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VRIAVVGAGAIGAYWGAAMHRGGAEVHLIARNAHLHAMREHGVRVLSDRGDFVAHPNATDDPHEIGPVDY VFLGLKAHSYPSCGPLIEPLLGEHTAVLAAQNGVPWWYFHELQGPYRGRRIEAVDPGGATSAVLAPERAI GCVVYPATTIEAPGVIRHLEGTRFSIGEPSGEISQRCIALSEAMIAGGLKAPVEADLRSDIWIKLMGNVA FNPLSALTRATMVEICQNPYTRQVVVQLMEETLDIASRLGAKPDISIEKRLRGAENVGHHKTSMLQDLEA GKQLELDAIVTAVVEMADLTGAPAPTLRTVHAATDLLARTAVPAAVPQEQALKPALR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0153 | panE | - | 100% (337) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_6374 | panE | 3e-17 | 26.52% (328) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_2919 | - | 8e-09 | 32.69% (104) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 1e-06 | 24.54% (269) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 5e-14 | 23.70% (346) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 1e-06 | 24.54% (269) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-13 | 23.84% (323) | ketopantoate reductase ApbA/PanE |
| M. marinum M | MMAR_0863 | apbA | 6e-12 | 25.62% (324) | ketopantoate reductase, ApbA |
| M. avium 104 | MAV_4625 | panE | 8e-14 | 25.61% (328) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 6e-07 | 39.34% (61) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_1742 | apbA_1 | 2e-08 | 26.72% (262) | 2-dehydropantoate 2-reductase |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 6e-14 | 23.70% (346) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0863|M.marinum_M MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVSGPG
MAV_4625|M.avium_104 MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVTGPG
Mflv_0533|M.gilvum_PYR-GCK MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-TEAITRYGLRITGRR
Mvan_0557|M.vanbaalenii_PYR-1 MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-AEAITRYGLRITGRR
Mb2603|M.bovis_AF2122/97 -----MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHTSPR
Rv2573|M.tuberculosis_H37Rv -----MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHTSPR
MUL_1742|M.ulcerans_Agy99 ---------------------------------------MVPGPVHTDPQ
MAB_3554|M.abscessus_ATCC_1997 --MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSG
MSMEG_0153|M.smegmatis_MC2_155 MRIAVVGAGAIGAYWGAAMHRGGAEVHLIARNAH-LHAMREHGVRVLSDR
TH_4612|M.thermoresistible__bu ---VIVGSGAIGGTVGGLLARSGADVVLVARGAH-AQALADRGLTLRTPD
MMAR_0863|M.marinum_M TDQLVSLR----AATTAPTEVMDLVVLAVKAADVAAGARQALCMLGADTP
MAV_4625|M.avium_104 CDQVVPLR----ASTGAVDETMDLVVLAVKAADVEAAARQALPMLGPDTA
Mflv_0533|M.gilvum_PYR-GCK GDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADGLRDCVSS
Mvan_0557|M.vanbaalenii_PYR-1 GDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADGLRDCVSS
Mb2603|M.bovis_AF2122/97 ----------------EVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
Rv2573|M.tuberculosis_H37Rv ----------------EVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
MUL_1742|M.ulcerans_Agy99 ----------------QLSGPVDVLIFAVKATQTGAAREWLARLCGEHTV
MAB_3554|M.abscessus_ATCC_1997 VLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAATAIAPLVGAHTI
MSMEG_0153|M.smegmatis_MC2_155 GDFVAHPN---ATDDPHEIGPVDYVFLGLKAHSYPSCGPLIEPLLGEHTA
TH_4612|M.thermoresistible__bu GTFEIGVTAAADPAEVRLTSRDVLVFATKTQHLEDALHAWVDRPVHHGDT
:. .
MMAR_0863|M.marinum_M VLTIQN--------------------GLGSAETVADIVGEQR------VA
MAV_4625|M.avium_104 VLTIQN--------------------GLGSAETVAGVVGAQR------VA
Mflv_0533|M.gilvum_PYR-GCK ALSVQN--------------------TVEKDATLAGWLGPD-------RV
Mvan_0557|M.vanbaalenii_PYR-1 ALSVQN--------------------TVEKDATLARWLGPD-------RV
Mb2603|M.bovis_AF2122/97 VAVLQN--------------------GVEQVEQVQPHCPSS-------AV
Rv2573|M.tuberculosis_H37Rv VAVLQN--------------------GVEQVEQVQPHCPSS-------AV
MUL_1742|M.ulcerans_Agy99 VAVLQN--------------------GVEQVEQVQPHCPSS-------SI
MAB_3554|M.abscessus_ATCC_1997 VLPLQN--------------------GIEAADDLANVIGPQ-------HV
MSMEG_0153|M.smegmatis_MC2_155 VLAAQNGVPWWYFHELQGPYRGRRIEAVDPGGATSAVLAPE-------RA
TH_4612|M.thermoresistible__bu VVGTAG-------------------STLPVLTALNGVVAEEMALRFFARV
. . : .
MMAR_0863|M.marinum_M VGIASGFGAARLAPGHVH--------HNAMKAMRFGAYSSLPHETVERIA
MAV_4625|M.avium_104 VGIASGFGASRVAPGHVH--------HNAMRAMRFGPYSSLPHARVESIA
Mflv_0533|M.gilvum_PYR-GCK IGASTIEGGTLLEPGLVRN------HLTAEVTAYFGELDGTSSARVDDLT
Mvan_0557|M.vanbaalenii_PYR-1 IGASTIEGGTLLEPGLVRN------HLTAEVTAYFGELDGTSSARVDDLT
Mb2603|M.bovis_AF2122/97 VPAIVWCSAETQPQGWVR--------LRGEAALVV-----PTGPAAEQFA
Rv2573|M.tuberculosis_H37Rv VPAIVWCSAETQPQGWVR--------LRGEAALVV-----PTGPAAEQFA
MUL_1742|M.ulcerans_Agy99 VAGSVWFAAETQPGGWVR--------LRGDAALVL-----PTGAAAETLA
MAB_3554|M.abscessus_ATCC_1997 LGCSCVVIAKRTKPWAVT-------CLGAHAHLEIGPISDSFAGELTSLV
MSMEG_0153|M.smegmatis_MC2_155 IGCVVYPATTIEAPGVIR--------HLEGTRFSIGEPSGEISQRCIALS
TH_4612|M.thermoresistible__bu FGVCVWMPAAHVVPGEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIA
. : :
MMAR_0863|M.marinum_M HAWTEAGFDAAAVTDIAAMQWEKLICNVAYSAPCALTGMT---VGQVLDD
MAV_4625|M.avium_104 RTWAHAGFDAAAVTDIAAMQWEKLICNVAYSAPCALTGMT---VGQVMDD
Mflv_0533|M.gilvum_PYR-GCK AAFTNAGLPAKAVGNIEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEG
Mvan_0557|M.vanbaalenii_PYR-1 AAFTNAGLPAKAVGNIEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEG
Mb2603|M.bovis_AF2122/97 GLLRGAGATVDCDPDFTTAAWRKLLV-NALAGFMVLSGR----RSAMFRR
Rv2573|M.tuberculosis_H37Rv GLLRGAGATVDCDPDFTTAAWRKLLV-NALAGFMVLSGR----RSAMFRR
MUL_1742|M.ulcerans_Agy99 GLLRAAGCRVDCDLDFTTVIWRKLVL-NALAGLMALSGR----RSGMFRR
MAB_3554|M.abscessus_ATCC_1997 AALHQAHISVTLSSDIRATLWRKFMLISSYGGVGVLCRQP---VGVTSTT
MSMEG_0153|M.smegmatis_MC2_155 EAMIAGGLKAPVEADLRSDIWIKLMGNVAFNPLSALTRAT---MVEICQN
TH_4612|M.thermoresistible__bu ATWTPAGLLVARPPDVAPWKYRKLLA-NLANAVVALTGSGRGDPVVIAAA
. . :. : *: :
MMAR_0863|M.marinum_M AELGPVSRAAAT---EAWAVARASG----------------IAVAVTDPV
MAV_4625|M.avium_104 AEMGPVSRAAAT---EAWSVARASG----------------VAIAVADAV
Mflv_0533|M.gilvum_PYR-GCK MEVREGAMYFVALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAI
Mvan_0557|M.vanbaalenii_PYR-1 MEVREGAMYFVALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAI
Mb2603|M.bovis_AF2122/97 DDVAALSRRYVA---ECLAVARAEG-------------ARLDDDVVDEVV
Rv2573|M.tuberculosis_H37Rv DDVAALSRRYVA---ECLAVARAEG-------------ARLDDDVVDEVV
MUL_1742|M.ulcerans_Agy99 DDIAELSRHYVA---ECLAVARAEG-------------ARLDDDVIDEMV
MAB_3554|M.abscessus_ATCC_1997 PETAALIRDAMF---EVLAVGQAHG-------------VALSHQDVDSMM
MSMEG_0153|M.smegmatis_MC2_155 PYTRQVVVQLME---ETLDIASRLG--------------AKPDISIEKRL
TH_4612|M.thermoresistible__bu QREGEAVLRHAG---IEFVPAEVER----------------EARRHGPRD
MMAR_0863|M.marinum_M AHARAFGAAMP----NAKPSALLDHEARRASEIDVINGAVGRHGARVGVP
MAV_4625|M.avium_104 EHVRAFGAQMP----DAKPSALLDHEARRVSEIDVINGAVPRQGARVGVD
Mflv_0533|M.gilvum_PYR-GCK EFVIGQGRAMREKGNSGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMD
Mvan_0557|M.vanbaalenii_PYR-1 EFVIGQGRVMREKGNLGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMD
Mb2603|M.bovis_AF2122/97 RLVRSAPQDMG-------TSMLADRAAHRPLEWDLRNGVIVRKARAHGLA
Rv2573|M.tuberculosis_H37Rv RLVRSAPQDMG-------TSMLADRAAHRPLEWDLRNGVIVRKARAHGLA
MUL_1742|M.ulcerans_Agy99 DLFASAPEDMG-------TSILADREAHRRLEWDLRNGVIIRKARAHGLA
MAB_3554|M.abscessus_ATCC_1997 AVFHAFDPLTT-------SSMHRDLLEGRPSELEHQSGAVLRYGRAVGVT
MSMEG_0153|M.smegmatis_MC2_155 RGAENVGHHKT--------SMLQDLEAGKQLELDAIVTAVVEMADLTGAP
TH_4612|M.thermoresistible__bu RDVADAGDVVAN------STWQSLARNSGSVETDYLNGEIVRIAHRHGMT
: * : . *
MMAR_0863|M.marinum_M TPVNTTLTALVKSVERQWSAVNSD-------------------------
MAV_4625|M.avium_104 APVNATLTAVVKSIERRWR------------------------------
Mflv_0533|M.gilvum_PYR-GCK TPTLRVAYQIIKTVDRFLA------------------------------
Mvan_0557|M.vanbaalenii_PYR-1 TPTLRVAYQIIKTVDRFLA------------------------------
Mb2603|M.bovis_AF2122/97 TPISDVLVPLLAAASDGPG------------------------------
Rv2573|M.tuberculosis_H37Rv TPISDVLVPLLAAASDGPG------------------------------
MUL_1742|M.ulcerans_Agy99 TPISQVLVPLLAAASDGPG------------------------------
MAB_3554|M.abscessus_ATCC_1997 TPIHWCIYASQLPAEIAARKPTEHAP-----------------------
MSMEG_0153|M.smegmatis_MC2_155 APTLRTVHAATDLLARTAVPAAVPQEQALKPALR---------------
TH_4612|M.thermoresistible__bu APVNAGLARLARAAARDGHPPGRYSGGELAEALGLVGEALGADVMVEGR
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