For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAELQATASTYDALVTELTDGPWQGPSAANMVAAAM PQVEWLRNTAALAEQAGSQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATEAQY GEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQTVSAAGLANQAAAVGQALNGAVDSQALAEIPKALSQLA GISNEPPWLTDLTGAIGLTGHAWNSNGDGIIVGGALGDIVQGVTGSAEVDAGVFMDTFSKWVSPARLAVT QFKDYVGLAHDLPKFAQEGAKAAAEAAKELPAVLPSLPGVGLGGITGAVGKAASVTGLSVPTSWMNSVGA AANPAIVTVNSLGAAAAEPAQAAVGGVPLMPASGVGRGMAAHFAAPRYGFKPTMVVHPPAGG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_5121 | - | - | 100% (413) | PPE family protein |
M. marinum M | MMAR_5117 | - | e-108 | 51.54% (421) | PPE family protein, PPE65 |
M. marinum M | MMAR_1849 | - | 3e-84 | 44.34% (442) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1836 | PPE31 | 6e-79 | 45.27% (433) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 9e-30 | 37.50% (200) | PPE protein |
M. tuberculosis H37Rv | Rv3621c | PPE65 | 1e-171 | 73.73% (415) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 2e-43 | 33.18% (437) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_0809c | - | 2e-30 | 46.25% (160) | PPE family protein |
M. avium 104 | MAV_0535 | - | 1e-121 | 54.63% (421) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-30 | 28.97% (428) | PPE family protein |
M. thermoresistible (build 8) | TH_3113 | - | 2e-35 | 31.37% (408) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_4195 | - | 1e-106 | 50.83% (421) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-33 | 41.79% (201) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5121|M.marinum_M ------------MLDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAE Rv3621c|M.tuberculosis_H37Rv ------------MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAE MAV_0535|M.avium_104 -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE MUL_4195|M.ulcerans_Agy99 ------------MLDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAE Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE .*: :* : *.*...: :*. * *. . MMAR_5121|M.marinum_M LQATASTYDALVTELTDGPWQGPSAANMVAAAMPQVEWLRNTAALAEQAG Rv3621c|M.tuberculosis_H37Rv LQTTASTYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAG MAV_0535|M.avium_104 LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA MUL_4195|M.ulcerans_Agy99 LQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA :* : : : * .: * *: : . . MMAR_5121|M.marinum_M SQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATE Rv3621c|M.tuberculosis_H37Rv SQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATE MAV_0535|M.avium_104 GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE MUL_4195|M.ulcerans_Agy99 RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE * .*. *: :*: . : *:: *: :*.:* *: .* * MMAR_5121|M.marinum_M AQYGEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQT-VSAAGLANQAAAV Rv3621c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYAGASAAATQLSPFNPAAQT-INPAGLASQAASV MAV_0535|M.avium_104 AQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPA-TDPAGLARQAAAT MUL_4195|M.ulcerans_Agy99 AEYAKMWAQDANAMYQYAATAAAAADLTSFVPPRPA-TTANGPAAQAAAV Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQT-TNASGLAAQSAAI Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPS-VLLPGVGEAGRAA Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPF-VLAPGVGEAGRAA MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPF-LLKPGVGEAGSAS MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPS-ILHD--------- TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPP-ILGAGTGESATAA MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE *:* .** * * :* * * . . MMAR_5121|M.marinum_M GQALN-GAVD-SQALA---------------------------------- Rv3621c|M.tuberculosis_H37Rv GQAVS-GAAN-AQALT---------------------------------- MAV_0535|M.avium_104 AQAAGTGAGDSAQGLG---------------------------------- MUL_4195|M.ulcerans_Agy99 GRATGDLLAGDAQSLQ---------------------------------- Mb1836|M.bovis_AF2122/97 AHATGASAGAQQTTLS---------------------------------- Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR-- Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR-- MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK-- MAB_0809c|M.abscessus_ATCC_199 ---HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG-- TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS--------------------------------- MMAR_5121|M.marinum_M ------------EIPKALS-QLAGIS--NEPPWLTDLTGAIGLTGHAWNS Rv3621c|M.tuberculosis_H37Rv ------------DIPKALF-GLSGIFT-NEPPWLTDLGKALGLTGHTWSS MAV_0535|M.avium_104 ------------AAPQSMS-TLAAGT--NNPPAAN---PGFSLGGISLNP MUL_4195|M.ulcerans_Agy99 ------------QLVEQLPNALRGLSEAALVPSLERILRALGLIGWKWTP Mb1836|M.bovis_AF2122/97 ------------QLIAAIPSVLQGLSSSTAATSASGPSGLLGILGSGSSW Mflv_0325|M.gilvum_PYR-GCK ------------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA--- Mvan_0415|M.vanbaalenii_PYR-1 ------------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA--- MSMEG_0619|M.smegmatis_MC2_155 ------------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFN MAB_0809c|M.abscessus_ATCC_199 ------------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA--- TH_3113|M.thermoresistible__bu LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA MLBr_01182|M.leprae_Br4923 --------------QAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVP : MMAR_5121|M.marinum_M NGDGIIVGGALGDIVQGVTGSAEVDAGVFMDTFSKWVSPARLAVTQFKDY Rv3621c|M.tuberculosis_H37Rv DGSGLIVGGVLGDFVQGVTGSAELDASVAMDTFGKWVSPARLMVTQFKDY MAV_0535|M.avium_104 EGDGLVIGGPLGDLLEGLTGSQTLDASTPFDAFIRLISPTRLFTTSFKDI MUL_4195|M.ulcerans_Agy99 NGDGIVLSGALGALIAGPTGSSTLDASTLSNTYIRLVSPFRLTTTALKDI Mb1836|M.bovis_AF2122/97 LDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFLGLLG------------ Mflv_0325|M.gilvum_PYR-GCK -VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEE Mvan_0415|M.vanbaalenii_PYR-1 -VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDA MSMEG_0619|M.smegmatis_MC2_155 LVGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDE MAB_0809c|M.abscessus_ATCC_199 -AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEP TH_3113|M.thermoresistible__bu VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADG MLBr_01182|M.leprae_Br4923 DSSSAAAPQLWG------GFAQHLSPINDTLSMINNHAGMANAGLSLVNG : MMAR_5121|M.marinum_M VGLAH-DLPKFAQEGAKAAAEAAKELPAVLP--SLPGVG-LGGITGAVGK Rv3621c|M.tuberculosis_H37Rv FGLAH-DLPKWASEGAKAAGEAAKALPAAVP--AIPSAG-LSGVAGAVGQ MAV_0535|M.avium_104 QGIAQGMMPAAKSAGEGVAKAAEAVLPAAVPGAGLGSLGSLGSIGGSVGK MUL_4195|M.ulcerans_Agy99 DGLSHSLFPAAAHAGQEAA-KAVEALPQALPKLSLSGVS--SGLGG-IGR Mb1836|M.bovis_AF2122/97 -GVAA-ADAAGDVLGEATSGGLGGALVAPLG--SAGGLG--GTVAAGLGN Mflv_0325|M.gilvum_PYR-GCK AAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGA Mvan_0415|M.vanbaalenii_PYR-1 PAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGA MSMEG_0619|M.smegmatis_MC2_155 APQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAA MAB_0809c|M.abscessus_ATCC_199 GSVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-P TH_3113|M.thermoresistible__bu GASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVP MLBr_01182|M.leprae_Br4923 MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSS-GGHVTAQLGR MMAR_5121|M.marinum_M AASVTGLSVPTSWMNSVGAAANPAIVTVN-SLG-AAAAEPAQAAVGGVPL Rv3621c|M.tuberculosis_H37Rv AASVGGLKVPAVWTATTPAASPAVLAASN-GLGAAAAAEGSTHAFGGMPL MAV_0535|M.avium_104 AASIGGLSVPASWASAAPTP-PSVAVALN-GATTAGAAEHAASAVGGVPM MUL_4195|M.ulcerans_Agy99 AAQIGGLSVPNAWASSMPGLGRVATVPLSSVAAAAAAADPSQHVFGGLPA Mb1836|M.bovis_AF2122/97 AATVGTLSVPPSWTAAAPLASPLGSALGG-----TPMVAPPPAVAAGMPG Mflv_0325|M.gilvum_PYR-GCK PAAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAAS Mvan_0415|M.vanbaalenii_PYR-1 PAAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAAS MSMEG_0619|M.smegmatis_MC2_155 PAPAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAAS MAB_0809c|M.abscessus_ATCC_199 PVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAET TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA MLBr_01182|M.leprae_Br4923 AASIGSLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPM .. . . . MMAR_5121|M.marinum_M MPA----------------------------------SGVGRGMAAHFAA Rv3621c|M.tuberculosis_H37Rv MG-----------------------------------SGAGRAFN-NFAA MAV_0535|M.avium_104 MPA----------------------------------GAAGRGAGAHFVV MUL_4195|M.ulcerans_Agy99 HG------------------------------------TPARGFAASAAP Mb1836|M.bovis_AF2122/97 MP-----------------------------------FGTMGGQGFGRAV Mflv_0325|M.gilvum_PYR-GCK AAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGA Mvan_0415|M.vanbaalenii_PYR-1 AAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGA MSMEG_0619|M.smegmatis_MC2_155 LASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGS MAB_0809c|M.abscessus_ATCC_199 AAARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGA TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGI MLBr_01182|M.leprae_Br4923 APMVP---------------------------------GGGSGTGGVNTA MMAR_5121|M.marinum_M PRYGFKPTMVVHPPAGG--------------------------------- Rv3621c|M.tuberculosis_H37Rv PRYGFKPTVIAQPPAGG--------------------------------- MAV_0535|M.avium_104 PRYGFKPTVIAQPPAGG--------------------------------- MUL_4195|M.ulcerans_Agy99 PRYGFHPRVMTRPPAAG--------------------------------- Mb1836|M.bovis_AF2122/97 PQYGFRPNFVARPPAAG--------------------------------- Mflv_0325|M.gilvum_PYR-GCK GPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRH Mvan_0415|M.vanbaalenii_PYR-1 GPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD-- MSMEG_0619|M.smegmatis_MC2_155 DAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP- MAB_0809c|M.abscessus_ATCC_199 GTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP------- TH_3113|M.thermoresistible__bu RVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN------ MLBr_01182|M.leprae_Br4923 LRLQPRAFVMPRNPAAG--------------------------------- . MMAR_5121|M.marinum_M ---------------- Rv3621c|M.tuberculosis_H37Rv ---------------- MAV_0535|M.avium_104 ---------------- MUL_4195|M.ulcerans_Agy99 ---------------- Mb1836|M.bovis_AF2122/97 ---------------- Mflv_0325|M.gilvum_PYR-GCK TDGRDGHDGHDGKEKP Mvan_0415|M.vanbaalenii_PYR-1 ----ERHNHHDGKDSQ MSMEG_0619|M.smegmatis_MC2_155 -----SPDDPEGGPRR MAB_0809c|M.abscessus_ATCC_199 -----EHGRQD----- TH_3113|M.thermoresistible__bu ---------------- MLBr_01182|M.leprae_Br4923 ----------------