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AVPPEVHSALLSAGPGPGPLQEAATAWASLSVEYASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAA WLTKASADYAVMAAEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIALNEADYARMW VQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEGVSAAALPAAPADGPSILWILVQIILILLEILY AIVAYTIILAFVLPFLILVEAFVFTILGLMFSIFVGFLGLLFGPPLLTIAAPLLLNGAVIGLSTGVPVSL ATALPIGIPAYLADQSRRGELGDAGQDQVVFVGARGGMAPSLAESTAPAPAAGLASAGSAVPASNPASAV ASERGADMSNFAGTSAKGSTVRPAGLMMLGGSEFEGGLREPMLPATW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3005 | - | - | 100% (398) | PPE family protein |
| M. marinum M | MMAR_3006 | - | e-175 | 79.40% (398) | PPE family protein |
| M. marinum M | MMAR_0787 | - | 5e-95 | 51.11% (405) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 8e-83 | 44.06% (438) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-69 | 37.96% (511) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 4e-82 | 43.84% (438) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 4e-55 | 53.85% (195) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-65 | 37.99% (458) | PPE-family protein |
| M. avium 104 | MAV_4867 | - | 3e-75 | 41.24% (468) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-66 | 44.06% (379) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-60 | 61.96% (184) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2247 | - | 4e-98 | 91.54% (201) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-66 | 36.91% (512) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3005|M.marinum_M -------------------MAVPPEVHSALLSAGPGPGPLQEAATAWASL
MUL_2247|M.ulcerans_Agy99 -------------MTAAFWMAVPPEVHSALLSAGPGPGPLQEAATAWASL
Mb3043c|M.bovis_AF2122/97 ----------MSSHRTPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv -------------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MAB_0669|M.abscessus_ATCC_1997 ----------MTA---PIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEI
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
:* ******::** ***.*.: *. * :
MMAR_3005|M.marinum_M SVEYASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYA
MUL_2247|M.ulcerans_Agy99 SVEYASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYA
Mb3043c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MAB_0669|M.abscessus_ATCC_1997 GNNYANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESS
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
. ** * :* :: . *:* :: :. *: ** ** : :. :
MMAR_3005|M.marinum_M VMAAEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIA
MUL_2247|M.ulcerans_Agy99 VMAAEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIA
Mb3043c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MAB_0669|M.abscessus_ATCC_1997 VIAAQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* . :. *: * :** ***:.**: *: * **: ***:********
MMAR_3005|M.marinum_M LNEADYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEGVS
MUL_2247|M.ulcerans_Agy99 LNEADYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEG--
Mb3043c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MAB_0669|M.abscessus_ATCC_1997 LNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARS
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* **.***::** *..*: : * .* :: .. *.
MMAR_3005|M.marinum_M AAAL----------------------------PAAPADGPSILWILVQII
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 AVAA----------------------------ATITPFPWHEIVQFLEET
Rv3018c|M.tuberculosis_H37Rv AVAA----------------------------ATITPFPWHEIVQFLEET
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQP--------------------MAAQAGAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQA--------------------QAAEAGSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQA--------------------TAAESGSSLDLSSIISDL
TH_3569|M.thermoresistible__bu AMATTQQIGSQA--------------------TAADSGTALNLSDLIANL
MAV_4867|M.avium_104 LAAN-----------------------------AAQNSSGDWWQNFIQQL
MAB_0669|M.abscessus_ATCC_1997 DQSD-------------------------------VPGSPDQIMKMLQGF
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MMAR_3005|M.marinum_M LILLEILY------------------------------------------
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 FAAYDQYL------------------------------------------
Rv3018c|M.tuberculosis_H37Rv FAAYDQYL------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNFLRDPIGNTF----------------------A
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDFLRDPLGNTI----------------------K
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGGQ-AILDFLKDPLGNLG----------------------R
TH_3569|M.thermoresistible__bu LQYYQDYLDQLFGPIVDFLRDPIGNLF----------------------Q
MAV_4867|M.avium_104 SQFFQN-------------------IQ----------------------K
MAB_0669|M.abscessus_ATCC_1997 QQWFEKMG------------------------------------------
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
MMAR_3005|M.marinum_M ----------AIVAYTIILAFVLPFLILVEAFVFTILGLMFSIFV--GFL
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
Mb3043c|M.bovis_AF2122/97 ----------SALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLL
Rv3018c|M.tuberculosis_H37Rv ----------SALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLL
Mflv_0325|M.gilvum_PYR-GCK LITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTL
Mvan_0415|M.vanbaalenii_PYR-1 LITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTL
MSMEG_0619|M.smegmatis_MC2_155 LLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPAL
TH_3569|M.thermoresistible__bu LIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLA
MAV_4867|M.avium_104 MLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLPLL
MAB_0669|M.abscessus_ATCC_1997 ----FNPATSAVLAVIMLFLYDLLWYPYYASYLLPFLIPALSGLSGLAAL
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
MMAR_3005|M.marinum_M GLLFGPPLLTIAAPLLL-------NGAVIGLSTGVPV-------SLATAL
MUL_2247|M.ulcerans_Agy99 ------------------------DGAVVGG-------------------
Mb3043c|M.bovis_AF2122/97 TEFAINASYVAVGLLYA-------IAGVIDIVVEWVIGNLFGVVPLLGGP
Rv3018c|M.tuberculosis_H37Rv TEFAINASYVAVGLLYA-------IAGVIDIVVEWVIGNLFGVVPLLGGP
Mflv_0325|M.gilvum_PYR-GCK AIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPP
Mvan_0415|M.vanbaalenii_PYR-1 AIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPP
MSMEG_0619|M.smegmatis_MC2_155 AALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAG
TH_3569|M.thermoresistible__bu ITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------------
MAV_4867|M.avium_104 LGIGLSSLLAAPAEIAP----VAAPAAITPVLASNKPPTLPAAVALAPSV
MAB_0669|M.abscessus_ATCC_1997 MHLRPAAPGPVPAAALS-----PGDRPIRRPTQHVEPNLAALPLPTSSVV
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
MMAR_3005|M.marinum_M PIGIPAYLADQSRRGELGDAGQDQ-VVFVG-----ARGGMAPSLAESTAP
MUL_2247|M.ulcerans_Agy99 -------------------------VNRAG-----AGG------------
Mb3043c|M.bovis_AF2122/97 LLGALAAAVVPGVAGLAGVAGLAA-VPAVG-----AAAGAPAALVGSVAP
Rv3018c|M.tuberculosis_H37Rv LLGALAAAVVPGVAGLAGVAGLAA-LPAVG-----AAAGAPAALVGSVAP
Mflv_0325|M.gilvum_PYR-GCK PPSGAPIAANTVSAGSPPAPGAPA-AAAATFVPYVVAGRDPYEGFSPTVR
Mvan_0415|M.vanbaalenii_PYR-1 PPSSAAATVGTVATGTAPAPGAPA-AATASFVPYAVAGRDPGTGFSPTVR
MSMEG_0619|M.smegmatis_MC2_155 VPGSAATAAAPAPAPAGTTVAAPA-PAAATFVPYAVANRDPGEGFTPTLG
TH_3569|M.thermoresistible__bu -----VRAEPQNPLPLTXXX------------------------------
MAV_4867|M.avium_104 ATPAGAPASTVAAGSGAAAAPGPA-AAAGNFAYLVAFGGDPDTGVGPTLS
MAB_0669|M.abscessus_ATCC_1997 PSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVPPGVSFGPKSTEK
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MMAR_3005|M.marinum_M A------PAAGLASAGSAVPASNPA-------------------------
MUL_2247|M.ulcerans_Agy99 --------GTGLGWIG----------------------------------
Mb3043c|M.bovis_AF2122/97 VSGGVVSPQARLVSAVEPAPASTSV-------------------------
Rv3018c|M.tuberculosis_H37Rv VSGGVVSPQARLVSAVEPAPASTSV-------------------------
Mflv_0325|M.gilvum_PYR-GCK DSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYE
Mvan_0415|M.vanbaalenii_PYR-1 DSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYE
MSMEG_0619|M.smegmatis_MC2_155 NKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 GRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFG
MAB_0669|M.abscessus_ATCC_1997 SSESAVDTVAAVAAARGAVAAQARRRLRGKNKAEAGGRRHEYLEETAGMG
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKV
MMAR_3005|M.marinum_M -------------SAVASERGADMSNFAGTSAKGSTVRPAGLMMLGGSEF
MUL_2247|M.ulcerans_Agy99 ---------------------------------GAGKQPG---------F
Mb3043c|M.bovis_AF2122/97 -------------SVLASDRGAGALGFVGTAGKESVGQPAGLTVLAD-EF
Rv3018c|M.tuberculosis_H37Rv -------------SVLASDRGAGALGFVGTAGKESVGQPAGLTVLAD-EF
Mflv_0325|M.gilvum_PYR-GCK ELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSR-GDEQAGGLTTLAGDSF
Mvan_0415|M.vanbaalenii_PYR-1 PEPDDEPPVRQEPRIAATERGAGPMGFAGTVSR-DAAQAGGLTTLPGDPF
MSMEG_0619|M.smegmatis_MC2_155 E-PDEDPAPQPEPRVRASERGSDAMGFTGTVTR-HDVTAAGLTTLTGDTF
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 VPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDDF
MAB_0669|M.abscessus_ATCC_1997 -----ATATADVPAYAATGRGTGPLGFAGTAPAAASTHVAATVRLSSD--
MLBr_01828|M.leprae_Br4923 TPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTF
MMAR_3005|M.marinum_M EGGLREPMLPATW-------------------------
MUL_2247|M.ulcerans_Agy99 GGGF----------------------------------
Mb3043c|M.bovis_AF2122/97 GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Mflv_0325|M.gilvum_PYR-GCK GGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------
MAV_4867|M.avium_104 GGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MAB_0669|M.abscessus_ATCC_1997 EARQVIPMLPSTWDADGGDQN-----------------
MLBr_01828|M.leprae_Br4923 SDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE