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DYAALPPEVNSARMYTGPGSGPMLAAALAWDGLSTELSSAAADYSSALAAMTSGPWRGPASTSMASAAAP YIAWMAGTATQALQASLQAKAAAGAYEAAFAVTVPPPMIAANRALLASLVATNLLGQNTPAIAAAEATYG EMWAQDAAAMYGYAACCATATRLTPFADPPPTTSPEAGLIAQAATTSSAQSQASLSQVMSMVPTALQGLA SPSASGVTITEVAGALGLGAPQLDGIQSWLGLQGIDLTTPSGLLAFFNGTDGSPLGTAVNAITTNAIGSG FYTPGNFFGTMCDFFGLSSFSAMDAAEDAAIAASSGLGGAAPGLGGFGGLGTAVSAGVGNAASIGSLSVP PTWAATSPVGAAVATLPSVAAGAPLTAHGPASMLGGLPLSGFGGRGFSEVPRYGFKPTVVMHPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1849 | - | - | 100% (418) | PPE family protein |
| M. marinum M | MMAR_2683 | - | 2e-89 | 48.47% (425) | PPE family protein, PPE31 |
| M. marinum M | MMAR_2681 | - | 3e-86 | 44.64% (457) | PPE family protein, PPE31_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 7e-99 | 49.30% (430) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-34 | 41.80% (189) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 2e-98 | 49.30% (430) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 8e-47 | 34.76% (443) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 4e-31 | 38.42% (190) | PPE family protein |
| M. avium 104 | MAV_0535 | - | 4e-86 | 44.22% (441) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-34 | 30.33% (422) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-37 | 30.16% (431) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 7e-89 | 48.24% (425) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-37 | 45.18% (197) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MUL_3074|M.ulcerans_Agy99 ---------MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAE
MMAR_1849|M.marinum_M -------------MDYAALPPEVNSARMYTGPGSGPMLAAALAWDGLSTE
MAV_0535|M.avium_104 -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** :* : *.*...: :*. :* *: *
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MUL_3074|M.ulcerans_Agy99 LRVTVLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESA
MMAR_1849|M.marinum_M LSSAAADYSSALAAMTSGPWRGPASTSMASAAAPYIAWMAGTATQALQAS
MAV_0535|M.avium_104 LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:. : : : * .: * *: : . .
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MUL_3074|M.ulcerans_Agy99 VQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVE
MMAR_1849|M.marinum_M LQAKAAAGAYEAAFAVTVPPPMIAANRALLASLVATNLLGQNTPAIAAAE
MAV_0535|M.avium_104 GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .*. *: *:: . : *:: *: :*.:* *: .** *
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQTTN-ASGLAAQSAAI
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQTTN-ASGLAAQSAAI
MUL_3074|M.ulcerans_Agy99 AQYCEMWAQDAMAMYGYAGSSAAATRLSEFLAPQHNTN-PAGLLAQ----
MMAR_1849|M.marinum_M ATYGEMWAQDAAAMYGYAACCATATRLTPFADPPPTTSPEAGLIAQAATT
MAV_0535|M.avium_104 AQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPATD-PAGLARQAAAT
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVL-LPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVL-APGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLL-KPGVGEAGSAS
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVL-SPDSGAAART-
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPIL-GAGTGESATAA
* * .** * * .* * : . . .
Mb1836|M.bovis_AF2122/97 AHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAA---------------
Rv1807|M.tuberculosis_H37Rv AHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAA---------------
MUL_3074|M.ulcerans_Agy99 -----------QSTLAQLMSAVPNVLQGLASSN-----------------
MMAR_1849|M.marinum_M SSAQS------QASLSQVMSMVPTALQGLASPSASG--------------
MAV_0535|M.avium_104 AQAAGTG----AGDSAQGLGAAPQSMSTLAAGTNN---------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQ--------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EVLRFL
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------ELLRFL
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QGVPGG
MAB_4783|M.abscessus_ATCC_1997 ------AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QHFLGM
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTL
:
Mb1836|M.bovis_AF2122/97 -------------TSASGPSGLLG----ILGSGSSWL----------DKL
Rv1807|M.tuberculosis_H37Rv -------------TFASGPSGLLG----IVGSGSSWL----------DKL
MUL_3074|M.ulcerans_Agy99 -------------TSASAPSGLLST--LLSGNGQSWL----------ATL
MMAR_1849|M.marinum_M -------------VTITEVAGALGLGAPQLDGIQSWLGLQGIDLTTPSGL
MAV_0535|M.avium_104 -------------PPAANPGFSLGGISLNPEGDGLVIG---------GPL
MLBr_01182|M.leprae_Br4923 -------------VDQQVNVDVATPQTAVPDSSSAAAP----------QL
Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA---
Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA---
MSMEG_0619|M.smegmatis_MC2_155 -QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFN
MAB_4783|M.abscessus_ATCC_1997 YRALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA---
TH_3113|M.thermoresistible__bu LAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVA
Mb1836|M.bovis_AF2122/97 WALLD-----PNSNFWNTIAS----SGLFLPSN----TIAPFLGLLGGVA
Rv1807|M.tuberculosis_H37Rv WALLD-----PNSNFWNTIAS----SGLFLPSN----TIAPFLGLLGGVA
MUL_3074|M.ulcerans_Agy99 WSEFG-----PNANIWNTIAS----TGFLLPSN----MVTPFLGMLDTAA
MMAR_1849|M.marinum_M LAFFNGTDGSPLGTAVNAITTNAIGSGFYTPGNFFG-TMCDFFG-LSSFS
MAV_0535|M.avium_104 GDLLEG---LTGSQTLDASTPFDAFIRLISPTRLFTTSFKDIQGIAQGMM
MLBr_01182|M.leprae_Br4923 WGGFAQ----HLSPINDTLSMINNHAGMANAGLS-------LVNGMGSAM
Mflv_0325|M.gilvum_PYR-GCK -VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ------HLLSLLNTPP
Mvan_0415|M.vanbaalenii_PYR-1 -VSWVGASILYPSLLLLPLVATT--LAIVLGVGA------YLLENLPAPA
MSMEG_0619|M.smegmatis_MC2_155 LVGWPTWGMIFASPFLIPALAALGITGLVLLIDH------VLNNPVDVPA
MAB_4783|M.abscessus_ATCC_1997 --TFAVMGTPIYAAIMGPAAGISIPLAITLAS---------LSQMPEAPP
TH_3113|M.thermoresistible__bu VSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGL---AGLAGLTAVPA
:
Mb1836|M.bovis_AF2122/97 -AADAAGDVLGEATSGGLGGALVAP-LGSAG-GLGGTVAAGLGNAATVG-
Rv1807|M.tuberculosis_H37Rv -AADAAGDVLGEATSGGLGGALVAP-LGSAG-GLGGTVAAGLGNAATVG-
MUL_3074|M.ulcerans_Agy99 -VADAAEDALRTTGSGALGGALSAP-LGSVG-GQAGLAAA--GNAAIVG-
MMAR_1849|M.marinum_M -AMDAAEDAAIAASSG-LGGAAPG--LGGFG-GLGTAVSAGVGNAASIG-
MAV_0535|M.avium_104 PAAKSAGEGVAKAAEAVLPAAVPGAGLGSLG-SLG-SIGGSVGKAASIG-
MLBr_01182|M.leprae_Br4923 KSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIG-
Mflv_0325|M.gilvum_PYR-GCK AEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP--
Mvan_0415|M.vanbaalenii_PYR-1 EDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA--
MSMEG_0619|M.smegmatis_MC2_155 EDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG--
MAB_4783|M.abscessus_ATCC_1997 VDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA--
TH_3113|M.thermoresistible__bu ADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGH
. .
Mb1836|M.bovis_AF2122/97 -TLSVPPSWTAAAP--LASPLG---SALGGTPMVAPPPAVAAGMPGMPFG
Rv1807|M.tuberculosis_H37Rv -TLSVPPSWTAAAP--LASPLG---SALGGTPMVAPPPAVAAGMPGMPFG
MUL_3074|M.ulcerans_Agy99 -KLSVPPSWTGAAP--LASPLG---SALGGTPMVAPPPTAAAGMPGMPFG
MMAR_1849|M.marinum_M -SLSVPPTWAATSP--VGAAVATLPSVAAGAPLTAHGPASMLG--GLPLS
MAV_0535|M.avium_104 -GLSVPASWASAAP--TPPSVAVALNGATTAGAAEHAASAVGGVPMMPAG
MLBr_01182|M.leprae_Br4923 -SLRVPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMV
Mflv_0325|M.gilvum_PYR-GCK ---PAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAA
Mvan_0415|M.vanbaalenii_PYR-1 ---PAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAA
MSMEG_0619|M.smegmatis_MC2_155 ---TTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAA
MAB_4783|M.abscessus_ATCC_1997 ---PAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVS
TH_3113|M.thermoresistible__bu SVPPAPHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSA
. : . .
Mb1836|M.bovis_AF2122/97 TMG--GQGFGRAVPQYGFRPNFVARPPAAG--------------------
Rv1807|M.tuberculosis_H37Rv TMG--GQGFGRAVPQYGFRPNFVARPPAAG--------------------
MUL_3074|M.ulcerans_Agy99 NMA--GQPFGRALPQYGFRPTFVARPPAAG--------------------
MMAR_1849|M.marinum_M GFG--GRGFS-EVPRYGFKPTVVMHPPAAG--------------------
MAV_0535|M.avium_104 AAGR-GAGAHFVVPRYGFKPTVIAQPPAGG--------------------
MLBr_01182|M.leprae_Br4923 PGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------------
Mflv_0325|M.gilvum_PYR-GCK ASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRV
Mvan_0415|M.vanbaalenii_PYR-1 ASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRI
MSMEG_0619|M.smegmatis_MC2_155 ASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRV
MAB_4783|M.abscessus_ATCC_1997 AAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTA
TH_3113|M.thermoresistible__bu AAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AAT
. . : . :
Mb1836|M.bovis_AF2122/97 --------------------------------------------------
Rv1807|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3074|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1849|M.marinum_M --------------------------------------------------
MAV_0535|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK TASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDP
Mvan_0415|M.vanbaalenii_PYR-1 AATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDP
MSMEG_0619|M.smegmatis_MC2_155 RASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDG
MAB_4783|M.abscessus_ATCC_1997 VASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDV
TH_3113|M.thermoresistible__bu APSAAGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPA
Mb1836|M.bovis_AF2122/97 -----------------------
Rv1807|M.tuberculosis_H37Rv -----------------------
MUL_3074|M.ulcerans_Agy99 -----------------------
MMAR_1849|M.marinum_M -----------------------
MAV_0535|M.avium_104 -----------------------
MLBr_01182|M.leprae_Br4923 -----------------------
Mflv_0325|M.gilvum_PYR-GCK DATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 TDDDR------------------
TH_3113|M.thermoresistible__bu EPN--------------------