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TPVTVCRACGVEPLENARFCHECGAPIGAADTRAEYKQVTVLFADVAHSMDIAAAVGPERLREIMAELVT RASVVVQRYAGRVDKFTGDGVMALFGAPAALEDHALRACLAALDIQDEVARLAADISRTDGVELRLRIGL NSGEVITGGIGPTALGYTAVGEQVGMAQRMESIAPVGGVMVSDTTARLVDGVVLLGAPQRVQVKGMGTVS ARELRSATAQHQRTDSAESTLVGRGWEVAAVSTMLDRAIHGRGSVVGVTGPVGIGKSRLVREAIGLARSR GVTVVHTYCESHAADVPFRVMTRLLRAVGQASGLDDEAARARVRDRVPDAQLPDLLLLDDLLGIAAPGAE LPRIDPDARRRRLTGLINASQLARTEPVVFVLEDVHWIDEASESMLADFLTVMLQTPSLVLFTYRPEYRG ALQLVPGAQTIALAPLTDADVSTLVAELLGQDPSVATIGRVISERAAGNPLFAEEMTRELAERGVLTGER GSYQCRTDVAEIRVPATVQAAIGARIDRLSPAAKQTLSAAAVVGSRFSSDLLIGLGIEPCIDELLDADLI DQVRFTTRAEYAFRHPLVRTVAYEAQLRADRAQLHRRLAQALENAEADPGDHHAALIAEHFEAAGDLAAA YRWHMRAGKWALNRDIAAARLSWERATRISDALPADTPDRSVKRIAPRTMLCGYAWRVHVNISDAHFAEL RELCLAAADKTSLAIATAGLVMDRIYQARIHEGSRLASEAMGLIESIGNPTLTVGLSLTAIVAKAEQAQW LDVLHWSQLVIELADGDPTKGNFMIGSPLALALTTRAIARYCLGRPGWRDDVHQAVQTAGATDPVAYATV VAFVHNPGIAFGVLSPDEAAIREIEQAVQIAQQAGDDLALSSAQISLGIALLERGTEPGRGRGYGYLADT GDTLMRRGYSLGDLPIVEAYLARERGRRGDRDDALPMLRTAVDTLYRQGQLLSWGLPATHALVETLLDRG TEADWSEAQAAIERVADEPPDGPQPLRDIWLLRMRAALAGARGAGGDYQRLRESYRDMARTLDFGGHLAW ADAMR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5254 | - | - | 100% (1056) | membrane-anchored adenylyl cyclase |
| M. marinum M | MMAR_5257 | - | 0.0 | 62.54% (1057) | membrane-anchored adenylyl cyclase |
| M. marinum M | MMAR_3043 | - | 1e-39 | 28.71% (634) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1651c | cya | 2e-14 | 28.57% (175) | membrane-anchored adenylyl cyclase Cya (ATP |
| M. gilvum PYR-GCK | Mflv_4653 | - | 2e-24 | 26.09% (506) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1625c | cya | 2e-14 | 28.57% (175) | membrane-anchored adenylyl cyclase Cya (ATP |
| M. leprae Br4923 | MLBr_02341 | - | 0.0 | 65.48% (733) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3361 | - | 4e-14 | 25.69% (506) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_4804 | - | 1e-20 | 24.73% (558) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0228 | - | 0.0 | 52.08% (1058) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_2942 | - | 4e-16 | 32.84% (204) | PUTATIVE adenylate cyclase |
| M. ulcerans Agy99 | MUL_3594 | - | 5e-19 | 31.03% (174) | adenylylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_1904 | - | 1e-180 | 40.64% (1026) | adenylyl cyclase class-3/4/guanylyl cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5254|M.marinum_M --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4804|M.avium_104 MLDLDDRVTDRQRELARLRAAVDAAARGGGECVLISGVPGVGKSALMKAF
MAB_3361|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4804|M.avium_104 GVEVAGRGCVFAYGRCRDGAPAPYAAVRDALGSLVRTMAATAPAERDRWR
MAB_3361|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M --------------------MTPVTVCRACGVEPLENARFCHECGAPIGA
MLBr_02341|M.leprae_Br4923 --------------------MTTALVCVACGAELRSIAKFCDECGSPVVE
MSMEG_0228|M.smegmatis_MC2_155 -----------------------MVACGTCGTELRQGARFCDSCGTAIVD
Mvan_1904|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK --------------MRYRLLGPLQVVHGEAAVDIGPRKQRSVLAALLLAQ
MAV_4804|M.avium_104 ADLAGGVSPIAGVLGELVPDLPRVLGETASHPELDATDSRRQLHRAATRL
MAB_3361|M.abscessus_ATCC_1997 ------------------------MLRGQAGVGKTALLRYVLGKASGQLI
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M ADTRAEYKQVTVLFADVAHS------------------------------
MLBr_02341|M.leprae_Br4923 AETPAEYKQVTVLFADVVGS------------------------------
MSMEG_0228|M.smegmatis_MC2_155 GSKHAEYKQVTVLFADVVDS------------------------------
Mvan_1904|M.vanbaalenii_PYR-1 ---------MTVLFADVVGS------------------------------
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv -------------MAARKCG------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK GRVVSTDRLVDVVWGDDVPAS----------------ATASLQVYISNLR
MAV_4804|M.avium_104 LSATASYRTVVLAIDDLQWADRDTLLLLAELLTVSLRDVLVVGAHRAGGF
MAB_3361|M.abscessus_ATCC_1997 AQASGIQSEMELAFAGLQQFCAP--------------------------L
MUL_3594|M.ulcerans_Agy99 --------MHVNGFGGLAAQ------------------------------
MMAR_5254|M.marinum_M MDIAAAVGPERLREIMAELVTRAS----------VVVQRYAGRVDKFTGD
MLBr_02341|M.leprae_Br4923 MDIAAAVGLERLREIMTELVSRAA----------GVIERYGGTVDKFTGD
MSMEG_0228|M.smegmatis_MC2_155 MRLAAAVGAERLREILSALVSRCS----------GVVGHYGGTVDKFTGD
Mvan_1904|M.vanbaalenii_PYR-1 MRLAAELDPERLREIMNDLFNRSA----------TVVQRYHGTMDKFTGD
Mb1651c|M.bovis_AF2122/97 ------------------MRTQAR----------APTQHYAESVARRQRV
Rv1625c|M.tuberculosis_H37Rv APPIAADGSTRRPDCVTAVRTQAR----------APTQHYAESVARRQRV
TH_2942|M.thermoresistible__bu -----------------VARQGVP----------ARTQRYAESIRSRYRM
Mflv_4653|M.gilvum_PYR-GCK RALRSGAGDRTVSSVAQPIVRQPPGYFLDAGPDESDIAVFTAACARAAAA
MAV_4804|M.avium_104 DPAAAGIAAENLTTIELEPLARDD-----VEELLATVCGQSGELPEVAAE
MAB_3361|M.abscessus_ATCC_1997 TKYSGAIPDPQREALTIAFGTRSG----------PPPDRFLIGLAVLSLL
MUL_3594|M.ulcerans_Agy99 QVAASPICCAPLDERSAIPGPQPP------------VRLLVVDDADGVET
MMAR_5254|M.marinum_M GVMALFGAPAALEDHALRACLAALDIQD-EVARLAADISRTDGVELRLRI
MLBr_02341|M.leprae_Br4923 GIMAIFGAPTALEDHALRACLAALGVQE-KARRLAAEVGDRDGVDLQLRV
MSMEG_0228|M.smegmatis_MC2_155 GIMALFGAPLALEDHALRACLAALDLQY-ESHRLADELDLPAGVGLQIRV
Mvan_1904|M.vanbaalenii_PYR-1 GLMALFGAPMALEDHALRACIAALEIQA-VVGELADEVEQRDGVRLQLRV
Mb1651c|M.bovis_AF2122/97 LTITAWLAVVVTGSFALMQLATG------AGGWYIALINVFTAVTFAIVP
Rv1625c|M.tuberculosis_H37Rv LTITAWLAVVVTGSFALMQLATG------AGGWYIALINVFTAVTFAIVP
TH_2942|M.thermoresistible__bu LTIAAWIAAAVSAGFGTLQLVLG------GQTRLLGVINLAVAVVFTLIP
Mflv_4653|M.gilvum_PYR-GCK IDGERWDEALAEADTALSLVRGELLEDIGDADWIREDAARFAEMRTECLA
MAV_4804|M.avium_104 FHHRTGGNPLQVRQLLYRAQREGALLPVGSGGPPRWDLRVLTSIEVSATA
MAB_3361|M.abscessus_ATCC_1997 AAAAEHQPVLCVIDDAQWLDRVSLQTLAFVTRRLGSEP---VAMLFAVRD
MUL_3594|M.ulcerans_Agy99 LFGARFRTELRCDEYDLSFSNDPVQALKMVGDSPDIEVLVTNLNMPQMNG
MMAR_5254|M.marinum_M GLNSGEVITGGIGPTALGYTAVGEQVGMAQR-------------------
MLBr_02341|M.leprae_Br4923 GLNSGQVIVGEIGSSALGYTAVGVQVGMAQR-------------------
MSMEG_0228|M.smegmatis_MC2_155 GLNSGQVIAGEMSAGGFGYTAIGEQVGMAQR-------------------
Mvan_1904|M.vanbaalenii_PYR-1 GLNSGDVVVGDIGSGPGRYTAIGHAVGMAQR-------------------
Mb1651c|M.bovis_AF2122/97 LLHRFGGLVAPLTFIGTAYVAIFAIG------------------------
Rv1625c|M.tuberculosis_H37Rv LLHRFGGLVAPLTFIGTAYVAIFAIG------------------------
TH_2942|M.thermoresistible__bu LLYRFGELLAPLSFFLFAYLSVGFMC------------------------
Mflv_4653|M.gilvum_PYR-GCK GKVMSLLALGKIPAALTAASQLGALDPLADRGCRLQMLALYRAGRTADAL
MAV_4804|M.avium_104 AEFLGRYLDQLRPADREVLSALSCIGGEFDLDDAAAAAARTPDVVAHALW
MAB_3361|M.abscessus_ATCC_1997 GTDSELAGLPELTVHGLRAADAGTLLDSVIP-------------------
MUL_3594|M.ulcerans_Agy99 LDLLTEVAKLGRPLKTIVLTACNDLAN-----------------------
MMAR_5254|M.marinum_M -----------MESIAPVGGVMVSDTTARLVDGVVLLGAPQ---------
MLBr_02341|M.leprae_Br4923 -----------MESVAPPGVVMLSESTARLVEQTAVLGAPQ---------
MSMEG_0228|M.smegmatis_MC2_155 -----------MESVAPHGGIMCSDTTARLVEDSVLLGAPE---------
Mvan_1904|M.vanbaalenii_PYR-1 -----------MEAAASAGAVVCSLSTADLVEHATRLGAVQ---------
Mb1651c|M.bovis_AF2122/97 ----------------------WDVGTDAGAQFFFLVAAAL---------
Rv1625c|M.tuberculosis_H37Rv ----------------------WDVGTDAGAQFFFLVAAAL---------
TH_2942|M.thermoresistible__bu ----------------------FSIGTGSGLQLYLLVAASL---------
Mflv_4653|M.gilvum_PYR-GCK EVYTRYARRLDAELGLEPGPELRDLQTAVLRQAPELSGWPR---------
MAV_4804|M.avium_104 ACLELRLLEALDMTGQRISNAISRDARYRFSHDRVAEAARAGLSPDEMRA
MAB_3361|M.abscessus_ATCC_1997 -----------------------GLLDERVRDRIVAETQGN---------
MUL_3594|M.ulcerans_Agy99 ------------------------IRAAMMRG-AFDFQLTP---------
MMAR_5254|M.marinum_M -------RVQVKGMG-TVSARELRSATAQHQRTDSAESTLVGRGWEVAAV
MLBr_02341|M.leprae_Br4923 -------TVRIKGAEDAVPARRLLRVAEPRQPTWFSESTLVGREWELATL
MSMEG_0228|M.smegmatis_MC2_155 -------MLRVKGCDRPVAARRLLAATN-AAHGGRSDPTLVGRSWELNTI
Mvan_1904|M.vanbaalenii_PYR-1 -------TVRIKGSDEPAPARRLVAVEAARMVVGRNEGLMLGRDGELHQL
Mb1651c|M.bovis_AF2122/97 -------VVLLVGIEHTALAVGLAAVAA---------GLVIALEFLVPPD
Rv1625c|M.tuberculosis_H37Rv -------VVLLVGIEHTALAVGLAAVAA---------GLVIALEFLVPPD
TH_2942|M.thermoresistible__bu -------VVLLLGVDRIVLAAGIVAVGV---------VGIIVLELVVPED
Mflv_4653|M.gilvum_PYR-GCK -------SPGWTGAA-AVTATEAVPVRLDTVESASHRAPLVGRRRELAAA
MAV_4804|M.avium_104 VHLRIGRRLITLGDDRLFEAARHVGVGGLAVSDEAERTRFVEVLRRAAHQ
MAB_3361|M.abscessus_ATCC_1997 -------PLALLELPRDMTAEELAGGFG-----WPDGGRLAGQIEQTFLR
MUL_3594|M.ulcerans_Agy99 ----------LDLEDLRVTISKAVTIVRELQAGEAARQRALELADQNRRV
MMAR_5254|M.marinum_M STMLDRAIHGRGSVVGVTGPVGIG--------------------------
MLBr_02341|M.leprae_Br4923 AAMLDRSIGGRGSVVGLVGPAGIG--------------------------
MSMEG_0228|M.smegmatis_MC2_155 AGLLDEAVEGRGGIVSVVGPPGIG--------------------------
Mvan_1904|M.vanbaalenii_PYR-1 CDSLDRRR--RRHLVSVVGAPGVG--------------------------
Mb1651c|M.bovis_AF2122/97 TGLQPPWAMSVSFVLTTVSACGVA--------------------------
Rv1625c|M.tuberculosis_H37Rv TGLQPPWAMSVSFVLTTVSACGVA--------------------------
TH_2942|M.thermoresistible__bu RGLGPAWMLTAGFVTSAVSSALII--------------------------
Mflv_4653|M.gilvum_PYR-GCK ADVLDRVTAGAARWLVLSGPPGIG--------------------------
MAV_4804|M.avium_104 ARAQASFPLALGYCRDALDLLGEQRWAGQFVLTRELALDAADAALRVGDV
MAB_3361|M.abscessus_ATCC_1997 RVQQLPAHTQTLLLAAATDPLGDV--------------------------
MUL_3594|M.ulcerans_Agy99 ENIFGRYVSEEVKTHLLACPEGHQ--------------------------
MMAR_5254|M.marinum_M --KSRLVREAIGLARSRGVTVVHTYCESHAADVPFRVMTRLLRAVGQASG
MLBr_02341|M.leprae_Br4923 --KTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVRAVAQISG
MSMEG_0228|M.smegmatis_MC2_155 --KSRMVRESIELARRRGVAVFYTYCESHASDVPFHVVVPLLREGFGVAG
Mvan_1904|M.vanbaalenii_PYR-1 --KSRLVEEFCRRLRGAGTEVVLAGCDAHAMPIAFRALSRLLRAMFSADD
Mb1651c|M.bovis_AF2122/97 --VATVWFALRDTAR-----------AEAVMEAEHDRSEALLANMLPAS-
Rv1625c|M.tuberculosis_H37Rv --VATVWFALRDTAR-----------AEAVMEAEHDRSEALLANMLPAS-
TH_2942|M.thermoresistible__bu --FATLWYALREIAR-----------TEAAMEAEYQRSESLLLNILPAS-
Mflv_4653|M.gilvum_PYR-GCK --KTRLAEEIAGLVAAGDGDVVWVNCPDERGTPPWWPMRQLVRALGADAD
MAV_4804|M.avium_104 PVLNTLLDEAEEFLREPPDRARLAYLRMKGRVAENRLQEALEIGLAALDE
MAB_3361|M.abscessus_ATCC_1997 ---TLLARAAQQLGIPMHAIAPAEAADLVELSTRVRFRHPLVRSAVYISA
MUL_3594|M.ulcerans_Agy99 ---NSERRTLTMLMADIRG-----FTRLSEILSPERALQVLNAYLERATD
*
MMAR_5254|M.marinum_M LDDEAARARVRD----------------------RVPDAQLPDLLLLDDL
MLBr_02341|M.leprae_Br4923 LDDRSARARVRE----------------------QIPDADTQDLLLLDDL
MSMEG_0228|M.smegmatis_MC2_155 LDPAAARVRVRS----------------------LVPDADPEDLLLLDDV
Mvan_1904|M.vanbaalenii_PYR-1 LGDDDARELVLS----------------------QVPMG-STDAQIIFEA
Mb1651c|M.bovis_AF2122/97 -IAERLKEPERN----------------------IIADKYDEASVLFADI
Rv1625c|M.tuberculosis_H37Rv -IAERLKEPERN----------------------IIADKYDEASVLFADI
TH_2942|M.thermoresistible__bu -VARRLKDPART----------------------VIADKYDDASVLFADI
Mflv_4653|M.gilvum_PYR-GCK EVLEIPPHADPD----------------------TARFLVYERIQRLLES
MAV_4804|M.avium_104 LGERVATQAGKPRMGNAIVRMRLTMARWSTERLLQLPHCTDQRVIALHPI
MAB_3361|M.abscessus_ATCC_1997 NPLERRRIHGVLAG-------------------ATDPGADPDRRAWHRAH
MUL_3594|M.ulcerans_Agy99 VVIRWNG----------------------------TINEILGDGLLVFFG
MMAR_5254|M.marinum_M LGIAAPGAELPRIDPDARRRRLTGLINASQLARTEPVVFVL---------
MLBr_02341|M.leprae_Br4923 LGIADPAVELPRLDPDARRRRLTALINVAQLALSRPAVFVV---------
MSMEG_0228|M.smegmatis_MC2_155 LGIADPDVPMPDLDADARRRRVAALVNAASLARREPGLYVL---------
Mvan_1904|M.vanbaalenii_PYR-1 MGIADGAAPPLHVGADGRRHRLVETMAQFVRLRSTPMVLVL---------
Mb1651c|M.bovis_AF2122/97 VGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVS---------
Rv1625c|M.tuberculosis_H37Rv VGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVS---------
TH_2942|M.thermoresistible__bu AGYTRWAGATTPSELVLFLDRLYTELDALVDRHGLEKVKTS---------
Mflv_4653|M.gilvum_PYR-GCK APRLLAVVVDDVQWADTTSAACLAYIAGTLRDRPVLVVVTV---------
MAV_4804|M.avium_104 LAELCNMAVLVRPNLLPLLVRKQLELTLAHGHTSSSPLVITGYGIVLVLL
MAB_3361|M.abscessus_ATCC_1997 AAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATELTA---------
MUL_3594|M.ulcerans_Agy99 VPNTDGEAAEHAVAAALELQLAMGELNVSHREQGLPELGIG---------
.
MMAR_5254|M.marinum_M ----EDVHWIDEASESMLADFLTVMLQTPSLVLFTYRPEYRGALQLVPGA
MLBr_02341|M.leprae_Br4923 ----EDVHWIDEVSDSMLADFLAVIPQTRSMALVTYRPEYHGALRHVVGA
MSMEG_0228|M.smegmatis_MC2_155 ----EDAHWIDEVSESMLAEFLTVVTHTHSVMLITYRPEYTGVLARVSGA
Mvan_1904|M.vanbaalenii_PYR-1 ----EDAHWIDAASEAVLCEFATVLERTSTVLVTTCRPEYRGGLRKRS-A
Mb1651c|M.bovis_AF2122/97 ----GDSYMVVSG-------------------VPRPRPDHTQALADFALD
Rv1625c|M.tuberculosis_H37Rv ----GDSYMVVSG-------------------VPRPRPDHTQALADFALD
TH_2942|M.thermoresistible__bu ----GDSYMVVSG-------------------VPQPRPDHLEALADFALD
Mflv_4653|M.gilvum_PYR-GCK ----RDGEHPAEVSR--LLSTVARGEANRLIEVPALSSEDVATLANEVAE
MAV_4804|M.avium_104 GDHAGSQRFGEVGMLLAQRPELREARPQTVFMYLDYIHHWRHPIRDGLGE
MAB_3361|M.abscessus_ATCC_1997 ----DPAARGRRALAAAQSKYDAAAFDAARELLGVADMTPLDPLARARAT
MUL_3594|M.ulcerans_Agy99 -------------------------------IGVHTGEAVVGTIGSPRRQ
:
MMAR_5254|M.marinum_M QTIALAPLTDADVSTLV---------------------AELLGQDPSVAT
MLBr_02341|M.leprae_Br4923 QIIAVAPLSDVETSTLV---------------------AELLGLDQSVTQ
MSMEG_0228|M.smegmatis_MC2_155 QTIALRPLTDGQTSTLL---------------------TELLGPDAAAHQ
Mvan_1904|M.vanbaalenii_PYR-1 HTVTVAPLNDSLTMDLV---------------------LNLLGGDGAMGG
Mb1651c|M.bovis_AF2122/97 MTNVAAQLKDPRGNPVP---------------------LRVG--------
Rv1625c|M.tuberculosis_H37Rv MTNVAAQLKDPRGNPVP---------------------LRVG--------
TH_2942|M.thermoresistible__bu MAAAVGRLRDPQGRTVP---------------------LRIG--------
Mflv_4653|M.gilvum_PYR-GCK EVVTAAEAAELADRTGG---------------------NPFFVSEYARLP
MAV_4804|M.avium_104 LRDAVEEALDRGDQENAGFLTAVLLSQSFWVGRPLPEIDALASSLIPHIR
MAB_3361|M.abscessus_ATCC_1997 RLRAKIAFAESRVGAFG---------------------------------
MUL_3594|M.ulcerans_Agy99 KYTAIGKNVNLVARIES---------------------------------
. :
MMAR_5254|M.marinum_M IGRVISERAAGNPLFAEEMTRELAERGVLTGERGS--------YQCRTDV
MLBr_02341|M.leprae_Br4923 IGELITERAAGNPFFAQEITRELAERGVLTGERGR--------YACSTDV
MSMEG_0228|M.smegmatis_MC2_155 LAGLIADRAAGNPFFTQEIVRDLAERGVLRGERGA--------YRFHGAD
Mvan_1904|M.vanbaalenii_PYR-1 LASRIVGVAAGNPYFVEEIVRDLVGRGVLAGSRGD--------YRLIRDV
Mb1651c|M.bovis_AF2122/97 ------------------LATGPVVAGVVGSRRFF--------YDVWGDA
Rv1625c|M.tuberculosis_H37Rv ------------------LATGPVVAGVVGSRRFF--------YDVWGDA
TH_2942|M.thermoresistible__bu ------------------LAAGPVVAGVVGARKFF--------YDVWGDA
Mflv_4653|M.gilvum_PYR-GCK REERAGNEIPRAVRSVLDRRLAALDPAVMQVLRAA--------AVIADVL
MAV_4804|M.avium_104 SQPVPSALCQAVQQLCLNLMGRSADPFLLAGESGYDERQVLPAARQQGDE
MAB_3361|M.abscessus_ATCC_1997 -----------------SVTVSEAAIGLVEAARCL---------ENLDDN
MUL_3594|M.ulcerans_Agy99 ---------------------NTVGGQVLVSESTY--------HEICAIA
::
MMAR_5254|M.marinum_M AEIRVPATVQAAIGARIDRLSPAAKQTLSAAAVVGSRFSSDLLIGLGIEP
MLBr_02341|M.leprae_Br4923 AEVCVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDL
MSMEG_0228|M.smegmatis_MC2_155 VEIGVPATLQATIAARIDRLEVEAKRTLSAAAVIGLRFGPDMLAALGADV
Mvan_1904|M.vanbaalenii_PYR-1 DDIGVPVTVQAVLAARIDRLAPATKAVLNAAAVIGNRFDAETLQVLTPNA
Mb1651c|M.bovis_AF2122/97 VNVAS---------------------------------------------
Rv1625c|M.tuberculosis_H37Rv VNVAS---------------------------------------------
TH_2942|M.thermoresistible__bu VNVGS---------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK DSVTVPLLARTTALDLDTLADYLDEAADERIIVNSHTGDGYVFAHGLLRE
MAV_4804|M.avium_104 VALGAAAAMKQGLHFWCGDHAGAAEATTEAIEHLGGLAGVAASQLVHLIG
MAB_3361|M.abscessus_ATCC_1997 LARET---------------------------------------------
MUL_3594|M.ulcerans_Agy99 DTSGS---------------------------------------------
MMAR_5254|M.marinum_M C------------IDELLDADLIDQVRFTTRAEYAFRHPLVRTV------
MLBr_02341|M.leprae_Br4923 S------------VDELIDANLVDQVRFTAPVEYAFRHPLIRTV------
MSMEG_0228|M.smegmatis_MC2_155 S------------MQALIDAELVDQVMFAPRPEYAFRHPLIRMV------
Mvan_1904|M.vanbaalenii_PYR-1 RSGE---------LAELVATELIDQMEFAPRQRYCFRHPLVRAV------
Mb1651c|M.bovis_AF2122/97 ---------------RMESTDSVGQIQVPDEVYERLKDDFVLRE------
Rv1625c|M.tuberculosis_H37Rv ---------------RMESTDSVGQIQVPDEVYERLKDDFVLRE------
TH_2942|M.thermoresistible__bu ---------------RMESTDVVGRIQVAQDVRDRLRDSFVFEE------
Mflv_4653|M.gilvum_PYR-GCK QLLTGMPALR-RQRVHAKVADVLADSALPDAPTWRAQHLVAAQP------
MAV_4804|M.avium_104 ALSMIHCAPRDSATIRFVRQALASHRKWAAGAPENYAAPYALIQGAWARA
MAB_3361|M.abscessus_ATCC_1997 -------------YLDAVGAAMYGGRLCPRGGAVEVAEPARLAP------
MUL_3594|M.ulcerans_Agy99 --------------TQVRVKGLTEPITVHDITGLAGRYNLRLPS------
MMAR_5254|M.marinum_M -----------------AYEAQLRADRAQLHRRLAQALENAEADPGDHHA
MLBr_02341|M.leprae_Br4923 -----------------AYESQLKSDRARLHRRLAAAIEARAPHSVDQHA
MSMEG_0228|M.smegmatis_MC2_155 -----------------ALESQLKSDRAELHRRLAVDIERRAPHAADEHA
Mvan_1904|M.vanbaalenii_PYR-1 -----------------AYDSQISANRARAHRLLAGAIETRDPAAKDENA
Mb1651c|M.bovis_AF2122/97 -----------------RGHINVKGK------------------------
Rv1625c|M.tuberculosis_H37Rv -----------------RGHINVKGK------------------------
TH_2942|M.thermoresistible__bu -----------------RGAIEVKGK------------------------
Mflv_4653|M.gilvum_PYR-GCK -----------------LVEPTVVVPACRLAAEQATQQWSSDIAAGWWQA
MAV_4804|M.avium_104 RGQHGKAERHLHQAIELAEEHRLPAIGARAHEEAAALYAETGRQTLREHM
MAB_3361|M.abscessus_ATCC_1997 -------------------AGAQPARPSDLLLDGLARRITHGAAASAQTL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M ALIAEHFEAAGDLAAAYRWHMRAGKWALNRDIAAARLSWERA--TRISDA
MLBr_02341|M.leprae_Br4923 VLIAEHLEAAGDLHAAYGWHMRAAAWATNQDVRAARVSWEHA--TKIADA
MSMEG_0228|M.smegmatis_MC2_155 ALIADHYEEAGDLRAAFTWHMRAGTWLTNRDIDAARLSWQRA--RHVADQ
Mvan_1904|M.vanbaalenii_PYR-1 ALIATHLEGAGDFETACRWHLRAADWLRMRDLLAARNQWEIA--MRVADG
Mb1651c|M.bovis_AF2122/97 -------------GVMRTWYLIGRKVAAD------------------PGE
Rv1625c|M.tuberculosis_H37Rv -------------GVMRTWYLIGRKVAAD------------------PGE
TH_2942|M.thermoresistible__bu -------------GVMHTWYLLGRRSDRQGSDRQGSGRQGSG--RQGSGR
Mflv_4653|M.gilvum_PYR-GCK ALDAYDRLPASERDDADRDALTVELLEAHSRAGRGQLVLDSV--TRYLGE
MAV_4804|M.avium_104 LRSAYQRWLNLGFAVRADWLAREHPWLLRRDLRTGSAGIDPIGAHQLVHA
MAB_3361|M.abscessus_ATCC_1997 GEALTLIRCEADRPANTSWMEQAFPIALES---ATHEVWDDDMWHHLATR
MUL_3594|M.ulcerans_Agy99 ----------IDRKVIPLVVPRPTGIAVIENKIIGAAHPAEVVGSGDGAV
MMAR_5254|M.marinum_M LPADTPDRSVKRIAPRTMLCGYAWRVHVNI-SDAHFAELRELCLA-----
MLBr_02341|M.leprae_Br4923 LTAEDPHRAAMCIAPRTRLCGIAWRGRFNS-SSG-FDEVRQLCNA-----
MSMEG_0228|M.smegmatis_MC2_155 LPHDAEDRAAMTIAPRTLLCLSTWRAGGHL-SDTGFDELCALAAA-----
Mvan_1904|M.vanbaalenii_PYR-1 LPGADDAVTALRIAPRTMLVSTELFVGADPDNDQRLVELRELTAR-----
Mb1651c|M.bovis_AF2122/97 VRGAEPRTAGV---------------------------------------
Rv1625c|M.tuberculosis_H37Rv VRGAEPRTAGV---------------------------------------
TH_2942|M.thermoresistible__bu QGGTEASTAARTHG------------------------------------
Mflv_4653|M.gilvum_PYR-GCK ALRTGRAASAGRVASALLRASGGWPWLAPGNDPGELLTLLSRAAT-----
MAV_4804|M.avium_104 LSGARTPDALANIILGSVADTTGAGRVLFITGEADNQSVRAIHDHGEVLI
MAB_3361|M.abscessus_ATCC_1997 AVHIAREVGALSLLPAALIYRAGMHVHAGELDAAAELVQEADAIS-----
MUL_3594|M.ulcerans_Agy99 RVRTGLQVAPFCDLVLDVAGAQVFAKVVDCGVDGGICELMAVFTS-----
MMAR_5254|M.marinum_M -------AADKTSLAIATAGLVMDRIYQA-RIHEGSRLASEAMGLIE---
MLBr_02341|M.leprae_Br4923 -------TGDKAPLAVATVGPAIDHVYQD-RLH-----------------
MSMEG_0228|M.smegmatis_MC2_155 -------ADDKVSLATAMAGQVSALLVHA-HYRESSSLASELTSLLE---
Mvan_1904|M.vanbaalenii_PYR-1 -------VDDSHSLALALAGRIVTFIVNSNRVPEALPLAAELAELVD---
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK -------LSEGEPASAARVLPALAVGHCYHPDPTIAPELLDRAERLA---
MAV_4804|M.avium_104 VEGPWTEVPYRRDVVRRVIDGGAPVIVAADRAAATNSVLAAPIALHDRTL
MAB_3361|M.abscessus_ATCC_1997 ------------AATGHAPIRYHSLILAAWRGSEPTAIRLIDEAMRDG--
MUL_3594|M.ulcerans_Agy99 ---------VSDDVRRALAAPSTANSLS----------------------
MMAR_5254|M.marinum_M -----SIG-NPTLTVGLSLTAI-VAKAEQAQWLDVLHWSQLVIELADGDP
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 -----SVG-DRRLTVALLFAAL-GAKFQTGEANEVVRLADRLIELADGDA
Mvan_1904|M.vanbaalenii_PYR-1 -----TLGPTPAAELEIIYTAMSFAHLASCEFDAALEVIGRSIALEPEYP
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK -----EATGDPDVIADVLIGRLITFSGVATLSAQSLEWVQRLNALRHSRS
MAV_4804|M.avium_104 GVIYAEQGEPGRNFGADHEEAIAFLCAQAAAPLWSFQLEARLRAADEYRQ
MAB_3361|M.abscessus_ATCC_1997 ----------AARGEGRLLGAMGYAAGVLNNSLGRYELAFMAARRACEHE
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M TKGNFMIGSPLALALTTRAIARYCLGRPGWRD-DVHQAVQTAGATDPVAY
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 NMGNLIIGSPLVTAWTVGGMARACLGDPDWRT-GLDRATPLVRDFG-ITT
Mvan_1904|M.vanbaalenii_PYR-1 -------STDRALAYAIGGLCEVCLGSRERGIGHIRLATELARAMSPVSF
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK REDAVIAHSVATMAAMNLGDVDGARRHVQAGIAGSEELQLPVLRAQLRWM
MAV_4804|M.avium_104 SLIDVQSRFVPNELLRILDIDDLRRVRNGHRVEREMTVLISDIRSYTAMI
MAB_3361|M.abscessus_ATCC_1997 DLGLYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAAQSDWSQGMVAR
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M ATVVAFVHNPGIAFGVLSPDEAAIREIEQAVQIAQQAGDDLALS---SAQ
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 RALMLTYKCIGLPTGLLLPSPELLEESCEVLEVAQRSADDLALA---GAQ
Mvan_1904|M.vanbaalenii_PYR-1 SAVSLYWGILAAMG--MHVAEDLVDDMREWLARAESFGDRFGII---AAQ
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK EAVLAVWHGDFAEAGRHHAIAAHVHEQTELYEAGSGLLARATLLRERGGP
MAV_4804|M.avium_104 EDMNVAEAGNLAMGFLRAVELPIISYHGMIQDVRGDEIVAVFESEADAVR
MAB_3361|M.abscessus_ATCC_1997 SRALITVG----------------------HDAEPHYREAIQRLTNTRIS
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M ISLGIALLERGTEPGRGRGYGYLADTGDTLMRRGYSLGDLPIVEAYLARE
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 VSRGLLLLWQG-GPYRDEALELLSLGREASVREQFTMAAVPAVDTELARD
Mvan_1904|M.vanbaalenii_PYR-1 WTYATLLLQAG-SPRRDEAFVLLRRAEVGITTHNLQSFALAITGMQLARE
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK VDPSWTDLNAQQAGGLGMVGVVRTGVLTLLSGPKARAEALATLRHWAQHT
MAV_4804|M.avium_104 AGLGMLRSLHEHNQERRALGSEELRAGIGINTGAVAVGLVGGVNRMVLTI
MAB_3361|M.abscessus_ATCC_1997 AHLARAHLIYGEWLRRCNRRSDARTELTAAHGSFVNMGTAAFAERAEREL
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M RGRRGDRDDALPMLRTAVDTLYRQGQLLSWGLPATHALVETLLDRGTEAD
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 MAARGDLDGAIELARDVVDTSIDSGEAINMSASVT-VLVQSLIARGDRDD
Mvan_1904|M.vanbaalenii_PYR-1 AARNGHRDEAIDSIRHLVTLHTRDAPLLHLGCPAE-SLCEMLIDRGGTRD
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK DRAHIWTTLGHHTLLAHLAVDHDLPDFAEPLLAQLDPYRDRIAVIGQVGM
MAV_4804|M.avium_104 IGDAVNLAARIESTNKRYGSALLISDRTYQRIAGSEEFDVRRMERVMVVN
MAB_3361|M.abscessus_ATCC_1997 RATGAKVRKRSASSEKALTAQEAQIARMAGQGLTNQEIAAQLFISSHTVE
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M WSEAQAAIERVADEPPDGPQPLRDIWLLR--------MRAALAGARGAGG
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 LDHAQRVIDRFAALPTDPGFVLYDVQLMR--------LRALLARARGDEE
Mvan_1904|M.vanbaalenii_PYR-1 LLEVEEVLEQWCSRSP--GTAPMDLWTIR--------IRALLASARGERQ
Mb1651c|M.bovis_AF2122/97 --------------------------------------------------
Rv1625c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2942|M.thermoresistible__bu --------------------------------------------------
Mflv_4653|M.gilvum_PYR-GCK AGPVALATARLHALRGDKAAALADLALARSIAERSAGVPTLLRCRLLECE
MAV_4804|M.avium_104 RRRPVTIYEVYNGDSGPLRAAKRAAQPAFDEAFALFDAGDVDAARAAFQR
MAB_3361|M.abscessus_ATCC_1997 WHLRKVFAKRGITSRRQLRSGR----------------------------
MUL_3594|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5254|M.marinum_M DYQRLRESYRDMARTLDFGGHLAWADAMR--------
MLBr_02341|M.leprae_Br4923 -------------------------------------
MSMEG_0228|M.smegmatis_MC2_155 RYRECSDRYRELATAYRYEGHMALAARMA--------
Mvan_1904|M.vanbaalenii_PYR-1 RYAQLADEYAAACEFTGYRHHWGGPYPVLSDRRG---
Mb1651c|M.bovis_AF2122/97 -------------------------------------
Rv1625c|M.tuberculosis_H37Rv -------------------------------------
TH_2942|M.thermoresistible__bu -------------------------------------
Mflv_4653|M.gilvum_PYR-GCK LTEESPGRSTAASTLAAEAADLGMAAVAEAASRLL--
MAV_4804|M.avium_104 CRDMLPDDPIAPLHLAHCDAVARGEMLPGQEIALQNK
MAB_3361|M.abscessus_ATCC_1997 -------------------------------------
MUL_3594|M.ulcerans_Agy99 -------------------------------------