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KIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVSGPGTDQLVSLRAATTAPTEVMDLV VLAVKAADVAAGARQALCMLGADTPVLTIQNGLGSAETVADIVGEQRVAVGIASGFGAARLAPGHVHHNA MKAMRFGAYSSLPHETVERIAHAWTEAGFDAAAVTDIAAMQWEKLICNVAYSAPCALTGMTVGQVLDDAE LGPVSRAAATEAWAVARASGIAVAVTDPVAHARAFGAAMPNAKPSALLDHEARRASEIDVINGAVGRHGA RVGVPTPVNTTLTALVKSVERQWSAVNSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0863 | apbA | - | 100% (310) | ketopantoate reductase, ApbA |
| M. marinum M | MMAR_2157 | apbA_1 | 4e-13 | 27.59% (261) | ketopantoate reductase, ApbA_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 2e-10 | 27.38% (263) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 1e-20 | 27.25% (334) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 2e-10 | 27.38% (263) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-22 | 28.90% (301) | ketopantoate reductase ApbA/PanE |
| M. avium 104 | MAV_4625 | panE | 1e-136 | 79.28% (304) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_6374 | panE | 3e-27 | 30.89% (327) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 7e-13 | 26.22% (328) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_0617 | apbA | 1e-165 | 96.15% (312) | ketopantoate reductase, ApbA |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 6e-20 | 27.25% (334) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0863|M.marinum_M ---MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVS
MUL_0617|M.ulcerans_Agy99 ---MKIAIIGCGAMGSIYAARLAGADNDVAVIDRHQPNVDQITRTGLRVS
MAV_4625|M.avium_104 ---MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVT
Mb2603|M.bovis_AF2122/97 --------MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHT
Rv2573|M.tuberculosis_H37Rv --------MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHT
Mflv_0533|M.gilvum_PYR-GCK ---MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-TEAITRYGLRIT
Mvan_0557|M.vanbaalenii_PYR-1 ---MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-AEAITRYGLRIT
MSMEG_6374|M.smegmatis_MC2_155 MSDARILVVGAGAIGGVTAAHLARAGRDVTVLDANAEHVRLMNSPGLKFD
MAB_3554|M.abscessus_ATCC_1997 -----MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTT
TH_4612|M.thermoresistible__bu ------VIVGSGAIGGTVGGLLARSGADVVLVARGAH-AQALADRGLTLR
. .. . . . . .: .
MMAR_0863|M.marinum_M GPGTDQLVSLR----AATTAPTEVMDLVVLAVKAADVAAGARQALC----
MUL_0617|M.ulcerans_Agy99 GPGTDQLVSLR----AATTAPTEVMDLVVLAVKAADVAAGARQALC----
MAV_4625|M.avium_104 GPGCDQVVPLR----ASTGAVDETMDLVVLAVKAADVEAAARQALP----
Mb2603|M.bovis_AF2122/97 SPR----------------EVAGPVDVLILAVKATQNDAARPWLTR----
Rv2573|M.tuberculosis_H37Rv SPR----------------EVAGPVDVLILAVKATQNDAARPWLTR----
Mflv_0533|M.gilvum_PYR-GCK GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADG----
Mvan_0557|M.vanbaalenii_PYR-1 GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADG----
MSMEG_6374|M.smegmatis_MC2_155 ELGETSHVTIT--AVDSPAALTGRFDFALVALKAP-YLQAALGPLV----
MAB_3554|M.abscessus_ATCC_1997 SSGVLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAATAIAP----
TH_4612|M.thermoresistible__bu TPDGTFEIGVTAAADPAEVRLTSR-DVLVFATKTQHLEDALHAWVDRPVH
* :.* * .
MMAR_0863|M.marinum_M ----MLGADTPVLTIQNGLGSAETVADIVGEQRVAVGIASGFGAARLAPG
MUL_0617|M.ulcerans_Agy99 ----MLGADTPVLTIQNGLGSAETVADIVGEQRVAVGIASGFGAARLAPG
MAV_4625|M.avium_104 ----MLGPDTAVLTIQNGLGSAETVAGVVGAQRVAVGIASGFGASRVAPG
Mb2603|M.bovis_AF2122/97 ----LCDERTVVAVLQNGVEQVEQVQPHCPSS-AVVPAIVWCSAETQPQG
Rv2573|M.tuberculosis_H37Rv ----LCDERTVVAVLQNGVEQVEQVQPHCPSS-AVVPAIVWCSAETQPQG
Mflv_0533|M.gilvum_PYR-GCK ----LRDCVSSALSVQNTVEKDATLAGWLGPD-RVIGASTIEGGTLLEPG
Mvan_0557|M.vanbaalenii_PYR-1 ----LRDCVSSALSVQNTVEKDATLARWLGPD-RVIGASTIEGGTLLEPG
MSMEG_6374|M.smegmatis_MC2_155 ----ERGLVDTYVSLGNGLVQN-TIQQIVGTERFVVGITEWG-ATNLGPG
MAB_3554|M.abscessus_ATCC_1997 ----LVGAHTIVLPLQNGIEAADDLANVIGPQ-HVLGCSCVVIAKRTKPW
TH_4612|M.thermoresistible__bu HGDTVVGTAGSTLPVLTALNGVVAEEMALRFFARVFGVCVWMPAAHVVPG
. : . : .. .
MMAR_0863|M.marinum_M --HV-HHNAMKAMRFGAYSSLPHET-----VERIAHAWTEAGFDAAAVTD
MUL_0617|M.ulcerans_Agy99 HVHV-HHNAMKAMRFGAYSSLPHET-----VERIAHAWTEVGFDAAAVTD
MAV_4625|M.avium_104 --HV-HHNAMRAMRFGPYSSLPHAR-----VESIARTWAHAGFDAAAVTD
Mb2603|M.bovis_AF2122/97 WVR---LRGEAALVV-----PTGPA-----AEQFAGLLRGAGATVDCDPD
Rv2573|M.tuberculosis_H37Rv WVR---LRGEAALVV-----PTGPA-----AEQFAGLLRGAGATVDCDPD
Mflv_0533|M.gilvum_PYR-GCK LVRN-HLTAEVTAYFGELDGTSSAR-----VDDLTAAFTNAGLPAKAVGN
Mvan_0557|M.vanbaalenii_PYR-1 LVRN-HLTAEVTAYFGELDGTSSAR-----VDDLTAAFTNAGLPAKAVGN
MSMEG_6374|M.smegmatis_MC2_155 --HV-AQTTVAPFVIGEVDGTLTAR-----LETLRGVLS-AAAEVGVSTD
MAB_3554|M.abscessus_ATCC_1997 AVT--CLGAHAHLEIGPISDSFAGE-----LTSLVAALHQAHISVTLSSD
TH_4612|M.thermoresistible__bu EVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLLVARPPD
. : . . :
MMAR_0863|M.marinum_M IAAMQWEKLICNVAYSAPCALTGMT---VGQVLDDAELGPVSRAAAT---
MUL_0617|M.ulcerans_Agy99 IAAMQWEKLICNVAYSAPCALTGMT---VGQVLDDAEMGPVSRAAAT---
MAV_4625|M.avium_104 IAAMQWEKLICNVAYSAPCALTGMT---VGQVMDDAEMGPVSRAAAT---
Mb2603|M.bovis_AF2122/97 FTTAAWRKLLV-NALAGFMVLSGR----RSAMFRRDDVAALSRRYVA---
Rv2573|M.tuberculosis_H37Rv FTTAAWRKLLV-NALAGFMVLSGR----RSAMFRRDDVAALSRRYVA---
Mflv_0533|M.gilvum_PYR-GCK IEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALAK
Mvan_0557|M.vanbaalenii_PYR-1 IEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALAK
MSMEG_6374|M.smegmatis_MC2_155 VMNQVWTKLLLNSTFSGLAGVTGML---YGEIAADPLGRTMAYHVWT---
MAB_3554|M.abscessus_ATCC_1997 IRATLWRKFMLISSYGGVGVLCRQP---VGVTSTTPETAALIRDAMF---
TH_4612|M.thermoresistible__bu VAPWKYRKLLANLANAVVALTGSGRGDPVVIAAAQREGEAVLRHAGI---
. : *: : .
MMAR_0863|M.marinum_M EAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN---
MUL_0617|M.ulcerans_Agy99 EAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN---
MAV_4625|M.avium_104 EAWSVARASG----------------VAIAVADAVEHVRAFGAQMPD---
Mb2603|M.bovis_AF2122/97 ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDMG----
Rv2573|M.tuberculosis_H37Rv ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDMG----
Mflv_0533|M.gilvum_PYR-GCK DLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRAMREKGN
Mvan_0557|M.vanbaalenii_PYR-1 DLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVMREKGN
MSMEG_6374|M.smegmatis_MC2_155 ESYDVARAAGFEVGPLIG--IQPDDLVVRSEADRERADAAIEVLMSKLG-
MAB_3554|M.abscessus_ATCC_1997 EVLAVGQAHG----------------VALSHQDVDSMMAVFHAFDPLT--
TH_4612|M.thermoresistible__bu -EFVPAEVER----------------EARRHGPRDRDVADAGDVVAN---
..
MMAR_0863|M.marinum_M -AKPSALLDHEARRASEIDVINGAVGRHGARVGVPTPVNTTLTALVKSVE
MUL_0617|M.ulcerans_Agy99 -AKPSALLDHEARRASEIDVINGAVG-------VPTPVNTTLTALVKSVE
MAV_4625|M.avium_104 -AKPSALLDHEARRVSEIDVINGAVPRQGARVGVDAPVNATLTAVVKSIE
Mb2603|M.bovis_AF2122/97 ---TSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAAS
Rv2573|M.tuberculosis_H37Rv ---TSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAAS
Mflv_0533|M.gilvum_PYR-GCK SGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKTVD
Mvan_0557|M.vanbaalenii_PYR-1 LGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKTVD
MSMEG_6374|M.smegmatis_MC2_155 ATKASMLQDLERGATTEVDVINGGVCTTAAKAGVASPFNARIVELVHECE
MAB_3554|M.abscessus_ATCC_1997 --TSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQLPAE
TH_4612|M.thermoresistible__bu ---STWQSLARNSGSVETDYLNGEIVRIAHRHGMTAPVNAGLARLARAAA
.: * : . : :*
MMAR_0863|M.marinum_M RQWSAVNSD-------------------------
MUL_0617|M.ulcerans_Agy99 RQWSAVNSD-------------------------
MAV_4625|M.avium_104 RRWR------------------------------
Mb2603|M.bovis_AF2122/97 DGPG------------------------------
Rv2573|M.tuberculosis_H37Rv DGPG------------------------------
Mflv_0533|M.gilvum_PYR-GCK RFLA------------------------------
Mvan_0557|M.vanbaalenii_PYR-1 RFLA------------------------------
MSMEG_6374|M.smegmatis_MC2_155 QGLRSPGRETLEALAQISARQ-------------
MAB_3554|M.abscessus_ATCC_1997 IAARKPTEHAP-----------------------
TH_4612|M.thermoresistible__bu RDGHPPGRYSGGELAEALGLVGEALGADVMVEGR