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VLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSGVLAVSGIHVVADIAEARIDPTA DLIIVAVKAWQVSAAATAIAPLVGAHTIVLPLQNGIEAADDLANVIGPQHVLGCSCVVIAKRTKPWAVTC LGAHAHLEIGPISDSFAGELTSLVAALHQAHISVTLSSDIRATLWRKFMLISSYGGVGVLCRQPVGVTST TPETAALIRDAMFEVLAVGQAHGVALSHQDVDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAVLR YGRAVGVTTPIHWCIYASQLPAEIAARKPTEHAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3554 | - | - | 100% (314) | ketopantoate reductase ApbA/PanE |
| M. abscessus ATCC 19977 | MAB_2908c | - | 2e-15 | 26.37% (311) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 2e-15 | 30.04% (223) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 7e-13 | 27.98% (193) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 2e-15 | 30.04% (223) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0863 | apbA | 2e-22 | 28.90% (301) | ketopantoate reductase, ApbA |
| M. avium 104 | MAV_4625 | panE | 9e-25 | 30.38% (293) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_0153 | panE | 3e-13 | 23.84% (323) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0617 | apbA | 6e-18 | 27.04% (307) | ketopantoate reductase, ApbA |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 5e-13 | 24.68% (316) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0533|M.gilvum_PYR-GCK MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHTEAITRYGLRITGRR
Mvan_0557|M.vanbaalenii_PYR-1 MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHAEAITRYGLRITGRR
MMAR_0863|M.marinum_M MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVSGPG
MUL_0617|M.ulcerans_Agy99 MKIAIIGCGAMGSIYAARLAGADNDVAVIDRHQPNVDQITRTGLRVSGPG
MAV_4625|M.avium_104 MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVTGPG
Mb2603|M.bovis_AF2122/97 -----MHKAGYSPLLCGHTPRAG-----IELRRDGADPIVVPGPVHTSPR
Rv2573|M.tuberculosis_H37Rv -----MHKAGYSPLLCGHTPRAG-----IELRRDGADPIVVPGPVHTSPR
MAB_3554|M.abscessus_ATCC_1997 --MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSG
MSMEG_0153|M.smegmatis_MC2_155 MRIAVVGAGAIGAYWGAAMHRGGAEVHLIA-RNAHLHAMREHGVRVLSDR
. .. . . . : .
Mflv_0533|M.gilvum_PYR-GCK GDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADGLRDCVSS
Mvan_0557|M.vanbaalenii_PYR-1 GDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADGLRDCVSS
MMAR_0863|M.marinum_M TDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGARQALCMLGADTP
MUL_0617|M.ulcerans_Agy99 TDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGARQALCMLGADTP
MAV_4625|M.avium_104 CDQVVP----LRASTGAVDETMDLVVLAVKAADVEAAARQALPMLGPDTA
Mb2603|M.bovis_AF2122/97 ----------------EVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
Rv2573|M.tuberculosis_H37Rv ----------------EVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
MAB_3554|M.abscessus_ATCC_1997 VLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAATAIAPLVGAHTI
MSMEG_0153|M.smegmatis_MC2_155 GDFVAHPN---ATDDPHEIGPVDYVFLGLKAHSYPSCGPLIEPLLGEHTA
* :.:.:*. . : . :
Mflv_0533|M.gilvum_PYR-GCK ALSVQN--------------------TVEKDATLAGWLGPDRVIG-ASTI
Mvan_0557|M.vanbaalenii_PYR-1 ALSVQN--------------------TVEKDATLARWLGPDRVIG-ASTI
MMAR_0863|M.marinum_M VLTIQN--------------------GLGSAETVADIVGEQRVAVGIASG
MUL_0617|M.ulcerans_Agy99 VLTIQN--------------------GLGSAETVADIVGEQRVAVGIASG
MAV_4625|M.avium_104 VLTIQN--------------------GLGSAETVAGVVGAQRVAVGIASG
Mb2603|M.bovis_AF2122/97 VAVLQN--------------------GVEQVEQVQPHCPSSAVVP-AIVW
Rv2573|M.tuberculosis_H37Rv VAVLQN--------------------GVEQVEQVQPHCPSSAVVP-AIVW
MAB_3554|M.abscessus_ATCC_1997 VLPLQN--------------------GIEAADDLANVIGPQHVLG--CSC
MSMEG_0153|M.smegmatis_MC2_155 VLAAQNGVPWWYFHELQGPYRGRRIEAVDPGGATSAVLAPERAIG-CVVY
. ** : . .
Mflv_0533|M.gilvum_PYR-GCK EGGTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAKA
Mvan_0557|M.vanbaalenii_PYR-1 EGGTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAKA
MMAR_0863|M.marinum_M FGAARLAPG--HVHHNAMKAMRFGAYSSLPHETVERIAHAWTEAGFDAAA
MUL_0617|M.ulcerans_Agy99 FGAARLAPGHVHVHHNAMKAMRFGAYSSLPHETVERIAHAWTEVGFDAAA
MAV_4625|M.avium_104 FGASRVAPG--HVHHNAMRAMRFGPYSSLPHARVESIARTWAHAGFDAAA
Mb2603|M.bovis_AF2122/97 CSAETQPQGWVRLRGEAALVVPTGP-------AAEQFAGLLRGAGATVDC
Rv2573|M.tuberculosis_H37Rv CSAETQPQGWVRLRGEAALVVPTGP-------AAEQFAGLLRGAGATVDC
MAB_3554|M.abscessus_ATCC_1997 VVIAKRTKPWAVTCLGAHAHLEIGPISDSFAGELTSLVAALHQAHISVTL
MSMEG_0153|M.smegmatis_MC2_155 PATTIEAPG--VIRHLEGTRFSIGEPSGEISQRCIALSEAMIAGGLKAPV
* : .
Mflv_0533|M.gilvum_PYR-GCK VGNIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYFVAL
Mvan_0557|M.vanbaalenii_PYR-1 VGNIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYFVAL
MMAR_0863|M.marinum_M VTDIAAMQWEKLICNVAYSAP--CALTGMTVGQVLDDAELGP---VSRAA
MUL_0617|M.ulcerans_Agy99 VTDIAAMQWEKLICNVAYSAP--CALTGMTVGQVLDDAEMGP---VSRAA
MAV_4625|M.avium_104 VTDIAAMQWEKLICNVAYSAP--CALTGMTVGQVMDDAEMGP---VSRAA
Mb2603|M.bovis_AF2122/97 DPDFTTAAWRKLLVNALAGFMVLSGRR----SAMFRRDDVAA---LSRRY
Rv2573|M.tuberculosis_H37Rv DPDFTTAAWRKLLVNALAGFMVLSGRR----SAMFRRDDVAA---LSRRY
MAB_3554|M.abscessus_ATCC_1997 SSDIRATLWRKFMLISSYGGVG--VLCRQPVGVTSTTPETAA---LIRDA
MSMEG_0153|M.smegmatis_MC2_155 EADLRSDIWIKLMGNVAFNPLS--ALTRATMVEICQNPYTRQ---VVVQL
:: * *:
Mflv_0533|M.gilvum_PYR-GCK AKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRAMREK
Mvan_0557|M.vanbaalenii_PYR-1 AKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVMREK
MMAR_0863|M.marinum_M ATEAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN-
MUL_0617|M.ulcerans_Agy99 ATEAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN-
MAV_4625|M.avium_104 ATEAWSVARASG----------------VAIAVADAVEHVRAFGAQMPD-
Mb2603|M.bovis_AF2122/97 VAECLAVARAEG-----------------ARLDDDVVDEVVRLVRSAPQD
Rv2573|M.tuberculosis_H37Rv VAECLAVARAEG-----------------ARLDDDVVDEVVRLVRSAPQD
MAB_3554|M.abscessus_ATCC_1997 MFEVLAVGQAHG----------------VALSHQDVDSMMAVFHAFDPLT
MSMEG_0153|M.smegmatis_MC2_155 MEETLDIASRLG-----------------AKPDISIEKRLRGAENVGHHK
: : * * .
Mflv_0533|M.gilvum_PYR-GCK GNSGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKT
Mvan_0557|M.vanbaalenii_PYR-1 GNLGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKT
MMAR_0863|M.marinum_M ---AKPSALLDHEARRASEIDVINGAVGRHGARVGVPTPVNTTLTALVKS
MUL_0617|M.ulcerans_Agy99 ---AKPSALLDHEARRASEIDVINGAVG-------VPTPVNTTLTALVKS
MAV_4625|M.avium_104 ---AKPSALLDHEARRVSEIDVINGAVPRQGARVGVDAPVNATLTAVVKS
Mb2603|M.bovis_AF2122/97 ---MGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
Rv2573|M.tuberculosis_H37Rv ---MGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
MAB_3554|M.abscessus_ATCC_1997 ----TSSMHRDLLEGRPSELEHQSGAVLRYGRAVGVTTPIHWCIYASQLP
MSMEG_0153|M.smegmatis_MC2_155 -----TSMLQDLEAGKQLELDAIVTAVVEMADLTGAPAPTLRTVHAATDL
.* * : * : :*
Mflv_0533|M.gilvum_PYR-GCK VDRFLA---------------
Mvan_0557|M.vanbaalenii_PYR-1 VDRFLA---------------
MMAR_0863|M.marinum_M VERQWSAVNSD----------
MUL_0617|M.ulcerans_Agy99 VERQWSAVNSD----------
MAV_4625|M.avium_104 IERRWR---------------
Mb2603|M.bovis_AF2122/97 ASDGPG---------------
Rv2573|M.tuberculosis_H37Rv ASDGPG---------------
MAB_3554|M.abscessus_ATCC_1997 AEIAARKPTEHAP--------
MSMEG_0153|M.smegmatis_MC2_155 LARTAVPAAVPQEQALKPALR