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MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAELRSAAASFGSVITGVGDAGWQGPAASS MMAAAAPQLAWLSGTAGRAELAAGQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIA DVEAQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPATDPAGLARQAAATAQAAGTGAGDSAQGLGAA PQSMSTLAAGTNNPPAANPGFSLGGISLNPEGDGLVIGGPLGDLLEGLTGSQTLDASTPFDAFIRLISPT RLFTTSFKDIQGIAQGMMPAAKSAGEGVAKAAEAVLPAAVPGAGLGSLGSLGSIGGSVGKAASIGGLSVP ASWASAAPTPPSVAVALNGATTAGAAEHAASAVGGVPMMPAGAAGRGAGAHFVVPRYGFKPTVIAQPPAG G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0535 | - | - | 100% (421) | PPE family protein |
| M. avium 104 | MAV_2926 | - | 8e-78 | 42.99% (442) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 2e-77 | 41.95% (441) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 1e-84 | 45.54% (426) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-32 | 39.70% (199) | PPE protein |
| M. tuberculosis H37Rv | Rv3621c | PPE65 | 1e-119 | 56.43% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-46 | 33.26% (436) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 5e-30 | 29.95% (414) | PPE family protein |
| M. marinum M | MMAR_5121 | - | 1e-121 | 54.63% (421) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-34 | 32.08% (427) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 7e-37 | 33.18% (428) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4195 | - | 1e-102 | 51.06% (423) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-36 | 30.54% (429) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3621c|M.tuberculosis_H37Rv ------------MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAE
MMAR_5121|M.marinum_M ------------MLDFAQLPPEVNSALMYSGPGSGPMLTAAAAWDVLAAE
MAV_0535|M.avium_104 -------MLNFGQLDFAQLPPEINSGLMYSGPGAGPLLAAAAAWNGLAAE
MUL_4195|M.ulcerans_Agy99 ------------MLDFALLPPKVNSTLMYSGPGSGSMLAAAAAWQALGAE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.*: :* : *.*...: :*. :* *. *
Rv3621c|M.tuberculosis_H37Rv LQTTASTYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAG
MMAR_5121|M.marinum_M LQATASTYDALVTELTDGPWQGPSAANMVAAAMPQVEWLRNTAALAEQAG
MAV_0535|M.avium_104 LRSAAASFGSVITGVGDAGWQGPAASSMMAAAAPQLAWLSGTAGRAELAA
MUL_4195|M.ulcerans_Agy99 LQCTADSYRSLLSGLVSGPWSGPAAAAMSAAAAPHLAWLSATAAQAEQVG
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
:* : : : * .: * *: : . ..
Rv3621c|M.tuberculosis_H37Rv SQAVAAASAYEAAFFATVPPPEIAANRALLMALLATNFLGQNTAAIAATE
MMAR_5121|M.marinum_M SQAVAAAGAYEAAFVATVPPPVIAANRALLMALMATNFLGQNTGAIAATE
MAV_0535|M.avium_104 GQALAAVSAYETAFAETVPPPVIAANRALLLQLLATNFLGQNTPAIADVE
MUL_4195|M.ulcerans_Agy99 RQAAAAASAYEAAFAGMVPPAVVAANRAMLATLVATNLFGQNTPAIAVVE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* .*. *: *: . : *:: *: :*.:* *: .** *
Rv3621c|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYAGASAAATQLSPFNPAAQTINPAGLASQAASVG
MMAR_5121|M.marinum_M AQYGEMWAQDAAAMYGYAGSSAAAAQLAPFDPAAQTVSAAGLANQAAAVG
MAV_0535|M.avium_104 AQYGEMWAQDAAAMYGYALASAAASTLPPFEPAKPATDPAGLARQAAATA
MUL_4195|M.ulcerans_Agy99 AEYAKMWAQDANAMYQYAATAAAAADLTSFVPPRPATTANGPAAQAAAVG
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAATQLTPFTEPVQTTNASGLAAQSAAIA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* .** * * .* * : . .
Rv3621c|M.tuberculosis_H37Rv QAVS-GAAN-AQALTDIPKALF-GLSGIFT-NEPP---------------
MMAR_5121|M.marinum_M QALN-GAVD-SQALAEIPKALS-QLAGIS--NEPP---------------
MAV_0535|M.avium_104 QAAGTGAGDSAQGLGAAPQSMS-TLAAGT--NNPP---------------
MUL_4195|M.ulcerans_Agy99 RATGDLLAGDAQSLQQLVEQLPNALRGLSEAALVP---------------
Mb1836|M.bovis_AF2122/97 HATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAAT---------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVP---------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG----------EVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG----------ELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLD-LSSIISDLLNQYL----------QGVPGG-
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPD-PNDPIEMLLKNS-----------QHFLGMY
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
:
Rv3621c|M.tuberculosis_H37Rv ----------WLTDLGKALGLTGHTWSSDGSGLIVGGVLGDFVQGVTGSA
MMAR_5121|M.marinum_M ----------WLTDLTGAIGLTGHAWNSNGDGIIVGGALGDIVQGVTGSA
MAV_0535|M.avium_104 ----------AAN---PGFSLGGISLNPEGDGLVIGGPLGDLLEGLTGSQ
MUL_4195|M.ulcerans_Agy99 ----------SLERILRALGLIGWKWTPNGDGIVLSGALGALIAGPTGSS
Mb1836|M.bovis_AF2122/97 ----------SASGPSGLLGILGSGSSWLDKLWALLDPNSNFWNTIASSG
MLBr_01182|M.leprae_Br4923 ----------QVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLS--P
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLR---DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLR---DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 QAILDFLK---DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_4783|M.abscessus_ATCC_1997 RALKGLIT---DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Rv3621c|M.tuberculosis_H37Rv ELDASVAMDTFGKWVSPARLMVTQFKDYFGLAH---------DLPKWASE
MMAR_5121|M.marinum_M EVDAGVFMDTFSKWVSPARLAVTQFKDYVGLAH---------DLPKFAQE
MAV_0535|M.avium_104 TLDASTPFDAFIRLISPTRLFTTSFKDIQGIAQG--------MMPAAKSA
MUL_4195|M.ulcerans_Agy99 TLDASTLSNTYIRLVSPFRLTTTALKDIDGLSHS--------LFPAAAHA
Mb1836|M.bovis_AF2122/97 LFLPSNTIAPFLGLLG-------------GVAA---------ADAAGDVL
MLBr_01182|M.leprae_Br4923 INDTLSMINNHAGMANAG----LSLVNGMGSAMK--------SLAPTTTK
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPVDVPAEDEA
MAB_4783|M.abscessus_ATCC_1997 -TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMPEAPPVDAP
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
.
Rv3621c|M.tuberculosis_H37Rv GAKAAGEAAKALPAAVP--AIPSAG-LSGVAGAVGQAASVGGLK------
MMAR_5121|M.marinum_M GAKAAAEAAKELPAVLP--SLPGVG-LGGITGAVGKAASVTGLS------
MAV_0535|M.avium_104 GEGVAKAAEAVLPAAVPGAGLGSLGSLGSIGGSVGKAASIGGLS------
MUL_4195|M.ulcerans_Agy99 GQEAA-KAVEALPQALPKLSLSGVS--SGLGG-IGRAAQIGGLS------
Mb1836|M.bovis_AF2122/97 GEATSGGLGGALVAPLG--SAGGLG--GTVAAGLGNAATVGTLS------
MLBr_01182|M.leprae_Br4923 AAESAFKAMGSAVQSTGRGLLGSSS-GGHVTAQLGRAASIGSLR------
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSP-----P
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTA-----P
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAG-----T
MAB_4783|M.abscessus_ATCC_1997 AETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPGSA-----P
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
. .
Rv3621c|M.tuberculosis_H37Rv VPAVWTATTPAASPAVLAASN-GLGAAAAAEGSTHAFGGMPLMG-S-GAG
MMAR_5121|M.marinum_M VPTSWMNSVGAAANPAIVTVN-SLG-AAAAEPAQAAVGGVPLMPAS-GVG
MAV_0535|M.avium_104 VPASWASAAPTP-PSVAVALN-GATTAGAAEHAASAVGGVPMMPAG-AAG
MUL_4195|M.ulcerans_Agy99 VPNAWASSMPGLGRVATVPLSSVAAAAAAADPSQHVFGGLPAHG---TPA
Mb1836|M.bovis_AF2122/97 VPPSWTAAAPLASPLGSALGG-----TPMVAPPPAVAAGMPGMP-F-GTM
MLBr_01182|M.leprae_Br4923 VPQTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGG
Mflv_0325|M.gilvum_PYR-GCK APGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGI
Mvan_0415|M.vanbaalenii_PYR-1 APGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGV
MSMEG_0619|M.smegmatis_MC2_155 TVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGV
MAB_4783|M.abscessus_ATCC_1997 AP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEPAGSAAAAA
. .
Rv3621c|M.tuberculosis_H37Rv RAFN-NFAAPRYGFKPTVIAQPPAGG------------------------
MMAR_5121|M.marinum_M RGMAAHFAAPRYGFKPTMVVHPPAGG------------------------
MAV_0535|M.avium_104 RGAGAHFVVPRYGFKPTVIAQPPAGG------------------------
MUL_4195|M.ulcerans_Agy99 RGFAASAAPPRYGFHPRVMTRPPAAG------------------------
Mb1836|M.bovis_AF2122/97 GGQGFGRAVPQYGFRPNFVARPPAAG------------------------
MLBr_01182|M.leprae_Br4923 SGTGGVNTALRLQPRAFVMPRNPAAG------------------------
Mflv_0325|M.gilvum_PYR-GCK AASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTAST
Mvan_0415|M.vanbaalenii_PYR-1 AASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATE
MSMEG_0619|M.smegmatis_MC2_155 AASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASE
MAB_4783|M.abscessus_ATCC_1997 LACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-----------AATAPSA
. : . :
Rv3621c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5121|M.marinum_M --------------------------------------------------
MAV_0535|M.avium_104 --------------------------------------------------
MUL_4195|M.ulcerans_Agy99 --------------------------------------------------
Mb1836|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK RGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATD
Mvan_0415|M.vanbaalenii_PYR-1 RGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEP
MSMEG_0619|M.smegmatis_MC2_155 RGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENP
MAB_4783|M.abscessus_ATCC_1997 TGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDD
TH_3113|M.thermoresistible__bu AGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRAHRPAEPN-
Rv3621c|M.tuberculosis_H37Rv -------------------
MMAR_5121|M.marinum_M -------------------
MAV_0535|M.avium_104 -------------------
MUL_4195|M.ulcerans_Agy99 -------------------
Mb1836|M.bovis_AF2122/97 -------------------
MLBr_01182|M.leprae_Br4923 -------------------
Mflv_0325|M.gilvum_PYR-GCK DRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 D------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 R------------------
TH_3113|M.thermoresistible__bu -------------------