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TDTTPHPVVVYGTGAVGGVIAAQLRLGGFDVTAVARGDHLRAIRAGGLKLVTQAGERTVPLPAAADAGEV DWSDEPVVILAVKSHQTGAALDDLATHAPAHTAIFAAQNGVANEMAILRRFADVYGVTVMLPAAHLEPGV VVQQSHPLAGILDLGRYPSGADAVAHDVAAMLRASQFLSEVRPDIMAWKHRKLIMNLGNGVTAIFRPGPA ADELAAQARAEAEEVLGAAGIPVVPPEQDTERRGRFLAGRVRDDVHGSTWQSVARGHTEVETDYFNGEIA LQARLIGRSAPVNEYLQRVTADHARHGRPPRSLDAAEALSHITAGAAAPEHL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2919 | - | - | 100% (333) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_6374 | panE | 5e-11 | 27.57% (341) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_0153 | panE | 8e-09 | 32.69% (104) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 3e-06 | 26.34% (243) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 1e-05 | 27.46% (142) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 3e-06 | 26.34% (243) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2908c | - | 6e-14 | 26.83% (328) | 2-dehydropantoate 2-reductase |
| M. marinum M | MMAR_2157 | apbA_1 | 2e-10 | 29.15% (247) | ketopantoate reductase, ApbA_1 |
| M. avium 104 | MAV_4625 | panE | 2e-12 | 26.35% (315) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 1e-48 | 37.99% (329) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_1742 | apbA_1 | 7e-09 | 28.34% (247) | 2-dehydropantoate 2-reductase |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 2e-06 | 28.17% (142) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0533|M.gilvum_PYR-GCK ------MRVLILGAGGLGSVLGGYLANIGVDVTLVGRP-AHTEAITRYGL
Mvan_0557|M.vanbaalenii_PYR-1 ------MRVLILGAGGLGSVLGGYLANIGVDVTLVGRP-AHAEAITRYGL
Mb2603|M.bovis_AF2122/97 -----------MHKAGYSPLLCGHTPRAGIELRRDG--------------
Rv2573|M.tuberculosis_H37Rv -----------MHKAGYSPLLCGHTPRAGIELRRDG--------------
MMAR_2157|M.marinum_M ------------------MLLCGHTARDSIELRPDG--------------
MUL_1742|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2919|M.smegmatis_MC2_155 MTDTTPHPVVVYGTGAVGGVIAAQLRLGGFDVTAVARG-DHLRAIRAGGL
TH_4612|M.thermoresistible__bu ---------VIVGSGAIGGTVGGLLARSGADVVLVARG-AHAQALADRGL
MAV_4625|M.avium_104 ------MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGL
MAB_2908c|M.abscessus_ATCC_199 ------MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLS
Mflv_0533|M.gilvum_PYR-GCK RITGRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQAL------
Mvan_0557|M.vanbaalenii_PYR-1 RITGRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQAL------
Mb2603|M.bovis_AF2122/97 -----ADPIVVPG--PVHTSPREVAGPVDVLILAVKATQNDAAR------
Rv2573|M.tuberculosis_H37Rv -----ADPIVVPG--PVHTSPREVAGPVDVLILAVKATQNDAAR------
MMAR_2157|M.marinum_M -----ASPIVVPG--PVHTDPQQLSGPVDVLILAVKATQTGAAR------
MUL_1742|M.ulcerans_Agy99 ---------MVPG--PVHTDPQQLSGPVDVLIFAVKATQTGAAR------
MSMEG_2919|M.smegmatis_MC2_155 KLVTQAGERTVPLP-AAADAGEVDWSDEPVVILAVKSHQTGAAL------
TH_4612|M.thermoresistible__bu TLRTPDGTFEIGVT-AAADPAEVRLTSRDVLVFATKTQHLEDALHAWVDR
MAV_4625|M.avium_104 RVTGPGCDQVVPLR----ASTGAVDETMDLVVLAVKAADVEAAAR-----
MAB_2908c|M.abscessus_ATCC_199 LSDYLGWSAAIPASECAFSEDIDTVRSADIVLVTVKSAATAQMA------
: ::.:.*
Mflv_0533|M.gilvum_PYR-GCK -----AEADGLRDCVSSALSVQNTVEKDATLAGWLGPD-RVIGASTIEGG
Mvan_0557|M.vanbaalenii_PYR-1 -----AEADGLRDCVSSALSVQNTVEKDATLARWLGPD-RVIGASTIEGG
Mb2603|M.bovis_AF2122/97 -----PWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSS-AVVPAIVWCSA
Rv2573|M.tuberculosis_H37Rv -----PWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSS-AVVPAIVWCSA
MMAR_2157|M.marinum_M -----EWLARLCGEHTVVAVLQNGVEQVEQVRPHCPSS-SIVAGSVWFAA
MUL_1742|M.ulcerans_Agy99 -----EWLARLCGEHTVVAVLQNGVEQVEQVQPHCPSS-SIVAGSVWFAA
MSMEG_2919|M.smegmatis_MC2_155 -----DDLATHAPAHTAIFAAQNGVANEMAILRRFAD---VYGVTVMLPA
TH_4612|M.thermoresistible__bu PVHHGDTVVGTAGSTLPVLTALNGVVAEEMALRFFAR---VFGVCVWMPA
MAV_4625|M.avium_104 ------QALPMLGPDTAVLTIQNGLGSAETVAGVVGAQRVAVGIASGFGA
MAB_2908c|M.abscessus_ATCC_199 -----ESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQH-NVITGIVGFNV
* :
Mflv_0533|M.gilvum_PYR-GCK TLLEPGLVRNHLTAEVTAYFGE------LDGTSSARVDDLTAAFTNAGLP
Mvan_0557|M.vanbaalenii_PYR-1 TLLEPGLVRNHLTAEVTAYFGE------LDGTSSARVDDLTAAFTNAGLP
Mb2603|M.bovis_AF2122/97 ETQPQGWVR--LRGEAALVV-----------PTGPAAEQFAGLLRGAGAT
Rv2573|M.tuberculosis_H37Rv ETQPQGWVR--LRGEAALVV-----------PTGPAAEQFAGLLRGAGAT
MMAR_2157|M.marinum_M ETQPGGWVR--LRGDAALVL-----------PTGAAAETLAGLLRAAGCR
MUL_1742|M.ulcerans_Agy99 ETQPGGWVR--LRGDAALVL-----------PTGAAAETLAGLLRAAGCR
MSMEG_2919|M.smegmatis_MC2_155 AHLEPGVVVQQSHPLAGILDLGRYPSG-----ADAVAHDVAAMLRASQFL
TH_4612|M.thermoresistible__bu AHVVPGEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLL
MAV_4625|M.avium_104 SRVAPGHVHHNAMRAMRFGPYS--------SLPHARVESIARTWAHAGFD
MAB_2908c|M.abscessus_ATCC_199 AQVGAAHFHQGTQGKLSLSTG---------------AESLAGALTHGGLL
. . .: .
Mflv_0533|M.gilvum_PYR-GCK AKAVGNIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYF
Mvan_0557|M.vanbaalenii_PYR-1 AKAVGNIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYF
Mb2603|M.bovis_AF2122/97 VDCDPDFTTAAWRKLLVNALAGFMVLSGR----RSAMFRRDDVAALSRRY
Rv2573|M.tuberculosis_H37Rv VDCDPDFTTAAWRKLLVNALAGFMVLSGR----RSAMFRRDDVAALSRRY
MMAR_2157|M.marinum_M VDCDPDFTTVIWRKLVLNALAGLMALSGR----RSGMFRRDDIAELSRHY
MUL_1742|M.ulcerans_Agy99 VDCDLDFTTVIWRKLVLNALAGLMALSGR----RSGMFRRDDIAELSRHY
MSMEG_2919|M.smegmatis_MC2_155 SEVRPDIMAWKHRKLIMNLGNGVTAIFRPGPAADELAAQARAEAEEVLGA
TH_4612|M.thermoresistible__bu VARPPDVAPWKYRKLLANLANAVVALTGSGRGDPVVIAAAQREGEAVLRH
MAV_4625|M.avium_104 AAAVTDIAAMQWEKLICNVAYSAPCALTG-----MTVGQVMDDAEMGPVS
MAB_2908c|M.abscessus_ATCC_199 TTVRDDMAAVQWGKLVVNLNNSVNALSGLP------LKAELGDRDYRLVL
:. ** .
Mflv_0533|M.gilvum_PYR-GCK VALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRAM
Mvan_0557|M.vanbaalenii_PYR-1 VALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVM
Mb2603|M.bovis_AF2122/97 VA---ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDM
Rv2573|M.tuberculosis_H37Rv VA---ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDM
MMAR_2157|M.marinum_M VA---ECLAVARAEG-------------ARLDDDVIDEMVDLFASAPEDM
MUL_1742|M.ulcerans_Agy99 VA---ECLAVARAEG-------------ARLDDDVIDEMVDLFASAPEDM
MSMEG_2919|M.smegmatis_MC2_155 AG-----IPVVPPEQ--------------DTERRGRFLAGR----VRDDV
TH_4612|M.thermoresistible__bu AG-----IEFVPAEV--------------EREARRHGPRDRDVADAGDVV
MAV_4625|M.avium_104 RAAATEAWSVARASG----------------VAIAVADAVEHVRAFGAQM
MAB_2908c|M.abscessus_ATCC_199 AAAQREALGLLRRAG---QPVVSPLAAPLSLMPWVLTMPNPIFTRAARQM
. . :
Mflv_0533|M.gilvum_PYR-GCK REKGNSGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQI
Mvan_0557|M.vanbaalenii_PYR-1 REKGNLGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQI
Mb2603|M.bovis_AF2122/97 G-------TSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPL
Rv2573|M.tuberculosis_H37Rv G-------TSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPL
MMAR_2157|M.marinum_M G-------TSILADREAHRRLEWDLRNGVIIRKARAHGLATPISQVLVPL
MUL_1742|M.ulcerans_Agy99 G-------TSILADREAHRRLEWDLRNGVIIRKARAHGLATPISQVLVPL
MSMEG_2919|M.smegmatis_MC2_155 HG------STWQSVARGHTEVETDYFNGEIALQARLIGRSAPVNEYLQRV
TH_4612|M.thermoresistible__bu AN------STWQSLARNSGSVETDYLNGEIVRIAHRHGMTAPVNAGLARL
MAV_4625|M.avium_104 PD----AKPSALLDHEARRVSEIDVINGAVPRQGARVGVDAPVNATLTAV
MAB_2908c|M.abscessus_ATCC_199 VAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAPVNAALVSL
.: * * . . * :* :
Mflv_0533|M.gilvum_PYR-GCK IKTVDRFLA------------------------------
Mvan_0557|M.vanbaalenii_PYR-1 IKTVDRFLA------------------------------
Mb2603|M.bovis_AF2122/97 LAAASDGPG------------------------------
Rv2573|M.tuberculosis_H37Rv LAAASDGPG------------------------------
MMAR_2157|M.marinum_M LAAASDGPG------------------------------
MUL_1742|M.ulcerans_Agy99 LAAASDGPG------------------------------
MSMEG_2919|M.smegmatis_MC2_155 TADHARHGRPP---RSLDAAEALSHITAGAAAPEHL---
TH_4612|M.thermoresistible__bu ARAAARDGHPPGRYSGGELAEALGLVGEALGADVMVEGR
MAV_4625|M.avium_104 VKSIERRWR------------------------------
MAB_2908c|M.abscessus_ATCC_199 IRDVTSSHEITRWPGPKLRREINHRAAASHMLS------