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VPGPVHTDPQQLSGPVDVLIFAVKATQTGAAREWLARLCGEHTVVAVLQNGVEQVEQVQPHCPSSSIVAG SVWFAAETQPGGWVRLRGDAALVLPTGAAAETLAGLLRAAGCRVDCDLDFTTVIWRKLVLNALAGLMALS GRRSGMFRRDDIAELSRHYVAECLAVARAEGARLDDDVIDEMVDLFASAPEDMGTSILADREAHRRLEWD LRNGVIIRKARAHGLATPISQVLVPLLAAASDGPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1742 | apbA_1 | - | 100% (246) | 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_0617 | apbA | 3e-11 | 26.72% (232) | ketopantoate reductase, ApbA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 1e-111 | 79.67% (246) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2573 | - | 1e-111 | 79.67% (246) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-15 | 29.60% (223) | ketopantoate reductase ApbA/PanE |
| M. marinum M | MMAR_2157 | apbA_1 | 1e-137 | 98.78% (246) | ketopantoate reductase, ApbA_1 |
| M. avium 104 | MAV_3448 | - | 1e-106 | 74.80% (246) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_2919 | - | 7e-09 | 28.34% (247) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1742|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2157|M.marinum_M -------------------------------MLLCGH----TARDSIELR
Mb2603|M.bovis_AF2122/97 ------------------------MHKAGYSPLLCGH----TPRAGIELR
Rv2573|M.tuberculosis_H37Rv ------------------------MHKAGYSPLLCGH----TPRAGIELR
MAV_3448|M.avium_104 --------------------------------MVCGR----TPRERIELR
MAB_3554|M.abscessus_ATCC_1997 --------MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQ
MSMEG_2919|M.smegmatis_MC2_155 MTDTTPHPVVVYGTGAVGGVIAAQLRLGGFDVTAVARGDHLRAIRAGGLK
MUL_1742|M.ulcerans_Agy99 --------MVPGPVHTDP----QQLSGPVDVLIFAVKATQTGAAREWLAR
MMAR_2157|M.marinum_M PDGAS-PIVVPGPVHTDP----QQLSGPVDVLILAVKATQTGAAREWLAR
Mb2603|M.bovis_AF2122/97 RDGAD-PIVVPGPVHTSP----REVAGPVDVLILAVKATQNDAARPWLTR
Rv2573|M.tuberculosis_H37Rv RDGAD-PIVVPGPVHTSP----REVAGPVDVLILAVKATQNDAARPWLTR
MAV_3448|M.avium_104 PDDAD-PIVVPGPVHTDP----GRVSGPVDVVLLAVKATQNAGAAGWLAR
MAB_3554|M.abscessus_ATCC_1997 LTTSS-GVLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAATAIAP
MSMEG_2919|M.smegmatis_MC2_155 LVTQAGERTVPLPAAADAG---EVDWSDEPVVILAVKSHQTGAALDDLAT
. . . :::.***: * .* ::
MUL_1742|M.ulcerans_Agy99 LCGEHTVVAVLQNGVEQVEQVQPHCPSSSIVAGSVWFAAETQPGGWVRLR
MMAR_2157|M.marinum_M LCGEHTVVAVLQNGVEQVEQVRPHCPSSSIVAGSVWFAAETQPGGWVRLR
Mb2603|M.bovis_AF2122/97 LCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLR
Rv2573|M.tuberculosis_H37Rv LCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLR
MAV_3448|M.avium_104 LCGEHTVVVVLQNGVEQVEQVRPLCPDSPVIPGIVWYSATTQPQGWVRLR
MAB_3554|M.abscessus_ATCC_1997 LVGAHTIVLPLQNGIEAADDLANVIG-PQHVLGCSCVVIAKRTKPWAVTC
MSMEG_2919|M.smegmatis_MC2_155 HAPAHTAIFAAQNGVANEMAILRRFADVYGVT-VMLPAAHLEPGVVVQQS
:* : ***: : : .. .
MUL_1742|M.ulcerans_Agy99 GDAALVLPTG-------AAAETLAGLLR-------AAGCRVDCDLDFTTV
MMAR_2157|M.marinum_M GDAALVLPTG-------AAAETLAGLLR-------AAGCRVDCDPDFTTV
Mb2603|M.bovis_AF2122/97 GEAALVVPTG-------PAAEQFAGLLR-------GAGATVDCDPDFTTA
Rv2573|M.tuberculosis_H37Rv GEAALVVPTG-------PAAEQFAGLLR-------GAGATVDCDPDFTTA
MAV_3448|M.avium_104 TEPALVLPSG-------PSAQAVAALLR-------DAGCRVDCDPDIITA
MAB_3554|M.abscessus_ATCC_1997 LGAHAHLEIG-------PISDSFAGELTSLVAALHQAHISVTLSSDIRAT
MSMEG_2919|M.smegmatis_MC2_155 HPLAGILDLGRYPSGADAVAHDVAAMLR-------ASQFLSEVRPDIMAW
: * . :. .*. * : *: :
MUL_1742|M.ulcerans_Agy99 IWRKLVLN-ALAGLMALSGRRSGMFRRD-DIAELSRHYVAECLAVARAEG
MMAR_2157|M.marinum_M IWRKLVLN-ALAGLMALSGRRSGMFRRD-DIAELSRHYVAECLAVARAEG
Mb2603|M.bovis_AF2122/97 AWRKLLVN-ALAGFMVLSGRRSAMFRRD-DVAALSRRYVAECLAVARAEG
Rv2573|M.tuberculosis_H37Rv AWRKLLVN-ALAGFMVLSGRRSAMFRRD-DVAALSRRYVAECLAVARAEG
MAV_3448|M.avium_104 AWRKLLTN-ALAGFMALSRRRSGMFRRD-DVAALSRRYVAECLAVARAEG
MAB_3554|M.abscessus_ATCC_1997 LWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAVGQAHG
MSMEG_2919|M.smegmatis_MC2_155 KHRKLIMN-LGNGVTAIFRPGP----AADELAAQARAEAEEVLGAAGIPV
**:: *. .: : * * * *...
MUL_1742|M.ulcerans_Agy99 ARLDDDVIDEMVDLFASAPEDMGTSILADREA-HRRLEWDLRNGVIIRKA
MMAR_2157|M.marinum_M ARLDDDVIDEMVDLFASAPEDMGTSILADREA-HRRLEWDLRNGVIIRKA
Mb2603|M.bovis_AF2122/97 ARLDDDVVDEVVRLVRSAPQDMGTSMLADRAA-HRPLEWDLRNGVIVRKA
Rv2573|M.tuberculosis_H37Rv ARLDDDVVDEVVRLVRSAPQDMGTSMLADRAA-HRPLEWDLRNGVIVRKA
MAV_3448|M.avium_104 ARLSDDVVDELVELFRRAPEDMGTSILSDAEA-HRPMEWDVRNGVIARKG
MAB_3554|M.abscessus_ATCC_1997 VALSHQDVDSMMAVFHAFDPLTTSSMHRDLLE-GRPSELEHQSGAVLRYG
MSMEG_2919|M.smegmatis_MC2_155 VPPEQDTERRGRFLAGRVRDDVHGSTWQSVARGHTEVETDYFNGEIALQA
. ..: : * . * : .* : .
MUL_1742|M.ulcerans_Agy99 RAHGLATPISQVLVPLLAAASDGPG------------------------
MMAR_2157|M.marinum_M RAHGLATPISQVLVPLLAAASDGPG------------------------
Mb2603|M.bovis_AF2122/97 RAHGLATPISDVLVPLLAAASDGPG------------------------
Rv2573|M.tuberculosis_H37Rv RAHGLATPISDVLVPLLAAASDGPG------------------------
MAV_3448|M.avium_104 RAHGLPTPISDVLVPLLAAASDGPG------------------------
MAB_3554|M.abscessus_ATCC_1997 RAVGVTTPIHWCIYASQLPAEIAARKPTEHAP-----------------
MSMEG_2919|M.smegmatis_MC2_155 RLIGRSAPVNEYLQRVTADHARHGRPPRSLDAAEALSHITAGAAAPEHL
* * .:*: :