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MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTAAELSGLLGAVPGWAWQGPSAEWYVA AHLPYVAWLTQASADAAGAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTG FYGWMLQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLP AGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAP APAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDE FLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQG SNEPEAPDGSGRGGGDGLPHDSK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | - | 100% (513) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | e-109 | 46.91% (550) | PPE family protein |
| M. tuberculosis H37Rv | Rv0453 | PPE11 | 1e-97 | 44.18% (541) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 0.0 | 100.00% (513) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-115 | 46.69% (544) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 3e-76 | 37.80% (574) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-108 | 47.45% (510) | PPE family protein |
| M. marinum M | MMAR_0545 | - | 0.0 | 70.26% (501) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 1e-148 | 56.24% (505) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-129 | 49.03% (518) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-94 | 55.02% (329) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 0.0 | 69.86% (501) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-119 | 47.99% (523) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
.*:*:* ******::** ***...::.*. * **
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
*: * ** :* . :*:* :. *. :: **: ** * *. .* *
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
:. *.** :** ***:.** *: * **: ***:*:*:***: .*
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR-AA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR-AA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS-AS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD-AM
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSR-MS
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS---
** ***::** *. ** .: .: :.. : ..* :: ..
Rv0286|M.tuberculosis_H37Rv -------AASTVGAVN----------------------------------
Mb0294|M.bovis_AF2122/97 -------AASTVGAVN----------------------------------
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSD----------------------------------
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSD----------------------------------
MAV_4867|M.avium_104 ----ANNLAANAAQNS----------------------------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAG----------------------------------
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAG----------------------------------
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESG----------------------------------
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSG----------------------------------
MAB_2230c|M.abscessus_ATCC_199 ADMSGMAAQAQAAESG----------------------------------
MLBr_01828|M.leprae_Br4923 -DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQG
.
Rv0286|M.tuberculosis_H37Rv ----------PWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIK
Mb0294|M.bovis_AF2122/97 ----------PWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIK
MMAR_0545|M.marinum_M ----------PWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIK
MUL_1208|M.ulcerans_Agy99 ----------PWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIK
MAV_4867|M.avium_104 ----------SGDWWQNFIQQLS---------------QFFQN----IQK
Mflv_0325|M.gilvum_PYR-GCK ----------AAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFA
Mvan_0415|M.vanbaalenii_PYR-1 ----------SALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIK
MSMEG_0619|M.smegmatis_MC2_155 ----------SSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGR
TH_3569|M.thermoresistible__bu ----------TALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQ
MAB_2230c|M.abscessus_ATCC_199 ----------MALDDS----------ESFFDKLMRQIQEFFSDPLGTLQK
MLBr_01828|M.leprae_Br4923 MFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGA
:: :
Rv0286|M.tuberculosis_H37Rv IIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAG
Mb0294|M.bovis_AF2122/97 IIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAG
MMAR_0545|M.marinum_M IIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSPFLLPAA
MUL_1208|M.ulcerans_Agy99 IIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSPFLLPAA
MAV_4867|M.avium_104 MLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLPLL
Mflv_0325|M.gilvum_PYR-GCK LITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTL
Mvan_0415|M.vanbaalenii_PYR-1 LITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTL
MSMEG_0619|M.smegmatis_MC2_155 LLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPAL
TH_3569|M.thermoresistible__bu LIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLA
MAB_2230c|M.abscessus_ATCC_199 ILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLP--
MLBr_01828|M.leprae_Br4923 DLAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPM
: . :: : :: ..
Rv0286|M.tuberculosis_H37Rv LGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVSMAVTGA
Mb0294|M.bovis_AF2122/97 LGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVSMAVTGA
MMAR_0545|M.marinum_M LGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAASLASPGT
MUL_1208|M.ulcerans_Agy99 LGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAASLASPGT
MAV_4867|M.avium_104 LGIGLSSLLAAPAEIAP--VAAPAAITPVLASNKPP-TLPAAVALAPSVA
Mflv_0325|M.gilvum_PYR-GCK AIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPP
Mvan_0415|M.vanbaalenii_PYR-1 AIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPP
MSMEG_0619|M.smegmatis_MC2_155 AALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAG
TH_3569|M.thermoresistible__bu ITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------------
MAB_2230c|M.abscessus_ATCC_199 --LLLVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMP
MLBr_01828|M.leprae_Br4923 ILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVV
. .
Rv0286|M.tuberculosis_H37Rv GTAGAATPAAGAAPSAGAAPAPAAPATAS--FAYAVGGSGDWGPSLGPTV
Mb0294|M.bovis_AF2122/97 GTAGAATPAAGAAPSAGAAPAPAAPATAS--FAYAVGGSGDWGPSLGPTV
MMAR_0545|M.marinum_M GSAGAPASGAGAGAPGSAPPGPAAPAPAS--FLYAVGGSGDWGPSLGPTV
MUL_1208|M.ulcerans_Agy99 GSAGAPASGAGAGAPGTAPPGPGAPAPAS--FLYAVGGSGDWGPSLGPTV
MAV_4867|M.avium_104 TPAGAPASTVAAGSGAAAAPGP-AAAAGN--FAYLVAFGGDPDTGVGPTL
Mflv_0325|M.gilvum_PYR-GCK PPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGRDPYEGFSPTV
Mvan_0415|M.vanbaalenii_PYR-1 PPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGRDPGTGFSPTV
MSMEG_0619|M.smegmatis_MC2_155 VPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANRDPGEGFTPTL
TH_3569|M.thermoresistible__bu -----VRAEPQNPLPLTXXX------------------------------
MAB_2230c|M.abscessus_ATCC_199 GGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTL
MLBr_01828|M.leprae_Br4923 PPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG
.
Rv0286|M.tuberculosis_H37Rv GGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDS--
Mb0294|M.bovis_AF2122/97 GGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDS--
MMAR_0545|M.marinum_M GGRSGAKAPAATIPAAGAAAASRASARSRRRRRTEMRDYGDEFLDMDA--
MUL_1208|M.ulcerans_Agy99 GGRSGAKAPAVTIPAAGAAAASRASARSRRRRRTEMRDYGDEFLDMDA--
MAV_4867|M.avium_104 SGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGF
Mflv_0325|M.gilvum_PYR-GCK RDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADY
Mvan_0415|M.vanbaalenii_PYR-1 RDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADY
MSMEG_0619|M.smegmatis_MC2_155 GNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 NEGSGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPAPQFMDMNSPV
MLBr_01828|M.leprae_Br4923 YLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAK
Rv0286|M.tuberculosis_H37Rv ---DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVR--AVGLTALAG
Mb0294|M.bovis_AF2122/97 ---DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVR--AVGLTALAG
MMAR_0545|M.marinum_M ---NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQ--AAGLTELAV
MUL_1208|M.ulcerans_Agy99 ---NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQ--AAGLTELAV
MAV_4867|M.avium_104 GV-PPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQ--AAGLTKLAD
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ---AGGLTTLAG
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQ---AGGLTTLPG
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVT---AAGLTTLTG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 DP-DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAA
MLBr_01828|M.leprae_Br4923 VTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGP--ATGLVTLSN
Rv0286|M.tuberculosis_H37Rv DEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK------
Mb0294|M.bovis_AF2122/97 DEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK------
MMAR_0545|M.marinum_M DEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE--------
MUL_1208|M.ulcerans_Agy99 DEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE--------
MAV_4867|M.avium_104 DDFGGSPRMPMVPGTWEQD---TQN------GAHPTEPGKGG------
Mflv_0325|M.gilvum_PYR-GCK DSFGGGPREPMLPGTWDPD--ATDDRHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 DPFGGGPKAPMLPGTWDPD--TEPD------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 DTFDDRPVTPMLPGTWDGD--ENPA------PSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu ------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 SEMDGTRTVPMLPTSWGTD--PEPDPDRAPSVPAPDEDWPPGERGAST
MLBr_01828|M.leprae_Br4923 GTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE----------