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LDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAFGVEVAGRGCVFAYGRCRDGAP APYAAVRDALGSLVRTMAATAPAERDRWRADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRR QLHRAATRLLSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRAGGFDPAAAGIAAEN LTTIELEPLARDDVEELLATVCGQSGELPEVAAEFHHRTGGNPLQVRQLLYRAQREGALLPVGSGGPPRW DLRVLTSIEVSATAAEFLGRYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWACLELR LLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRAVHLRIGRRLITLGDDRLFEAARHVGV GGLAVSDEAERTRFVEVLRRAAHQARAQASFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALR VGDVPVLNTLLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDELGERVATQAGKPRMGN AIVRMRLTMARWSTERLLQLPHCTDQRVIALHPILAELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSS PLVITGYGIVLVLLGDHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGELRDAVE EALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRSQPVPSALCQAVQQLCLNLMGRSADP FLLAGESGYDERQVLPAARQQGDEVALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLV HLIGALSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARARGQHGKAERHLHQAIE LAEEHRLPAIGARAHEEAAALYAETGRQTLREHMLRSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGS AGIDPIGAHQLVHALSGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIVEGPWT EVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLGVIYAEQGEPGRNFGADHEEAIAFLC AQAAAPLWSFQLEARLRAADEYRQSLIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSY TAMIEDMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRAGLGMLRSLHEHNQER RALGSEELRAGIGINTGAVAVGLVGGVNRMVLTIIGDAVNLAARIESTNKRYGSALLISDRTYQRIAGSE EFDVRRMERVMVVNRRRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRCRDMLP DDPIAPLHLAHCDAVARGEMLPGQEIALQNK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4804 | - | - | 100% (1432) | GAF domain-containing protein |
| M. avium 104 | MAV_0578 | - | 2e-11 | 27.70% (444) | transcriptional regulator, LuxR family protein |
| M. avium 104 | MAV_0518 | - | 4e-10 | 29.07% (172) | adenylate cyclase, family protein 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 4e-11 | 30.05% (183) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4653 | - | 9e-17 | 28.20% (539) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv3645 | - | 4e-11 | 30.05% (183) | transmembrane protein |
| M. leprae Br4923 | MLBr_00201 | - | 3e-11 | 29.51% (183) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_1459c | - | 2e-10 | 30.51% (177) | hypothetical protein MAB_1459c |
| M. marinum M | MMAR_5254 | - | 3e-20 | 24.73% (558) | membrane-anchored adenylyl cyclase |
| M. smegmatis MC2 155 | MSMEG_0228 | - | 7e-15 | 27.64% (351) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_0858 | - | 5e-11 | 30.46% (174) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3594 | - | 4e-19 | 30.04% (233) | adenylylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_1815 | - | 1e-20 | 27.99% (536) | transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1815|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5254|M.marinum_M --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4804|M.avium_104 MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAF
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK -------------------------MRYRLLGPLQVVHGEAAVDIGPRKQ
Mvan_1815|M.vanbaalenii_PYR-1 -----------------------------MLGPLQVVHGETVIDVGPRKQ
MMAR_5254|M.marinum_M -------------------------------MTPVTVCRACGVEPLENAR
MSMEG_0228|M.smegmatis_MC2_155 ----------------------------------MVACGTCGTELRQGAR
MAV_4804|M.avium_104 GVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERDRWR
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR-----
Rv3645|M.tuberculosis_H37Rv --------MDAEAFVGFRQVPAARYGGLMATTAA-LPRRIHAFVR-----
MLBr_00201|M.leprae_Br4923 ----------------------------MATQAAGLPGRIGAFVR-----
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------MANESIRAVSRRVGRALG--AITGQTGNINTGNGYGS-----
Mflv_4653|M.gilvum_PYR-GCK RSVLAALLLAQGRVVSTDRLVDVVWGDDVPASATASLQVYISNLRRALRS
Mvan_1815|M.vanbaalenii_PYR-1 RAVLAVLLLAQGRVVSTDRLADAVWGDDVPASVTASLQVYISNLRRALRD
MMAR_5254|M.marinum_M FCHECGAPIGAADTRAEYKQVTVLF-ADVAHSMDIAAAVGPERLR-----
MSMEG_0228|M.smegmatis_MC2_155 FCDSCGTAIVDGSKHAEYKQVTVLF-ADVVDSMRLAAAVGAERLR-----
MAV_4804|M.avium_104 ADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAATRL
MUL_3594|M.ulcerans_Agy99 -------MHVNGFGGLAAQQVAASPICCAPLDERSAIPGPQPPVR-----
Mb3669|M.bovis_AF2122/97 --------------------WVVRTPWPLFSLSMLQSDIIGALFVLGFLR
Rv3645|M.tuberculosis_H37Rv --------------------WVVRTPWPLFSLSMLQSDIIGALFVLGFLR
MLBr_00201|M.leprae_Br4923 --------------------WGIRTPWPLFSLSMLQSDIIGALFVLGFLR
TH_0858|M.thermoresistible__bu ----------------------------VFALGMVQADIIGALFVLGFLR
MAB_1459c|M.abscessus_ATCC_199 --------------------WLLGTADESTFIQRIRIQLILTVFVVAANL
Mflv_4653|M.gilvum_PYR-GCK GAGDRTVSSVAQPIVRQPPGYFLDAGPDESDIAVFTAACARAAAAIDGER
Mvan_1815|M.vanbaalenii_PYR-1 -------SQMASPIVRQPPGYFLDVGPDEVDVSAFTAGCARAAAAIDAER
MMAR_5254|M.marinum_M --------EIMAELVTRASVVVQRYAG---RVDKFTGDGVMALFGAPAAL
MSMEG_0228|M.smegmatis_MC2_155 --------EILSALVSRCSGVVGHYGG---TVDKFTGDGIMALFGAPLAL
MAV_4804|M.avium_104 LS----ATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHR
MUL_3594|M.ulcerans_Agy99 ----------------------LLVVDDADGVETLFGARFRTELRCDEYD
: .
Mb3669|M.bovis_AF2122/97 YG--LPPQDNIQLQDLPPVN------------------------------
Rv3645|M.tuberculosis_H37Rv YG--LPPQDNIQLQDLPPVN------------------------------
MLBr_00201|M.leprae_Br4923 YG--LPPQDRVELQDLPIRN------------------------------
TH_0858|M.thermoresistible__bu FG--LPPGDRLELQDLPAFN------------------------------
MAB_1459c|M.abscessus_ATCC_199 IG--IGVVILLVTVAFPTPN------------------------------
Mflv_4653|M.gilvum_PYR-GCK WD--EALAEADTALSLVRGELL---------------------EDIGDAD
Mvan_1815|M.vanbaalenii_PYR-1 WE--EALTEADTALGLVRGELL---------------------EDMADAD
MMAR_5254|M.marinum_M ED--HALRACLAALDIQD-----------------------------EVA
MSMEG_0228|M.smegmatis_MC2_155 ED--HALRACLAALDLQY-----------------------------ESH
MAV_4804|M.avium_104 AGGFDPAAAGIAAENLTTIELEPLARDDVEELLATVCGQSGELPEVAAEF
MUL_3594|M.ulcerans_Agy99 LSFSNDPVQALKMVGDS---------------------------------
Mb3669|M.bovis_AF2122/97 -----------------LLIFVSTVIILFLAGAVVNLKLLMPVFRWQR--
Rv3645|M.tuberculosis_H37Rv -----------------LLIFVSTVIILFLAGAVVNLKLLMPVFRWQR--
MLBr_00201|M.leprae_Br4923 -----------------LAISTLSVVVAFSTGFAVNLKLLMPVFRWQR--
TH_0858|M.thermoresistible__bu -----------------LALFLGYLVVSFTVGAYVTLRLLLPVIRWQR--
MAB_1459c|M.abscessus_ATCC_199 -----------------VFDAPAWVNFVIVP-VYIALAVLIGAVWGTRR-
Mflv_4653|M.gilvum_PYR-GCK WIREDAARFAEMRTECLAGKVMSLLALGKIPAALTAASQLGALDPLADRG
Mvan_1815|M.vanbaalenii_PYR-1 WVREAAARVAEMRTECLANKVMALLALGKVPAALTEVSRLREVDPLGDRS
MMAR_5254|M.marinum_M RLAADISRTDGVELRLRIGLNSGEVITGGIGPTALGYTAVGEQVGMAQR-
MSMEG_0228|M.smegmatis_MC2_155 RLADELDLPAGVGLQIRVGLNSGQVIAGEMSAGGFGYTAIGEQVGMAQR-
MAV_4804|M.avium_104 HHRTGGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATAA
MUL_3594|M.ulcerans_Agy99 -------------------PDIEVLVTNLNMPQMNGLDLLTEVAKLGRP-
: :
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK CRLQMLALYRAGRTADALEVYTRYARRLDAELGLEPGP--ELRDLQTAVL
Mvan_1815|M.vanbaalenii_PYR-1 CKLQMLTLYRAGRAAEALEAYTRHARLLDAELGLEPGP--ELRELQTAVL
MMAR_5254|M.marinum_M -----------------MESIAPVGGVMVSDT--------------TARL
MSMEG_0228|M.smegmatis_MC2_155 -----------------MESVAPHGGIMCSDT--------------TARL
MAV_4804|M.avium_104 EFLGRYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALWA
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 -----------------------------RDNLLTEPDPAATELARSRAL
Rv3645|M.tuberculosis_H37Rv -----------------------------RDNLLTEPDPAATELARSRAL
MLBr_00201|M.leprae_Br4923 -----------------------------RDNRLAEADPAATELARSRAL
TH_0858|M.thermoresistible__bu -----------------------------RDTLLADPDPAATELARARAL
MAB_1459c|M.abscessus_ATCC_199 ---------------------------IFKAVRWALDERPPTKADQRNAF
Mflv_4653|M.gilvum_PYR-GCK RQAPELSGWPRSPGWTGAAAVTAT--EAVPVRLDTVESASHRAPLVGRRR
Mvan_1815|M.vanbaalenii_PYR-1 RQAPELAGWPRSPEWTGAAALPQPQPEPATVPPAAMEAVSHRAPLVGRER
MMAR_5254|M.marinum_M VDGVVLLGAPQRVQVKGMG-TVSAR-ELRSATAQHQRTDSAESTLVGRGW
MSMEG_0228|M.smegmatis_MC2_155 VEDSVLLGAPEMLRVKGCDRPVAAR-RLLAATNAAHG-GRSDPTLVGRSW
MAV_4804|M.avium_104 CLELRLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRAV
MUL_3594|M.ulcerans_Agy99 ----------------------------LKTIVLTACNDLANIRAAMMRG
Mb3669|M.bovis_AF2122/97 RMPLYRTLISLAVW--------------------ATGGGVFILASWSVAK
Rv3645|M.tuberculosis_H37Rv RMPLYRTLISLAVW--------------------ATGGGVFILASWSVAK
MLBr_00201|M.leprae_Br4923 RMPFYHTIISLVTW--------------------GIGGAVFIIASWSAAR
TH_0858|M.thermoresistible__bu RMPFYRTLISGTNW--------------------FLGTIVFIVASWPVAG
MAB_1459c|M.abscessus_ATCC_199 AVPWRLTVIQSVLW--------------------AGGVALFTLLYGLYDP
Mflv_4653|M.gilvum_PYR-GCK ELAAAADVLDRVTA--------------------GAARWLVLSGPPGIGK
Mvan_1815|M.vanbaalenii_PYR-1 ELARAADVLARAAA--------------------GATRWLVLSGPPGIGK
MMAR_5254|M.marinum_M EVAAVSTMLDRAIH--------------------GRGSVVGVTGPVGIGK
MSMEG_0228|M.smegmatis_MC2_155 ELNTIAGLLDEAVE--------------------GRGGIVSVVGPPGIGK
MAV_4804|M.avium_104 HLRIGRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQA
MUL_3594|M.ulcerans_Agy99 AFDFQLTPLDLEDLR------------------VTISKAVTIVRELQAGE
. : :
Mb3669|M.bovis_AF2122/97 HAAPVVAVATALGATATAIIG-------YLQSERVLRPVAVAALRSGVP-
Rv3645|M.tuberculosis_H37Rv HAAPVVAVATALGATATAIIG-------YLQSERVLRPVAVAALRSGVP-
MLBr_00201|M.leprae_Br4923 HSAPIVALATALGATATAIIG-------YLQSERVLRPVAVAALRSGVP-
TH_0858|M.thermoresistible__bu HSAPVIAVATGLGATATAIIG-------YLQAERVLRPVAVAALRGGVP-
MAB_1459c|M.abscessus_ATCC_199 MYIPKIFFAVGFSGAVVCAAN-------YLFTEFAMRPVAARALEAGYR-
Mflv_4653|M.gilvum_PYR-GCK TRLAEEIAGLVAAGDGDVVWV-------NCPDERGTPPWWPMRQLVRALG
Mvan_1815|M.vanbaalenii_PYR-1 TRLAEEIAGLVGARGGEVAWV-------SCPDERATPPWWPMRRLVRALG
MMAR_5254|M.marinum_M SRLVREAIGLARSRGVTVVHT-------YCESHAADVPFRVMTRLLRAV-
MSMEG_0228|M.smegmatis_MC2_155 SRMVRESIELARRRGVAVFYT-------YCESHASDVPFHVVVPLLREG-
MAV_4804|M.avium_104 RAQASFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDVP
MUL_3594|M.ulcerans_Agy99 AARQRALELADQNRRVENIFG-------RYVSEEVKTHLLACPEGHQNS-
.
Mb3669|M.bovis_AF2122/97 ----------------------ENVNAPGVILRLMLAWIPSTGVPLLAIV
Rv3645|M.tuberculosis_H37Rv ----------------------ENVNAPGVILRLMLAWIPSTGVPLLAIV
MLBr_00201|M.leprae_Br4923 ----------------------ENVKTPGVTLRLMLTWVPSTGVPVLAIV
TH_0858|M.thermoresistible__bu ----------------------ENFRAPGVVLRQVLTWVLSTGVPVLAIV
MAB_1459c|M.abscessus_ATCC_199 ----------------------RRRLASGVMVRTVLAWMLGSGVPAAGIV
Mflv_4653|M.gilvum_PYR-GCK AD--------------ADEVLEIPPHADPDTARFLVYERIQRLLESAPRL
Mvan_1815|M.vanbaalenii_PYR-1 AD--------------ADEVLEIPAHADPDTARFLVYERIQALLEAAPRL
MMAR_5254|M.marinum_M -----------------GQASGLDDEAARARVRDRVPDAQLPDLLLLDDL
MSMEG_0228|M.smegmatis_MC2_155 -----------------FGVAGLDPAAARVRVRSLVPDADPEDLLLLDDV
MAV_4804|M.avium_104 VLNTLLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDEL
MUL_3594|M.ulcerans_Agy99 -----------------------ERRTLTMLMADIRGFTRLSEILSPERA
:
Mb3669|M.bovis_AF2122/97 LAVAADKIALLHATPEALFN---------------------PILMMALAA
Rv3645|M.tuberculosis_H37Rv LAVAADKIALLHATPEALFN---------------------PILMMALAA
MLBr_00201|M.leprae_Br4923 LAVVADKIALLHAVPEQLFS---------------------PILLLALAV
TH_0858|M.thermoresistible__bu LALVASKVGILTAPAEQLTT---------------------PLLVLAIAT
MAB_1459c|M.abscessus_ATCC_199 ITGIG-ALVLHNLTVSQLAV---------------------AVIIIAGAI
Mflv_4653|M.gilvum_PYR-GCK LAVVVDDVQWADTTSAACLAYIAGTLRDRPVLVVVTVRDGEHPAEVSRLL
Mvan_1815|M.vanbaalenii_PYR-1 LAVVVDDVQWSDTASAACLAYIAGALRDHPVLVIATVRDGEHAPEVARLL
MMAR_5254|M.marinum_M LGIAAPGAELPRIDPDARRRRLTGLIN------ASQLARTEPVVFVLEDV
MSMEG_0228|M.smegmatis_MC2_155 LGIADPDVPMPDLDADARRRRVAALVN------AASLARREPGLYVLEDA
MAV_4804|M.avium_104 GERVATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPIL
MUL_3594|M.ulcerans_Agy99 LQVLNAYLERATDVVIRWNG---------------------TINEILGDG
:
Mb3669|M.bovis_AF2122/97 LGIGSVSTLLVAMSIADPLRQLRWALSEVQRGNYN------------AHM
Rv3645|M.tuberculosis_H37Rv LGIGSVSTLLVAMSIADPLRQLRWALSEVQRGNYN------------AHM
MLBr_00201|M.leprae_Br4923 LVVGLVSTWLVAMSIADPLRQLRWALSEVQRGNYN------------AHM
TH_0858|M.thermoresistible__bu LVIGLSGTVLVAMSIADPLRQLRWALGEVQRGNFN------------AHM
MAB_1459c|M.abscessus_ATCC_199 PSFGLILIWIASWLMATPVKEVQTAIKRVAQNDLD------------IDL
Mflv_4653|M.gilvum_PYR-GCK STVARGEANRLIEVPALSSEDVATLANEVAEEVVT------------AAE
Mvan_1815|M.vanbaalenii_PYR-1 STVARGEDNRHIEVPALSSADVATLANEVAEETVT------------AAE
MMAR_5254|M.marinum_M HWIDEASESMLADFLTVMLQTPSLVLFTYRPEYRG------------ALQ
MSMEG_0228|M.smegmatis_MC2_155 HWIDEVSESMLAEFLTVVTHTHSVMLITYRPEYTG------------VLA
MAV_4804|M.avium_104 AELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLLG
MUL_3594|M.ulcerans_Agy99 LLVFFGVPNTDGEAAEHAVAAALELQLAMGELNVS--------------H
.
Mb3669|M.bovis_AF2122/97 QIYDASELG---LLQAGFNDMVRELSE------------RQRLRDLFG--
Rv3645|M.tuberculosis_H37Rv QIYDASELG---LLQAGFNDMVRELSE------------RQRLRDLFG--
MLBr_00201|M.leprae_Br4923 QIYDASELG---LLQAGFNDMVRELSE------------RQRLRDLFG--
TH_0858|M.thermoresistible__bu QIYDASELG---LLQAGFNDMVRDLAE------------RQRLRDLFG--
MAB_1459c|M.abscessus_ATCC_199 VVYDGTELG---ELQAGFNTMVEGLRE------------RERVRDLFG--
Mflv_4653|M.gilvum_PYR-GCK AAELADRTGGNPFFVSEYARLPREERA------------GNEIPRAVRSV
Mvan_1815|M.vanbaalenii_PYR-1 AAELAARTGGNPFFVSEYARLPREERA------------GNEIPRAVRSV
MMAR_5254|M.marinum_M LVPGAQTIALAPLTDADVSTLVAELLG------------QDPSVATIGRV
MSMEG_0228|M.smegmatis_MC2_155 RVSGAQTIALRPLTDGQTSTLLTELLG------------PDAAAHQLAGL
MAV_4804|M.avium_104 DHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGEL
MUL_3594|M.ulcerans_Agy99 REQGLPELGIGIGVHTGEAVVGTIGSP------------RRQKYTAIG--
. : .
Mb3669|M.bovis_AF2122/97 ---------------------RYVGEDVARRALERGTELGGQERDVAVLF
Rv3645|M.tuberculosis_H37Rv ---------------------RYVGEDVARRALERGTELGGQERDVAVLF
MLBr_00201|M.leprae_Br4923 ---------------------RYVGEDVARRALEHGTELGGQERDVAVLF
TH_0858|M.thermoresistible__bu ---------------------RYVGEDVARRALERGTELGGQERDVAVLF
MAB_1459c|M.abscessus_ATCC_199 ---------------------KHVGREVAAAAEQQQPELGGEERHIAVLF
Mflv_4653|M.gilvum_PYR-GCK ------------------LDRRLAALDPAVMQVLRAAAVIADVLDS-VTV
Mvan_1815|M.vanbaalenii_PYR-1 ------------------LDRRLAALDPAVVQVLRAAAVIGDVIDA-SAV
MMAR_5254|M.marinum_M ------------------ISERAAGNPLFAEEMTRELAERGVLTGERGSY
MSMEG_0228|M.smegmatis_MC2_155 ------------------IADRAAGNPFFTQEIVRDLAERGVLRGERGAY
MAV_4804|M.avium_104 RDAVEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIRS
MUL_3594|M.ulcerans_Agy99 -------------------------KNVNLVARIESNTVGGQVLVSESTY
.
Mb3669|M.bovis_AF2122/97 VDLVGSTQLAATRPPAEVVQLLNEFFRVVVETVARHGGFVNKFQGDAALA
Rv3645|M.tuberculosis_H37Rv VDLVGSTQLAATRPPAEVVQLLNEFFRVVVETVARHGGFVNKFQGDAALA
MLBr_00201|M.leprae_Br4923 VDLIGSTQLAETKPPTKVVHLLNEFFRVVVDTVGRHGGFVNKFQGDAALA
TH_0858|M.thermoresistible__bu VDLVGSTRLAATTPPADVVNLLNEFFRVVVDTVNRHGGFVNKFQGDAALA
MAB_1459c|M.abscessus_ATCC_199 ADIVGSTRLAATRPAVEVVALLNRFFTVVVEEIDRYEGMVNKFEGDATLA
Mflv_4653|M.gilvum_PYR-GCK PLLARTTALDLDTLADYLDEAADERIIVNSHTGDGYVFAHGLLREQLLTG
Mvan_1815|M.vanbaalenii_PYR-1 PVLAQATRLDLDTLADYLDEAADERIVVAAHAGDGYAFAHGLLREQLLAS
MMAR_5254|M.marinum_M QCRTDVAEIRVPATVQAAIGARIDRLSPAAKQTLSAAAVVGSRFSSDLLI
MSMEG_0228|M.smegmatis_MC2_155 RFHGADVEIGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLA
MAV_4804|M.avium_104 QPVPSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDEV
MUL_3594|M.ulcerans_Agy99 HEICAIADTSGSTQVRVKGLTEPITVHDITGLAGRYNLRLPSIDRKVIPL
.
Mb3669|M.bovis_AF2122/97 IFGAPIEHPDGAGAALSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIG
Rv3645|M.tuberculosis_H37Rv IFGAPIEHPDGAGAALSAARELHDELIPVLGSAEFGIGVSAGRAIAGHIG
MLBr_00201|M.leprae_Br4923 IFGAPIEHPDSAGAALSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIG
TH_0858|M.thermoresistible__bu IFGAPIEHPDACGAALAAARELHDELIAVLGETEFGIGVSAGRAIAGHIG
MAB_1459c|M.abscessus_ATCC_199 VFGAPVRQDRPESQALAAARAIARRLRTEVPECQAGIGVASGQAVAGNIG
Mflv_4653|M.gilvum_PYR-GCK MPALRRQRVHAKVADVLADSALPDAPTWRAQHLVAAQPLVEPTVVVPACR
Mvan_1815|M.vanbaalenii_PYR-1 MPALRRQRMHAKVAEVLADSTAPDAPTRRAQHLIAAQPLVEPAAVVQACR
MMAR_5254|M.marinum_M GLGIEPCIDELLDADLIDQVRFTTRAEYAFRHPLVRTVAYEAQLRADRAQ
MSMEG_0228|M.smegmatis_MC2_155 ALGADVSMQALIDAELVDQVMFAPRPEYAFRHPLIRMVALESQLKSDRAE
MAV_4804|M.avium_104 ALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIGA
MUL_3594|M.ulcerans_Agy99 VVPRPTG-----IAVIENKIIGAAHPAEVVGSGDGAVRVRTGLQVAPFCD
Mb3669|M.bovis_AF2122/97 AQARFEYTVIGDPVN-----------EAARLTELAKLEDGHVLASAIAVS
Rv3645|M.tuberculosis_H37Rv AQARFEYTVIGDPVN-----------EAARLTELAKLEDGHVLASAIAVS
MLBr_00201|M.leprae_Br4923 AQARFEYTVIGDPVN-----------EAARLTELAKLEDGHVLASAIAVS
TH_0858|M.thermoresistible__bu AQARFEYTVIGDPVN-----------EAARLTELAKLEEGHVLASAMAVS
MAB_1459c|M.abscessus_ATCC_199 AHDRFEYTVIGDPVN-----------EAARLCELSKTVPGHLVASLDTVL
Mflv_4653|M.gilvum_PYR-GCK LAAEQATQQWSSDIAAGWWQAALDAYDRLPASERDDADRDALTVELLEAH
Mvan_1815|M.vanbaalenii_PYR-1 LAAEQATAQWSSDIAAGWWQAALDAYDRLPASERDDTERDALTVELLEAH
MMAR_5254|M.marinum_M LHRRLAQALENAEADPGDHHAALIAEHFEAAGDLAAAYRWHMRAGKWALN
MSMEG_0228|M.smegmatis_MC2_155 LHRRLAVDIERRAPHAADEHAALIADHYEEAGDLRAAFTWHMRAGTWLTN
MAV_4804|M.avium_104 LSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARAR
MUL_3594|M.ulcerans_Agy99 LVLDVAG-----------------------AQVFAKVVDCGVDGGICELM
:
Mb3669|M.bovis_AF2122/97 GALDAEALCWD----VGEVVELRGRAAPTQLARPMNLAAP----EEVSSE
Rv3645|M.tuberculosis_H37Rv GALDAEALCWD----VGEVVELRGRAAPTQLARPMNLAAP----EEVSSE
MLBr_00201|M.leprae_Br4923 GALDAEALCWN----VGEIVELRGRTAPTQLARPLNLAVP----EQITSE
TH_0858|M.thermoresistible__bu GALDAEALCWD----VGETVELRGRTVPTQLARPVKLAFSNGPGPSNNSD
MAB_1459c|M.abscessus_ATCC_199 RAHHREALHWR----SGDTVTLRGRTEPTELAVPV---------------
Mflv_4653|M.gilvum_PYR-GCK SRAGRGQLVLDSVTRYLGEALRTGRAASAGRVASALLRASGGWPWLAPGN
Mvan_1815|M.vanbaalenii_PYR-1 SRAGRGQLVLDSVQRYLGEALRTGRAASAGRVASALLRASGGWPWLAPGH
MMAR_5254|M.marinum_M RDIAAARLSWERATRISDALPADTPDRSVKRIAPRTMLCGYAWRVHVNIS
MSMEG_0228|M.smegmatis_MC2_155 RDIDAARLSWQRARHVADQLPHDAEDRAAMTIAPRTLLCLSTWRAGGHLS
MAV_4804|M.avium_104 GQHGKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHML
MUL_3594|M.ulcerans_Agy99 AVFTS----------VSDDVRRALAAPSTANSLS----------------
. .
Mb3669|M.bovis_AF2122/97 VRG-----------------------------------------------
Rv3645|M.tuberculosis_H37Rv VRG-----------------------------------------------
MLBr_00201|M.leprae_Br4923 VTG-----------------------------------------------
TH_0858|M.thermoresistible__bu APGTRTTGSVSRAD------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK DPGELLTLLSRAAT------------------------------------
Mvan_1815|M.vanbaalenii_PYR-1 DPGELLALLGRAAT------------------------------------
MMAR_5254|M.marinum_M DAH---FAELRELC------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 DTG---FDELCALA------------------------------------
MAV_4804|M.avium_104 RSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHAL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu ----------------AETTAPES--------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK ----------------LSEGEPASAARVLPALAVGHCYHPDPTIAPELLD
Mvan_1815|M.vanbaalenii_PYR-1 ----------------LSEGQPASAARVLPALAVGHCYHPDRRVAEDLLD
MMAR_5254|M.marinum_M ----------------LAAADKTSLAIATAGLVMDRIYQARIHEGSRLAS
MSMEG_0228|M.smegmatis_MC2_155 ----------------AAADDKVSLATAMAGQVSALLVHAHYRESSSLAS
MAV_4804|M.avium_104 SGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLIV
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK R--------AERLAEATGDPDVIADVLIGRLITFSGVATLSAQSLEWVQR
Mvan_1815|M.vanbaalenii_PYR-1 R--------AERLAEETGDPDVLADVLMGRLITFSGVATVSHETLQWVER
MMAR_5254|M.marinum_M E--------AMGLIESIGNPTLTVGLSLTAIVAKAEQA-QWLDVLHWSQL
MSMEG_0228|M.smegmatis_MC2_155 E--------LTSLLESVGDRRLTVALLFAALGAKFQTG-EANEVVRLADR
MAV_4804|M.avium_104 EGPWTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTLG
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK LNALRHSRSREDAVIAHSVATMAAMNLGDVDGARRHVQAGIAGSEELQLP
Mvan_1815|M.vanbaalenii_PYR-1 LNALGHKRSREDSVIAHSVATMAAMNLGDVAATRRHVEAGIAGSEELQLP
MMAR_5254|M.marinum_M VIELADGDPTKGNFMIGSPLALALT----TRAIARYCLGRPGWRDDVHQA
MSMEG_0228|M.smegmatis_MC2_155 LIELADGDANMGNLIIGSPLVTAWT----VGGMARACLGDPDWRTGLDRA
MAV_4804|M.avium_104 VIYAEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQS
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK VLRAQLRWMEAVLAVWHGDFAEAGRHHAIAAHVHEQTELYEAGSGLLARA
Mvan_1815|M.vanbaalenii_PYR-1 VLRAQLRWMEAVLAMWIGDFAEAARHHAIAAHVHEQTELYEAGSGLLATA
MMAR_5254|M.marinum_M VQTAGATDPVAYATVVAFVHNPGIAFGVLSPDEAAIREIEQAVQIAQQAG
MSMEG_0228|M.smegmatis_MC2_155 TPLVRDFGITTRALMLTYKC-IGLPTGLLLPSPELLEESCEVLEVAQRSA
MAV_4804|M.avium_104 LIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMIE
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK TLLRERGGPVDPSWTDLNA-QQAGGLGMVGVVRTGVLTLLSGPKARAEAL
Mvan_1815|M.vanbaalenii_PYR-1 SLVRERGGPVDAGWAAVQASKETGGQDMVGVVRTALLTLESGPQARAEAV
MMAR_5254|M.marinum_M DDLALSSAQISLGIALLERGTEPGRGRGYGYLADTGDTLMRRGYSLGDLP
MSMEG_0228|M.smegmatis_MC2_155 DDLALAGAQVSRGLLLLWQGG-PYRDEALELLSLGREASVREQFTMAAVP
MAV_4804|M.avium_104 DMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVRA
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK -------ATLRHWAQH-TDRAHIWTTLGHHTLLAHLAVDHDLPDFAEPLL
Mvan_1815|M.vanbaalenii_PYR-1 -------ARLRKWARTSTGRGDIWTTLGHHALLAHMAADHGLDEFAEPLL
MMAR_5254|M.marinum_M -------IVEAYLARERGRRGDRDDALPMLRTAVDTLYRQ--GQLLSWGL
MSMEG_0228|M.smegmatis_MC2_155 -------AVDTELARDMAARGDLDGAIELARDVVDTSIDS--GEAINMSA
MAV_4804|M.avium_104 GLGMLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTII
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK AQLDPYRDRIAVIGQVGMAGPVALATARLHALRGDKAAALADLALARSIA
Mvan_1815|M.vanbaalenii_PYR-1 AELDPFRDRIAVLGQVGMAGPVALATARLHALRGDTRRALADVTVARQIA
MMAR_5254|M.marinum_M PATHALVETLLDRGTEADWSEAQAAIERVADEPPDGPQPLRDIWLLR---
MSMEG_0228|M.smegmatis_MC2_155 SVT-VLVQSLIARGDRDDLDHAQRVIDRFAALPTDPGFVLYDVQLMR---
MAV_4804|M.avium_104 GDAVNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVNR
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 --------------------------------------------------
Rv3645|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00201|M.leprae_Br4923 --------------------------------------------------
TH_0858|M.thermoresistible__bu --------------------------------------------------
MAB_1459c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK ERSAGVPTLLRCRLLECELTEESPGRSTAASTLAAEAADLGMAAVAEAAS
Mvan_1815|M.vanbaalenii_PYR-1 ERSAGVPTLLRCRLLVCQLAEPSADRAADAAALATEADSVGMAAVAAAAR
MMAR_5254|M.marinum_M ---------MRAALAGARGAGGDYQRLRESYRDMARTLDFGGHLAWADAM
MSMEG_0228|M.smegmatis_MC2_155 ---------LRALLARARGDEERYRECSDRYRELATAYRYEGHMALAARM
MAV_4804|M.avium_104 RRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQRC
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
Mb3669|M.bovis_AF2122/97 ------------------------------------
Rv3645|M.tuberculosis_H37Rv ------------------------------------
MLBr_00201|M.leprae_Br4923 ------------------------------------
TH_0858|M.thermoresistible__bu ------------------------------------
MAB_1459c|M.abscessus_ATCC_199 ------------------------------------
Mflv_4653|M.gilvum_PYR-GCK RLL---------------------------------
Mvan_1815|M.vanbaalenii_PYR-1 RLA---------------------------------
MMAR_5254|M.marinum_M R-----------------------------------
MSMEG_0228|M.smegmatis_MC2_155 A-----------------------------------
MAV_4804|M.avium_104 RDMLPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK
MUL_3594|M.ulcerans_Agy99 ------------------------------------