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RVLILGAGGLGSVLGGYLANIGVDVTLVGRPAHAEAITRYGLRITGRRGDLVITDNLTAVDQTAKATGHF DYLVLAVKGKDTAQALAEADGLRDCVSSALSVQNTVEKDATLARWLGPDRVIGASTIEGGTLLEPGLVRN HLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAKAVGNIEQVEWEKLAQIALAAAWSVTALGAIPDAS VFEGMEVREGAMYFVALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVMREKGNL GHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKTVDRFLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | - | 100% (334) | ketopantoate reductase ApbA/PanE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0533 | - | 0.0 | 98.80% (334) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2908c | - | 5e-18 | 25.08% (331) | 2-dehydropantoate 2-reductase |
| M. marinum M | MMAR_0863 | apbA | 7e-20 | 27.25% (334) | ketopantoate reductase, ApbA |
| M. avium 104 | MAV_4625 | panE | 1e-22 | 28.57% (336) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_6374 | panE | 1e-15 | 27.79% (331) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 1e-07 | 26.94% (219) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_0617 | apbA | 5e-19 | 26.65% (334) | ketopantoate reductase, ApbA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0557|M.vanbaalenii_PYR-1 ---MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHAEAITRYGLRIT
Mflv_0533|M.gilvum_PYR-GCK ---MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHTEAITRYGLRIT
MMAR_0863|M.marinum_M ---MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVS
MUL_0617|M.ulcerans_Agy99 ---MKIAIIGCGAMGSIYAARLAGADNDVAVIDRHQPNVDQITRTGLRVS
MAV_4625|M.avium_104 ---MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVT
MSMEG_6374|M.smegmatis_MC2_155 MSDARILVVGAGAIGGVTAAHLARAGRDVTVLDANAEHVRLMNSPGLKFD
MAB_2908c|M.abscessus_ATCC_199 ---MRIAVAGAGSIGCYVGGRLQAAGHQVVYIG-RPSLGRAIAEHGLSLS
TH_4612|M.thermoresistible__bu ------VIVGSGAIGGTVGGLLARSGADVVLVA-RGAHAQALADRGLTLR
: *.*.:* .. * . :* : . : ** .
Mvan_0557|M.vanbaalenii_PYR-1 G-RRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADG---
Mflv_0533|M.gilvum_PYR-GCK G-RRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALAEADG---
MMAR_0863|M.marinum_M G-PGTDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGARQALC---
MUL_0617|M.ulcerans_Agy99 G-PGTDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGARQALC---
MAV_4625|M.avium_104 G-PGCDQVVP----LRASTGAVDETMDLVVLAVKAADVEAAARQALP---
MSMEG_6374|M.smegmatis_MC2_155 E-LGETSHVT--ITAVDSPAALTGRFDFALVALKAP-YLQAALGPLV---
MAB_2908c|M.abscessus_ATCC_199 DYLGWSAAIPASECAFSEDIDTVRSADIVLVTVKSAATAQMAESLAG---
TH_4612|M.thermoresistible__bu T-PDGTFEIG-VTAAADPAEVRLTSRDVLVFATKTQHLEDALHAWVDRPV
: * :.: *
Mvan_0557|M.vanbaalenii_PYR-1 -----LRDCVSSALSVQNTVEKDATLARWLGPDRVIG-ASTIEGGTLLEP
Mflv_0533|M.gilvum_PYR-GCK -----LRDCVSSALSVQNTVEKDATLAGWLGPDRVIG-ASTIEGGTLLEP
MMAR_0863|M.marinum_M -----MLGADTPVLTIQNGLGSAETVADIVGEQRVAVGIASGFGAARLAP
MUL_0617|M.ulcerans_Agy99 -----MLGADTPVLTIQNGLGSAETVADIVGEQRVAVGIASGFGAARLAP
MAV_4625|M.avium_104 -----MLGPDTAVLTIQNGLGSAETVAGVVGAQRVAVGIASGFGASRVAP
MSMEG_6374|M.smegmatis_MC2_155 -----ERGLVDTYVSLGNGLVQN-TIQQIVGTERFVVGITEWG-ATNLGP
MAB_2908c|M.abscessus_ATCC_199 -----RLEPGAVVVSLQNGIRNPAQLSRYIKQHNVITGIVGFN-------
TH_4612|M.thermoresistible__bu HHGDTVVGTAGSTLPVLTALNGVVAEEMALRFFARVFGVCVWMPAAHVVP
:.: . : :
Mvan_0557|M.vanbaalenii_PYR-1 GLVRNHLTAEV-TAYFG----ELDGTSSAR-VDDLTAAFTNAGLPAKAVG
Mflv_0533|M.gilvum_PYR-GCK GLVRNHLTAEV-TAYFG----ELDGTSSAR-VDDLTAAFTNAGLPAKAVG
MMAR_0863|M.marinum_M G--HVHHNAMK-AMRFG----AYSSLPHET-VERIAHAWTEAGFDAAAVT
MUL_0617|M.ulcerans_Agy99 GHVHVHHNAMK-AMRFG----AYSSLPHET-VERIAHAWTEVGFDAAAVT
MAV_4625|M.avium_104 G--HVHHNAMR-AMRFG----PYSSLPHAR-VESIARTWAHAGFDAAAVT
MSMEG_6374|M.smegmatis_MC2_155 G--HVAQTTVA-PFVIG----EVDGTLTAR-LETLRGVLS-AAAEVGVST
MAB_2908c|M.abscessus_ATCC_199 ----VAQVGAA-HFHQG----TQGKLSLSTGAESLAGALTHGGLLTTVRD
TH_4612|M.thermoresistible__bu GEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLLVARPP
. . : . : . .
Mvan_0557|M.vanbaalenii_PYR-1 NIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALAK
Mflv_0533|M.gilvum_PYR-GCK NIEQVEWEKLAQIALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALAK
MMAR_0863|M.marinum_M DIAAMQWEKLICNVAYSAP--CALTGMTVGQVLDDAELGP---VSRAAAT
MUL_0617|M.ulcerans_Agy99 DIAAMQWEKLICNVAYSAP--CALTGMTVGQVLDDAEMGP---VSRAAAT
MAV_4625|M.avium_104 DIAAMQWEKLICNVAYSAP--CALTGMTVGQVMDDAEMGP---VSRAAAT
MSMEG_6374|M.smegmatis_MC2_155 DVMNQVWTKLLLNSTFSGL--AGVTGMLYGEIAADPLGRT---MAYHVWT
MAB_2908c|M.abscessus_ATCC_199 DMAAVQWGKLVVNLNNSVN---ALSGLPLKAELGDRDYRL---VLAAAQR
TH_4612|M.thermoresistible__bu DVAPWKYRKLLANLANAVV---ALTGSGRGDPV----------VIAAAQR
:: : ** : .: .
Mvan_0557|M.vanbaalenii_PYR-1 DLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVMREKGN
Mflv_0533|M.gilvum_PYR-GCK DLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRAMREKGN
MMAR_0863|M.marinum_M EAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN---
MUL_0617|M.ulcerans_Agy99 EAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN---
MAV_4625|M.avium_104 EAWSVARASG----------------VAIAVADAVEHVRAFGAQMPD---
MSMEG_6374|M.smegmatis_MC2_155 ESYDVARAAGFEVGPLIG---IQPDDLVVRSEADRERADAAIEVLMSKLG
MAB_2908c|M.abscessus_ATCC_199 EALGLLRRAG---QPVVSPLAAPLSLMPWVLTMPNPIFTRAARQMVAMDP
TH_4612|M.thermoresistible__bu EGEAVLRHAG-------------IEFVPAEVEREARRHGPRDRDVADAGD
: : * * :
Mvan_0557|M.vanbaalenii_PYR-1 LGHPSMYEDVLRRR-KTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKTV
Mflv_0533|M.gilvum_PYR-GCK SGHPSMYEDVLRRR-KTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKTV
MMAR_0863|M.marinum_M -AKPSALLDHEARR-ASEIDVINGAVGRHGARVGVPTPVNTTLTALVKSV
MUL_0617|M.ulcerans_Agy99 -AKPSALLDHEARR-ASEIDVINGAVG-------VPTPVNTTLTALVKSV
MAV_4625|M.avium_104 -AKPSALLDHEARR-VSEIDVINGAVPRQGARVGVDAPVNATLTAVVKSI
MSMEG_6374|M.smegmatis_MC2_155 ATKASMLQDLERGA-TTEVDVINGGVCTTAAKAGVASPFNARIVELVHEC
MAB_2908c|M.abscessus_ATCC_199 QARSSMLDDITLGR-PTEIDYINGEVVELAKRLGAKAPVNAALVSLIRDV
TH_4612|M.thermoresistible__bu VVANSTWQSLARNSGSVETDYLNGEIVRIAHRHGMTAPVNAGLARLARAA
* . * * : . :* : :
Mvan_0557|M.vanbaalenii_PYR-1 DRFLA------------------------------
Mflv_0533|M.gilvum_PYR-GCK DRFLA------------------------------
MMAR_0863|M.marinum_M ERQWSAVNSD-------------------------
MUL_0617|M.ulcerans_Agy99 ERQWSAVNSD-------------------------
MAV_4625|M.avium_104 ERRWR------------------------------
MSMEG_6374|M.smegmatis_MC2_155 EQGLRSPGRETLEALAQISARQ-------------
MAB_2908c|M.abscessus_ATCC_199 TSSHEITRWPGPKLRREINHRAAASHMLS------
TH_4612|M.thermoresistible__bu ARDGHPPGRYSGGELAEALGLVGEALGADVMVEGR