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M. marinum M MMAR_5121 (-)

annotation: PPE family protein
coordinates: 6199804 - 6201045
length: 413

LDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAELQATASTYDALVTELTDGPWQGPSAANMVAAAM
PQVEWLRNTAALAEQAGSQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATEAQY
GEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQTVSAAGLANQAAAVGQALNGAVDSQALAEIPKALSQLA
GISNEPPWLTDLTGAIGLTGHAWNSNGDGIIVGGALGDIVQGVTGSAEVDAGVFMDTFSKWVSPARLAVT
QFKDYVGLAHDLPKFAQEGAKAAAEAAKELPAVLPSLPGVGLGGITGAVGKAASVTGLSVPTSWMNSVGA
AANPAIVTVNSLGAAAAEPAQAAVGGVPLMPASGVGRGMAAHFAAPRYGFKPTMVVHPPAGG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_5121--100% (413)PPE family protein
M. marinum MMMAR_5117-e-10851.54% (421) PPE family protein, PPE65
M. marinum MMMAR_1849-3e-8444.34% (442) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1836PPE316e-7945.27% (433) PPE family protein
M. gilvum PYR-GCKMflv_0325-9e-3037.50% (200) PPE protein
M. tuberculosis H37RvRv3621cPPE651e-17173.73% (415) PPE family protein
M. leprae Br4923MLBr_01182-2e-4333.18% (437) PPE-family protein
M. abscessus ATCC 19977MAB_0809c-2e-3046.25% (160) PPE family protein
M. avium 104MAV_0535-1e-12154.63% (421) PPE family protein
M. smegmatis MC2 155MSMEG_0619-3e-3028.97% (428) PPE family protein
M. thermoresistible (build 8)TH_3113-2e-3531.37% (408) PUTATIVE PPE protein
M. ulcerans Agy99MUL_4195-1e-10650.83% (421) PPE family protein
M. vanbaalenii PYR-1Mvan_0415-1e-3341.79% (201) PPE protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_5121|M.marinum_M               ------------MLDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAE
Rv3621c|M.tuberculosis_H37Rv        ------------MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAE
MAV_0535|M.avium_104                -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE
MUL_4195|M.ulcerans_Agy99           ------------MLDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAE
Mb1836|M.bovis_AF2122/97            -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Mflv_0325|M.gilvum_PYR-GCK          MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1       ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155      ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199      ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu      ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923          ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
                                                       .*: :*  :  *.*...: :*.  *  *. .

MMAR_5121|M.marinum_M               LQATASTYDALVTELTDGPWQGPSAANMVAAAMPQVEWLRNTAALAEQAG
Rv3621c|M.tuberculosis_H37Rv        LQTTASTYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAG
MAV_0535|M.avium_104                LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA
MUL_4195|M.ulcerans_Agy99           LQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG
Mb1836|M.bovis_AF2122/97            LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Mflv_0325|M.gilvum_PYR-GCK          YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1       YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155      YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199      YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu      YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923          LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
                                       :*    : :       : * .:        *   *:   :  .   .

MMAR_5121|M.marinum_M               SQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATE
Rv3621c|M.tuberculosis_H37Rv        SQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATE
MAV_0535|M.avium_104                GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE
MUL_4195|M.ulcerans_Agy99           RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE
Mb1836|M.bovis_AF2122/97            AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Mflv_0325|M.gilvum_PYR-GCK          VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1       AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155      VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199      VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu      AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923          TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
                                     *  .*. *: :*:    .   :  *::    *: :*.:* *: .*   *

MMAR_5121|M.marinum_M               AQYGEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQT-VSAAGLANQAAAV
Rv3621c|M.tuberculosis_H37Rv        AQYAEMWAQDAAAMYGYAGASAAATQLSPFNPAAQT-INPAGLASQAASV
MAV_0535|M.avium_104                AQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPA-TDPAGLARQAAAT
MUL_4195|M.ulcerans_Agy99           AEYAKMWAQDANAMYQYAATAAAAADLTSFVPPRPA-TTANGPAAQAAAV
Mb1836|M.bovis_AF2122/97            AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQT-TNASGLAAQSAAI
Mflv_0325|M.gilvum_PYR-GCK          ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPS-VLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1       ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPF-VLAPGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155      ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPF-LLKPGVGEAGSAS
MAB_0809c|M.abscessus_ATCC_199      ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPS-ILHD---------
TH_3113|M.thermoresistible__bu      ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPP-ILGAGTGESATAA
MLBr_01182|M.leprae_Br4923          AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
                                    *:* .** * * :*  *      *   .    .                 

MMAR_5121|M.marinum_M               GQALN-GAVD-SQALA----------------------------------
Rv3621c|M.tuberculosis_H37Rv        GQAVS-GAAN-AQALT----------------------------------
MAV_0535|M.avium_104                AQAAGTGAGDSAQGLG----------------------------------
MUL_4195|M.ulcerans_Agy99           GRATGDLLAGDAQSLQ----------------------------------
Mb1836|M.bovis_AF2122/97            AHATGASAGAQQTTLS----------------------------------
Mflv_0325|M.gilvum_PYR-GCK          ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR--
Mvan_0415|M.vanbaalenii_PYR-1       ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR--
MSMEG_0619|M.smegmatis_MC2_155      ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK--
MAB_0809c|M.abscessus_ATCC_199      ---HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG--
TH_3113|M.thermoresistible__bu      ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL
MLBr_01182|M.leprae_Br4923          VVEEVVEEVVEAEQAIS---------------------------------
                                                                                      

MMAR_5121|M.marinum_M               ------------EIPKALS-QLAGIS--NEPPWLTDLTGAIGLTGHAWNS
Rv3621c|M.tuberculosis_H37Rv        ------------DIPKALF-GLSGIFT-NEPPWLTDLGKALGLTGHTWSS
MAV_0535|M.avium_104                ------------AAPQSMS-TLAAGT--NNPPAAN---PGFSLGGISLNP
MUL_4195|M.ulcerans_Agy99           ------------QLVEQLPNALRGLSEAALVPSLERILRALGLIGWKWTP
Mb1836|M.bovis_AF2122/97            ------------QLIAAIPSVLQGLSSSTAATSASGPSGLLGILGSGSSW
Mflv_0325|M.gilvum_PYR-GCK          ------------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA---
Mvan_0415|M.vanbaalenii_PYR-1       ------------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA---
MSMEG_0619|M.smegmatis_MC2_155      ------------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFN
MAB_0809c|M.abscessus_ATCC_199      ------------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA---
TH_3113|M.thermoresistible__bu      LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA
MLBr_01182|M.leprae_Br4923          --------------QAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVP
                                                         :                            

MMAR_5121|M.marinum_M               NGDGIIVGGALGDIVQGVTGSAEVDAGVFMDTFSKWVSPARLAVTQFKDY
Rv3621c|M.tuberculosis_H37Rv        DGSGLIVGGVLGDFVQGVTGSAELDASVAMDTFGKWVSPARLMVTQFKDY
MAV_0535|M.avium_104                EGDGLVIGGPLGDLLEGLTGSQTLDASTPFDAFIRLISPTRLFTTSFKDI
MUL_4195|M.ulcerans_Agy99           NGDGIVLSGALGALIAGPTGSSTLDASTLSNTYIRLVSPFRLTTTALKDI
Mb1836|M.bovis_AF2122/97            LDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFLGLLG------------
Mflv_0325|M.gilvum_PYR-GCK          -VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEE
Mvan_0415|M.vanbaalenii_PYR-1       -VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDA
MSMEG_0619|M.smegmatis_MC2_155      LVGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDE
MAB_0809c|M.abscessus_ATCC_199      -AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEP
TH_3113|M.thermoresistible__bu      VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADG
MLBr_01182|M.leprae_Br4923          DSSSAAAPQLWG------GFAQHLSPINDTLSMINNHAGMANAGLSLVNG
                                                        :                             

MMAR_5121|M.marinum_M               VGLAH-DLPKFAQEGAKAAAEAAKELPAVLP--SLPGVG-LGGITGAVGK
Rv3621c|M.tuberculosis_H37Rv        FGLAH-DLPKWASEGAKAAGEAAKALPAAVP--AIPSAG-LSGVAGAVGQ
MAV_0535|M.avium_104                QGIAQGMMPAAKSAGEGVAKAAEAVLPAAVPGAGLGSLGSLGSIGGSVGK
MUL_4195|M.ulcerans_Agy99           DGLSHSLFPAAAHAGQEAA-KAVEALPQALPKLSLSGVS--SGLGG-IGR
Mb1836|M.bovis_AF2122/97            -GVAA-ADAAGDVLGEATSGGLGGALVAPLG--SAGGLG--GTVAAGLGN
Mflv_0325|M.gilvum_PYR-GCK          AAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGA
Mvan_0415|M.vanbaalenii_PYR-1       PAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGA
MSMEG_0619|M.smegmatis_MC2_155      APQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAA
MAB_0809c|M.abscessus_ATCC_199      GSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-P
TH_3113|M.thermoresistible__bu      GASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVP
MLBr_01182|M.leprae_Br4923          MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSS-GGHVTAQLGR
                                                                                      

MMAR_5121|M.marinum_M               AASVTGLSVPTSWMNSVGAAANPAIVTVN-SLG-AAAAEPAQAAVGGVPL
Rv3621c|M.tuberculosis_H37Rv        AASVGGLKVPAVWTATTPAASPAVLAASN-GLGAAAAAEGSTHAFGGMPL
MAV_0535|M.avium_104                AASIGGLSVPASWASAAPTP-PSVAVALN-GATTAGAAEHAASAVGGVPM
MUL_4195|M.ulcerans_Agy99           AAQIGGLSVPNAWASSMPGLGRVATVPLSSVAAAAAAADPSQHVFGGLPA
Mb1836|M.bovis_AF2122/97            AATVGTLSVPPSWTAAAPLASPLGSALGG-----TPMVAPPPAVAAGMPG
Mflv_0325|M.gilvum_PYR-GCK          PAAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAAS
Mvan_0415|M.vanbaalenii_PYR-1       PAAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAAS
MSMEG_0619|M.smegmatis_MC2_155      PAPAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAAS
MAB_0809c|M.abscessus_ATCC_199      PVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAET
TH_3113|M.thermoresistible__bu      PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923          AASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPM
                                    ..      .                .                   .    

MMAR_5121|M.marinum_M               MPA----------------------------------SGVGRGMAAHFAA
Rv3621c|M.tuberculosis_H37Rv        MG-----------------------------------SGAGRAFN-NFAA
MAV_0535|M.avium_104                MPA----------------------------------GAAGRGAGAHFVV
MUL_4195|M.ulcerans_Agy99           HG------------------------------------TPARGFAASAAP
Mb1836|M.bovis_AF2122/97            MP-----------------------------------FGTMGGQGFGRAV
Mflv_0325|M.gilvum_PYR-GCK          AAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGA
Mvan_0415|M.vanbaalenii_PYR-1       AAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGA
MSMEG_0619|M.smegmatis_MC2_155      LASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGS
MAB_0809c|M.abscessus_ATCC_199      AAARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGA
TH_3113|M.thermoresistible__bu      AARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGI
MLBr_01182|M.leprae_Br4923          APMVP---------------------------------GGGSGTGGVNTA
                                                                                      

MMAR_5121|M.marinum_M               PRYGFKPTMVVHPPAGG---------------------------------
Rv3621c|M.tuberculosis_H37Rv        PRYGFKPTVIAQPPAGG---------------------------------
MAV_0535|M.avium_104                PRYGFKPTVIAQPPAGG---------------------------------
MUL_4195|M.ulcerans_Agy99           PRYGFHPRVMTRPPAAG---------------------------------
Mb1836|M.bovis_AF2122/97            PQYGFRPNFVARPPAAG---------------------------------
Mflv_0325|M.gilvum_PYR-GCK          GPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRH
Mvan_0415|M.vanbaalenii_PYR-1       GPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD--
MSMEG_0619|M.smegmatis_MC2_155      DAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP-
MAB_0809c|M.abscessus_ATCC_199      GTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP-------
TH_3113|M.thermoresistible__bu      RVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN------
MLBr_01182|M.leprae_Br4923          LRLQPRAFVMPRNPAAG---------------------------------
                                            .                                         

MMAR_5121|M.marinum_M               ----------------
Rv3621c|M.tuberculosis_H37Rv        ----------------
MAV_0535|M.avium_104                ----------------
MUL_4195|M.ulcerans_Agy99           ----------------
Mb1836|M.bovis_AF2122/97            ----------------
Mflv_0325|M.gilvum_PYR-GCK          TDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1       ----ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155      -----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199      -----EHGRQD-----
TH_3113|M.thermoresistible__bu      ----------------
MLBr_01182|M.leprae_Br4923          ----------------