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M. tuberculosis H37Rv Rv1625c (cya)

annotation: MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)
coordinates: 1826614 - 1827945
length: 443

AARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGA
GGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLV
GIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAV
MEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYS
AFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGP
VVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYL
IGRKVAADPGEVRGAEPRTAGV*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1625ccya-100% (443)MEMBRANE-ANCHORED ADENYLYL CYCLASE CYA (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)
M. tuberculosis H37RvRv2435c-5e-3133.81% (210) cyclase
M. tuberculosis H37RvRv1318c-2e-1334.25% (146) adenylate cyclase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1651ccya0.0100.00% (418) membrane-anchored adenylyl cyclase Cya (ATP
M. gilvum PYR-GCKMflv_3576-1e-13258.51% (388) putative adenylate/guanylate cyclase
M. leprae Br4923MLBr_02341-3e-1529.24% (171) putative regulatory protein
M. abscessus ATCC 19977MAB_0490c-9e-1328.12% (192) putative adenylate cyclase
M. marinum MMMAR_2428cya1e-18072.85% (442) membrane-anchored adenylyl cyclase Cya
M. avium 104MAV_3162-0.072.01% (443) adenylate cyclase
M. smegmatis MC2 155MSMEG_3578-1e-2425.74% (272) putative cyclase
M. thermoresistible (build 8)TH_2942-1e-13556.93% (411) PUTATIVE adenylate cyclase
M. ulcerans Agy99MUL_3698-1e-2427.94% (204) adenylate or guanylate cyclase
M. vanbaalenii PYR-1Mvan_2839-1e-13657.77% (412) putative adenylate/guanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2942|M.thermoresistible__bu      --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2428|M.marinum_M               --------------------------------------------------
MAV_3162|M.avium_104                --------------------------------------------------
MSMEG_3578|M.smegmatis_MC2_155      -------------------MLSRISIQSKLLAMLLVTSVLSAAVVGFIGY
MUL_3698|M.ulcerans_Agy99           -----------------MLRFLRVGIPAKLLVTLLVCSILSVAVVGVIGY
MAB_0490c|M.abscessus_ATCC_199      -----MTGAEGRPDRRPLARAARYSRWVMRTPWPLFIMGIAQSNLVGALF
MLBr_02341|M.leprae_Br4923          MTTALVCVACGAELRSIAKFCDECGSPVVEAETPAEYKQVTVLFADVVGS
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2942|M.thermoresistible__bu      --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        ----------------------------------------MAARKCGAPP
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2428|M.marinum_M               ------------------------------------MPAKKSAKKCRTAR
MAV_3162|M.avium_104                ----------------------------------------MAAKSCGAAP
MSMEG_3578|M.smegmatis_MC2_155      QSGRSSLRDSVFDRLTEIRTAQARQLETQFRSFRNSLVIYTRGTTAIEAA
MUL_3698|M.ulcerans_Agy99           VSGRNALQRVAVERLHQLREAQKRQVEALFSELTKSVMVYSNGMSANEAT
MAB_0490c|M.abscessus_ATCC_199      VLGFLRFGLPPSDRVELTELGPTRLIILGFSLFILFVVGAIVSTYLLLPV
MLBr_02341|M.leprae_Br4923          MDIAAAVGLERLREIMTELVSRAAGVIERYGGTVDKFTGDGIMAIFGAPT
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       -----MRPVCVPEVTLGRRAWSPSRHRHER--------------------
TH_2942|M.thermoresistible__bu      --------------VARQGVPARTQRYAES--------------------
Rv1625c|M.tuberculosis_H37Rv        IAADGSTRRPDCVTAVRTQARAPTQHYAES--------------------
Mb1651c|M.bovis_AF2122/97           ---------------MRTQARAPTQHYAES--------------------
MMAR_2428|M.marinum_M               RSSDG-LPRPDSVAAVREQTRDLNQHYAHS--------------------
MAV_3162|M.avium_104                LWPTGSSKRPDCVAAARAQSRARNQHYADS--------------------
MSMEG_3578|M.smegmatis_MC2_155      RAFTAGFDQLGDATISPAQQKAITDWYENQFSATTEHSDAADNLDGNEVD
MUL_3698|M.ulcerans_Agy99           AALTDGFAQLANATVDPVQQQAIVDYYVN------ELIKPIDQATGHELD
MAB_0490c|M.abscessus_ATCC_199      LRWQYRSPDFESEGSEAVRVRALQMPFYRT--------------------
MLBr_02341|M.leprae_Br4923          ALEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLRVGLNSGQVIVGE
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          -------MGRRQSVLMIAGWIAAAVSAAFGAFQLTLGGSLWWLGAVNVLC
Mvan_2839|M.vanbaalenii_PYR-1       -------VARRQRVLMIASWIAAAASVGFGVFQLTFGGPLWWLGAVNIGC
TH_2942|M.thermoresistible__bu      -------IRSRYRMLTIAAWIAAAVSAGFGTLQLVLGGQTRLLGVINLAV
Rv1625c|M.tuberculosis_H37Rv        -------VARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFT
Mb1651c|M.bovis_AF2122/97           -------VARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFT
MMAR_2428|M.marinum_M               -------AARRARVLSIAALLAVLISSSFILVQFLTQAWIWQITLINIAA
MAV_3162|M.avium_104                -------AARQSRVLAIAAWLAVLVCADFILLQVVTGAWTWQIVSLNVVA
MSMEG_3578|M.smegmatis_MC2_155      V---EALLPSSNPQKYLQALYTAPFTDWDKAIENDDAGDGSGWSAANALF
MUL_3698|M.ulcerans_Agy99           L---EAVLSASPAQTYLQAYYTAPFSSSSESMRFNNAGDGSAWSAANARF
MAB_0490c|M.abscessus_ATCC_199      ------VISVATWLVGGAIFVAVTWSSTHSSVLVAAFATVLGATTTSIIG
MLBr_02341|M.leprae_Br4923          IGSSALGYTAVGVQVGMAQRMESVAPPGVVMLSESTARLVEQTAVLGAPQ
                                                                   .              .   

Mflv_3576|M.gilvum_PYR-GCK          ALVFLWIPRLCPLGELLAPLTFVTFAYMS---------------------
Mvan_2839|M.vanbaalenii_PYR-1       GVVFLAIPRLCPLGELIAPLTFVVFAYTS---------------------
TH_2942|M.thermoresistible__bu      AVVFTLIPLLYRFGELLAPLSFFLFAYLS---------------------
Rv1625c|M.tuberculosis_H37Rv        AVTFAIVPLLHRFGGLVAPLTFIGTAYVA---------------------
Mb1651c|M.bovis_AF2122/97           AVTFAIVPLLHRFGGLVAPLTFIGTAYVA---------------------
MMAR_2428|M.marinum_M               TLVFATVPMLHRFGELVAPLTFVGAAYVS---------------------
MAV_3162|M.avium_104                ALIFAIVPWLHRFGDLVAPLTFLGAAYVT---------------------
MSMEG_3578|M.smegmatis_MC2_155      NGFFREIVTRSGFDDALLLDTRGNVVYTAYKGSDLGTNIYTGPYKGGELS
MUL_3698|M.ulcerans_Agy99           NDFFRGIVTRFQYRDALLLDLQGNVVYSVNEGPDLGTNLFTGPYRETNLR
MAB_0490c|M.abscessus_ATCC_199      YLQSERVLRPVAIQALRRGVPENVTAPGVIVR------------------
MLBr_02341|M.leprae_Br4923          TVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVG---------------
                                                             .                        

Mflv_3576|M.gilvum_PYR-GCK          ------------------------------VTFFCYTIGTGSGMQ--FYF
Mvan_2839|M.vanbaalenii_PYR-1       ------------------------------VGFICYTIGTGSGLQ--FYF
TH_2942|M.thermoresistible__bu      ------------------------------VGFMCFSIGTGSGLQ--LYL
Rv1625c|M.tuberculosis_H37Rv        ------------------------------IFAIGWDVGTDAGAQ--FFF
Mb1651c|M.bovis_AF2122/97           ------------------------------IFAIGWDVGTDAGAQ--FFF
MMAR_2428|M.marinum_M               ------------------------------VFASCWNVGTGSGAQ--MFF
MAV_3162|M.avium_104                ------------------------------VFVSCWDVGTASGGQ--YFF
MSMEG_3578|M.smegmatis_MC2_155      EAYREALNSNTVDYVAVTDFGIYQPS-GTPTAWMVSPIGGGGRIEGVLAL
MUL_3698|M.ulcerans_Agy99           TAYQKALASNEIDFVWITDFQRYQPEVDAPTAWLVSPVGVDGKLQGVMAL
MAB_0490c|M.abscessus_ATCC_199      -------------------------------QILTWALSTGVPILAIVLT
MLBr_02341|M.leprae_Br4923          -------REWELATLAAMLDRSIGGRGSVVGLVGPAGIGKTRLVAEAVQL
                                                                         :.           

Mflv_3576|M.gilvum_PYR-GCK          LVAASLVLLVLGIERVALAAVIAGVGVVITVVLELTVPEDRGLGP-----
Mvan_2839|M.vanbaalenii_PYR-1       LVAASLVVLVLGIERIALAAAIAAAGVIITIVLELTVPDDRGLGP-----
TH_2942|M.thermoresistible__bu      LVAASLVVLLLGVDRIVLAAGIVAVGVVGIIVLELVVPEDRGLGP-----
Rv1625c|M.tuberculosis_H37Rv        LVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQP-----
Mb1651c|M.bovis_AF2122/97           LVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQP-----
MMAR_2428|M.marinum_M               LVGACLVVLVLGIEHVVLASGLAALAAALIITVEFVVPRNTGAQS-----
MAV_3162|M.avium_104                LVGACLVLLVMGIEHTVLAAVLAAIGAGLVIAVEFAFPRDTGLQP-----
MSMEG_3578|M.smegmatis_MC2_155      QFPISVVNQLMTMDGKWEESGLGETGETYLVGPDGLMRSDSRLFLENPEQ
MUL_3698|M.ulcerans_Agy99           ALPPTNLNQIMNANEKWEAVGMGRSTETYLAGSDNLMRSDSRLFLESPDE
MAB_0490c|M.abscessus_ATCC_199      VVGQRAGYLKSNADNLTGSILILAIIALAIGLMGTLLVATSIADP-----
MLBr_02341|M.leprae_Br4923          AKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISGLDDRSARARVREQ
                                                 :       :                            

Mflv_3576|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2942|M.thermoresistible__bu      --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv        --------------------------------------------------
Mb1651c|M.bovis_AF2122/97           --------------------------------------------------
MMAR_2428|M.marinum_M               --------------------------------------------------
MAV_3162|M.avium_104                --------------------------------------------------
MSMEG_3578|M.smegmatis_MC2_155      FKADVIEAGTPPGVAEQSILHGGTTLVQPVSDEASKLAGQGQSGSIIERD
MUL_3698|M.ulcerans_Agy99           YRREALAGGTREDVVNKAMWLGTTVLVQPVPSAGLRAALRGQSGITKDTD
MAB_0490c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_02341|M.leprae_Br4923          IPDADTQDLLLLDDLLG-------------------------IADPAVEL
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          ----------------------------------------SWTLTAGFIS
Mvan_2839|M.vanbaalenii_PYR-1       ----------------------------------------SWTLTAGFIS
TH_2942|M.thermoresistible__bu      ----------------------------------------AWMLTAGFVT
Rv1625c|M.tuberculosis_H37Rv        ----------------------------------------PWAMSVSFVL
Mb1651c|M.bovis_AF2122/97           ----------------------------------------PWAMSVSFVL
MMAR_2428|M.marinum_M               ----------------------------------------AWLQSLGFII
MAV_3162|M.avium_104                ----------------------------------------AWAQSMSFVV
MSMEG_3578|M.smegmatis_MC2_155      YLGQETLQAYAPLDLTG--LDWSVVAKIDTAEAFAPVTKFTRTLVLSTVA
MUL_3698|M.ulcerans_Agy99           YLGNRELEAYAPLDVPNSDLRWAILATRDDWDAYERLSSFGRTVVLAVAG
MAB_0490c|M.abscessus_ATCC_199      ------------------------------------------LRQLRWAL
MLBr_02341|M.leprae_Br4923          PRLDPDARRRRLTALINVAQLALSRPAVFVVEDVHWIDEVSDSMLADFLA
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          AVTSSAVMIVATIWYTLREIERAES-------------------------
Mvan_2839|M.vanbaalenii_PYR-1       AVVSSVVIIVATIWYTLREIDRAEA-------------------------
TH_2942|M.thermoresistible__bu      SAVSSALIIFATLWYALREIARTEA-------------------------
Rv1625c|M.tuberculosis_H37Rv        TTVSACGVAVATVWFALRDTARAEA-------------------------
Mb1651c|M.bovis_AF2122/97           TTVSACGVAVATVWFALRDTARAEA-------------------------
MMAR_2428|M.marinum_M               TTVSACLLVFVTVWFALRDTARAEA-------------------------
MAV_3162|M.avium_104                TIVSACIMVFVAVWFALRDTQRAEA-------------------------
MSMEG_3578|M.smegmatis_MC2_155      MIFAVCIAAILLARVFVRPIRRLEAGAQQISAGDYGVALPVVSRDEFGDL
MUL_3698|M.ulcerans_Agy99           ITLFICVVSMVLAKLLVRPIRRLEAGTEKIRSGDYEVTVPVKSRDELGDL
MAB_0490c|M.abscessus_ATCC_199      SEVQRGNYNAHVPIYDASELGLLQAGFN----------------------
MLBr_02341|M.leprae_Br4923          VIPQTRSMALVTYRPEYHGALRHVVGAQIIAVAPLSDVETSTLVAELLG-
                                                                                      

Mflv_3576|M.gilvum_PYR-GCK          ----------------AMENEYERSERLLANILPATIAER---LKEPTRT
Mvan_2839|M.vanbaalenii_PYR-1       ----------------AMAAEYERSEELLANILPATIADR---LKEPTRT
TH_2942|M.thermoresistible__bu      ----------------AMEAEYQRSESLLLNILPASVARR---LKDPART
Rv1625c|M.tuberculosis_H37Rv        ----------------VMEAEHDRSEALLANMLPASIAER---LKEPERN
Mb1651c|M.bovis_AF2122/97           ----------------VMEAEHDRSEALLANMLPASIAER---LKEPERN
MMAR_2428|M.marinum_M               ----------------VMEAQYDRSEALLANMLPVSVADR---LKEPERN
MAV_3162|M.avium_104                ----------------VMESEYQRSEALLANMLPGSIAER---LKHSDGD
MSMEG_3578|M.smegmatis_MC2_155      TVAFNEMSRNLRIKEDLLDEQRKENDRLLLSLMPEPVVQR---YRE-GEE
MUL_3698|M.ulcerans_Agy99           TAAFNEMSSNLKVKDQLLTEQRSQNEQLLLALMPEPVVQR---YRA-DGE
MAB_0490c|M.abscessus_ATCC_199      -------------DMVRDLGERQRLRDLFGRYVGEDVARR---ALEYGTE
MLBr_02341|M.leprae_Br4923          -------LDQSVTQIGELITERAAGNPFFAQEITRELAERGVLTGERGRY
                                                        :      ::   :   :. *          

Mflv_3576|M.gilvum_PYR-GCK          VIADKYDDASILFADIAGYTKRASDTAPAELVRFLDLLYTDLDALVDRHG
Mvan_2839|M.vanbaalenii_PYR-1       VIADKYDDASILFADIAGYTKRASETPPSELVRFLDRLYTDLDALVDRHG
TH_2942|M.thermoresistible__bu      VIADKYDDASVLFADIAGYTRWAGATTPSELVLFLDRLYTELDALVDRHG
Rv1625c|M.tuberculosis_H37Rv        IIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHG
Mb1651c|M.bovis_AF2122/97           IIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHG
MMAR_2428|M.marinum_M               IIADKYEEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDALVDKYG
MAV_3162|M.avium_104                IIADKYDDASVLFADIVGFTERASGTAPADLVRFLNRLYIAFDELVDKHG
MSMEG_3578|M.smegmatis_MC2_155      TIAQDHQNVTVLFADLMGLDRLSASMSSDEHLSIVNKLVRQFDAAAESLG
MUL_3698|M.ulcerans_Agy99           VIAEEHQDVTVIFAELIGLEEISDGLSGDELVGIVDELFRQFDSAAQSLG
MAB_0490c|M.abscessus_ATCC_199      LGGQE-RSVAVLFVDLVGSTQLASTRGPAVVVRVLNEFFRVIVDTVNKHG
MLBr_02341|M.leprae_Br4923          ACSTDVAEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLA
                                      . .  .. :  .                   .:      :    :  .

Mflv_3576|M.gilvum_PYR-GCK          LEKVKTSGDSYMVVSGVPTPRPDHLEALATLALDMSEAVADLKDPRGRDV
Mvan_2839|M.vanbaalenii_PYR-1       LEKVKTSGDSYMVVSGVPNPRADHLEALALLALDMADAVADLKDPQGHDV
TH_2942|M.thermoresistible__bu      LEKVKTSGDSYMVVSGVPQPRPDHLEALADFALDMAAAVGRLRDPQGRTV
Rv1625c|M.tuberculosis_H37Rv        LEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPV
Mb1651c|M.bovis_AF2122/97           LEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPV
MMAR_2428|M.marinum_M               LEKIKVSGDSYMVVSGVPRPRPDHVQALADFALDMVDVAAGMKDPHNRSV
MAV_3162|M.avium_104                LEKIKVSGDSYMVVSGVPRVRPDHATALADFALDMVKVAAALKDPYGRPV
MSMEG_3578|M.smegmatis_MC2_155      VERVRTLHNGYLASCGLTVPRLDNVRRTVDFAFEMQRIVDRFRGETGYDL
MUL_3698|M.ulcerans_Agy99           VEPIRTFHNGYLAACGATTPRLDNVHRGIEFALEIELIVNRFANQSQHPL
MAB_0490c|M.abscessus_ATCC_199      GFVNKFQGDAALAIFGAPIDHPDGAAAALAAARELSGELTNVLGSND---
MLBr_02341|M.leprae_Br4923          SLGIDLSVDELIDANLVDQVR---FTAPVEYAFRHPLIRTVAYESQLKSD
                                            :  :        :          *                  

Mflv_3576|M.gilvum_PYR-GCK          PLRIGMAMGPVVAGVVGAKK-FFYDVWGDAVNVASRMETTDEE---GRIQ
Mvan_2839|M.vanbaalenii_PYR-1       PLRIGMASGPVVAGVVGAKK-FFYDVWGDAVNVASRMETTDVE---GRIQ
TH_2942|M.thermoresistible__bu      PLRIGLAAGPVVAGVVGARK-FFYDVWGDAVNVGSRMESTDVV---GRIQ
Rv1625c|M.tuberculosis_H37Rv        PLRVGLATGPVVAGVVGSRR-FFYDVWGDAVNVASRMESTDSV---GQIQ
Mb1651c|M.bovis_AF2122/97           PLRVGLATGPVVAGVVGSRR-FFYDVWGDAVNVASRMESTDSV---GQIQ
MMAR_2428|M.marinum_M               PLRVGLATGPVVAGVVGSRR-FFYDVWGDAVNVASRMESTDSV---GKIQ
MAV_3162|M.avium_104                PLRVGMACGPVVAGVVGSRR-FFYDVWGDAVNVASRMESTDSV---GRIQ
MSMEG_3578|M.smegmatis_MC2_155      RLRAGIDTGTVSSGLVGRSS-LAYDMWGAAVDLAYQVQRGMPQ---PGVY
MUL_3698|M.ulcerans_Agy99           RVRVGVTTGRVVSGRVGRSN-LAYDMWGGAVQMAYRMLGHLSD---PGIY
MAB_0490c|M.abscessus_ATCC_199      -FGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKNEP-GNVL
MLBr_02341|M.leprae_Br4923          RARLHRRLAAAIEARAPHSVDQHAVLIAEHLEAAGDLHAAYGWHMRAAAW
                                            . .  .           : .  :: .  :             

Mflv_3576|M.gilvum_PYR-GCK          VPDNVYQRLRHAFVLEERGLIDVKGKGPMHTWYLVGHR------------
Mvan_2839|M.vanbaalenii_PYR-1       VPDNVYERLRDRFVLEERGVVDVKGKGPMHTWYLVAHR------------
TH_2942|M.thermoresistible__bu      VAQDVRDRLRDSFVFEERGAIEVKGKGVMHTWYLLGRRSDRQGSDRQGSG
Rv1625c|M.tuberculosis_H37Rv        VPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGE-----
Mb1651c|M.bovis_AF2122/97           VPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGE-----
MMAR_2428|M.marinum_M               VPDEVYERLNKDFVLQERGHINVKGKGVMRTWYLIGRKPIDEPTA-----
MAV_3162|M.avium_104                VPETMYERLASEFVLQERGRIEVKGKGVMRTWYLIGRKPAEAPTD-----
MSMEG_3578|M.smegmatis_MC2_155      VTDQVHDAVRDIRQFTAVGSVTVDGTE-RPIWRLSERQS-----------
MUL_3698|M.ulcerans_Agy99           VSARVHDAMREIWTFTPAGAISVRGSQ-QQIWQVSERR------------
MAB_0490c|M.abscessus_ATCC_199      ASASAVMEARDEEALRWDVGETVELRGRTVSTQVARPRHG----------
MLBr_02341|M.leprae_Br4923          ATNQDVRAARVSWEHATKIADALTAEDPHRAAMCIAPRTRLCGIAWRGRF
                                    ..                    :              :            

Mflv_3576|M.gilvum_PYR-GCK          --------------ARAVTPSSSPP---------------
Mvan_2839|M.vanbaalenii_PYR-1       --------------AEAVTPSGSPT---------------
TH_2942|M.thermoresistible__bu      RQGSGRQGSGRQGGTEASTAARTHG---------------
Rv1625c|M.tuberculosis_H37Rv        --------------VRGAEPRTAGV---------------
Mb1651c|M.bovis_AF2122/97           --------------VRGAEPRTAGV---------------
MMAR_2428|M.marinum_M               --------------VPADEPNAARV---------------
MAV_3162|M.avium_104                --------------LVAEQPHTAHV---------------
MSMEG_3578|M.smegmatis_MC2_155      ----------------------------------------
MUL_3698|M.ulcerans_Agy99           ----------------------------------------
MAB_0490c|M.abscessus_ATCC_199      ----------------------------------------
MLBr_02341|M.leprae_Br4923          NSSSGFDEVRQLCNATGDKAPLAVATVGPAIDHVYQDRLH