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MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVTGPGCDQVVPLRASTGAVDETMDL VVLAVKAADVEAAARQALPMLGPDTAVLTIQNGLGSAETVAGVVGAQRVAVGIASGFGASRVAPGHVHHN AMRAMRFGPYSSLPHARVESIARTWAHAGFDAAAVTDIAAMQWEKLICNVAYSAPCALTGMTVGQVMDDA EMGPVSRAAATEAWSVARASGVAIAVADAVEHVRAFGAQMPDAKPSALLDHEARRVSEIDVINGAVPRQG ARVGVDAPVNATLTAVVKSIERRWR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4625 | panE | - | 100% (305) | 2-dehydropantoate 2-reductase |
| M. avium 104 | MAV_3448 | - | 2e-16 | 28.79% (264) | 2-dehydropantoate 2-reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 6e-11 | 25.48% (263) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 1e-23 | 28.87% (336) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 6e-11 | 25.48% (263) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2908c | - | 7e-25 | 28.48% (323) | 2-dehydropantoate 2-reductase |
| M. marinum M | MMAR_0863 | apbA | 1e-136 | 79.28% (304) | ketopantoate reductase, ApbA |
| M. smegmatis MC2 155 | MSMEG_6374 | panE | 8e-29 | 30.89% (327) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 1e-13 | 26.59% (331) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_0617 | apbA | 1e-129 | 76.80% (306) | ketopantoate reductase, ApbA |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 1e-22 | 28.57% (336) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0863|M.marinum_M ---MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGLRVS
MUL_0617|M.ulcerans_Agy99 ---MKIAIIGCGAMGSIYAARLAGADNDVAVIDRHQPNVDQITRTGLRVS
MAV_4625|M.avium_104 ---MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGLRVT
Mb2603|M.bovis_AF2122/97 --------MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHT
Rv2573|M.tuberculosis_H37Rv --------MHKAGYSPLLCGHTPRAGIELRRDG-----ADPIVVPGPVHT
Mflv_0533|M.gilvum_PYR-GCK ---MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-TEAITRYGLRIT
Mvan_0557|M.vanbaalenii_PYR-1 ---MRVLILGAGGLGSVLGGYLANIGVDVTLVGRPAH-AEAITRYGLRIT
MAB_2908c|M.abscessus_ATCC_199 ---MRIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPS-LGRAIAEHGLSLS
MSMEG_6374|M.smegmatis_MC2_155 MSDARILVVGAGAIGGVTAAHLARAGRDVTVLDANAEHVRLMNSPGLKFD
TH_4612|M.thermoresistible__bu ------VIVGSGAIGGTVGGLLARSGADVVLVARGAH-AQALADRGLTLR
.. . . . :: : *
MMAR_0863|M.marinum_M -GPGTDQLVSLR----AATTAPTEVMDLVVLAVKAADVAAGAR-------
MUL_0617|M.ulcerans_Agy99 -GPGTDQLVSLR----AATTAPTEVMDLVVLAVKAADVAAGAR-------
MAV_4625|M.avium_104 -GPGCDQVVPLR----ASTGAVDETMDLVVLAVKAADVEAAAR-------
Mb2603|M.bovis_AF2122/97 -SPR----------------EVAGPVDVLILAVKATQNDAARP-------
Rv2573|M.tuberculosis_H37Rv -SPR----------------EVAGPVDVLILAVKATQNDAARP-------
Mflv_0533|M.gilvum_PYR-GCK -GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALA-------
Mvan_0557|M.vanbaalenii_PYR-1 -GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQALA-------
MAB_2908c|M.abscessus_ATCC_199 DYLGWSAAIPASECAFSEDIDTVRSADIVLVTVKSAATAQMAE-------
MSMEG_6374|M.smegmatis_MC2_155 -ELGETSHVTIT--AVDSPAALTGRFDFALVALKAPYLQAALG-------
TH_4612|M.thermoresistible__bu -TPDGTFEIGVT-AAADPAEVRLTSRDVLVFATKTQHLEDALHAWVDRPV
* :.: *
MMAR_0863|M.marinum_M ----QALCMLGADTPVLTIQNGLGSAETVADIVGEQR---VAVGIASGFG
MUL_0617|M.ulcerans_Agy99 ----QALCMLGADTPVLTIQNGLGSAETVADIVGEQR---VAVGIASGFG
MAV_4625|M.avium_104 ----QALPMLGPDTAVLTIQNGLGSAETVAGVVGAQR---VAVGIASGFG
Mb2603|M.bovis_AF2122/97 ----WLTRLCDERTVVAVLQNGVEQVEQVQPHCPSS----AVVPAIVWCS
Rv2573|M.tuberculosis_H37Rv ----WLTRLCDERTVVAVLQNGVEQVEQVQPHCPSS----AVVPAIVWCS
Mflv_0533|M.gilvum_PYR-GCK ----EADGLRDCVSSALSVQNTVEKDATLAGWLGPD----RVIGASTIEG
Mvan_0557|M.vanbaalenii_PYR-1 ----EADGLRDCVSSALSVQNTVEKDATLARWLGPD----RVIGASTIEG
MAB_2908c|M.abscessus_ATCC_199 ----SLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHN---VITGIVG-FN
MSMEG_6374|M.smegmatis_MC2_155 ----PLVER-GLVDTYVSLGNGLVQN-TIQQIVGTER---FVVGITE-WG
TH_4612|M.thermoresistible__bu HHGDTVVGTAGSTLPVLTALNGVVAEEMALRFFARVFGVCVWMPAAHVVP
* :
MMAR_0863|M.marinum_M AARLAPG--HVHHNAMKAMRFGAYSSLPHETVERIAHAWTEAGFDAAAVT
MUL_0617|M.ulcerans_Agy99 AARLAPGHVHVHHNAMKAMRFGAYSSLPHETVERIAHAWTEVGFDAAAVT
MAV_4625|M.avium_104 ASRVAPG--HVHHNAMRAMRFGPYSSLPHARVESIARTWAHAGFDAAAVT
Mb2603|M.bovis_AF2122/97 AETQPQGWVR--LRGEAALVV-----PTGPAAEQFAGLLRGAGATVDCDP
Rv2573|M.tuberculosis_H37Rv AETQPQGWVR--LRGEAALVV-----PTGPAAEQFAGLLRGAGATVDCDP
Mflv_0533|M.gilvum_PYR-GCK GTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAKAVG
Mvan_0557|M.vanbaalenii_PYR-1 GTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAKAVG
MAB_2908c|M.abscessus_ATCC_199 VAQVGAAHFHQGTQGKLSLSTG---------AESLAGALTHGGLLTTVRD
MSMEG_6374|M.smegmatis_MC2_155 ATNLGPG--HVAQTTVAPFVIGEVDGTLTARLETLRGVLS-AAAEVGVST
TH_4612|M.thermoresistible__bu GEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLLVARPP
. . : . .
MMAR_0863|M.marinum_M DIAAMQWEKLICNVAYSAPCALTG------MTVGQVLDDAELGPVSRAAA
MUL_0617|M.ulcerans_Agy99 DIAAMQWEKLICNVAYSAPCALTG------MTVGQVLDDAEMGPVSRAAA
MAV_4625|M.avium_104 DIAAMQWEKLICNVAYSAPCALTG------MTVGQVMDDAEMGPVSRAAA
Mb2603|M.bovis_AF2122/97 DFTTAAWRKLLV-NALAGFMVLSGR----RSAMFRRDDVAALSRRYVA--
Rv2573|M.tuberculosis_H37Rv DFTTAAWRKLLV-NALAGFMVLSGR----RSAMFRRDDVAALSRRYVA--
Mflv_0533|M.gilvum_PYR-GCK NIEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALA
Mvan_0557|M.vanbaalenii_PYR-1 NIEQVEWEKLAQ-IALAAAWSVTALGAIPDASVFEGMEVREGAMYFVALA
MAB_2908c|M.abscessus_ATCC_199 DMAAVQWGKLVVNLNNSVN-ALSG------LPLKAELGDRDYRLVLAAAQ
MSMEG_6374|M.smegmatis_MC2_155 DVMNQVWTKLLLNSTFSGLAGVTG------MLYGEIAADPLGRTMAYHVW
TH_4612|M.thermoresistible__bu DVAPWKYRKLLANLANAVVALTGS--------------GRGDPVVIAAAQ
:. : ** : .
MMAR_0863|M.marinum_M TEAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN--
MUL_0617|M.ulcerans_Agy99 TEAWAVARASG----------------IAVAVTDPVAHARAFGAAMPN--
MAV_4625|M.avium_104 TEAWSVARASG----------------VAIAVADAVEHVRAFGAQMPD--
Mb2603|M.bovis_AF2122/97 -ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDMG---
Rv2573|M.tuberculosis_H37Rv -ECLAVARAEG-------------ARLDDDVVDEVVRLVRSAPQDMG---
Mflv_0533|M.gilvum_PYR-GCK KDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRAMREKG
Mvan_0557|M.vanbaalenii_PYR-1 KDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQGRVMREKG
MAB_2908c|M.abscessus_ATCC_199 REALGLLRRAG---QPVVSPLAAPLSLMPWVLTMPNPIFTRAARQMVAMD
MSMEG_6374|M.smegmatis_MC2_155 TESYDVARAAG---FEVGPLIGIQPDDLVVRSEADRERADAAIEVLMSKL
TH_4612|M.thermoresistible__bu REGEAVLRHAG-------------IEFVPAEVEREARRHGPRDRDVADAG
: : * * :
MMAR_0863|M.marinum_M --AKPSALLDHEARR-ASEIDVINGAVGRHGARVGVPTPVNTTLTALVKS
MUL_0617|M.ulcerans_Agy99 --AKPSALLDHEARR-ASEIDVINGAVG-------VPTPVNTTLTALVKS
MAV_4625|M.avium_104 --AKPSALLDHEARR-VSEIDVINGAVPRQGARVGVDAPVNATLTAVVKS
Mb2603|M.bovis_AF2122/97 ----TSMLADRAAHR-PLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
Rv2573|M.tuberculosis_H37Rv ----TSMLADRAAHR-PLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
Mflv_0533|M.gilvum_PYR-GCK NSGHPSMYEDVLRRR-KTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKT
Mvan_0557|M.vanbaalenii_PYR-1 NLGHPSMYEDVLRRR-KTEVDFMLAPYLAAAQELGMDTPTLRVAYQIIKT
MAB_2908c|M.abscessus_ATCC_199 PQARSSMLDDITLGR-PTEIDYINGEVVELAKRLGAKAPVNAALVSLIRD
MSMEG_6374|M.smegmatis_MC2_155 GATKASMLQDLERGA-TTEVDVINGGVCTTAAKAGVASPFNARIVELVHE
TH_4612|M.thermoresistible__bu DVVANSTWQSLARNSGSVETDYLNGEIVRIAHRHGMTAPVNAGLARLARA
* . * * . :* :
MMAR_0863|M.marinum_M VERQWSAVNSD-------------------------
MUL_0617|M.ulcerans_Agy99 VERQWSAVNSD-------------------------
MAV_4625|M.avium_104 IERRWR------------------------------
Mb2603|M.bovis_AF2122/97 ASDGPG------------------------------
Rv2573|M.tuberculosis_H37Rv ASDGPG------------------------------
Mflv_0533|M.gilvum_PYR-GCK VDRFLA------------------------------
Mvan_0557|M.vanbaalenii_PYR-1 VDRFLA------------------------------
MAB_2908c|M.abscessus_ATCC_199 VTSSHEITRWPGPKLRREINHRAAASHMLS------
MSMEG_6374|M.smegmatis_MC2_155 CEQGLRSPGRETLEALAQISARQ-------------
TH_4612|M.thermoresistible__bu AARDGHPPGRYSGGELAEALGLVGEALGADVMVEGR