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIVEGP
                                         ::      :                                    

MUL_3594|M.ulcerans_Agy99           ---LMAVFTSVSDDVRR----ALAAPSTANSLS-----------------
MMAR_0730|M.marinum_M               ---LMAVFTSVSDDVRR----ALAAPSTANSLS-----------------
Mflv_1395|M.gilvum_PYR-GCK          ---VADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRVEEKVAD
TH_0858|M.thermoresistible__bu      ---VSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGPGPSNNS
Mb3669|M.bovis_AF2122/97            ---VSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSS
Rv3645|M.tuberculosis_H37Rv         ---VSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAP----EEVSS
MLBr_00201|M.leprae_Br4923          ---VSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVP----EQITS
MAB_1459c|M.abscessus_ATCC_199      ---VLRAHHREALHWRSGDTVTLRGRTEPTELAVPV--------------
MSMEG_0228|M.smegmatis_MC2_155      ---AHYR-ESSSLASELTSLLESVGDR-RLTVALLFAALG-AKFQTGEAN
Mvan_1904|M.vanbaalenii_PYR-1       ---SNRVPEALPLAAELAELVDTLGPTPAAELEIIYTAMSFAHLASCEFD
MAV_4804|M.avium_104                WTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLGVIY
                                                            .                         

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          DVP------STTR-------------------------------------
TH_0858|M.thermoresistible__bu      DAPGTRTTGSVSRADAETTAPES---------------------------
Mb3669|M.bovis_AF2122/97            EVRG----------------------------------------------
Rv3645|M.tuberculosis_H37Rv         EVRG----------------------------------------------
MLBr_00201|M.leprae_Br4923          EVTG----------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      EVVRLADRLIELADGDANMGNLIIGSPLVTAWTVGGMARACLGDPDWRTG
Mvan_1904|M.vanbaalenii_PYR-1       AALEVIGRSIALEPEYP-------STDRALAYAIGGLCEVCLGSRERGIG
MAV_4804|M.avium_104                AEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQSLID
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      -LDRATPLVRDFGITTRALMLTYKCIGLPTGLLLPSPELLEESCEVLEVA
Mvan_1904|M.vanbaalenii_PYR-1       HIRLATELARAMSPVSFSAVSLYWGILAAMGMHV-AEDLVDDMREWLARA
MAV_4804|M.avium_104                VQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIEDMN
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      QRSADDLALAGAQVSRGLLLLWQGGPYRDEALELLSLGREASVREQFTMA
Mvan_1904|M.vanbaalenii_PYR-1       ESFGDRFGIIAAQWTYATLLLQAGSPRRDEAFVLLRRAEVGITTHNLQSF
MAV_4804|M.avium_104                VAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRAGLG
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      AVPAVDTELARDMAARGDLDGAIELARDVVDTSIDSGEAINMSASVTVLV
Mvan_1904|M.vanbaalenii_PYR-1       ALAITGMQLAREAARNGHRDEAIDSIRHLVTLHTRDAPLLHLGCPAESLC
MAV_4804|M.avium_104                MLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTIIGDA
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      QSLIARGDRDDLDHAQRVIDRFAALPTDPGFVLYDVQLMRLRALLARARG
Mvan_1904|M.vanbaalenii_PYR-1       EMLIDRGGTRDLLEVEEVLEQWCSR--SPGTAPMDLWTIRIRALLASARG
MAV_4804|M.avium_104                VNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNRRRP
                                                                                      

MUL_3594|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0730|M.marinum_M               --------------------------------------------------
Mflv_1395|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0858|M.thermoresistible__bu      --------------------------------------------------
Mb3669|M.bovis_AF2122/97            --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00201|M.leprae_Br4923          --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155      DEERYRECSDRYRELATAYRYEGHMA-----LAARMA-------------
Mvan_1904|M.vanbaalenii_PYR-1       ERQRYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG-------------
MAV_4804|M.avium_104                VTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRCRDM
                                                                                      

MUL_3594|M.ulcerans_Agy99           ---------------------------------
MMAR_0730|M.marinum_M               ---------------------------------
Mflv_1395|M.gilvum_PYR-GCK          ---------------------------------
TH_0858|M.thermoresistible__bu      ---------------------------------
Mb3669|M.bovis_AF2122/97            ---------------------------------
Rv3645|M.tuberculosis_H37Rv         ---------------------------------
MLBr_00201|M.leprae_Br4923          ---------------------------------
MAB_1459c|M.abscessus_ATCC_199      ---------------------------------
MSMEG_0228|M.smegmatis_MC2_155      ---------------------------------
Mvan_1904|M.vanbaalenii_PYR-1       ---------------------------------
MAV_4804|M.avium_104                LPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK