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TAAIWMASPPEVHSALLSSGPGPGPLLASAAAHRELSAEYTTAAAELAELLGGVTAGAWEGPSAQSYVAA HQPYLAWLLGAGADNSIAAVAYEEAAAAYVSALAAMPTLAELAANHVTHLVLMATNFFGINTIPIAVNEA DYVRMWIQAAATMGSYDAISSSAVASVPATSPAPVLLKSAAGEAGAAAATTAAVVQPFRFLFMAFLWTIA LTFEAGYYLVTVVVPALVEFLNAAGALLMTALGVVYRTLFMAFLWTIALTFEAGFFLVTVAIPAIVAFLA EYPAVALLLVPVAVGAGAAAAAVPATAAIGAGIALPISLPLGITAYAGDPTLPGFDGRSGQDEMAAAQAD PSPPNADRGFRIGTAATDVRARPAGLTVFGGSEFSAGTRVPMLPAGWEPSALAAVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5277 | - | - | 100% (407) | PPE family protein |
| M. marinum M | MMAR_3005 | - | 2e-79 | 43.59% (429) | PPE family protein |
| M. marinum M | MMAR_0787 | - | 2e-78 | 43.29% (432) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 1e-76 | 42.86% (427) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-69 | 39.45% (403) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 3e-76 | 40.60% (500) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 7e-55 | 35.97% (442) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-65 | 40.90% (423) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 9e-74 | 40.13% (476) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-73 | 42.20% (436) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-67 | 64.62% (195) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1154 | - | 5e-76 | 43.84% (406) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-70 | 42.37% (413) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_2230c|M.abscessus_ATCC_199 ----------MSA---PIWMASPPEVHSALLSAGPGPGALLAAAAQWQAL
Rv0286|M.tuberculosis_H37Rv ----------MAA---PIWMASPPEVHSALLSNGPGPGSLVAAATAWSQL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MMAR_5277|M.marinum_M ----------MTA---AIWMASPPEVHSALLSSGPGPGPLLASAAAHREL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MUL_1154|M.ulcerans_Agy99 ----------MTA---PLWMASAPEAHSALLSAGPGPGSLLAAAQTWTEL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
::: .:*:* .**.**::** ***.*.: .:. *
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_2230c|M.abscessus_ATCC_199 SVQYTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSA
Rv0286|M.tuberculosis_H37Rv SAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MMAR_5277|M.marinum_M SAEYTTAAAELAELLGGVTAGAWEGPSAQSYVAAHQPYLAWLLGAGADNS
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MUL_1154|M.ulcerans_Agy99 SAEYLAVAEELTAILTGVQAGAWDGPSAQCCIAAYLPYLSWLMQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
* * * ** :: . *:* :: :: **: ** .. :
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_2230c|M.abscessus_ATCC_199 TNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIA
Rv0286|M.tuberculosis_H37Rv GAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPIT
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MMAR_5277|M.marinum_M IAAVAYEEAAAAYVSALAAMPTLAELAANHVTHLVLMATNFFGINTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MUL_1154|M.ulcerans_Agy99 ATAAAHQAAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* : *:.* :** ***: **: *: * **: ***:*:*****:
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_2230c|M.abscessus_ATCC_199 LNEADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSR
Rv0286|M.tuberculosis_H37Rv LNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPG-GGAAS
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MMAR_5277|M.marinum_M VNEADYVRMWIQAAATMGSYDAISSSAVASVPATSPAPVLLKSAAGEAGA
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MUL_1154|M.ulcerans_Agy99 LNEVDYVRMWIQAATTMSVYQAVAADALLAVPRTPPAPVIIKPGADAAAQ
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *. *: .: :.. : .** :: .
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
MAB_2230c|M.abscessus_ATCC_199 MSADMSGMAAQAQAAESGMALDDS----------ESFFDKLMRQIQEFFS
Rv0286|M.tuberculosis_H37Rv TVGAVNPW--QWLLALLQQLWNAY----------TGFYGWMLQLIWQFLQ
MAV_4867|M.avium_104 LAAN--------------AAQNSS----------GDWWQNFIQQLSQFFQ
MMAR_5277|M.marinum_M AAATTAAV--------------------------VQPFRFLFMAFLWTIA
Mb3047c|M.bovis_AF2122/97 AVAAATITPFPFG-------------------ELAKFLEMAAQAFTEVGE
MUL_1154|M.ulcerans_Agy99 FASAVVQAVAETP-------------------IQRLLLELATLVGAEF--
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIG--------YTDFYNTLVQPLITSLT
Mflv_0325|M.gilvum_PYR-GCK DP--IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASI-----
Mvan_0415|M.vanbaalenii_PYR-1 DP--LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASI-----
MSMEG_0619|M.smegmatis_MC2_155 DP--LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP-----
TH_3569|M.thermoresistible__bu DP--IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWP-----
MAB_2230c|M.abscessus_ATCC_199 DP--LGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFT-----
Rv0286|M.tuberculosis_H37Rv DP--IGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWP-----
MAV_4867|M.avium_104 N------IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWP-----
MMAR_5277|M.marinum_M LT--FEAGYYLVTVVVPALVEFLNAAGALLMTALGVVYRTLFMAF-----
Mb3047c|M.bovis_AF2122/97 LI--MKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFFATVGFA-----
MUL_1154|M.ulcerans_Agy99 ------------INVFELIVGIVVLS----TYGLKLPLLALLDFL-----
MLBr_01828|M.leprae_Br4923 NHPFFQGMFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQ
:
Mflv_0325|M.gilvum_PYR-GCK -------------------------------------------LYPSLFL
Mvan_0415|M.vanbaalenii_PYR-1 -------------------------------------------LYPSLLL
MSMEG_0619|M.smegmatis_MC2_155 -------------------------------------------TWGMIFA
TH_3569|M.thermoresistible__bu -------------------------------------------TWAMILA
MAB_2230c|M.abscessus_ATCC_199 -------------------------------------------FWGVMLS
Rv0286|M.tuberculosis_H37Rv -------------------------------------------TWGMILS
MAV_4867|M.avium_104 -------------------------------------------TWGAILT
MMAR_5277|M.marinum_M -------------------------------------------LWTIALT
Mb3047c|M.bovis_AF2122/97 -------------------------------------------LGVFVLV
MUL_1154|M.ulcerans_Agy99 -------------------------------------------TGHFSVA
MLBr_01828|M.leprae_Br4923 TFAFIGADLAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQ
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSF
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSP
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPL
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP------
MAB_2230c|M.abscessus_ATCC_199 APLWLP----LLLVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQ
Rv0286|M.tuberculosis_H37Rv SPFLLPAGLGLGLAAIAFLPIVLAP-----AVIPPASTPLAAAAVAAGSV
MAV_4867|M.avium_104 APFLLPLLLGIGLSSLLAAPAEIAP-----VAAPAAITPVLASNKPP-TL
MMAR_5277|M.marinum_M ------------FEAGFFLVTVAIP----------AIVAFLAEYP-----
Mb3047c|M.bovis_AF2122/97 PLLEFAVVLELAILSIGWIISNIFG-----------AIPVLAGPLLGALA
MUL_1154|M.ulcerans_Agy99 ----LSLLWNYAMLWFGFVVP---P-----------ALQIVFDPLL--VV
MLBr_01828|M.leprae_Br4923 SFVLLPMILPLLTAPLAVATAGAAG--SFAGLSELAGLVGVAPPGLPSAP
Mflv_0325|M.gilvum_PYR-GCK PATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVA-GRD
Mvan_0415|M.vanbaalenii_PYR-1 AIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVA-GRD
MSMEG_0619|M.smegmatis_MC2_155 AVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVA-NRD
TH_3569|M.thermoresistible__bu -------------VRAEPQNPLPLTXXX----------------------
MAB_2230c|M.abscessus_ATCC_199 PFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQ-EDP
Rv0286|M.tuberculosis_H37Rv WPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGD
MAV_4867|M.avium_104 PAAVALAPSVATPAGAPASTVAAGSGAAAAPGPAA-AAGNFAYLVAFGGD
MMAR_5277|M.marinum_M AVALLLVPVAVGAGAAAAAVPATAAIGAGIALPISLPLGITAYAGD----
Mb3047c|M.bovis_AF2122/97 AAVVPGVAGVTGLAGLAAVPAVGAAAGAPAALVG-SVAPVSGGVVS----
MUL_1154|M.ulcerans_Agy99 AAVIEWILG--GGAALGSVGALDANLAAGLALAAVAAAPVADAAVG----
MLBr_01828|M.leprae_Br4923 PVAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSV
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 PAARFGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPAP
Rv0286|M.tuberculosis_H37Rv WGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGD
MAV_4867|M.avium_104 PDTGVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSD
MMAR_5277|M.marinum_M ------PTLPGFDGRSGQDE-MAAAQADPSPPNADRGFR-----------
Mb3047c|M.bovis_AF2122/97 -------PQARLVSAVEPAPASTSVSVLASDR------------------
MUL_1154|M.ulcerans_Agy99 -------SLGVLTS----AAAVTAAAAAAPGQ------------------
MLBr_01828|M.leprae_Br4923 TGAGVESFGYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQA
Mflv_0325|M.gilvum_PYR-GCK GYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ---
Mvan_0415|M.vanbaalenii_PYR-1 AYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQ---
MSMEG_0619|M.smegmatis_MC2_155 GYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVT---
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 QFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSA
Rv0286|M.tuberculosis_H37Rv EFLDMDSDSGFGPSTG-DHG----AQASERGAGTLGFAGTATKERRVR--
MAV_4867|M.avium_104 EFLDMDSGFGVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQ--
MMAR_5277|M.marinum_M ----------------------------------IGTAATDVRARPAG--
Mb3047c|M.bovis_AF2122/97 ------------------------------GAGALGFVGTAGK-ESVGQP
MUL_1154|M.ulcerans_Agy99 ------------------------------GVGLVGFAATMPN-PTT-LP
MLBr_01828|M.leprae_Br4923 RSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGP--
Mflv_0325|M.gilvum_PYR-GCK AGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 AGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGE
Rv0286|M.tuberculosis_H37Rv AVGLTALAGDEFGNGPRMPMVPGTWEQGSNEP-------EAPDGSGRGGG
MAV_4867|M.avium_104 AAGLTKLADDDFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MMAR_5277|M.marinum_M ---LTVFGGSEFSAGTRVPMLPAGWEPSALAAVR----------------
Mb3047c|M.bovis_AF2122/97 AG--LTVLADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV---------
MUL_1154|M.ulcerans_Agy99 AGGLVTVGGADPCAGARVPMLPASW----VALG-----------------
MLBr_01828|M.leprae_Br4923 ATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE---
Mflv_0325|M.gilvum_PYR-GCK --------
Mvan_0415|M.vanbaalenii_PYR-1 --------
MSMEG_0619|M.smegmatis_MC2_155 --------
TH_3569|M.thermoresistible__bu --------
MAB_2230c|M.abscessus_ATCC_199 RGAST---
Rv0286|M.tuberculosis_H37Rv DGLPHDSK
MAV_4867|M.avium_104 --------
MMAR_5277|M.marinum_M --------
Mb3047c|M.bovis_AF2122/97 --------
MUL_1154|M.ulcerans_Agy99 --------
MLBr_01828|M.leprae_Br4923 --------