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MSDLFGLDGKVAVVTGGGRGIGLMIARGLLQAGASVYIAGRKEAELSAAVAELSPLGRVEAVPADLGTAE GVTTLTAAITGRENAVHALFNNAGAAWGAPYEDFPESGFDKVYNVNVKGVFLLTRALTPLLRAGATDDDP ARVINTGSIDGIVAPGRGRDNFSYSASKAAVHMLTRHLAGELAPHILVNAIAPGLFPSRMTKELLAAGED AVGSALPLRRVGRPDDIAGIAVFLASRASTYITGAVIPVDGGVSTIR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0121 | - | - | 100% (257) | rhamnolipids biosynthesis 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_4850 | - | 3e-34 | 40.96% (249) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4117 | - | 5e-33 | 37.65% (255) | 2-deoxy-D-gluconate 3-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 2e-32 | 36.11% (252) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2424 | - | 1e-32 | 41.27% (252) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 2e-32 | 36.11% (252) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-25 | 34.16% (243) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 1e-35 | 39.69% (257) | short chain dehydrogenase |
| M. marinum M | MMAR_4756 | - | 2e-30 | 38.55% (249) | oxidoreductase |
| M. avium 104 | MAV_2775 | - | 8e-32 | 36.47% (255) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3898 | - | 2e-33 | 37.98% (258) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_0327 | - | 6e-31 | 38.55% (249) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4228 | - | 5e-34 | 41.57% (255) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1963c|M.bovis_AF2122/97 -MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDALE
Rv1928c|M.tuberculosis_H37Rv -MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARHLDALE
MAV_2775|M.avium_104 ---MLDLFDLRGRRALVTGASTGIGKQVAQAYLQAGARVAIAARDFEALQ
MAB_4632|M.abscessus_ATCC_1997 --MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQLR
TH_3898|M.thermoresistible__bu --VILDRFRLDDRVAVVTGAGRGLGAAMAVAFAEAGADVLISARTQAQLE
MSMEG_0121|M.smegmatis_MC2_155 ---MSDLFGLDGKVAVVTGGGRGIGLMIARGLLQAGASVYIAGRKEAELS
Mflv_2424|M.gilvum_PYR-GCK MAITASDILLTGRVAVVTGGGAGIGRGIAQGLAAFGASVAIWERDPDTCA
Mvan_4228|M.vanbaalenii_PYR-1 MTIAPSDILLTGRVAVVTGGGAGIGKGIAHGLAAFGASVAIWERDPQTCG
MMAR_4756|M.marinum_M MAIDPADVLLNGRVAVVTGAGSGIGRGVAAGLAAFGASVAIWERDPQTCA
MUL_0327|M.ulcerans_Agy99 MAIDPADVLLNGRVAVVTGAGSGIGRGVAAGLAAFGASMAIWERDPQTCA
MLBr_01807|M.leprae_Br4923 --------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLV
: :. . * :: . *. *
Mb1963c|M.bovis_AF2122/97 KLADEIGTSG-GKVVPVC-----CDVSQHQQVTSMLDQVTAELGGIDIAV
Rv1928c|M.tuberculosis_H37Rv KLADEIGTSG-GKVVPVC-----CDVSQHQQVTSMLDQVTAELGGIDIAV
MAV_2775|M.avium_104 RTADELTAGGTGGVVAIR-----CDVTQPDEVSGMVDRMIAELGGIDIAV
MAB_4632|M.abscessus_ATCC_1997 EVAAKVQAAGRQAEVVV------ADLSDTEASAALAQKAVDRFGRLDVVV
TH_3898|M.thermoresistible__bu EVAAQIAATGRRAHVVA------ADLAHPEATAELAGAAVEAFGKLDIVV
MSMEG_0121|M.smegmatis_MC2_155 AAVAELSPLGR-VEAVP------ADLGTAEGVTTLTAAITGRENAVHALF
Mflv_2424|M.gilvum_PYR-GCK AAAAAIGGLGLEVDVRD------AAA-----VDTALDRTERELGTVSILV
Mvan_4228|M.vanbaalenii_PYR-1 EAAASVGALGLPTDVRD------AEA-----VQAALERTERELGTVSILV
MMAR_4756|M.marinum_M QAAAELGGLGIATDVRS------GDQ-----VDAALQRTQAELGEVTILV
MUL_0327|M.ulcerans_Agy99 QAAAELGGLGIATDVRS------GDQ-----VDAALQRTQAELGAVTILV
MLBr_01807|M.leprae_Br4923 ADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLV
: . . : .
Mb1963c|M.bovis_AF2122/97 CNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGV-
Rv1928c|M.tuberculosis_H37Rv CNAGIITVTPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGV-
MAV_2775|M.avium_104 CNAGIISVSPMLEMPAAEFQRIQDTNVTGVFLTAQAAARAMVRQGRGGA-
MAB_4632|M.abscessus_ATCC_1997 NNVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLK-SDNAS-
TH_3898|M.thermoresistible__bu NNVGGTMPGPLLNTSAKEMRDAFTFNVGTAHALTTAAVPLMLKHSGGGS-
MSMEG_0121|M.smegmatis_MC2_155 NNAGAAWGAPYEDFPESGFDKVYNVNVKGVFLLTRALTPLLRAGATDDDP
Mflv_2424|M.gilvum_PYR-GCK NNAGGTFNSPLLDTSENGWDALYRSNLRHVLLCTQRVARRLVAAEQTGS-
Mvan_4228|M.vanbaalenii_PYR-1 NNAGGTFNSPLLETSENGWDALYRSNLRHVLLCTQRVARRLVEVGQPGS-
MMAR_4756|M.marinum_M NNVGGVFWSPLLQTSEKGWDALYRSNLGHVLLCTQRVARRLVAAELPGS-
MUL_0327|M.ulcerans_Agy99 NNVGGVFWSPLLQTSEKGWDALYRSNLGHVLLCTQRVARRLVAAGLPGS-
MLBr_01807|M.leprae_Br4923 ANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRY-
*.* . *: :
Mb1963c|M.bovis_AF2122/97 --IINTASMSGHIIN-VPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVN
Rv1928c|M.tuberculosis_H37Rv --IINTASMSGHIIN-VPQQVSHYCASKAAVIHLTKAMAVELAPHKIRVN
MAV_2775|M.avium_104 --IITTASMSGHIIN-VPQQVGHYCASKAAVIQLTKAMAVEFAPHDIRVN
MAB_4632|M.abscessus_ATCC_1997 --VINITSTMGRLP---GRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVN
TH_3898|M.thermoresistible__bu --IINITSTMGRLA---GRGFAAYGTAKAALAHYTRLAALDLAPR-IRVN
MSMEG_0121|M.smegmatis_MC2_155 ARVINTGSIDGIVAPGRGRDNFSYSASKAAVHMLTRHLAGELAPH-ILVN
Mflv_2424|M.gilvum_PYR-GCK --VINVTSIEGSRA---APGYAAYAAAKAGVVNYTKTASFELAPYGIRVN
Mvan_4228|M.vanbaalenii_PYR-1 --VINITSIEGSRA---APGYAAYAAAKAGVVNYTKTASFELAPHRIRVN
MMAR_4756|M.marinum_M --IMAITSIEGVRA---APGYAAYAAAKAGVVNYTKTAALELAHHGIRVN
MUL_0327|M.ulcerans_Agy99 --IMAITSIEGVRA---APGYAAYAAAKAGVVNYTKTTALELAHHGIRVN
MLBr_01807|M.leprae_Br4923 ---IFMGSVVGLSG---VPGQANYAASKSGLIGMARSLARELGSRSITAN
: * * * ::*..: :: : ::. * .*
Mb1963c|M.bovis_AF2122/97 SVSPGYILTELVEPYTEYQ---PLWEPKIPLGRLGRPEELAGLYLYLASE
Rv1928c|M.tuberculosis_H37Rv SVSPGYILTELVEPYTEYQ---PLWEPKIPLGRLGRPEELAGLYLYLASE
MAV_2775|M.avium_104 SVSPGYIRTELVEPLHEYH---RQWQPKIPLGRMGRPDELAGIYLYLASA
MAB_4632|M.abscessus_ATCC_1997 GIAPGSILTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASP
TH_3898|M.thermoresistible__bu AIAPGSILTSALDVVASNDELRTPMEQATPLRRLGEPADIAAAAVYLASP
MSMEG_0121|M.smegmatis_MC2_155 AIAPGLFPSRMTKELLAAG--EDAVGSALPLRRVGRPDDIAGIAVFLASR
Mflv_2424|M.gilvum_PYR-GCK GLAPDLTMTEGLQKLAFGE-LSGTVARMVPMRRAGHVDEMASAAVFLASD
Mvan_4228|M.vanbaalenii_PYR-1 ALAPDLTMTEGLQKLAFGD-LSGTMADMVPMRRVGHVDEMASAAVFLASD
MMAR_4756|M.marinum_M AIAPDITMTEGLAQLGGAA-ALERIGSLVPLGRPGDIDEIASVAVFLASD
MUL_0327|M.ulcerans_Agy99 AIAPDITMTEGLAQLGGAA-ALERIGSLVPLGRPGDVDEIASVAVFLASD
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSKY--QEAALQAIPLGRIGAVEEIAGAVSFLASE
::*. : *: * * ::*. :***
Mb1963c|M.bovis_AF2122/97 ASSYMTGSDIVIDGGYTCP-----------------
Rv1928c|M.tuberculosis_H37Rv ASSYMTGSDIVIDGGYTCP-----------------
MAV_2775|M.avium_104 ASSYMTGSDIVIDGGYSCP-----------------
MAB_4632|M.abscessus_ATCC_1997 AGSFLTGKVLEVDGGLIAPNLDIPLPDLA-------
TH_3898|M.thermoresistible__bu AGSYLTGKVLEVDGGLTRPNLDMPIPDL--------
MSMEG_0121|M.smegmatis_MC2_155 ASTYITGAVIPVDGGVSTIR----------------
Mflv_2424|M.gilvum_PYR-GCK MASYITGQTIHVDGGTEAAGGWYFHPDNGAPTLGPA
Mvan_4228|M.vanbaalenii_PYR-1 MAAYITGQTIHVDGGTAAAGGWYFHPETGVPTLGPA
MMAR_4756|M.marinum_M MARYVTGQTIHVDGGTHAAAGWYRDPQTGEYRLGPG
MUL_0327|M.ulcerans_Agy99 MARYVTGQTIHVDGGTHAAAGWYRDPQTGEYRLGPG
MLBr_01807|M.leprae_Br4923 DAGYISGAVIPVDGGLGMGH----------------
. :::* : :***