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LHKAGYSPLLCGHTPRAGIELRRDGADPIVVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCD ERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGA GATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVVD EVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | - | 100% (275) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2573 | - | 1e-158 | 100.00% (275) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-15 | 30.04% (223) | ketopantoate reductase ApbA/PanE |
| M. marinum M | MMAR_2157 | apbA_1 | 1e-122 | 79.78% (267) | ketopantoate reductase, ApbA_1 |
| M. avium 104 | MAV_3448 | - | 1e-116 | 76.78% (267) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_0153 | panE | 1e-06 | 24.54% (269) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 8e-05 | 31.03% (145) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_1742 | apbA_1 | 1e-111 | 79.67% (246) | 2-dehydropantoate 2-reductase |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2603|M.bovis_AF2122/97 ------------------MHKAGYSPLLCGH----TPRAGIELRRDGADP
Rv2573|M.tuberculosis_H37Rv ------------------MHKAGYSPLLCGH----TPRAGIELRRDGADP
MMAR_2157|M.marinum_M -------------------------MLLCGH----TARDSIELRPDGASP
MUL_1742|M.ulcerans_Agy99 --------------------------------------------------
MAV_3448|M.avium_104 --------------------------MVCGR----TPRERIELRPDDADP
MAB_3554|M.abscessus_ATCC_1997 --MLVFGAGGVGLYFSAVLAQAGHHVTIVGRPATVTAAGQSDLQLTTSSG
MSMEG_0153|M.smegmatis_MC2_155 MRIAVVGAGAIGAYWGAAMHRGGAEVHLIARNAHLHAMREHGVRVLSDRG
TH_4612|M.thermoresistible__bu ---VIVGSGAIGGTVGGLLARSGADVVLVARGAHAQALADRGLTLRTPDG
Mb2603|M.bovis_AF2122/97 IVVPGPVHTSP----REVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
Rv2573|M.tuberculosis_H37Rv IVVPGPVHTSP----REVAGPVDVLILAVKATQNDAARPWLTRLCDERTV
MMAR_2157|M.marinum_M IVVPGPVHTDP----QQLSGPVDVLILAVKATQTGAAREWLARLCGEHTV
MUL_1742|M.ulcerans_Agy99 -MVPGPVHTDP----QQLSGPVDVLIFAVKATQTGAAREWLARLCGEHTV
MAV_3448|M.avium_104 IVVPGPVHTDP----GRVSGPVDVVLLAVKATQNAGAAGWLARLCGEHTV
MAB_3554|M.abscessus_ATCC_1997 VLAVSGIHVVADIAEARIDPTADLIIVAVKAWQVSAAATAIAPLVGAHTI
MSMEG_0153|M.smegmatis_MC2_155 DFVAHPNATDD----PHEIGPVDYVFLGLKAHSYPSCGPLIEPLLGEHTA
TH_4612|M.thermoresistible__bu TFEIGVTAAADP-AEVRLTSRDVLVFATKTQHLEDALHAWVDRPVHHGDT
. . . :: . . :
Mb2603|M.bovis_AF2122/97 VAVLQNGV--------------EQVEQVQP-----HCPSSAVVPAIVWCS
Rv2573|M.tuberculosis_H37Rv VAVLQNGV--------------EQVEQVQP-----HCPSSAVVPAIVWCS
MMAR_2157|M.marinum_M VAVLQNGV--------------EQVEQVRP-----HCPSSSIVAGSVWFA
MUL_1742|M.ulcerans_Agy99 VAVLQNGV--------------EQVEQVQP-----HCPSSSIVAGSVWFA
MAV_3448|M.avium_104 VVVLQNGV--------------EQVEQVRP-----LCPDSPVIPGIVWYS
MAB_3554|M.abscessus_ATCC_1997 VLPLQNGI--------------EAADDLAN-----VIG-PQHVLGCSCVV
MSMEG_0153|M.smegmatis_MC2_155 VLAAQNGVPWWYFHELQGPYRGRRIEAVDPGGATSAVLAPERAIGCVVYP
TH_4612|M.thermoresistible__bu VVGTAGSTLPVLTALN-----GVVAEEMALRFFARVFGVCVWMPAAHVVP
* .. : : .
Mb2603|M.bovis_AF2122/97 AETQPQGWVRLRGEAALVVPTGPAAEQFAGLLR-------GAGATVDCDP
Rv2573|M.tuberculosis_H37Rv AETQPQGWVRLRGEAALVVPTGPAAEQFAGLLR-------GAGATVDCDP
MMAR_2157|M.marinum_M AETQPGGWVRLRGDAALVLPTGAAAETLAGLLR-------AAGCRVDCDP
MUL_1742|M.ulcerans_Agy99 AETQPGGWVRLRGDAALVLPTGAAAETLAGLLR-------AAGCRVDCDL
MAV_3448|M.avium_104 ATTQPQGWVRLRTEPALVLPSGPSAQAVAALLR-------DAGCRVDCDP
MAB_3554|M.abscessus_ATCC_1997 IAKRTKPWAVTCLGAHAHLEIGPISDSFAGELTSLVAALHQAHISVTLSS
MSMEG_0153|M.smegmatis_MC2_155 ATTIEAPGVIRHLEGTRFSIGEPSGEISQRCIALS-EAMIAGGLKAPVEA
TH_4612|M.thermoresistible__bu GEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLLVARPP
: . .
Mb2603|M.bovis_AF2122/97 DFTTAAWRKLLVN-ALAGFMVLSGRRSAMFRRD-DVAALSRRYVAECLAV
Rv2573|M.tuberculosis_H37Rv DFTTAAWRKLLVN-ALAGFMVLSGRRSAMFRRD-DVAALSRRYVAECLAV
MMAR_2157|M.marinum_M DFTTVIWRKLVLN-ALAGLMALSGRRSGMFRRD-DIAELSRHYVAECLAV
MUL_1742|M.ulcerans_Agy99 DFTTVIWRKLVLN-ALAGLMALSGRRSGMFRRD-DIAELSRHYVAECLAV
MAV_3448|M.avium_104 DIITAAWRKLLTN-ALAGFMALSRRRSGMFRRD-DVAALSRRYVAECLAV
MAB_3554|M.abscessus_ATCC_1997 DIRATLWRKFMLISSYGGVGVLCRQPVGVTSTTPETAALIRDAMFEVLAV
MSMEG_0153|M.smegmatis_MC2_155 DLRSDIWIKLMGNVAFNPLSALTRATMVEICQNPYTRQVVVQLMEETLDI
TH_4612|M.thermoresistible__bu DVAPWKYRKLLANLANAVVALTGSGRGDPVVIAAAQREGEAVLRHAGIEF
*. . : *:: : . : .
Mb2603|M.bovis_AF2122/97 ARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVI
Rv2573|M.tuberculosis_H37Rv ARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVI
MMAR_2157|M.marinum_M ARAEGARLDDDVIDEMVDLFASAPEDMGTSILADREAHRRLEWDLRNGVI
MUL_1742|M.ulcerans_Agy99 ARAEGARLDDDVIDEMVDLFASAPEDMGTSILADREAHRRLEWDLRNGVI
MAV_3448|M.avium_104 ARAEGARLSDDVVDELVELFRRAPEDMGTSILSDAEAHRPMEWDVRNGVI
MAB_3554|M.abscessus_ATCC_1997 GQAHGVALSHQDVDSMMAVFHAFDPLTTSSMHRDLLEGRPSELEHQSGAV
MSMEG_0153|M.smegmatis_MC2_155 ASRLGAKPDISIEKRLRGAENVG--HHKTSMLQDLEAGKQLELDAIVTAV
TH_4612|M.thermoresistible__bu VPAEVEREARRHGPRDRDVADAGDVVANSTWQSLARNSGSVETDYLNGEI
:: * : :
Mb2603|M.bovis_AF2122/97 VRKARAHGLATPISDVLVP---LLAAASDGPG------------------
Rv2573|M.tuberculosis_H37Rv VRKARAHGLATPISDVLVP---LLAAASDGPG------------------
MMAR_2157|M.marinum_M IRKARAHGLATPISQVLVP---LLAAASDGPG------------------
MUL_1742|M.ulcerans_Agy99 IRKARAHGLATPISQVLVP---LLAAASDGPG------------------
MAV_3448|M.avium_104 ARKGRAHGLPTPISDVLVP---LLAAASDGPG------------------
MAB_3554|M.abscessus_ATCC_1997 LRYGRAVGVTTPIHWCIYA---SQLPAEIAARKPTEHAP-----------
MSMEG_0153|M.smegmatis_MC2_155 VEMADLTGAPAPTLRTVHAATDLLARTAVPAAVPQEQALKPALR------
TH_4612|M.thermoresistible__bu VRIAHRHGMTAPVNAGLARLARAAARDGHPPGRYSGGELAEALGLVGEAL
. . * .:* : .
Mb2603|M.bovis_AF2122/97 ---------
Rv2573|M.tuberculosis_H37Rv ---------
MMAR_2157|M.marinum_M ---------
MUL_1742|M.ulcerans_Agy99 ---------
MAV_3448|M.avium_104 ---------
MAB_3554|M.abscessus_ATCC_1997 ---------
MSMEG_0153|M.smegmatis_MC2_155 ---------
TH_4612|M.thermoresistible__bu GADVMVEGR